Clinical Trials on Epilepsy in South Africa

Total 113 results

Bial - Portela C S.A.

Completed

An Open-label, Multiple-dose, Single-centre Study, Investigating the Pharmacokinetics of BIA 2-093

Epilepsy

South Africa
Bial - Portela C S.A.

Completed

An Open-label, Single-dose, Single-centre Study, Investigating the Pharmacokinetics of BIA 2-093

Epilepsy

South Africa
University of Cape Town

Completed

The Role of Melatonin in the Effective Attainment of Sleep Electroencephalograms (EEG) in Children

Epilepsy | Children | Sedation | Electroencephalogram

South Africa
Medical University of South Carolina

Completed

The Effect of Music Periodicity on Interictal Epileptiform Discharges

Epilepsy | Seizures | Rolandic Epilepsy | Benign Childhood Epilepsy With Centrotemporal Spikes

United States
Cerebral Therapeutics LLC

Terminated

Study to Assess Intracerebroventricular (ICV) Delivery of CT-010 in Subjects With Focal Seizures, With Temporal Lobe Onset With or Without Secondary Generalization

Refractory Epilepsy

Israel, Australia
Monteris Medical

Terminated

Feasibility Study on LITT for Medical Refractory Epilepsy

Epilepsy

United States
Xenon Pharmaceuticals Inc.

Terminated

An Open-Label Extension of the Study XEN496 (Ezogabine) in Children With KCNQ2-DEE (EPIK-OLE)

Brain Diseases | Central Nervous System Diseases | Nervous System Diseases | Epilepsy | Epileptic Syndromes | Disease | Epilepsy; Seizure | Epilepsy in Children

United States, Australia, Belgium
Cerebral Therapeutics LLC

Terminated

Anti-Epilepsy Medication Valproate Administered Via ICV Route and Catheters and Pumps for CSF Infusion

Focal Epilepsy

Israel, Australia
Cerecin

Active, not recruiting

Tricaprilin Infantile Spasms Pilot Study

Infantile Spasm

Singapore, Australia
UCB Pharma

Completed

A Study to Look at the Efficacy and Safety of Keppra® Extended Release Formulation - XR

Epilepsy

Brazil, Finland, India, Mexico, Russian Federation, South Africa, Ukraine
UCB Pharma

Completed

A 19-week Cognition Study of Levetiracetam in Children With Partial Onset Seizures

Epilepsy, Partial

United States, South Africa, Canada
Xenon Pharmaceuticals Inc.

Terminated

XEN496 (Ezogabine) in Children With KCNQ2 Developmental and Epileptic Encephalopathy (EPIK)

Brain Diseases | Central Nervous System Diseases | Nervous System Diseases | Epilepsy | Epileptic Syndromes | Disease | Epilepsy; Seizure | Epilepsy in Children

United States, Spain, Australia, Belgium, Italy
Epitel, Inc.

Recruiting

Impact of Capturing Ictal Events With Ultra-long-term Ambulatory EEG Monitoring With Remote EEG Monitoring System. (REMI)

Epilepsy | Seizures

United States
UCB Biopharma SRL

Recruiting

A Study to Evaluate the Efficacy, Safety, and Tolerability of Brivaracetam as Monotherapy in Patients 2 to 25 Years of Age With Childhood Absence Epilepsy or Juvenile Absence Epilepsy (EXPAND)

Childhood Absence Epilepsy | Juvenile Absence Epilepsy

United States, Australia, Georgia, Italy, Poland, Romania, Slovakia, Spain, Ukraine, Belgium
VA Office of Research and Development

Enrolling by invitation

Testing a Novel Dry Electrode Headset for Electroencephalography Telehealth

Epilepsy

United States
Elpen Pharmaceutical Co. Inc.

Completed

LevetIracetam in Patients Being Treated for Epilepsy (LIBERTY)

Epilepsy

Greece
Eisai Inc.

Completed

A Double-blind Study to Compare the Efficacy and Safety of Zonisamide and Carbamazepine as Monotherapy, in Newly Diagnosed Partial Epilepsy

Epilepsy

Australia, France, Poland, Germany, Spain, India, Serbia, Greece, Korea, Republic of, Russian Federation, Taiwan, Hungary, Italy, Sweden, Denmark, Slovakia, United Kingdom, South Africa
Children's Hospital Medical Center, Cincinnati
Medical University of South Carolina; National Institute of Nursing Research... and other collaborators

Active, not recruiting

Epilepsy Adherence in Children and Technology (eACT) (eACT)

Epilepsy

United States
Stichting Epilepsie Instellingen Nederland
Leiden University

Recruiting

Smartphone Behavior and Epilepsy Management

Epilepsy

Netherlands
Medical University of South Carolina
MIND Research Institute

Completed

Reduction and Prevention of Seizure Occurrence From Exposure to Auditory Stimulation in Individuals With Neurological Handicaps

Epilepsy | Seizures

United States
Biohaven Therapeutics Ltd.

Recruiting

Study to Determine if BHV-7000 is Effective and Safe in Adults With Refractory Focal Onset Epilepsy (RISE 3)

Focal Epilepsy

United States
Eisai Limited

Completed

A Study to Investigate Dosage, Effectiveness, and Safety of Perampanel When Used as First Add-on Therapy in Participants >=12 Years With Partial Onset Seizures With or Without Secondary Generalization or With Primary Generalized Tonic-Clonic Seizures Associated With Idiopathic Generalized Epilepsy

Idiopathic Generalized Epilepsy | Partial Onset Seizures | Generalised Tonic-Clonic Seizures

France, Spain, Italy, Denmark, Germany, Portugal, Russian Federation
ElectroCore INC

Terminated

Neurostimulation to the Vagus Nerve for the Reduction in Frequency of Seizures Associated With Epilepsy

Seizure

Australia
UCB Pharma

Completed

Long-Term, Follow-Up Study Of the Safety And Efficacy Of Levetiracetam In Children With Partial Onset Seizures

Epilepsy, Partial

United States, France, United Kingdom, Germany, Belgium, Mexico, Poland, India, Romania, South Africa, Canada, Brazil, Russian Federation, Czech Republic, Hungary, Italy
Biogen

Completed

Phase 2 Efficacy, Safety, and Tolerability Study of Natalizumab in Focal Epilepsy (OPUS)

Epilepsy, Focal Seizures, Partial Seizures

United States
NYU Langone Health
The Epilepsy Study Consortium

Completed

The Human Epilepsy Project (HEP)

Focal Epilepsy

United States, Canada, Australia
SK Life Science, Inc.

Recruiting

Randomized, Double-Blind Study to Evaluate Efficacy and Safety of Cenobamate Adjunctive Therapy in PGTC Seizures

Primary Generalized Epilepsy

United States, Spain, Germany, Hungary, Korea, Republic of, Australia, Bulgaria, Czechia, Poland, Slovakia, Ukraine
Janssen Research & Development, LLC

Completed

A Study to Investigate the Safety of the Drugs Topiramate and Levetiracetam in Treating Children Recently Diagnosed With Epilepsy

Epilepsy

United States, France, Poland, Taiwan, Argentina, South Africa, Belgium, Germany, Russian Federation, Austria, Hungary, Canada, Philippines, Australia
GlaxoSmithKline

Completed

Treatment Of Primary Generalized Tonic-Clonic Seizures With An Investigational New Drug

Epilepsy, Tonic-Clonic

United States, Chile, Peru, Argentina
Stichting Epilepsie Instellingen Nederland
Epilepsiefonds

Completed

Cardiac Arrhythmias in Dravet Syndrome

Epilepsy

Netherlands, Germany, United Kingdom
Pfizer

Completed

Efficacy and Safety of Diazepam in the Management of Refractory Epilepsy in Selected Patients Who Require Intermittent Medical Intervention for Acute Repetitive Seizures.

Epilepsy | Epilepsy, Generalized | Seizures | Epilepsies, Partial | Epilepsy, Complex Partial

United States
Brain Sentinel

Completed

Detecting Generalized Tonic-Clonic Seizures With a Seizure Detection and Warning System in Epilepsy Patients

Epilepsy | Generalized Tonic-Clonic Seizures

United States
Eisai Limited

Terminated

Efficacy and Safety of Adjunctive Zonisamide in Myoclonic Seizures Associated With Idiopathic Generalised Epilepsy

Epilepsy

Australia, Serbia, Germany, Czech Republic, Romania, Estonia, Lithuania, Croatia, Finland, Hungary, Poland, Russian Federation, Ukraine
GlaxoSmithKline

Terminated

Open-Label Extension Study of the Phase 3 VRX-RET-E22-302 Double-Blind Trial. 115097

Epilepsy

Spain, Australia, Russian Federation, Israel, Belgium, Hungary, France, Germany, Poland, South Africa, Ukraine, United Kingdom
Sheffield Teaching Hospitals NHS Foundation Trust

Completed

Heart Rate Variability (HRV) Analysis in Patients With Nocturnal Epileptic Seizures

Epilepsy | Autonomic Nervous System | Heart Rate | Nocturnal Seizures

United Kingdom
Jazz Pharmaceuticals

Terminated

Efficacy and Safety of GWP42003-P Oral Solution in Children With Epilepsy With Myoclonic-atonic Seizures

Seizures Associated With EMAS

United States, Italy
Xenon Pharmaceuticals Inc.
Novotech Health Holdings Pte. Ltd.

Active, not recruiting

A Study to Evaluate XEN1101 as Adjunctive Therapy in Focal Epilepsy (X-TOLE)

Focal Epilepsy

Spain, United States, Ukraine, Canada, United Kingdom, Germany, Georgia, Italy, Moldova, Republic of
Medical University of South Carolina

Terminated

Prevention of Photoparoxysmal Abnormalities by Mozart K448

Epilepsy | Seizures | Photoparoxysmal Abnormalities

United States
Pfizer's Upjohn has merged with Mylan to form Viatris...

Completed

Comparative Study Of Pregabalin And Gabapentin As Adjunctive Therapy In Subjects With Partial Seizures

Epilepsy | Epilepsies, Partial | Partial Seizure Disorder | Complex Partial Seizure Disorder

Costa Rica, Peru, El Salvador, Guatemala
Neurocrine Biosciences

Completed

A Study to Investigate How Effective, Safe and Tolerable the Drug NBI-921352 is When Used With Anti-seizure Medications in Adults With Focal Onset Seizures

Focal Onset Seizure | Focal Onset Epilepsy

Spain, Belgium, Czechia, France, Italy, Australia, Hungary, United Kingdom
Pfizer

Completed

To Evaluate Long-Term Safety and Efficacy of Pregabalin in Patients With Partial Seizures.

Seizure Disorder, Partial

Spain, France, Italy, Australia, United Kingdom, Germany, Belgium, Netherlands, Austria, Sweden, Finland, South Africa, Switzerland
UCB Pharma SA

Completed

Brivaracetam as add-on Treatment in Adolescents and Adults Suffering From Epilepsy

Epilepsy

Ukraine, Belgium, Germany, Hong Kong, India, South Africa, Taiwan, Sweden, Korea, Republic of, Singapore, Russian Federation, Austria, Italy, Norway, Czechia
Engrail Therapeutics INC

Withdrawn

ENACT: A Study of ENX-101 as Adjunctive Treatment in Patients With Focal Seizures (ENACT)

Focal Epilepsy

United States
SK Life Science, Inc.

Recruiting

Safety and Efficacy Study of Cenobamate in Pediatric Subjects 2-17 Years of Age With Partial-onset (Focal) Seizures

Partial Epilepsy

United States, Spain, Korea, Republic of, Germany, Australia, Poland, Hungary
GlaxoSmithKline
Bausch Health Americas, Inc.

Completed

Retigabine Efficacy and Safety Trial for Partial Onset Refractory Seizures in Epilepsy (RESTORE2)

Seizures

Spain, Australia, Israel, Ukraine, Belgium, United States, South Africa, Hungary, United Kingdom, France, Germany, Poland, Russian Federation
SK Life Science, Inc.

Completed

A Double-Blind, Randomized, Placebo-Controlled, Phase 2 Trial of YKP3089 as Adjunctive Therapy in Subjects With Partial Onset Seizures

Partial Epilepsy

Australia, United States, Korea, Republic of, Germany, Hungary, Serbia, Bulgaria, Czechia, France, Israel, Poland, Romania, Spain, Thailand, Ukraine
GlaxoSmithKline

Completed

Conversion To Monotherapy With Lamictal Extended Release Tablets For Treatment Of Partial Epilepsy

Epilepsy, Partial

United States, Korea, Republic of, Ukraine, Chile, Costa Rica, Russian Federation, Puerto Rico, Argentina
Eisai Inc.

Completed

4-Year Open-Label Extension Phase of the Parallel-Group Study of E2007 in Patients With Refractory Partial Seizures

Epilepsy

Belgium, France, United States, Czech Republic, Estonia, Latvia, Spain, United Kingdom, Lithuania, Germany, Australia, Finland, Netherlands, Sweden
UCB BIOSCIENCES, Inc.

Completed

Determine Safety and Efficacy of Long-term Oral Lacosamide in Patients With Partial Seizures

Partial Epilepsies

United States
UCB Pharma

Completed

Assess Safety and Efficacy of Lacosamide in Patients With Partial Seizures

Epilepsy

France, Poland, United Kingdom, Germany, Spain, Finland, Australia, Russian Federation, Hungary, Lithuania, Sweden, Czechia, Croatia

Clinical Trials on Epilepsy in South Africa

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