Clinical Trials on Esophageal Adenocarcinomas

Total 13504 results

Memorial Sloan Kettering Cancer Center

Active, not recruiting

Evaluate Mesothelin as a Biomarker for the Clinical Management of Esophageal Adenocarcinoma (EAC)

Adenocarcinoma | Esophageal Cancer

United States
Great Ormond Street Hospital for Children NHS Foundation...
National Institute for Health Research, United Kingdom

Recruiting

Swallowing, Feeding and Eating in Children Born With Oesophageal Atresia/Trache-oesophageal Fistula (OA/TOF) (SaFE)

Esophageal Atresia With Tracheoesophageal Fistula

United Kingdom
University Medical Center Groningen
Technical University of Munich; Biomedical Research Foundation of the Academy... and other collaborators

Recruiting

Early Detection of Cancer Onset Based on Sensing Field Cancerization at the Organ Level in the Alimentary Tract Using an Integrated Stimulated Raman/Scattering Modality for Endoscopic Real-time in Vivo Measurements (SENSITIVE)

Colorectal Neoplasms | Carcinogenesis | Barrett Esophagus | Esophageal Adenocarcinoma | Colorectal Adenoma | Colorectal Adenocarcinoma | Colorectal Polyp

Netherlands
King's College Hospital NHS Trust
King's College London; Cardiff University; Brighton and Sussex University Hospitals...

Recruiting

Beta-blockers or Placebo for Primary Prophylaxis (BOPPP) of Oesophageal Varices Trial. (BOPPP)

Portal Hypertension | Cirrhosis, Liver | Variceal Hemorrhage | Varices, Esophageal

United Kingdom
Case Western Reserve University
Johns Hopkins University; Mayo Clinic; University of Pennsylvania; Washington University... and other collaborators

Recruiting

Genetic Determinants of Barrett's Esophagus and Esophageal Adenocarcinoma (FBE)

Barrett's Esophagus | Esophageal Neoplasm

United States
Alliance for Clinical Trials in Oncology
National Cancer Institute (NCI)

Completed

Irinotecan in Treating Patients With Advanced Cancer of the Stomach

Gastric Cancer | Esophageal Cancer

United States, Canada
Johannes Gutenberg University Mainz
Pfizer

Completed

Efficacy and Safety of Sunitinib in Metastatic Gastric Cancer

Gastric Adenocarcinoma | Barrett Esophagus

Germany
Organon and Co
World Health Information Science Consultants, LLC

Completed

Observational Study of Incidence Rates of Esophageal Cancer in Women Taking Medications for the Prevention or Treatment of Osteoporosis (MK-0217A-352)

Adenocarcinoma | Esophageal Cancer | Squamous Cell Carcinoma
National Taiwan University Hospital

Unknown

PLA for HCC and Esophageal ca Serum

Hepatocellular Carcinoma | Esophageal Cancer

Taiwan
Gustave Roussy, Cancer Campus, Grand Paris

Withdrawn

Basket Trial for Combination Therapy With Durvalumab (Anti-PDL1) (MEDI4736) and Tremelimumab (Anti-CTLA4) in Patients With Metastatic Solid Tumors (MATILDA)

Metastatic Colorectal Cancer | Triple Negative Breast Cancer | Esophageal Adenocarcinoma | Prostate Adenocarcinoma | Stomach Adenocarcinoma
AHS Cancer Control Alberta

Recruiting

A Study Involving Neoadjuvant Chemoradiotherapy With Hypofractionated Radiotherapy in Patients With Esophageal and Gastroesophageal Junction Adenocarcinoma

Esophageal Cancer

Canada
Mayo Clinic

Recruiting

Assessment of a Minimally Invasive Collection Device for Molecular Analysis of Esophageal Samples (SOS4C)

Barrett Esophagus | Esophageal Adenocarcinoma | Barrett's Esophagus Without Dysplasia | Barretts Esophagus With Dysplasia

United States
Ochsner Health System
The University of Queensland

Unknown

Microbiome Involvement With Barrett's Esophagus and Progression to Esophageal Adenocarcinoma

Esophageal Cancer | Barrett Esophagus

United States
Gangnam Severance Hospital

Recruiting

Investigator-initiated Pilot Study to Investigate the Efficacy and Safety of Immuncell-LC in Combination With Nivolumab (Opdivo) in Subjects With Advanced or Recurrent Gastric Cancer

Gastro-esophageal Junction Cancer | Relapsed or Advanced Gastric Adenocarcinoma

Korea, Republic of
Merck Sharp & Dohme LLC

Terminated

Efficacy and Safety Study of Pembrolizumab (MK-3475) Versus Paclitaxel in Asian Participants With Advanced Gastric or Gastroesophageal Junction Adenocarcinoma Who Progressed After First-line Therapy With Platinum and Fluoropyrimidine (MK-3475-063/KEYNOTE-063)

Gastric Neoplasms | Gastroesophageal Junction Adenocarcinoma

China, Korea, Republic of, Malaysia, Taiwan
Krankenhaus Nordwest

Completed

Oxaliplatin and 5-Fluorouracil With or Without Docetaxel in Elderly Patients (>65 y) With Stomach and Esophagus Cancer

Gastric Cancer | Adenocarcinoma of the Esophagogastric Junction

Germany
VA Office of Research and Development
VA Palo Alto Health Care System; VA Puget Sound Health Care System; Michael E... and other collaborators

Not yet recruiting

A Phase II Trial to Evaluate the Effect of Itraconazole on Pathologic Complete Response Rates in Resectable Esophageal Cancer

Esophageal Adenocarcinoma | Esophageal Squamous Cell Carcinoma | Gastroesophageal Junction Carcinoma

United States
GERCOR - Multidisciplinary Oncology Cooperative...

Not yet recruiting

POP-UP: a Single-arm, Two-cohort Study: Trimodal Prehab for Upper GI and Pancreatic Cancer (POP-UP)

Esophageal Cancer | Pancreatic Ductal Adenocarcinoma
University of Lausanne Hospitals

Completed

Prospective Evaluation of the Role of MRI in the Perioperative Management of Pancreas Adenocarcinomas

Pancreas Adenocarcinomas

Switzerland
Merck Sharp & Dohme LLC

Active, not recruiting

Pembrolizumab/Placebo Plus Trastuzumab Plus Chemotherapy in Human Epidermal Growth Factor Receptor 2 Positive (HER2+) Advanced Gastric or Gastroesophageal Junction (GEJ) Adenocarcinoma (MK-3475-811/KEYNOTE-811)

Gastric Neoplasms | Gastroesophageal Junction Adenocarcinoma

United States, Australia, Brazil, Chile, China, France, Germany, Guatemala, Ireland, Israel, Italy, Japan, Korea, Republic of, New Zealand, Poland, Russian Federation, Spain, Turkey, Ukraine, United Kingdom
Vrije Universiteit Brussel

Completed

Influence of Intrapulmonary Percussive Ventilation (IPV) on Gastro-oesophageal Reflux (GOR).

Gastro-oesophageal Reflux

Belgium
Vrije Universiteit Brussel

Completed

Influence of IPV on GOR in Infants From 0 to 12 Months.

Gastro-oesophageal Reflux

Belgium
Federation Francophone de Cancerologie Digestive
Shire

Active, not recruiting

Nal-iri/lv5-fu Versus Paclitaxel as Second Line Therapy in Patients With Metastatic Oesophageal Squamous Cell Carcinoma (OESIRI)

Squamous Cell Carcinoma

France
University of Aarhus
Aarhus University Hospital

Recruiting

Thromboprophylaxis in Oesophageal Cancer Patients (TOP-RCT)

Thrombosis | Esophageal Neoplasms | Thromboembolism

Denmark
Vrije Universiteit Brussel

Completed

Influence of Airway Clearance Techniques on GOR in Infants

Gastro-oesophageal Reflux

Belgium
University of Nottingham

Completed

The Accuracy and Acceptability of Magnet Assisted Capsule Endoscopy in the Diagnosis of Esophageal Pathology: a Pilot Study (MACE)

Oesophageal Varices | Barrett's Oesophagus

United Kingdom
Universitätsklinikum Hamburg-Eppendorf

Recruiting

Neoplastic Barrett Esophagus: Endoscopic Piecemeal vs. En Bloc Resection (BEEPER)

Barrett Esophagus | Barrett Adenocarcinoma | Esophagus Neoplasm

United States, Germany
Midwest Biomedical Research Foundation
Kansas City Veteran Affairs Medical Center

Recruiting

Progression of Gastroesophageal Reflux Disease and Barrett's Esophagus and the Creation of a Barrett's Registry

Gastroesophageal Reflux Disease | Barrett's Esophagus | Esophageal Adenocarcinoma

United States
Shanghai Junshi Bioscience Co., Ltd.

Recruiting

A Study to Evaluate the Efficacy and Safety of Toripalimab Injection in the Treatment of Recurrent or Metastatic Gastric or Gastroesophageal Junction Adenocarcinoma Who Have Failed at Least Two Prior Lines of Therapy and Are Positive Specific Markers

Recurrent or Metastatic Gastric or Gastroesophageal Junction Adenocarcinoma Who Have Failed at Least Two Prior Lines of Therapy

China
National University Hospital, Singapore

Recruiting

Trial of Lenvatinib Plus PembrolizumAb in Recurrent Gynecological Clear Cell Adenocarcinomas (LARA)

Adenocarcinomas | Recurrent Gynecological

Singapore
National Cancer Institute (NCI)

Completed

Bortezomib With or Without Irinotecan in Treating Patients With Cancer of the Gastroesophageal Junction or Stomach

Adenocarcinoma of the Gastroesophageal Junction | Stage IV Gastric Cancer | Recurrent Gastric Cancer | Diffuse Adenocarcinoma of the Stomach | Intestinal Adenocarcinoma of the Stomach | Mixed Adenocarcinoma of the Stomach | Stage IIIB Gastric Cancer | Stage IIIC Gastric Cancer

United States
MedImmune LLC

Completed

A Study to Evaluate the Safety and Tolerability of MEDI-565 in Adults With Gastrointestinal Adenocarcinomas

Gastrointestinal Adenocarcinomas

United States
Xiaofeng Chen

Recruiting

XELOX Combined With Fruquintinib and Sintilimab Regimen Conversion Therapy for Gastric Cancer/Gastroesophageal Junction Adenocarcinoma Only With Liver and/or Retroperitoneal Lymph Node Metastasis, a Prospective Single-arm, Multicenter Study

Gastric Cancer/Gastroesophageal Junction Adenocarcinoma

China
Philogen S.p.A.

Recruiting

A Study to Evaluate the Safety and Dosimetry of 68Ga-labelled OncoFAP Derivatives in Solid Tumors (FAPrimo)

Breast Cancer | Colorectal Cancer | Pancreas Adenocarcinoma | Oesophageal Cancer

Italy
Karolinska University Hospital
Ullevaal University Hospital; Oslo University Hospital; Sahlgrenska University... and other collaborators

Completed

Neoadjuvant Chemotherapy Versus Radiochemotherapy for Cancer of the Esophagus or Cardia (NeoRes)

Carcinoma, Squamous Cell | Adenocarcinoma of the Esophagus and Gastric Cardia

Sweden
Memorial Sloan Kettering Cancer Center
Genentech, Inc.; Weill Medical College of Cornell University

Completed

Pre-operative Chemotherapy Plus Bevacizumab With Early Salvage Therapy Based on PET Assessment of Response in Patients With Locally Advanced But Resectable Gastric and GEJ Adenocarcinoma

Gastric Cancer | Esophageal Cancer

United States
Columbia University

Completed

Trial to Assess the Effects of an Antimicrobial Mouthwash on the Esophageal Microbiome (Mouthwash)

Barrett's Esophagus | Esophageal Adenocarcinoma | Reflux Esophagitis

United States
EMD Serono Research & Development Institute, Inc.
Merck KGaA, Darmstadt, Germany

Completed

Avelumab in Third-Line Gastric Cancer (JAVELIN Gastric 300)

Unresectable, Recurrent, Locally Advanced or Metastatic Gastric or Gastroesophageal Junction Adenocarcinoma | Gastric Cancer Third Line

Spain, Italy, Australia, Korea, Republic of, Belgium, France, Poland, United States, Czechia, Germany
Shanghai Junshi Bioscience Co., Ltd.
Sponsor GmbH

Recruiting

A Phase I Clinical Study of Recombinant Humanized Anti-BTLA Monoclonal Antibody (JS004) Injection Combined With Toripalimab Injection in Patients With Advanced Solid Tumors

Liver Cancer, Esophageal Squamous Cell Carcinoma, Gastric Adenocarcinoma, Cervical Cancer, MSI-H Colorectal Cancer

China
The Leeds Teaching Hospitals NHS Trust
The Leeds Teaching Hospitals Charitable Foundation

Unknown

Evaluation of 4D-contrast Enhanced PET-CT in Tumour Volume Definition

Lung Carcinoma | Pancreatic Carcinoma | Lower Oesophageal Carcinoma

United Kingdom
UMC Utrecht

Completed

Esophagectomy for Patients With Esophageal Cancer and Cervical Lymph Node Metastases (Node)

Adenocarcinoma | Cancer | Squamous Cell Carcinoma | Malignancy

Netherlands
Lucid Diagnostics, Inc.

Recruiting

CLUE: CLinical Utility Study of EsoGuard (PR-0410)

Barrett Esophagus | Barretts Esophagus With Dysplasia | Esophagus Adenocarcinoma

United States
Shadia Jalal, MD
GlaxoSmithKline; Indiana University School of Medicine

Terminated

A Study Evaluating Safety and Efficacy of Niraparib in Patients With Previously Treated Metastatic Esophageal/Gastroesophageal Junction/Proximal Gastric Adenocarcinoma

Adenocarcinoma | Gastric Cancer | Esophageal Cancer

United States
EMD Serono Research & Development Institute, Inc.
Merck KGaA, Darmstadt, Germany

Completed

Avelumab in First-Line Maintenance Gastric Cancer (JAVELIN Gastric 100)

Unresectable, Locally Advanced or Metastatic, Adenocarcinoma of the Stomach, or of the Gastro Esophageal Junction

United States, Spain, Italy, Australia, Russian Federation, Taiwan, Korea, Republic of, Thailand, Canada, Turkey, Germany, Romania, United Kingdom, Hungary, Brazil, France, Japan
University of North Carolina, Chapel Hill
Interpace Diagnostics Corporation

Completed

Utility Of Mutational Load As A Predictor For Endoscopic Treatment Response In Barrett's Esophagus

Barretts Esophagus With Dysplasia | Intramucosal Adenocarcinoma

United States
BioNTech SE

Terminated

Safety, Pharmacokinetics, Pharmacodynamics, and Preliminary Efficacy Trial of BNT141 in Patients With Unresectable or Metastatic CLDN18.2-positive Gastric, Pancreatic, Ovarian and Biliary Tract Tumors

Gastric Cancer | Pancreatic Cancer | Solid Tumor | Metastatic Cancer | Cholangiocarcinoma | Esophageal Adenocarcinoma | Biliary Tract Cancer | Gastroesophageal Junction Adenocarcinoma

United States, Canada
Boston Scientific Corporation

Terminated

Efficacy and Safety of OncoGel™ Added to Chemotherapy and Radiation Before Surgery in Subjects With Esophageal Cancer

Esophageal Cancer | Squamous Cell Carcinoma | Adenocarcinoma of the Esophagus

United States, India, Czechia, Poland
Shanghai Zhongshan Hospital

Recruiting

NeoAdjuvant Therapy With Immunoreagent (SHR-1316) for Resectable Oesophageal Squamous Cell carciNoma (NATION1907II)

Oesophageal Squamous Cell Carcinoma

China
Medical University of Lublin
St Johns' Oncology Center in Lublin

Unknown

Comparison Study of Brachytherapy and Endoscopic Stenting for Dysphagia in Esophago-Gastric Junction Cancer (BRASTEGAC)

Adenocarcinoma of the Esophago-gastric Junction

Poland
Seagen Inc.

Recruiting

Tucatinib Plus Trastuzumab and Oxaliplatin-based Chemotherapy or Pembrolizumab-containing Combinations for HER2+ Gastrointestinal Cancers

Gastric Adenocarcinoma | Cholangiocarcinoma | Esophageal Adenocarcinoma | Colorectal Carcinoma | Gallbladder Carcinoma | GEJ Adenocarcinoma

United States, Japan

Clinical Trials on Esophageal Adenocarcinomas

Sponsors and Collaborators

Medical Conditions

Drug Interventions

CROs by country

CROs in Rwanda

Conditions

Rare Diseases

Drug Interventions

Dietary Supplements

Sponsor/Collaborators

Locations