Clinical Trials on Extrahepatic Cholestasis

Total 685 results

Richard Burt, MD
Northwestern Memorial Hospital

Withdrawn

Stem Cell Transplantation in Patients With Primary Biliary Cirrhosis

Primary Biliary Cirrhosis
Robert Chunhua Zhao, MD, PhD
Peking Union Medical College Hospital

Unknown

Efficacy and Safety Study of Allogenic Mesenchymal Stem Cells for Patients With Refractory Primary Biliary Cirrhosis (MSCsTreatPBC)

Primary Biliary Cirrhosis

China
National Center for Research Resources (NCRR)
Tufts Medical Center

Completed

Low-Dose Oral Methotrexate Versus Colchicine for Primary Biliary Cirrhosis

Liver Cirrhosis, Biliary
Indonesia University

Active, not recruiting

Probiotics in Pediatric Chronic Cholestasis

Cholestatic Liver Disease

Indonesia
Yilihamu·Abilitifu

Completed

The Effectiveness of Combining Ursodeoxycholic Acid With Vitamin D in Treating Patients With Primary Biliary Cholangitis

Primary Biliary Cholangitis

China
Mirum Pharmaceuticals, Inc.

Completed

Phase 2 Study to Evaluate LUM001 in Combination With Ursodeoxycholic Acid in Patients With Primary Biliary Cirrhosis (CLARITY)

Primary Biliary Cirrhosis | PBC

United States, United Kingdom, Canada
Chia Tai Tianqing Pharmaceutical Group Co., Ltd.

Recruiting

Study of Obeticholic Acid（OCA） Combination With Ursodeoxycholic Acid (UDCA) in Patients With Primay Biliary Cirrhosis (PBC)

Primary Biliary Cirrhosis

China
Calliditas Therapeutics Suisse SA

Active, not recruiting

A Trial of Setanaxib in Patients With Primary Biliary Cholangitis (PBC) and Liver Stiffness (TRANSFORM)

Primary Biliary Cholangitis | Liver Stiffness

United States, Spain, France, Australia, Israel, Canada, Switzerland, Italy, New Zealand, Germany, Poland, Greece, United Kingdom, Belgium, Austria, Czechia, Hungary, Sweden
University of Leipzig
Hannover Medical School; RWTH Aachen University; Academisch Medisch Centrum -... and other collaborators

Recruiting

Prospective, Multicenter Cohort Study on Primary Biliary Cholangitis (PBC-Cohort)

Primary Biliary Cholangitis | PBC

Germany
National Scientific Medical Center, Kazakhstan
Eurasia Invest Ltd.; Ministry of Education and Science, Republic of Kazakhstan

Completed

Clinical Trial on the Effect of the Sublimated Mare Milk Supplement on Primary Biliary Cholangitis

Primary Biliary Cirrhosis

Kazakhstan
Newcastle-upon-Tyne Hospitals NHS Trust
Newcastle University; National Institute for Health Research, United Kingdom; Department of Health, United Kingdom

Completed

B-Cell Depleting Therapy (Rituximab) as a Treatment for Fatigue in Primary Biliary Cirrhosis (RITPBC)

Fatigue | Primary Biliary Cirrhosis

United Kingdom
Mayo Clinic
National Cancer Institute (NCI)

Withdrawn

Ricolinostat, Gemcitabine Hydrochloride, and Cisplatin in Treating Patients With Unresectable or Metastatic Cholangiocarcinoma

Unresectable Extrahepatic Bile Duct Carcinoma | Recurrent Cholangiocarcinoma | Non-Resectable Cholangiocarcinoma | Stage III Intrahepatic Cholangiocarcinoma | Stage IIIA Hilar Cholangiocarcinoma | Stage IIIB Hilar Cholangiocarcinoma | Stage IVA Hilar Cholangiocarcinoma | Stage IVA Intrahepatic Cholangiocarcinoma and other conditions

United States
University of Birmingham
University Hospital Birmingham NHS Foundation Trust; Intercept Pharmaceuticals

Terminated

EXerCise Intervention in cholesTatic LivEr Disease: The EXCITED Study (EXCITED)

Primary Biliary Cholangitis

United Kingdom
University of Sao Paulo General Hospital

Completed

Development of Ursodeoxycholic Acid 300 mg at Hospital Das Clinicas of the University of São Paulo School of Medicine

Primary Biliary Cirrhosis | Ursodeoxycholic Acid

Brazil
University of Cape Town

Unknown

Self-expandable Metal Stents Versus Multiple Plastic Stents for Palliation of Biliary Obstruction

Biliary Stricture | Cancer of the Pancreas | Bile Duct Obstruction, Extrahepatic | Cancer of the Bile Duct

South Africa
University of Aarhus
Aarhus University Hospital; Hvidovre University Hospital

Recruiting

Bezafibrate in Patients With Primary Biliary Cholangitis (PBC)

Primary Biliary Cirrhosis

Denmark
CymaBay Therapeutics, Inc.

Recruiting

Seladelpar in Subjects With Primary Biliary Cholangitis (PBC)

Primary Biliary Cirrhosis

United States, Korea, Republic of, Belgium, Spain, France, Switzerland, Romania, United Kingdom, Austria, Israel, Australia, Argentina, Canada, Chile, Germany, Greece, Hungary, Italy, Mexico, Netherlands, Poland, Czechia, New Zealand, Turke... and more
Target PharmaSolutions, Inc.

Active, not recruiting

A 5-year Longitudinal Observational Study of Patients With Primary Biliary Cholangitis

Biliary Cirrhosis, Primary

United States
West China Hospital

Unknown

Ursodeoxycholic Acid Combined With Total Glucosides of Paeony in the Treatment of PBC With AIH Features 1

Hepatitis | Autoimmune | Primary Biliary Cholangitis

China
Xiaoli Fan

Completed

Retrospective Study About Primary Biliary Cholangitis During January 2001 to July 2016 at West China Hospital

Liver Diseases | Liver Cirrhosis | Cholangitis | Bile Duct Diseases | Cholestasis | Liver Cirrhosis, Biliary

China
National Institute of Diabetes and Digestive and...

Terminated

SAMe to Treat Biliary Cirrhosis Symptoms

Liver Cirrhosis, Biliary

United States
Zydus Therapeutics Inc.

Completed

Study to Evaluate Safety, Tolerability and Efficacy of Saroglitazar Mg in Patients With Primary Biliary Cholangitis (EPICS)

Primary Biliary Cirrhosis

United States
CymaBay Therapeutics, Inc.

Completed

Seladelpar (MBX-8025) in Subjects With Primary Biliary Cholangitis (PBC)

Primary Biliary Cirrhosis

United States, Germany, United Kingdom, Canada
Calliditas Therapeutics AB

Completed

Study to Assess Safety & Efficacy of GKT137831 in Patients With Primary Biliary Cholangitis Receiving Ursodiol.

Primary Biliary Cirrhosis

United States, Israel, Belgium, Germany, United Kingdom, Spain, Greece, Canada, Italy
Sun Yat-sen University

Unknown

Probiotics in PBC Patients of Poor Response to UDCA

Primary Biliary Cholangitis (PBC)

China
Pomeranian Medical University Szczecin
Laval University

Completed

Effectiveness of S-adenosyl-L-methionine in Patients With Primary Biliary Cirrhosis

Primary Biliary Cirrhosis

Poland
Ipsen

Active, not recruiting

Study of Elafibranor in Patients With Primary Biliary Cholangitis (PBC) (ELATIVE)

Primary Biliary Cirrhosis

United States, France, Spain, Belgium, Germany, Switzerland, Brazil, United Kingdom, Argentina, Canada, Chile, Italy, South Africa, Turkey
Instituto Mexicano del Seguro Social

Active, not recruiting

A Study to Assess Efficacy and Safety of Bezafibrate in Patients With Primary Biliary Cholangitis

Primary Biliary Cirrhosis

Mexico
National Institute of Diabetes and Digestive and...
Mayo Clinic

Completed

Pilot Study of Budesonide for Patients With Primary Sclerosing Cholangitis

Cholangitis, Sclerosing | Liver Cirrhosis, Biliary

United States
Ipsen

Recruiting

A Long-Term Study of Elafibranor in Adult Participants With Primary Biliary Cholangitis (ELFIDENCE)

Primary Biliary Cholangitis (PBC)

United States, Spain, Romania
CymaBay Therapeutics, Inc.

Recruiting

An Open-Label Study Following Oral Dosing of Seladelpar to Subjects With Primary Biliary Cholangitis (PBC) and Hepatic Impairment (HI)

Hepatic Impairment | Compensated Cirrhosis | Primary Biliary Cholangitis

Korea, Republic of, United States, Spain, United Kingdom
Genfit

Completed

Study to Evaluate the Efficacy and Safety of Elafibranor in Patients With Primary Biliary Cholangitis (PBC) and Inadequate Response to Ursodeoxycholic Acid

Primary Biliary Cholangitis (PBC)

United States, United Kingdom, France, Germany, Spain
CymaBay Therapeutics, Inc.

Terminated

Study to Evaluate the Effects of Two Doses of MBX-8025 in Subjects With Primary Biliary Cirrhosis (PBC)

Primary Biliary Cirrhosis (PBC)

Germany, United States, Canada, United Kingdom, Poland
Cascade Pharmaceuticals, Inc

Recruiting

CS0159 in Chinese Patients With PBC (Primary Biliary Cholangitis)

Primary Biliary Cholangitis (PBC)

China
GlaxoSmithKline

Recruiting

Linerixibat Long-term Safety, and Tolerability Study (LLSAT)

Cholestasis

United States, France, Japan, United Kingdom, Bulgaria, Germany, Greece, Italy, China, Argentina, Belgium, Brazil, Canada, Czechia, Israel, Mexico, Poland, Russian Federation, Spain, Switzerland
Humanity and Health Research Centre
Beijing 302 Hospital

Recruiting

Performance of Scoring Systems in Chinese Patients With Primary Biliary Cholangitis (PBC) on Ursodeoxycholic Acid

Primary Biliary Cholangitis (PBC)

China
University of Aarhus

Active, not recruiting

sCD163 in PBC Patients - Assessment of Disease Severity and Prognosis

Liver Inflammation | Primary Biliary Cirrhosis

Denmark
Xijing Hospital of Digestive Diseases

Unknown

Mesenchymal Stem Cell Transplantation for Refractory Primary Biliary Cholangitis

Primary Biliary Cirrhosis

China
University Health Network, Toronto

Unknown

Family Studies in Primary Biliary Cirrhosis (PBC)

Biliary Cirrhosis, Primary

Canada
University Health Network, Toronto

Unknown

Identification of the Genetic Variants Responsible for Primary Biliary Cirrhosis (PBC)

Liver Cirrhosis, Biliary | Biliary Cirrhosis, Primary

Canada
Mirum Pharmaceuticals, Inc.

Recruiting

A Study to Evaluate Efficacy and Safety of an Investigational Drug Named Volixibat in Patients With Itching Caused by Primary Biliary Cholangitis (VANTAGE)

Primary Biliary Cholangitis | PBC

United States, United Kingdom, Israel, Germany, Italy, France
University of Aarhus

Recruiting

sCD163 in PBC Patients - Assessment of Treatment Response

Liver Inflammation | Primary Biliary Cirrhosis | Ursodeoxycholic Acid

Denmark
HighTide Biopharma Pty Ltd

Completed

Open-Label Study of HTD1801 in Adult Subjects With Primary Biliary Cholangitis (PRONTO-PBC)

Biliary Tract Diseases | Cholangitis | Cholestasis | Primary Biliary Cholangitis | Primary Biliary Cirrhosis | Bile Duct Stricture

United States
University of Alberta

Completed

Mind-body Wellness Intervention in Primary Biliary Cholangitis (PBC)

Primary Biliary Cirrhosis

Canada
Kiminori Kimura, MD
Japan Agency for Medical Research and Development; Ohara Pharmaceutical Co....

Completed

Safety, Tolerability of OP-724 in Patients With Primary Biliary Cholangitis (Phase I)

Liver Cirrhosis, Biliary | Primary Biliary Cholangitis (PBC)

Japan
Guy's and St Thomas' NHS Foundation Trust
King's College Hospital NHS Trust

Unknown

Paternally Inherited Phenotypes in Cholestasis (PIP-C)

Primary Sclerosing Cholangitis | Cholestasis | Primary Biliary Cirrhosis

United Kingdom
University of Aarhus

Completed

Biliary Excretion of Conjugated Bile Acids in Humans Measured by 11C-cholylsarcosine PET/CT

Primary Sclerosing Cholangitis | Cholestasis | Primary Biliary Cirrhosis

Denmark
Arbor Research Collaborative for Health
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)

Recruiting

Longitudinal Study of Genetic Causes of Intrahepatic Cholestasis (LOGIC) (LOGIC)

Liver Diseases | Alpha 1-Antitrypsin Deficiency | Alagille Syndrome

United States, Canada
University of Alberta

Completed

Online Wellness Intervention for Primary Biliary Cholangitis (PBC)

Primary Biliary Cirrhosis

Canada
Teikyo University

Completed

Nalfurafine Hydrochloride for Pruritus in Patients With Primary Biliary Cholangitis

Primary Biliary Cirrhosis

Japan

Clinical Trials on Extrahepatic Cholestasis

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