Clinical Trials on Gastrointestinal Adenocarcinomas

Total 31057 results

Mayo Clinic

Completed

Endoscopic Mucosal Resection (EMR) in Barrett's Esophagus

Barrett's Esophagus | Early Esophageal Adenocarcinoma

United States
Mayo Clinic

Completed

Micro-RNA (miR) Expression in Upper Gastrointestinal Mucosal Tissue

Barrett's Esophagus | Esophageal Adenocarcinoma

United States
M.D. Anderson Cancer Center
National Cancer Institute (NCI)

Recruiting

Phase I/II Study of Perioperative Chemotherapy Plus Immunotherapy Followed by Surgery in Localized Esophageal and Gastroesophageal Adenocarcinoma

Clinical Stage III Gastroesophageal Junction Adenocarcinoma AJCC v8 | Clinical Stage II Esophageal Adenocarcinoma AJCC v8 | Clinical Stage IIA Esophageal Adenocarcinoma AJCC v8 | Clinical Stage III Esophageal Adenocarcinoma AJCC v8 | Pathologic Stage IB Esophageal Adenocarcinoma AJCC v8 | Pathologic... and other conditions

United States
University of Southern California
National Cancer Institute (NCI)

Active, not recruiting

Bevacizumab, Fluorouracil, Leucovorin Calcium, and Oxaliplatin Before Surgery in Treating Patients With Stage II-III Rectal Cancer

Mucinous Adenocarcinoma of the Rectum | Signet Ring Adenocarcinoma of the Rectum | Stage IIA Rectal Cancer | Stage IIB Rectal Cancer | Stage IIC Rectal Cancer | Stage IIIA Rectal Cancer | Stage IIIB Rectal Cancer | Stage IIIC Rectal Cancer

United States
University of Colorado, Denver

Recruiting

Seattle Biopsy Protocol Versus Wide-Area Transepithelial Sampling in Patients With Barrett's Esophagus Undergoing Surveillance (SWAT-BE)

Barrett Esophagus | Esophageal Adenocarcinoma | Barretts Esophagus With Dysplasia

United States
NuCana plc

Active, not recruiting

A Study of NUC-3373 in Combination With Other Agents in Patients With Colorectal Cancer

Colorectal Neoplasms | Colorectal Cancer | Colorectal Cancer Metastatic | Colorectal Adenocarcinoma | Neoplasm, Colorectal

United States, Spain, United Kingdom, Italy, Germany, France
University of Oklahoma

Completed

DCLK1 as a Marker/Indicator of Stem Cell Response in Barrett's Esophagus/Esophageal Adenocarcinoma

Barrett's Esophagus | Esophageal Adenocarcinoma

United States
Providence Health & Services
Oregon Health and Science University

Completed

Immunoscore in Rectal Cancer

Rectal Cancer | Rectal Adenocarcinoma | Cancer of the Rectum | Neoplasms, Rectal | Rectal Tumors

United States
University of East Anglia

Unknown

Exercise Prior to Oesophagectomy (ExPO)

Oesophageal Adenocarcinoma | Postoperative Complications (Cardiopulmonary)

United Kingdom
RemeGen Co., Ltd.

Recruiting

DV Combined With Cadonilimab in Subjects With HER2-expressing Gastric Cancer and Gastroesophageal Junction Adenocarcinoma After Progression on First-line Therapy

Gastric Cancer | Gastroesophageal Junction Adenocarcinoma

China
Memorial Sloan Kettering Cancer Center
Washington University School of Medicine; The Cleveland Clinic; Oregon Health... and other collaborators

Withdrawn

Study of Chemotherapy With or Without Hepatic Arterial Infusion for Patients With Unresectable Metastatic Colorectal Cancer to the Liver

Colorectal Adenocarcinoma Metastatic to the Liver

United States
Alliance for Clinical Trials in Oncology
National Cancer Institute (NCI)

Completed

Docetaxel, Oxaliplatin, Capecitabine, Fluorouracil, and Radiation Therapy in Treating Patients With Locally Advanced Cancer of the Esophagus or Gastroesophageal Junction

Gastric Cancer | Esophageal Cancer | Adenocarcinoma of the Gastroesophageal Junction

United States
MedPacto, Inc.
Merck Sharp & Dohme LLC

Active, not recruiting

Vactosertib in Combination With Pembrolizumab in Metastatic Colorectal or Gastric Cancer

Metastatic Colorectal Cancer | Gastric Cancer | Gastroesophageal Junction Adenocarcinoma

Korea, Republic of
ammar houssem

Completed

Factors Predicting Recurrence in Rectal Cancer After Surgery

Rectal Cancer | Rectal Adenocarcinoma
University Hospital, Brest

Active, not recruiting

Analysis of Histopathological Factors Predictive of Lymph Node Involvement and Management Practices in pT1 Colorectal Cancers Treated by Primary Endoscopic Resection: a Retrospective Population-based Study (PROMOT1) (PROMOT1)

Colorectal Cancer | Colorectal Adenocarcinoma

France
Universidade Federal do Amazonas

Enrolling by invitation

Effects of the Use of Probiotics on the Intestinal Microbiota of Patients With Gastric Cancer (PRONIC-G)

Gastric Cancer | Nutritional Status | Gastric Adenocarcinoma | Cytokines | Microbiome

Brazil
Dana-Farber Cancer Institute
Massachusetts General Hospital; Brigham and Women's Hospital

Completed

Capecitabine and Thalidomide in Previously Treated Metastatic Colorectal Carcinoma

Colorectal Adenocarcinoma

United States
Jonsson Comprehensive Cancer Center

Not yet recruiting

Fluoxetine for the Modification of Colorectal Tumor Immune Cells Before Surgery in Patients With Colorectal Cancer

Colorectal Adenocarcinoma

United States
D'Or Institute for Research and Education
HalioDx; Diagnosticos da America SA

Recruiting

Role of Immunoscore® in Stage II-III Colorectal Cancer

Colon Adenocarcinoma

Brazil
University Medical Center Mainz

Recruiting

RAMIE Versus MIE for Resectable Esophageal Cancer, a Randomized Controlled Trial (ROBOT-2 Trial). (ROBOT-2)

Esophageal Adenocarcinoma

Germany
Registre des Tumeurs Digestives du Finistère

Completed

Treatment and Outcomes of Stage III Colon Cancer in Patients 80 Years of Age and Older

Colon Adenocarcinoma

France
University of California, San Francisco

Terminated

Evaluation of Rectal Cancer Treatment Response Using PET/MRI (Rectal PET/MRI)

Rectal Adenocarcinoma

United States
IHU Strasbourg

Terminated

Evaluation of Rectal Tumor Margin Using Confocal Endomicroscopy and Comparison to Histopathology (TRaMA)

Rectal Cancer | Rectal Adenocarcinoma

France
National Cancer Institute (NCI)

Not yet recruiting

Testing the Combination of the Anticancer Drugs Trastuzumab Deruxtecan (DS-8201a) and Azenosertib (ZN-c3) in Patients With Stomach or Other Solid Tumors

Locally Advanced Malignant Solid Neoplasm | Unresectable Malignant Solid Neoplasm | Metastatic Malignant Solid Neoplasm | Clinical Stage III Gastric Cancer AJCC v8 | Clinical Stage III Gastroesophageal Junction Adenocarcinoma AJCC v8 | Clinical Stage IV Gastric Cancer AJCC v8 | Clinical Stage... and other conditions
National Cancer Institute (NCI)

Recruiting

Testing Immunotherapy (Atezolizumab) With or Without Chemotherapy in Locoregional MSI-H/dMMR Gastric and Gastroesophageal Junction (GEJ) Cancer

Gastric Adenocarcinoma | Clinical Stage III Gastric Cancer AJCC v8 | Clinical Stage III Gastroesophageal Junction Adenocarcinoma AJCC v8 | Gastroesophageal Junction Adenocarcinoma | Clinical Stage I Gastric Cancer AJCC v8 | Clinical Stage II Gastric Cancer AJCC v8 | Clinical Stage IVA Gastric... and other conditions

United States
National Cancer Institute (NCI)

Terminated

Phase I-II Study of Fluorouracil in Combination With Phenylbutyrate in Advanced Colorectal Cancer

Mucinous Adenocarcinoma of the Rectum | Signet Ring Adenocarcinoma of the Rectum | Mucinous Adenocarcinoma of the Colon | Signet Ring Adenocarcinoma of the Colon | Recurrent Colon Cancer | Recurrent Rectal Cancer | Stage IVA Colon Cancer | Stage IVA Rectal Cancer | Stage IVB Colon Cancer | Stage IVB Rectal...

United States
Tampere University Hospital
Turku University Hospital; Helsinki University Central Hospital; Oulu University... and other collaborators

Not yet recruiting

Nordic ORgan Preservation Pilot Approach Nonrandomised Single-Arm Trial for Non-Operative Management of Rectal Cancer (NORPPA-1)

Rectal Cancer | Rectal Adenocarcinoma

Finland, Estonia
Liz-Anne Lewsley
AstraZeneca; NHS Greater Glasgow and Clyde; University of Glasgow

Not yet recruiting

A Trial of Durvalumab (MEDI 4736) in Combination With Extended Neoadjuvant Regimens in Rectal Cancer (PRIME-RT)

Rectal Cancer | Rectal Neoplasms | Rectal Adenocarcinoma
University Hospital, Lille
National Cancer Institute, France

Recruiting

Surgical Resection Plus Chemotherapy Versus Chemotherapy Alone in Oligometastatic Stage IV Gastric Cancer (SURGIGAST)

Gastric Adenocarcinoma

France
Niguarda Hospital
Mayo Clinic

Completed

Oncological Impact of Lateral Nodes in Rectal Cancer (I-ONARC)

Colorectal Adenocarcinoma
University Hospital, Lille
University of Lille Nord de France

Active, not recruiting

Determinants of Patient Delay in Doctor Consultation in Oeso-gastric Cancers (DELOGAST)

Gastric Adenocarcinoma | Oesophageal Carcinoma

France
National Cancer Institute (NCI)

Terminated

Phase I Study of Cetuximab With RO4929097 in Metastatic Colorectal Cancer

Recurrent Colon Carcinoma | Recurrent Rectal Carcinoma | Stage IVA Colon Cancer | Stage IVA Rectal Cancer | Stage IVB Colon Cancer | Stage IVB Rectal Cancer | Colon Mucinous Adenocarcinoma | Colon Signet Ring Cell Adenocarcinoma | Rectal Mucinous Adenocarcinoma | Rectal Signet Ring Cell Adenocarcinoma

United States
Fox Chase Cancer Center

Terminated

Chemoembolization Using Irinotecan in Treating Patients With Liver Metastases From Metastatic Colon or Rectal Cancer

Mucinous Adenocarcinoma of the Rectum | Signet Ring Adenocarcinoma of the Rectum | Liver Metastases | Mucinous Adenocarcinoma of the Colon | Signet Ring Adenocarcinoma of the Colon | Stage IV Colon Cancer | Stage IV Rectal Cancer | Recurrent Colon Cancer | Recurrent Rectal Cancer

United States
Fox Chase Cancer Center
National Cancer Institute (NCI)

Terminated

Telomere Length in Predicting Toxicity in Older Patients With Stage III-IV Colorectal Cancer Undergoing Chemotherapy

Mucinous Adenocarcinoma of the Rectum | Signet Ring Adenocarcinoma of the Rectum | Stage IIIA Rectal Cancer | Stage IIIB Rectal Cancer | Stage IIIC Rectal Cancer | Mucinous Adenocarcinoma of the Colon | Signet Ring Adenocarcinoma of the Colon | Stage IIIA Colon Cancer | Stage IIIB Colon Cancer | Stage... and other conditions

United States
University of Southern California
National Cancer Institute (NCI)

Withdrawn

Ziv-Aflibercept Followed by Ziv-Aflibercept, Fluorouracil, and Leucovorin Calcium in Treating Patients With Stage IV Colorectal Cancer

Mucinous Adenocarcinoma of the Rectum | Signet Ring Adenocarcinoma of the Rectum | Mucinous Adenocarcinoma of the Colon | Signet Ring Adenocarcinoma of the Colon | Recurrent Colon Cancer | Recurrent Rectal Cancer | Stage IVA Colon Cancer | Stage IVA Rectal Cancer | Stage IVB Colon Cancer | Stage IVB Rectal...

United States
City of Hope Medical Center
National Cancer Institute (NCI)

Completed

Pembrolizumab and Palliative Radiation Therapy in Treating Patients With Metastatic Esophagus, Stomach, or Gastroesophageal Junction Cancer

Gastric Adenocarcinoma | Gastric Squamous Cell Carcinoma | Gastroesophageal Junction Adenocarcinoma | Metastatic Malignant Neoplasm in the Stomach | Stage IV Esophageal Adenocarcinoma AJCC v7 | Stage IV Esophageal Squamous Cell Carcinoma AJCC v7

United States
Xiaofeng Chen

Recruiting

XELOX Combined With Fruquintinib and Sintilimab Regimen Conversion Therapy for Gastric Cancer/Gastroesophageal Junction Adenocarcinoma Only With Liver and/or Retroperitoneal Lymph Node Metastasis, a Prospective Single-arm, Multicenter Study

Gastric Cancer/Gastroesophageal Junction Adenocarcinoma

China
City of Hope Medical Center
National Cancer Institute (NCI)

Recruiting

Botensilimab, Balstilimab and Regorafenib for the Treatment of Patients With Microsatellite Stable Metastatic Colorectal Cancer Who Have Progressed on Prior Chemotherapy

Metastatic Colorectal Adenocarcinoma | Stage IV Colorectal Cancer AJCC v8 | Stage III Colorectal Cancer AJCC v8 | Metastatic Microsatellite Stable Colorectal Carcinoma | Advanced Microsatellite Stable Colorectal Carcinoma | Advanced Colorectal Adenocarcinoma

United States
CENTOGENE GmbH Rostock

Completed

Peptide-based Immunization for Colon- and and Pancreas-carcinoma (PICOP-GLOBAL)

Pancreatic Neoplasms | Pancreatic Cancer | Pancreatic Adenocarcinoma | Rectal Cancer | Rectal Neoplasms | Colon Cancer | Pancreas Cancer | Colo-rectal Cancer | Rectal Adenocarcinoma | Colon Neoplasm | Rectal Tumors | Colon Adenocarcinoma

Pakistan
Centre of Postgraduate Medical Education
Maria Sklodowska-Curie National Research Institute of Oncology

Recruiting

Endoscopic Radiofrequency Ablation Versus Hybrid Argon Plasma Coagulation in the Treatment of Barrett's Esophagus (RATE)

Barrett Esophagus | Esophageal Adenocarcinoma | Reflux Disease

Poland
Shanghai Junshi Bioscience Co., Ltd.

Recruiting

A Study to Evaluate the Efficacy and Safety of Toripalimab Injection in the Treatment of Recurrent or Metastatic Gastric or Gastroesophageal Junction Adenocarcinoma Who Have Failed at Least Two Prior Lines of Therapy and Are Positive Specific Markers

Recurrent or Metastatic Gastric or Gastroesophageal Junction Adenocarcinoma Who Have Failed at Least Two Prior Lines of Therapy

China
CDx Diagnostics
Icahn School of Medicine at Mount Sinai; NYU Langone Health; University of Kansas... and other collaborators

Completed

WATS3D for the Detection of Esophageal Dysplasia

Barrett Esophagus | Esophagus Adenocarcinoma | Esophageal Dysplasia

United States
M.D. Anderson Cancer Center
Sanofi-Synthelabo

Completed

Docetaxel, 5-Fluorouracil and Oxaliplatin in Adenocarcinoma of the Stomach or Gastroesophageal Junction Patients

Gastrointestinal Diseases

United States
Mayo Clinic
National Cancer Institute (NCI)

Completed

Endoscopic Therapy of Early Cancer in Barretts Esophagus

Barrett Esophagus | Early Stage Esophageal Adenocarcinoma

United States
Hunan Cancer Hospital

Completed

Anti-PD-1 Antibody Plus Regorafenib in Refractory Microsatellite Stable Metastatic Colorectal Cancer

Metastatic Colorectal Adenocarcinoma

China
Hunan Cancer Hospital

Completed

Trifluridine/Tipiracil Plus Bevacizumab Versus Trifluridine/Tipiracil Monotherapy in Refractory Metastatic Colorectal Cancer

Metastatic Colorectal Adenocarcinoma

China
Seagen Inc.
National Cancer Institute (NCI); Academic and Community Cancer Research United

Completed

Tucatinib Plus Trastuzumab in Patients With HER2+ Colorectal Cancer

Metastatic Colorectal Adenocarcinoma

United States, Spain, Belgium, France, Italy
Federation Francophone de Cancerologie Digestive
Eli Lilly and Company

Active, not recruiting

Second-Line Chemotherapy With Ramucirumab +/- Paclitaxel in Elderly Advanced Gastric or Gastroesophageal Junction Cancer Patients (SOCRATE)

Stomach Cancer | Gastric Cancer | Gastroesophageal Junction Adenocarcinoma | Stomach Neoplasm

France
Fudan University

Unknown

PD-1 Antibody Combined With Modified FLOT Regimen in the Treatment of Unresectable Locally Advanced or Limited Metastatic Gastric Cancer

Metastatic Gastric Cancer | Locally Advanced Gastric Adenocarcinoma

China
EMD Serono Research & Development Institute, Inc.
Merck KGaA, Darmstadt, Germany

Completed

Avelumab in Third-Line Gastric Cancer (JAVELIN Gastric 300)

Unresectable, Recurrent, Locally Advanced or Metastatic Gastric or Gastroesophageal Junction Adenocarcinoma | Gastric Cancer Third Line

Spain, Italy, Australia, Korea, Republic of, Belgium, France, Poland, United States, Czechia, Germany

Clinical Trials on Gastrointestinal Adenocarcinomas

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