Clinical Trials on Genetic Pleomorphism in Czechia

Total 292 results

Thomayer University Hospital
Masaryk University

Recruiting

Czech AATD Registry

Alpha-1-antitrypsin Deficiency

Czechia
The Institute of Molecular and Translational Medicine...

Recruiting

Assesment of Multiomics Profiles in Health and Disease. (ENIGMA)

Genetic Predisposition to Disease

Czechia
Sanofi

Recruiting

A Study to Evaluate the Quality of Life of Male and Female Adult Patients With Severe Refractory Atopic Dermatitis Treated With Dupilumab in Czech Republic

Atopic Dermatitis

Czechia
University Hospital Olomouc

Not yet recruiting

CRT-P or CRT-D in Dilated Cardiomyopathy (CRT-REALITY)

Cardiomyopathy, Dilated, 3B

Czechia
General University Hospital, Prague
Charles University, Czech Republic; Amicus Therapeutics; Klinické centrum ISCARE

Unknown

Screening of Fabry Disease in Patients With GI Symptoms (GiFD)

Fabry Disease

Czechia
Saniona

Completed

Co-administration of Tesofensine/Metoprolol in Subjects With Prader-Willi Syndrome (PWS) (2016-003694-18)

Confirmed Genetic Diagnosis of Prader-Willi Syndrome

Czechia, Hungary
University Hospital, Motol
Brno University Hospital

Recruiting

COVID-19 Antibody Responses in Cystic Fibrosis (CAR-CF)

Cystic Fibrosis

Czechia
Masaryk Memorial Cancer Institute
Masaryk University

Recruiting

Pancreatic Cancer Screening in a Population at High Risk (ScrePan)

Pancreatic Ductal Adenocarcinoma | Pancreatitis, Chronic | Hereditary Diseases

Czechia
Novartis Pharmaceuticals

Completed

A Study to Assess the Efficacy and Safety of CMK389 in Patients With Moderate to Severe Atopic Dermatitis.

Atopic Dermatitis

Germany, Czechia, France, Hungary, Spain, Poland
The Institute of Molecular and Translational Medicine...
University Hospital Olomouc

Recruiting

Pulmonary Condensate: Non-invasive Evaluation of Pulmonary Involvement in Asthma and Cystic Fibrosis.

Bronchial Asthma | Pulmonary Cystic Fibrosis

Czechia
Ever Neuro Pharma GmbH
XClinical GmbH; idv Datenanalyse & Versuchsplanung

Recruiting

CERebrolysin In CADASIL (CERICA)

Cadasil

Czechia
University Hospital, Motol

Completed

Respiratory Physiotherapy Performed by Simeox In Patients With Primary Ciliary Dyskinesia

Primary Ciliary Dyskinesia

Czechia
General University Hospital, Prague
University of Iowa

Unknown

FFR Versus iFR in Assessment of Hemodynamic Lesion Significance (FiGARO)

Hemodynamics | Tomography, Optical Coherence | Coronary Circulation | Endothelial Cells | Polymorphism, Genetic

Czech Republic
Baxalta now part of Shire

Completed

Pharmacokinetics, Efficacy and Safety Study of IMMUNATE SD (Human Plasma-Derived Coagulation Factor VIII Concentrate) in Hemophilia A Patients

Hemophilia A

Czechia, Bulgaria, Hungary, Poland
University Hospital Olomouc
University Hospital Ostrava; Tomas Bata Hospital, Czech Republic; General University... and other collaborators

Recruiting

Surgical Treatment of Adrenal Diseases- Laparoscopic vs. Robotic-assisted Adrenalectomy

Cushing Syndrome | Pheochromocytoma | Adrenocortical Carcinoma | Adrenal Cortex Diseases | Adrenocortical Adenoma | Adrenal Tumor | Adrenalectomy; Status | Adrenal Mass | Adrenal Hyperplasia | Adrenal Disease | Adrenocortical Tumor | Conn Adenoma | Adrenal Gland Metastasis

Czechia
Zymenex A/S
European Commission

Completed

The Natural History of Alpha-Mannosidosis (HUE-MAN)

Alpha Mannosidosis

Czechia, Germany, Norway, United Kingdom
LEO Pharma

Active, not recruiting

Tralokinumab Monotherapy for Children With Moderate-to-severe Atopic Dermatitis - TRAPEDS 1 (TRAlokinumab PEDiatric Trial no. 1)

Atopic Dermatitis

Spain, United Kingdom, Czechia, France, Netherlands
Chiesi Farmaceutici S.p.A.

Completed

Pharmacokinetic Study of Bramitob® Administered for Inhalation by PARI eFlow® vs PARI LC® PLUS Nebulizer

Cystic Fibrosis

Czechia, Moldova, Republic of, Slovakia
Bristol-Myers Squibb

Recruiting

A Study to Evaluate the Safety, Tolerability, Drug Levels, and Drug Effects of BMS-986326 in Participants With Atopic Dermatitis

Dermatitis, Atopic

France, Czechia, Germany, Poland, Spain
Faculty Hospital Kralovske Vinohrady

Completed

The Epidemiology, Management and Comorbidities in Alopecia Areata in Czech Republic

Infections | Multiple Sclerosis | Autoimmune Diseases | Diabetes Mellitus, Type 1 | Rheumatoid Arthritis | Vaccine Reaction | Inflammatory Bowel Diseases | Psoriasis | Crohn Disease | Ulcerative Colitis | Down Syndrome | Atopic Dermatitis | Vitiligo | Alopecia Areata | COVID-19 Pandemic | Ankylosing Spondylitis | Lupus Erythematosus and other conditions

Czechia
Laboratoire français de Fractionnement et de Biotechnologies
LFB USA, Inc.

Completed

A Phase III Study on the Safety, Pharmacokinetics and Efficacy of Coagulation Factor VIIa (PERSEPT2)

Hemophilia A With Inhibitors | Hemophilia B With Inhibitors

Bulgaria, Ukraine, Czechia, United States, Georgia, South Africa
Shire

Completed

Short Term Observational Study in DEB Patients

Dystrophic Epidermolysis Bullosa

United States, Czechia, Italy, Austria, Australia, France, Germany
Baxalta now part of Shire

Completed

BAX 326 Surgery Study in Hemophilia B Patients

Hemophilia B

Colombia, Bulgaria, Chile, Poland, Romania, Argentina, Czechia, Russian Federation, Ukraine, United Kingdom
Regeneron Pharmaceuticals
Sanofi

Completed

Study of Dupilumab in Adult Patients With Extrinsic Moderate-to-Severe Atopic Dermatitis

Atopic Dermatitis

Poland, Germany, France, Hungary, Czechia
Institute of Health Information and Statistics...
Centre of Cardiovascular and Transplantation Surgery, Czech Republic; The Central... and other collaborators

Recruiting

Pilot Project of Familial Hypercholesterolemia Screening in Newborns in the Czech Republic (CzeCH-IN)

Familial Hypercholesterolaemia

Czechia
Rocket Pharmaceuticals Inc.

Completed

Natural History of Danon Disease

Danon Disease

Ireland, Czechia, France, Italy, Spain
Shire

Completed

Sophisticated Assessment of Disease Burden in Patients With Fabry Disease (SOPHIA)

Fabry Disease

Finland, Sweden, Germany, Belgium, Czechia, Denmark
Denali Therapeutics Inc.

Enrolling by invitation

An Extension Study of the Long-Term Safety, Tolerability, and Efficacy of Tividenofusp Alfa (DNL310) in Participants With Mucopolysaccharidosis Type II (MPS II) From Study DNLI-E-0002 or Study DNLI-E-0007

Mucopolysaccharidosis II

United States, Canada, Belgium, Czechia, Netherlands
Regeneron Pharmaceuticals
Sanofi

Completed

A Study to Determine the Safety and Tolerability of Dupilumab (REGN668/SAR231893) in Patients Aged ≥6 to <18 Years With Atopic Dermatitis (Eczema)

Atopic Dermatitis

Germany, Poland, United Kingdom, Hungary, Canada, Czechia
Baxalta now part of Shire

Completed

IMMUNINE Pre-Treatment Study

Hemophilia B

Colombia, Bulgaria, Chile, Poland, Romania, Argentina, Brazil, Czechia, Russian Federation, Ukraine
Swedish Orphan Biovitrum
Cerner Enviza

Active, not recruiting

An International Study to Evaluate the Real-world Effectiveness and Usage of Alprolix in Patients With Haemophilia B (B-MORE)

Hemophilia B

Czechia, Greece, Ireland, Italy, Norway, Saudi Arabia, Spain, Sweden, United Kingdom
CENTOGENE GmbH Rostock

Completed

The Efficacy and Safety of Switch Between Agalsidase Beta to Agalsidase Alfa for Enzyme Replacement in Patients With Anderson-Fabry Disease (SWITCH)

Fabry Disease | Anderson-Fabry Disease | Fabry´s Disease

Argentina, Belgium, Croatia, Czechia, Denmark, France, Germany, United Kingdom
Bayer

Completed

A Study to Learn How Well the Study Treatment Zabedosertib (BAY1834845) Works and How Safe it is Compared to Placebo in Adult Participants With Moderate-to-severe Atopic Dermatitis (Damask)

Atopic Dermatitis

France, Czechia, Italy, Poland, United States, Germany, United Kingdom
Protalix
Chiesi Farmaceutici S.p.A.

Completed

Safety and Efficacy of PRX-102 in Patients With Fabry Disease Currently Treated With REPLAGAL® (Agalsidase Alfa)

Fabry Disease

Australia, Netherlands, United Kingdom, Canada, Czechia, Norway, Slovenia
Shire

Completed

Extension Study of TKT028 Evaluating Safety and Clinical Outcomes of Replagal® in Adult Patients With Fabry Disease

Fabry Disease

United States, Slovenia, Australia, Finland, Poland, Czechia, United Kingdom
Alexion Pharmaceuticals

Completed

Safety, Tolerability and Pharmacokinetics of SBC-102 (Sebelipase Alfa) in Adult Participants With Lysosomal Acid Lipase Deficiency

Lysosomal Acid Lipase Deficiency | Cholesterol Ester Storage Disease(CESD) | LAL-Deficiency

France, United States, United Kingdom, Czechia
LEO Pharma

Completed

Efficacy and Safety of LEO 152020 Tablets for the Treatment of Adults With Moderate to Severe Atopic Dermatitis

Atopic Dermatitis

United States, Canada, Czechia, Germany, Poland, Spain, Australia, Japan
Baxalta now part of Shire

Completed

Pivotal Study (Pharmacokinetics, Efficacy, Safety) of BAX 326 (rFIX) in Hemophilia B Patients

Hemophilia B

Poland, United Kingdom, Spain, Bulgaria, Romania, Japan, Russian Federation, Brazil, Chile, Sweden, Colombia, Ukraine, Argentina, Czechia
University Hospital, Motol

Unknown

Impact of Immunonutrition on the Patients With Cystic Fibrosis

Malnutrition | Cystic Fibrosis | Oxidative Stress

Czech Republic
Novo Nordisk A/S

Enrolling by invitation

A Study Following Males With Haemophilia B on Prophylaxis With Refixia/REBINYN

Haemophilia B

Canada, United Kingdom, Czechia, Germany, Greece, Austria, Belgium, Croatia, Denmark, Finland, Norway, Portugal
Octapharma

Active, not recruiting

Efficacy, PK, Immunogenicity and Safety of Wilate in Severe Von Willebrand Disease VWD) Patients <6 Years of Age

Von Willebrand Disease

United States, Moldova, Republic of, Czechia, Germany, North Macedonia, Russian Federation, Ukraine
Flatley Discovery Lab LLC

Completed

A Study to Evaluate Safety, PK and PD of FDL169 in Cystic Fibrosis Subjects

Cystic Fibrosis

United Kingdom, Australia, Germany, Czechia
Novartis Pharmaceuticals

Completed

Study of Efficacy and Safety of Dabrafenib in Combination With Trametinib in Pediatric Patients With BRAF V600 Mutation Positive LGG or Relapsed or Refractory HGG Tumors

Glioblastoma | Astrocytoma | Anaplastic Astrocytoma | Anaplastic Ganglioglioma | Anaplastic Pleomorphic Xanthoastrocytoma | Ganglioglioma | Pleomorphic Xanthoastrocytoma | Diffuse Astrocytoma | Anaplastic Oligodendroglioma | Pilocytic Astrocytoma | Gangliocytoma | Central Neurocytoma | Oligodendroglioma, Childhood and other conditions

United States, Italy, Japan, Germany, Spain, France, Canada, Australia, Brazil, Israel, Russian Federation, Argentina, United Kingdom, Finland, Belgium, Denmark, Czechia, Sweden, Switzerland, Netherlands
Novartis Pharmaceuticals

Recruiting

Pediatric Long-Term Follow-up and Rollover Study

Glioblastoma | Astrocytoma | Anaplastic Astrocytoma | Neurofibromatosis Type 1 | Anaplastic Ganglioglioma | Anaplastic Pleomorphic Xanthoastrocytoma | Ganglioglioma | Pleomorphic Xanthoastrocytoma | Diffuse Astrocytoma | Anaplastic Oligodendroglioma | Pilocytic Astrocytoma | Gangliocytoma | Central Neurocytoma | Oligodendroglioma... and other conditions

United States, Belgium, Spain, Denmark, Germany, Czechia, Italy, Australia, Russian Federation, France, Brazil, Netherlands, Japan, Canada, Finland, Sweden, United Kingdom, Argentina, Israel
Wave Life Sciences Ltd.

Terminated

Efficacy and Safety Study of WVE-210201 (Suvodirsen) With Open-label Extension in Ambulatory Patients With Duchenne Muscular Dystrophy (DYSTANCE 51)

Duchenne Muscular Dystrophy

United States, Belgium, United Kingdom, Czechia, Canada, France, Italy, Sweden
Grifols Therapeutics LLC

Completed

Efficacy, Pharmacokinetics, Safety, and Tolerability of IGSC 20% in Subjects With Primary Immunodeficiency

Primary Immunodeficiency

Spain, France, Germany, United Kingdom, Australia, Czechia, Hungary, Poland, Sweden
Sanofi

Completed

Proof of Concept Study of Rilzabrutinib in Adult Patients With Moderate-to-severe Atopic Dermatitis

Atopic Dermatitis

Netherlands, Chile, United States, Canada, Czechia, Germany, Poland
Laboratoire français de Fractionnement et de Biotechnologies

Completed

Willebrand International Non-interventional Global Surveillance

Von Willebrand Disease

Norway, Germany, Italy, Belgium, Czechia, Finland, Greece
Shire

Completed

Safety and Efficacy Study of Several Replagal Dosing Regimens on Cardiac Function in Adults With Fabry Disease

Fabry Disease

United States, United Kingdom, Australia, Czechia, Finland, Paraguay, Poland, Slovenia
Astellas Pharma Inc

Completed

Clinical Trial to Assess the Efficacy and Safety of Tacrolimus Ointment Treatment of Atopic Dermatitis in Adult Patients

Dermatitis, Atopic

Poland, Czech Republic, Hungary

Clinical Trials on Genetic Pleomorphism in Czechia

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