Clinical Trials on Genetic Disease

Total 382499 results

Pfizer

Completed

Evaluation Of The Ability Of Fesoterodine To Increase Urethral Pressure In Stress Urinary Incontinence Patients

Stress Urinary Incontinence

Denmark
INSYS Therapeutics Inc

Completed

Histologic Effect/Safety of Pre/Post-Operative IL13-PE38QQR in Recurrent Resectable Supratentorial Malignant Glioma Patients

Glioblastoma Multiforme | Malignant Glioma | Anaplastic Astrocytoma | Mixed Oligoastrocytoma | Malignant Astrocytoma

United States
Antisoma Research

Unknown

Phase III Randomized Study of Amonafide (AS1413) and Cytarabine Versus Daunorubicin and Cytarabine in Patients With Secondary Acute Myeloid Leukemia (AML)- the ACCEDE Study

Secondary Acute Myeloid Leukemia (Secondary AML, sAML)

Korea, Republic of, United States, Spain, United Kingdom, Australia, Austria, Taiwan, Israel, Italy, Belgium, Germany, France, Romania, Estonia, Canada, Ukraine, Ecuador, Hungary, Poland, Chile, Argentina, Czech Republic, Russian Federation
National Taiwan University Hospital

Completed

The Role of Glycosyltransferases in the Oncogenesis of Neuroblastoma

Neuroblastoma
Radboud University Medical Center
ZonMw: The Netherlands Organisation for Health Research and Development

Terminated

Value of Urodynamics Prior to Stress Incontinence Surgery (VUSIS)

Stress Urinary Incontinence

Netherlands
University of Medicine and Dentistry of New Jersey
Nintendo of North America

Completed

Does Distraction With a Hand Held Video Game Reduce Preoperative and Emergence Anxiety in Children?

Pediatric Emergence Agitation and Pain

United States
University Of Perugia

Completed

Pelvic Organ Prolapse Repair With or Without Concomitant Burch Colposuspension in Patients With Urinary Incontinence

Urinary Incontinence | Pelvic Organ Prolapse

Italy
Ethicon, Inc.

Completed

A Clinical Evaluation of the Tension-Free Vaginal Tape Obturator System For Treatment of Stress Urinary Incontinence (Urinary Leakage)

Stress Urinary Incontinence

Korea, Republic of, United States, Canada, France, Germany, Singapore, United Kingdom
Eli Lilly and Company
Boehringer Ingelheim

Completed

To Evaluate the Safety in Patients Taking Duloxetine for Stress Urinary Incontinence

Stress Urinary Incontinence

United States
Rabin Medical Center

Unknown

Treatment of Enuresis Nocturna by Circular Muscle Exercise (Paula Method)

Monosymptomatic Enuresis Nocturna

Israel
Dan Zandberg

Recruiting

Pulsed Dose Chemotherapy Plus Pembrolizumab in Recurrent/Metastatic HNSCC

Recurrent/Metastatic Head and Neck Squamous Cell Carcinoma (R/M HNSCC)

United States
Mental Health Services in the Capital Region, Denmark
Innovation Fund Denmark; Danish Medical Association; Doctor Gerhard Linds scholarship and other collaborators

Recruiting

T-PEMF Headband Stimulation for Patients With Moderate to Servere Depression

Moderate Depression | Recurrent Depressive Disorder, Current Episode Moderate | Severe Depressive Episode Without Psychotic Symptoms | Recurrent Depressive Disorder, Current Episode Severe Without Psychotic Symptoms

Denmark
Lei Li

Recruiting

PD-1 Antibody and Radiotherapy for Recurrent Cervical Cancer

Recurrent Cervical Carcinoma | Radiotherapy | Immune Checkpoint Inhibitors | Overall Survival | Anti-programmed Death-1 Antibody | Metastatic Cervical Carcinoma | Persistent Advanced Cervical Carcinoma | Objective Remission Rate | Progression-free Survival | Severe Adverse Events

China
Yale University

Terminated

FAAH Availability in Psychiatric Disorders: A PET Study

Post Traumatic Stress Disorder | Psychosis | Alcohol Use Disorder

United States
Nektar Therapeutics
Merck Sharp & Dohme LLC; SFJ Pharmaceuticals, Inc.

Terminated

BEMPEG With Pembrolizumab vs Pembrolizumab Alone in Patients With Metastatic or Recurrent HNSCC (PROPEL-36)

Recurrent Head and Neck Cancer | Metastatic Head and Neck Cancer

United States, Austria, Greece, Italy
University of Texas Southwestern Medical Center

Withdrawn

Feasibility Trial of Pregnenolone for Posttraumatic Stress Disorder and Alcohol Use Disorder

Post Traumatic Stress Disorder | Alcohol Use Disorder
Duke University
Brain & Behavior Research Foundation

Completed

Neuromodulation Enhanced Cognitive Restructuring: A Proof of Concept Study

Personality Disorders | Depression | Anxiety | Eating Disorders | Somatic Disorders | Trauma and Stress-related Disorders | Obsessive Compulsive Disorders | Difficulties With Cognitive Emotion Regulation

United States
Seattle Institute for Biomedical and Clinical Research
United States Department of Defense; VA Puget Sound Health Care System

Completed

Prazosin and Naltrexone (PaN) Study for Veterans With Alcohol Use Disorders (PaN)

Alcohol Use Disorder | Posttraumatic Stress Disorder (PTSD)

United States
University of Washington
National Institute on Alcohol Abuse and Alcoholism (NIAAA)

Completed

Brief Restructuring Intervention Following Trauma Exposure (BRITE)

Alcohol Use Disorders | Posttraumatic Stress Disorder

United States
Fred Hutchinson Cancer Center
National Cancer Institute (NCI); National Heart, Lung, and Blood Institute...

Completed

Mycophenolate Mofetil and Cyclosporine in Reducing Graft-Versus-Host Disease in Patients With Hematologic Malignancies or Metastatic Kidney Cancer Undergoing Donor Stem Cell Transplant

Clear Cell Renal Cell Carcinoma | Chronic Myelomonocytic Leukemia | Recurrent Adult Acute Myeloid Leukemia | Juvenile Myelomonocytic Leukemia | Extranodal Marginal Zone B-cell Lymphoma of Mucosa-associated Lymphoid Tissue | Nodal Marginal Zone B-cell Lymphoma | Recurrent Adult Burkitt Lymphoma | Recurrent... and other conditions

United States, Germany, Italy
GOG Foundation
National Cancer Institute (NCI)

Active, not recruiting

Radiation Therapy With or Without Chemotherapy in Patients With Stage I-IIA Cervical Cancer Who Previously Underwent Surgery

Cervical Adenocarcinoma | Cervical Adenosquamous Carcinoma | Cervical Squamous Cell Carcinoma, Not Otherwise Specified | Stage IIA Cervical Cancer AJCC v7 | Stage IB Cervical Cancer AJCC v6 and v7 | Stage I Cervical Cancer AJCC v6 and v7 | Stage IA Cervical Cancer AJCC v6 and v7

United States, Korea, Republic of, Japan
City of Hope Medical Center
National Cancer Institute (NCI)

Terminated

Dasatinib, Cytarabine, and Idarubicin in Treating Patients With High-Risk Acute Myeloid Leukemia

Recurrent Adult Acute Myeloid Leukemia | Adult Acute Myeloid Leukemia With 11q23 (MLL) Abnormalities | Adult Acute Myeloid Leukemia With Del(5q) | Adult Acute Myeloid Leukemia With Inv(16)(p13;q22) | Adult Acute Myeloid Leukemia With t(16;16)(p13;q22) | Adult Acute Myeloid Leukemia With t(8... and other conditions

United States
NRG Oncology
National Cancer Institute (NCI)

Completed

Comprehensive Patient Questionnaires in Predicting Complications in Older Patients With Gynecologic Cancer Undergoing Surgery

Fallopian Tube Carcinoma | Endometrial Serous Adenocarcinoma | Ovarian Carcinoma | Malignant Female Reproductive System Neoplasm | Primary Peritoneal Carcinoma | Stage IIIA Uterine Corpus Cancer AJCC v7 | Stage IIIB Uterine Corpus Cancer AJCC v7 | Stage IIIC Uterine Corpus Cancer AJCC v7 | Stage IVA... and other conditions

United States, Canada
Wake Forest University Health Sciences
National Cancer Institute (NCI)

Withdrawn

Gemtuzumab Ozogamicin in Treating Patients With Acute Myeloid Leukemia

Recurrent Adult Acute Myeloid Leukemia | Adult Acute Myeloid Leukemia With 11q23 (MLL) Abnormalities | Adult Acute Myeloid Leukemia With Del(5q) | Adult Acute Myeloid Leukemia With Inv(16)(p13;q22) | Adult Acute Myeloid Leukemia With t(16;16)(p13;q22) | Adult Acute Myeloid Leukemia With t(8... and other conditions
National Cancer Institute (NCI)

Completed

Romidepsin in Treating Patients With Relapsed or Refractory Acute Myeloid Leukemia

Recurrent Adult Acute Myeloid Leukemia | Adult Acute Myeloid Leukemia With 11q23 (MLL) Abnormalities | Adult Acute Myeloid Leukemia With Del(5q) | Adult Acute Myeloid Leukemia With Inv(16)(p13;q22) | Adult Acute Myeloid Leukemia With t(16;16)(p13;q22) | Adult Acute Myeloid Leukemia With t(8... and other conditions

United States
National Cancer Institute (NCI)

Terminated

EF5 to Evaluate Tumor Hypoxia in Patients With High-Grade Soft Tissue Sarcoma or Mouth Cancer

Stage III Adult Soft Tissue Sarcoma | Stage I Adult Soft Tissue Sarcoma | Stage II Adult Soft Tissue Sarcoma | Stage I Squamous Cell Carcinoma of the Lip and Oral Cavity | Stage II Squamous Cell Carcinoma of the Lip and Oral Cavity | Stage III Squamous Cell Carcinoma of the Lip and Oral Cavity

United States
Northwestern University

Terminated

Metformin+Cytarabine for the Treatment of Relapsed/Refractory AML

Recurrent Adult Acute Myeloid Leukemia | Adult Acute Megakaryoblastic Leukemia (M7) | Adult Acute Minimally Differentiated Myeloid Leukemia (M0) | Adult Acute Monoblastic Leukemia (M5a) | Adult Acute Monocytic Leukemia (M5b) | Adult Acute Myeloblastic Leukemia With Maturation (M2) | Adult Acute... and other conditions

United States
Fred Hutchinson Cancer Center
National Cancer Institute (NCI)

Completed

Reduced Intensity Donor Peripheral Blood Stem Cell Transplant in Treating Patients With De Novo or Secondary Acute Myeloid Leukemia in Remission

Acute Myeloid Leukemia With Multilineage Dysplasia Following Myelodysplastic Syndrome | Adult Acute Megakaryoblastic Leukemia (M7) | Adult Acute Minimally Differentiated Myeloid Leukemia (M0) | Adult Acute Monoblastic Leukemia (M5a) | Adult Acute Monocytic Leukemia (M5b) | Adult Acute Myeloblastic... and other conditions

United States
National Cancer Institute (NCI)

Completed

Tipifarnib in Treating Patients With Relapsed or Refractory Acute Myeloid Leukemia

Recurrent Adult Acute Myeloid Leukemia | Acute Myeloid Leukemia With Multilineage Dysplasia Following Myelodysplastic Syndrome | Adult Acute Megakaryoblastic Leukemia (M7) | Adult Acute Minimally Differentiated Myeloid Leukemia (M0) | Adult Acute Monoblastic Leukemia (M5a) | Adult Acute Monocytic... and other conditions

United States
City of Hope Medical Center
National Cancer Institute (NCI)

Active, not recruiting

Remote Telemonitoring of Patient-Generated Physiologic Health Data and Patient-Reported Outcomes

Stage IV Prostate Cancer AJCC v8 | Hepatobiliary Neoplasm | Stage III Renal Cell Cancer AJCC v8 | Stage IV Renal Cell Cancer AJCC v8 | Stage III Uterine Corpus Cancer AJCC v8 | Stage IV Uterine Corpus Cancer AJCC v8 | Stage IVA Uterine Corpus Cancer AJCC v8 | Stage IVB Uterine Corpus Cancer AJCC v8 | Malignant Neoplasm and other conditions

United States
Stanford University
Eunice Kennedy Shriver National Institute of Child Health and Human Development...

Recruiting

Interventions in Mathematics and Cognitive Skills

Cognitive Dysfunction | Cognitive Change | Learning Disabilities | Individuality | Child Development | Developmental Disability | Behavior | Cognition | Learning Curve | Decision Making | Behavior and Behavior Mechanisms | Behavior, Child | Cognitive Impairment, Mild | Cognition Disorder | Neuroscience | Cognitive Orientation and other conditions

United States
Wake Forest University Health Sciences
National Cancer Institute (NCI)

Completed

Symptom-Adapted Physical Activity Intervention in Minimizing Physical Function Decline in Older Patients With Acute Myeloid Leukemia Undergoing Chemotherapy

Recurrent Adult Acute Myeloid Leukemia | Adult Acute Myeloid Leukemia With 11q23 (MLL) Abnormalities | Adult Acute Myeloid Leukemia With Del(5q) | Adult Acute Myeloid Leukemia With Inv(16)(p13;q22) | Adult Acute Myeloid Leukemia With t(16;16)(p13;q22) | Adult Acute Myeloid Leukemia With t(8... and other conditions

United States
Mayo Clinic
National Cancer Institute (NCI)

Active, not recruiting

Fluorine F 18 Fluorodopa-Labeled PET Scan in Planning Surgery and Radiation Therapy in Treating Patients With Newly Diagnosed High- or Low-Grade Malignant Glioma

Adult Anaplastic Astrocytoma | Adult Anaplastic Ependymoma | Adult Anaplastic Oligodendroglioma | Adult Diffuse Astrocytoma | Adult Ependymoma | Adult Giant Cell Glioblastoma | Adult Glioblastoma | Adult Gliosarcoma | Adult Mixed Glioma | Adult Myxopapillary Ependymoma | Adult Oligodendroglioma | Adult Pilocytic... and other conditions

United States
National Cancer Institute (NCI)
Radiation Therapy Oncology Group

Completed

Bevacizumab, Radiation Therapy, and Cisplatin in Treating Patients With Previously Untreated Locally Advanced Cervical Cancer

Cervical Adenocarcinoma | Cervical Adenosquamous Carcinoma | Cervical Squamous Cell Carcinoma, Not Otherwise Specified | Stage IIA Cervical Cancer AJCC v7 | Stage IIB Cervical Cancer AJCC v6 and v7 | Stage III Cervical Cancer AJCC v6 and v7 | Stage IB Cervical Cancer AJCC v6 and v7

United States, Canada
Orthofix Inc.

Not yet recruiting

Post Market Evaluation of Clinical Safety and Performance of the Fitbone Transport and Lengthening System

Fractures, Bone | Fractures, Closed | Fractures, Open | Fracture of Femur | Fracture of Tibia | Limb Fracture | Fracture Nonunion | Limb Deformity | Limb Defect | Limb Asymmetry
Haukeland University Hospital

Recruiting

A Therapist Guided Internet-delivered Treatment for Adults With ADHD (Attention Deficit / Hyperactivity Disorder) - an Open Effectiveness Trial in Routine Care (MinADHD)

ADHD | ADHD Predominantly Inattentive Type | ADHD - Combined Type | ADHD, Predominantly Hyperactive - Impulsive

Norway
Beijing Tiantan Hospital
ZhongSheng BioTech Inc.

Recruiting

Safety and Efficacy Study for DC Vaccine in Recurrent or Progressive High-grade Gliomas

WHO Grade III Gliomas | WHO Grade IV Gliomas

China
Universidad Europea de Madrid

Recruiting

Update on the Detection of Frailty in the Older Adult

Depression | Quality of Life | Pain | Anxiety | Sarcopenia | Kinesiophobia | Strength | Functionality | Functional Independence

Spain
Jasper Gerritsen
Massachusetts General Hospital; Universitaire Ziekenhuizen KU Leuven; University... and other collaborators

Recruiting

The RESBIOP-study: Resection Versus Biopsy in High-grade Glioma Patients (ENCRAM 2202) (RESBIOP)

Glioblastoma | Glioblastoma Multiforme | Glioblastoma, IDH-wildtype | Glioblastoma Multiforme, Adult | Glioblastoma Multiforme of Brain

United States, Belgium, Switzerland, Germany, Netherlands
Fuzhou Hua

Recruiting

Correlation Between Perioperative EEG Features and Delirium After General Anesthesia

Postoperative Delirium | Postoperative Cognitive Dysfunction | Perioperative Period | Anesthetic

China
Corporacion Parc Tauli

Recruiting

Analysis of Circulating DNA in Blood Samples of Glioma-affected Patients

Glioma | Circulating Tumor Cell

Spain
Fundacion para la Investigacion y Formacion en...
Instituto de Investigación Biomédica de Salamanca; Castilla-León Health Service

Recruiting

Relationship of Addictions to Obesity, Physical Activity and Vascular Ageing in Young Adults

Drug Addiction | Young Adult | Technology Addiction

Spain
The Hong Kong Polytechnic University

Recruiting

Social Virtual-reality on Enhancing Social Interaction Skills in Children With Attention-deficit/Hyperactivity Disorder

Attention-deficit/Hyperactivity Disorder | Virtual Reality | Social Interaction

Hong Kong
Leiden University Medical Center
Pierre Fabre Laboratories

Recruiting

(Neo)Adjuvant BRAF/MEK Inhibition in pN1c Melanoma

Melanoma Stage III | In-Transit Metastasis of Cutaneous Melanoma

Netherlands
University of Aberdeen
NHS Grampian

Recruiting

Chemotherapy Induced Cognitive Impairment (CONCERT)

Breast Cancer

United Kingdom
University Medical Centre Ljubljana
University of Ljubljana, Faculty of Medicine

Recruiting

Effectiveness of Magnetic Stimulation in the Treatment of Female UUI.

Urinary Incontinence | Pelvic Floor Disorders | Urinary Incontinence, Urge

Slovenia
Al-Azhar University

Recruiting

Laparoscopic Burch Colposuspension Versus Modified Burch Colposuspension

Stress Urinary Incontinence | Burch Colposuspention

Egypt
Nova Scotia Health Authority
Takeda

Recruiting

Effect of Stimulant Medication on Loss of Control Eating in Youth With Attention Deficit/Hyperactivity Disorder

Attention Deficit/Hyperactivity Disorder | Loss of Control Eating

Canada
Chinese University of Hong Kong

Recruiting

Vitamin D to Improve Quadricep Muscle Strength

Anterior Cruciate Ligament Injuries | Anterior Cruciate Ligament Rupture | Anterior Cruciate Ligament Tear | Quadriceps Muscle Atrophy

Hong Kong
National Institute of Mental Health (NIMH)

Recruiting

Transcranial Electric Stimulation Therapy (TEST) for Treatment Resistant Depression (TRD

Bipolar Disorder | Major Depressive Disorder | Unipolar Major Depression

United States

Clinical Trials on Genetic Disease

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