Clinical Trials on Genomic Instability in Italy

Total 1234 results

IRCCS San Raffaele
Indena S.p.A

Unknown

Safety of Ginkgo Biloba Leaf Extract (GiBiEx)

Healthy

Italy
Fondazione Policlinico Universitario Agostino Gemelli...

Recruiting

Mutational Oncology in Clinical Practice (FPG-500)

Genetic Predisposition to Disease | Gene Rearrangement | Genome Instability

Italy
Gruppo Oncologico del Nord-Ovest

Recruiting

TremelImumab aNd Durvalumab For the Non-operatIve Management (NOM) of MSI-high Resectable GC/GEJC. (INFINITY)

Gastric Cancer | Microsatellite Instability

Italy
IFOM ETS - The AIRC Institute of Molecular Oncology

Active, not recruiting

Pembrolizumab in MMR-Proficient Metastatic Colorectal Cancer Pharmacologically Primed to Trigger Hypermutation Status (ARETHUSA)

Colorectal Neoplasms | Microsatellite Instability

Italy
Università Politecnica delle Marche

Completed

Validation of a New Method to Measure Cardiac Output: Comparison With Thermodilution

Hemodynamic Instability

Italy
Istituto Ortopedico Galeazzi

Recruiting

The Caton-Deschamps Index Reliability in Patellar Stabilization Surgery.

Patellar Instability

Italy
Gorm Greisen

Completed

An Optical Neuro-monitor of Cerebral Oxygen Metabolism and Blood Flow for Neonatology (BabyLux)

Hemodynamic Instability

Denmark, Italy
University of Bologna

Completed

Italian Version of The Cumberland Ankle Instability Tool (CAIT) (CAIT-I)

Ankle Injuries | Sport Injury | Ankle Sprains | Instability, Joint | Chronic Instability of Joint | Chronic Instability, Capsular Ligament | Ankle Inversion Sprain

Italy
Istituto Ortopedico Rizzoli

Completed

Evaluation of Proprioception in Patients Treated With Surgical External Ankle Ligament Recontruction for Traumatic Ankle Instability (ANKLE-PRO)

Ankle Sprains | Instability, Joint

Italy
Istituto Ortopedico Rizzoli

Completed

Muscle Strength Assessment in Patients With Chronic Ankle Instability (KNEE-CAI)

Chronic Ankle Instability

Italy
Humanitas Clinical and Research Center
Azienda Ospedaliero Universitaria Maggiore della Carita

Unknown

End-expiratory Occlusion Test and Lung Recruitment Maneuver to Assess Fluid responsiVeness In Surgical Patients (ELVIS)

Surgery | Fluid Overload | Hemodynamic Instability

Italy
Istituto Ortopedico Rizzoli

Completed

Evaluation of Ankle Propriocement and Stability (ANKLE-INT)

Ankle Sprains | Instability, Joint

Italy
Humanitas Clinical and Research Center

Completed

Mini Fluid chAlleNge and End-expiratory Occlusion Test and to Assess flUid responsiVEness in opeRating Room (MANEUVER)

Surgery | Anesthesia | Hemodynamic Instability

Italy
Humanitas Clinical and Research Center

Recruiting

Hemodynamic Monitoring During Abdominal Aortic Surgery (HEMAS)

Hemodynamic Instability

Italy
Fondazione Policlinico Universitario Agostino Gemelli...

Completed

Hemodynamic Optimization During Major Urological Surgery (INTAT)

Hemodynamic Instability

Italy
Smith & Nephew Orthopaedics AG

Completed

Safety and Performance of the SUTUREFIX ULTRA and SUTUREFIX CURVED Suture Anchors in Shoulder and Hip Arthroscopic Repair (SuturefixUltra)

Instability, Joint

Spain, Italy, United States, Denmark, Finland, United Kingdom
Fondazione Policlinico Universitario Agostino Gemelli...
Massimo Antonelli; Flavia Torrini; Alessandra Bisanti; Eleonora Filipponi; Domenica... and other collaborators

Recruiting

Patient Management During Major Abdominal Surgery: an Oxygen Consumption Protocol Compared to Standard Approach (HEART-CORE)

Hemodynamic Instability

Italy
Thermo Fisher Scientific Oy
ICON plc

Completed

Stability of Tacrolimus, Cyclosporine A, Everolimus and Sirolimus in Whole Blood Patient Samples

Transplantation Drugs Stability

Italy
Fondazione Policlinico Universitario Agostino Gemelli...

Completed

Perioperative Hypotension in Gynaecologic Oncologic Surgery: HPI-ClearSight Versus Arterial Waveform Analysis

Gynecologic Cancer | Hypotension | Hemodynamic Instability

Italy
Fondazione Policlinico Universitario Agostino Gemelli...

Completed

Hypotension Prediction With HPI Algorithm During Major Gynecologic Oncologic Surgery (HPI-GOS)

Gynecologic Cancer | Hemodynamic Instability | Intraoperative Hypotension

Italy
Fondazione Policlinico Universitario Agostino Gemelli...

Completed

Prevention or Treatment of Arterial Hypotension and Oxygen Cerebral Saturation During Major Abdominal Surgery

Hemodynamic Instability | Hypotension During Surgery

Italy
Osstem AIC

Completed

Osseointegration With a New Hydrophilic Surface

Dental Implant Stability

Italy
Fondazione Policlinico Universitario Agostino Gemelli...

Recruiting

Hemodynamic OptimizaTion in Sitting POsition Surgery Trial (HOTSPOT)

Orthopedic Disorder | Hemodynamic Instability | Blood Pressure, Low

Italy
Giacomo Fabbri

Recruiting

A 3-YEAR CLINICAL INVESTIGATION ON THE NOBEL ACTIVE® TIULTRA™ IMPLANT AND ON1™ BASE XEAL1™ _____________________________________________________________

to Study Soft Tissue Health and Stability

Italy
Merck Sharp & Dohme LLC

Recruiting

A Study of Pembrolizumab (MK-3475) in Pediatric Participants With an Advanced Solid Tumor or Lymphoma (MK-3475-051/KEYNOTE-051)

Melanoma | Lymphoma | Solid Tumor | Classical Hodgkin Lymphoma | Microsatellite-instability-high Solid Tumor

France, Germany, Italy, Netherlands, Sweden, United Kingdom, Brazil, Israel, Korea, Republic of, United States
Merck Sharp & Dohme LLC

Recruiting

Evaluation of Co-formulated Pembrolizumab/Quavonlimab (MK-1308A) Versus Other Treatments in Participants With Microsatellite Instability-High (MSI-H) or Mismatch Repair Deficient (dMMR) Stage IV Colorectal Cancer (CRC) (MK-1308A-008/KEYSTEP-008)

Colorectal Cancer

United States, Belgium, Canada, Germany, Italy, Korea, Republic of, Poland, Russian Federation, Spain, Turkey, United Kingdom, France, Denmark, Romania, Estonia, Hungary, Guatemala, Costa Rica, Lithuania, Greece, Colombia, Netherl...
Istituto Ortopedico Rizzoli

Recruiting

Clinical and Radiographic Assessment After Surgical Treatment of Anterior Shoulder Dislocation

Shoulder Instability | Anterior Shoulder Dislocation | Bone Defects

Italy
Humanitas Clinical and Research Center

Recruiting

Sigh35 and End-expiratory Occlusion Test (EEOT) for Assessing flUid Responsiveness in Critically Ill Patients Undergoing Pressure Support Ventilation (SETUP)

Critically Ill Patients | Hemodynamic Instability | Mechanical Ventilation Pressure High

Italy
Novartis Pharmaceuticals

Recruiting

Study of HRO761 Alone or in Combination in Cancer Patients With Specific DNA Alterations Called Microsatellite Instability or Mismatch Repair Deficiency.

MSIhi or dMMR Advanced Unresectable or Metastatic Solid Tumors, Including Colorectal Cancers

Japan, Italy, Spain, Singapore, Belgium, Germany, Korea, Republic of, Sweden, Taiwan, France, Israel, Norway, United States
Bristol-Myers Squibb
Ono Pharmaceutical Co. Ltd

Recruiting

A Study of Nivolumab, Nivolumab Plus Ipilimumab, or Investigator's Choice Chemotherapy for the Treatment of Participants With Deficient Mismatch Repair (dMMR)/Microsatellite Instability High (MSI-H) Metastatic Colorectal Cancer (mCRC) (CheckMate 8HW)

Metastatic Colorectal Cancer

United States, Belgium, China, Canada, Denmark, France, Norway, Romania, Spain, United Kingdom, Austria, Brazil, Germany, Netherlands, Argentina, Czechia, Ireland, Italy, Turkey, Chile, Greece, Puerto Rico, Australia, Japan
Unit of neurosurgery, Departement of Neurosciences...
University of Roma La Sapienza; University of Pavia; Fondazione IRCCS Ca' Granda... and other collaborators

Active, not recruiting

Registry for Evaluation of Lumbar Arthrodesis Sagittal alignmEnt (RELAPSE)

Lumbar Spine Disease | Lumbar Spine Instability | Instabilities Lumbar

Italy
Istituto Ortopedico Rizzoli

Recruiting

Functional Instability in Patients Suffering From Collagen Disease and Joint Hypermobility (VIPIA)

Collagen Diseases | Joint Hypermobility | Hypermobility Syndrome | Laxity of Ligament | Danlos Disease, Ehlers

Italy
University of Roma La Sapienza

Recruiting

Spinal Stenosis and Listhesis Treated With Percutaneous Interspinous Spacer: a Non-surgical Trial

Lumbar Spinal Stenosis | Lumbar Spondylolisthesis | Lumbar Spine Degeneration | Lumbar Spine Instability

Italy
Azienda Ospedaliera San Gerardo di Monza

Completed

International Observational Study on Airway Management in Critically Ill Patients (INTUBE)

Critical Illness | Respiratory Failure | Coma | Hemodynamic Instability

Italy
University of Padova

Recruiting

Manually Controlled Infusion vs Target Controlled Infusion for StrokeThrombectomy (HASTE)

Anesthesia | Stroke, Ischemic | Hemodynamic Instability | Stroke/Brain Attack

Italy
Azienda Ospedaliera Universitaria Integrata Verona

Unknown

PERiX: Comparison of Efficacy Between Placement of Epidural Catheters X-ray Guided and LOS Technique (PERiX)

Postoperative Complications | Postoperative Pain | Pancreatic Cancer | Haemodynamic Instability

Italy
Universitätsklinikum Hamburg-Eppendorf
University of Giessen; University of Rostock

Completed

Individualized Perioperative Hemodynamic Goal-directed Therapy in Major Abdominal Surgery (iPEGASUS-trial) (iPEGASUS)

Hemodynamic Instability | Peroperative Complication | Cardiac Output, High

Germany, Italy, Spain
IRCCS Azienda Ospedaliero-Universitaria di Bologna

Recruiting

Hemodynamic Monitoring During Craniosynostosis Surgery: Comparing Traditional and Newer Technology Monitors (CRASY-PRAM) (CRASY-PRAM)

Hemorrhage | Hypovolemia | Hemodynamic Instability | Craniosynostoses

Italy
Zimmer Biomet

Recruiting

Clinical Outcomes Study of the Nexel Total Elbow

Post-traumatic Arthritis | Degenerative Arthritis | Elbow Joint Destruction | Post-traumatic Lesions | Ankylosed Joints | Advanced Rheumatoid Arthritis | Joint Instability or Loss of Motion | Acute Comminuted Articular Fracture of Elbow Joint Surfaces | Bone Loss Contributing to Elbow Instability | Bilateral...

United States, Australia, Finland, France, Germany, Italy, Netherlands, United Kingdom
Menarini Biomarkers Singapore

Recruiting

Fetal Cell Analysis From Maternal Blood

Pregnancy Related | Genetic Disease | Prenatal Screening

Italy
Neuromed IRCCS

Recruiting

Implementation of Molecular Diagnostic Pathways

Genetic Disease

Italy
Meyer Children's Hospital IRCCS

Recruiting

Transcranial Magnetic Stimulation (TMS) in Genetic Epilepsies

Epilepsy | Genetic Disease

Italy
European Hospital

Unknown

The Results of Preimplantation Genetic Diagnosis and Preimplantation Genetic Screening of Embryos Obtained From GnRH-agonist Long and GnRH-antagonist Ovarian Stimulation Protocol

Embryo's Genetic and Chromosomal Quality

Italy
IRCCS San Raffaele
Federico II University

Not yet recruiting

PROSPECTIVE MULTICENTER REGISTRY OF GENDER, DIVERSITY AND INCLUSION (GEDI) OF WOMEN WITH ACUTE CORONARY SYNDROME (ACS GEDI)

Acute Coronary Syndrome | Genetic Predisposition | Gender

Italy
Neuromed IRCCS
Institute of Genetics and Biophysics CNR

Unknown

Functional Genomics of Rare Genetic Diseases: Realization of Innovative Tools With High Diagnostic Power

Rare Diseases

Italy
Catholic University of the Sacred Heart

Unknown

Saffron Supplementation in Stargardt's Disease (STARSAF02)

Retinal Degeneration | Genetic Disease | Single-Gene Defects | Macular Dystrophy

Italy
Societa Italiana di Dermatologia Medica, Chirurgica...

Recruiting

National Register of Moderate and Severe Adult Atopic Dermatitis (ATOPYREG)

Atopic Dermatitis

Italy
Relife S.r.l.

Completed

Clinical Investigation on the Efficacy and Safety of Relizema Cream in Paedriatric Patients (YOUNG)

Atopic Dermatitis

Italy
Federico II University

Unknown

Probiotic Lactobacillus Rhamnosus GG for Pediatric Atopic Dermatitis (PROPAD)

Atopic Dermatitis

Italy
Ospedale San Raffaele

Completed

Pharmacogenetics of Torasemide and Spironolactone in Hypertension Treatment (ALTUM)

Hypertension | Drug Effect | Genetic Predisposition

Italy

Clinical Trials on Genomic Instability in Italy

Sponsors and Collaborators

Medical Conditions

Drug Interventions

CROs by country

CROs in Serbia

Conditions

Rare Diseases

Drug Interventions

Dietary Supplements

Sponsor/Collaborators

Locations