Clinical Trials on Hepatic Insufficiency in United Kingdom

Total 4367 results

Bristol-Myers Squibb

Withdrawn

A Study to Evaluate the Pharmacokinetics of BMS-986141 in Participants With Hepatic Impairment Compared to Healthy Participants

Hepatic Impairment

United States
Octapharma

Terminated

Evaluation of the Safety of Octaplas™ Versus Plasma in Patients Undergoing Orthotopic Liver Transplantation

Coagulopathy | Endstage Liver Disease

United States
FUJIFILM Toyama Chemical Co., Ltd.
Celerion

Completed

PK Study of T-817 in Subjects With Hepatic Impairment

Healthy | Hepatic Impairment

United States
MDVI, LLC

Completed

Pharmacokinetics of Favipiravir in Volunteers With Hepatic Impairment

Healthy | Hepatic Impairment

United States
University of Edinburgh
Medical Research Council; NHS Lothian

Unknown

Heme Arginate in Cardiac Surgery Patients (HACS)

Acute Kidney Injury

United Kingdom
Papworth Hospital NHS Foundation Trust
Aalborg University

Completed

Mathematically Arterialised Testing of Hypercapnic Subjects Study (MATHS)

Hypercapnic Respiratory Failure

United Kingdom
Insmed Incorporated

Completed

A Study to Evaluate the Pharmacokinetics (PK) and Safety of a Single Dose of Brensocatib in Participants With Normal Hepatic Function and Participants With Hepatic Impairment

Hepatic Impairment

United States
Galectin Therapeutics Inc.

Completed

A Single-dose, Open-label, Pharmacokinetic Study of Belapectin (GR-MD-02) in Subjects With Normal Hepatic Function and Subjects With Varying Degrees of Hepatic Impairment

Hepatic Impairment

United States
Eli Lilly and Company
AstraZeneca

Withdrawn

A Study of LY3314814 in Participants With Liver Impairment

Hepatic Impairment

United States
Janssen Research & Development, LLC

Completed

A Pharmacokinetic Study of Abiraterone Acetate in Patients With Severe Hepatic Impairment Compared to Patients With Normal Hepatic Function

Hepatic Impairment

United States
AstraZeneca

Recruiting

Pharmacokinetics of Mitiperstat in Participants With Hepatic Impairment

Hepatic Impairment

United States
Array Biopharma, now a wholly owned subsidiary...

Terminated

MEK162 in Healthy Subjects With Normal Hepatic Function and Subjects With Impaired Hepatic Function (MEK162)

Hepatic Impairment

United States
Janssen Research & Development, LLC

Completed

A Study to Evaluate the Pharmacokinetics of PCI-32765 in Participants With Varying Degrees of Hepatic Impairment

Hepatic Impairment

United States
Pfizer

Completed

A Study To Compare Pharmacokinetics Of Dacomitinib (PF-00299804) Between Healthy Subjects And Subjects With Mild And Moderate Hepatic Impairment

Healthy | Otherwise Healthy Volunteers With Mild or Moderate Hepatic Dysfunction

United States
University of Nottingham

Not yet recruiting

Validation of Renal Perfusion CEUS Against MRI, and Its Application in Acute Kidney Injury

Kidney Diseases | Ultrasonography | Kidney Injury, Acute | Perfusion Imaging

United Kingdom
Novartis Pharmaceuticals

Completed

Single-dose Iloperidone Pharmacokinetics in Patients With Mild or Moderate Liver Disease, Compared to Healthy Volunteers

Hepatic Impairment

United States
Amgen

Completed

Study of the Pharmacokinetics and Safety of Carfilzomib in Patients With Advanced Malignancies and Hepatic Impairment

Hepatic Impairment | Solid Tumors | Hematologic Malignancies

United Kingdom, Netherlands, United States, France
Lateral Pharma Pty Ltd

Completed

Oral LAT8881 in Neuropathic Pain

Neuropathic Pain | Diabetic Peripheral Neuropathy (DPN) | Post Herpetic Neuralgia (PHN)

Australia, United Kingdom
University of South Florida
University of Miami; University of Alabama at Birmingham; Icahn School of Medicine... and other collaborators

Completed

Evidence-based Assessment of Medication Sensitivity in Acute Hepatic Porphyria

Porphyrias

United States
Queen Mary University of London

Completed

Skeletal Muscle Wasting and Renal Dysfunction After Critical Illness Trauma - Outcomes Study (KRATOS)

Quality of Life | Critical Illness | Chronic Kidney Diseases | Acute Kidney Injury | Muscle Loss | Major Trauma

United Kingdom
Kadmon, a Sanofi Company

Completed

KD025 Hepatic Impairment Study With Normal Hepatic Function and Subjects With Varying Degrees of Hepatic Impairment

Hepatic Impairment

United States
Celgene

Completed

A Study to Assess the Pharmacokinetics of CC-90001 in Subjects With Mild, Moderate, and Severe Hepatic Impairment Compared With Healthy Subjects

Hepatic Impairment

United States
SecuraBio

Completed

Duvelisib in Hepatically Impaired Subjects Compared to Healthy Subjects (IPI-145-14)

Hepatic Impairment

United States
University Hospital Birmingham NHS Foundation Trust
British Heart Foundation

Completed

The Role of Myocardial Fibrosis in Degenerative Mitral Regurgitation

Mitral Regurgitation | Mitral Valve Regurgitation

United Kingdom
NewAmsterdam Pharma
Veranex

Recruiting

PK and Safety in Participants Taking Obicetrapib With Moderate Hepatic Impairment Relative to Normal Hepatic Function

Healthy | Hepatic Impairment

United States
Royal Brompton & Harefield NHS Foundation Trust

Unknown

The Role of Gastroesophageal Reflux in Scleroderma Pulmonary Fibrosis

Gastroesophageal Reflux | Systemic Sclerosis | Interstitial Lung Disease

United Kingdom
Novartis Pharmaceuticals

Completed

INC280 in Healthy Subjects With Impaired Hepatic Function and Subjects With Normal Hepatic Function

Hepatic Impairment

United States
University Hospitals Coventry and Warwickshire...

Recruiting

Arterial Stiffness in Heart Failure and Chronic Kidney Disease (ASHFCKD)

Arterial Stiffness

United Kingdom
Mayo Clinic
Amra Medical AB

Recruiting

Adverse Outcomes and Mortality in Liver Transplant

Cirrhosis | Sarcopenia | Sarcopenic Obesity | End Stage Liver DIsease

United States
Imperial College London

Completed

Effects of Obesity Surgery on Renal Function

Impaired Renal Function

United Kingdom
Lexicon Pharmaceuticals

Completed

PK Study of Sotagliflozin in Subjects With Hepatic Impairment

Healthy | Hepatic Impairment

United States
Celgene

Completed

A Study to Assess the Pharmacokinetics of Enasidenib (CC-90007) in Subjects With Moderate and Severe Hepatic Impairment.

Hepatic Impairment

United States
University of Birmingham

Completed

The Effects of Serum Vitamin D and IVF Outcome (VIDIO)

Infertility | Vitamin D Deficiency | Vitamin D Insufficiency

United Kingdom
Mirati Therapeutics Inc.

Completed

A Study to Evaluate the Effect of Mild, Moderate, and Severe Hepatic Impairment on Pharmacokinetics of Sitravatinib

Hepatic Impairment

United States
AstraZeneca

Completed

To Assess the Pharmacokinetics, Safety and Tolerability of Selumetinib in Patients With Hepatic Impairment and Healthy Subjects

Solid Tumors

United States
Hull University Teaching Hospitals NHS Trust
University of Hull

Active, not recruiting

Endovenous Laser Therapy (EVLT) for Sapheno-Popliteal Incompetence and Short Saphenous Vein (SSV) Reflux: A RCT

Varicose Veins | Venous Insufficiency

United Kingdom
Reata, a wholly owned subsidiary of Biogen

Completed

Single-Dose, Open-Label Pharmacokinetic Study of Bardoxolone Methyl in Subjects With Mild, Moderate, and Severe Hepatic Impairment and Normal Hepatic Function

Healthy | Hepatic Impairment

United States
Triomed AB
Iqvia Pty Ltd

Enrolling by invitation

Carry Life@ UF System Clinical Study

End Stage Renal Disease

Sweden, United Kingdom
Methodist Health System

Recruiting

Outcomes Using MARS for Patients With ALF

Acute Liver Failure | Alcoholic Hepatitis

United States
Pfizer

Completed

Study of PF-05221304 in Subjects With Varying Degrees of Hepatic Impairment

Hepatic Impairment

United States, Belgium, Czechia, Slovakia
University of California, Los Angeles

Enrolling by invitation

Angiotensin 2 for AKI After OLT

Acute Kidney Injury | Liver Transplant; Complications | Cirrhosis, Liver | End Stage Liver DIsease

United States
GlaxoSmithKline

Terminated

Anemia Study in Chronic Kidney Disease (CKD) : Erythropoiesis Via a Novel Prolyl Hydroxylase Inhibitor (PHI) Daprodustat -Forearm Blood Flow (ASCEND-FBF)

Anaemia

United Kingdom
Novartis Pharmaceuticals

Terminated

Pharmacokinetics of Dabrafenib in Subjects With Hepatic Impairment

Hepatic Impairment

United States
Healthgen Biotechnology Corp.

Completed

A Study of OsrHSA in Adult Healthy Male and Female Volunteers

Ascites Hepatic

United States
Novartis Pharmaceuticals

Completed

PK and Safety of Midostaurin in Subjects With Impaired Hepatic Function and Subjects With Normal Hepatic Function

Hepatic Impairment

Germany, Belgium, Lithuania, United States, Bulgaria, Romania
University of Leeds
Baxter Healthcare Corporation; National Health Service, United Kingdom; Foundation... and other collaborators

Completed

Developing and Evaluating the Yorkshire Dialysis Decision Aid (YoDDA)

Chronic Kidney Failure

United Kingdom
Pfizer

Completed

STUDY OF PF-06882961 IN PARTICIPANTS WITH AND WITHOUT VARYING DEGREES OF HEPATIC IMPAIREMENT

Healthy Volunteers | Hepatic Impairment

United States
ObsEva SA

Completed

Safety and Pharmacokinetics Study of Linzagolix in Female Subjects With Normal and Impaired Hepatic Function

Hepatic Impairment | Healthy Participants

United States
Belfast Health and Social Care Trust

Recruiting

High VS Low Flow Nasal O2 for Acute Hypercapnic Respiratory Failure

Acute Hypercapnic Respiratory Failure | Acute Exacerbation of COPD

United Kingdom
Imperial College London

Completed

The Right Ventricular Pulmonary Circulation Continuum in Mitral Valve Disease Study (RIPCOM1)

Mitral Regurgitation | Pulmonary Hypertension

United Kingdom

Clinical Trials on Hepatic Insufficiency in United Kingdom

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