Clinical Trials on Hepatic Steatosis in United Kingdom

Total 1850 results

Colibri Heart Valve LLC

Recruiting

Colibri Transcatheter Aortic Heart Valve System Study

Severe Aortic Stenosis

France, United Kingdom
M.D. Anderson Cancer Center

Recruiting

Stereotactic Liver Ablation Assisted With Intra-Arterial CT Hepatic Arteriography and Ablation Confirmation Software Assessment (STEREOLAB)

Liver Ablation | Hepatic

United States
University of Nottingham

Completed

The Metabolic Effects of a High Fructose Versus a High Glucose Diet in Overweight Men

Oxidative Stress | Hepatic Fatty Acid Metabolism | Systemic Insulin Resistance | Cardiovascular Status

United Kingdom
University of Edinburgh
NHS Lothian; British Heart Foundation

Completed

Role of Active Valvular Calcification and Inflammation in Patients With Aortic Stenosis

Aortic Stenosis

United Kingdom
BeiGene

Completed

Safety and Pharmacokinetics of Zanubrutinib (BGB-3111) in Healthy Subjects and Those With Impaired Liver Function

Hepatic Insufficiency & Healthy Subjects

United States
Institut für Pharmakologie und Präventive Medizin
Edwards Lifesciences

Completed

Early Detection of Aortic Stenosis in the Community During Flu Vaccination (FluClinic)

Aortic Stenosis

United Kingdom
The University of Texas Health Science Center at...
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)

Active, not recruiting

Empagliflozin and Hepatic Glucose Metabolism

Hepatic Glucose Metabolism

United States
Seagen Inc.

Completed

A Safety Study of Tucatinib in Healthy and Hepatically-Impaired Subjects

Hepatic Impairment

United States
Case Comprehensive Cancer Center

Completed

Comparison of Yttrium-90 Absorbed Doses Using PET/CT Versus PET/MR Imaging for Hepatic Malignancies

Hepatic Malignancies

United States
Genfit

Completed

Nitazoxanide Pharmacokinetic Parameters in Hepatic Impaired Patients

Liver Diseases | Moderate Hepatic Impairment | Severe Hepatic Impairment

United States
Medical University of Vienna
Medical University of South Carolina; IRCCS Azienda Ospedaliero-Universitaria... and other collaborators

Recruiting

Aortic Stenosis and Cardiac Amyloidosis

Aortic Stenosis | Cardiac Amyloidosis

Austria, United Kingdom
Royal Brompton & Harefield NHS Foundation Trust

Completed

Does Cardiac REhabilitation Improve Functional, Independence, Frailty and Emotional outCOmes Following Trans Catheter Aortic ValvE Replacement? (RECOVER-TAVR)

Aortic Stenosis

United Kingdom
AstraZeneca

Completed

Open-label Study to Assess the Pharmacokinetics of NKTR-118 in Patients With Impaired Hepatic Function

Hepatic; Functional Disturbance

United States
Acerta Pharma BV
AstraZeneca

Completed

Investigate the Influence of Severe Hepatic Impairment on the Pharmacokinetics of Acalabrutinib and Its Metabolite

Hepatic Insufficiency | Healthy Subjects | Hepatic Impairment

United States
London North West Healthcare NHS Trust

Completed

Clinical Value of Stress Echocardiography in Moderate Aortic Stenosis

Aortic Valve Stenosis

United Kingdom
St George's, University of London
King's College Hospital NHS Trust; Guy's and St Thomas' NHS Foundation Trust

Completed

Exercise Training in Hypertrophic Cardiomyopathy: (SAFE-HCM) (SAFE-HCM)

Hypertrophic Cardiomyopathy

United Kingdom
Imperial College Healthcare NHS Trust

Recruiting

Transplant Renal Artery Stenosis: Observation Versus Stenting (TRASOS)

Transplant Renal Artery Stenosis

United Kingdom
University Hospitals, Leicester

Completed

Microvascular Dysfunction in Aortic Stenosis (PRIMID-AS)

Aortic Stenosis

United Kingdom
University College London Hospitals
Medical Research Council

Unknown

Predictive Utility of DASIMAR as a Prognostic Biomarker in Acute-on-chronic Liver Failure (ACLF) (DASIMAR)

Liver Cirrhosis

United Kingdom
University College, London
British Heart Foundation

Unknown

Trimetazidine Therapy in Hypertrophic Cardiomyopathy

Hypertrophic Cardiomyopathy

United Kingdom
King's College London
Royal Centre for Defence Medicine

Unknown

Macro and Micro Haemodynamic Responses to Shock in the Renal and Systemic - MICROSHOCK - RENAL

Septic Shock | Acute Kidney Injury

United Kingdom
Barts & The London NHS Trust
Barts Cardiovascular CTU (Queen Mary University of London)

Not yet recruiting

Non-Invasive Radiation Ablation in Patients With Hypertrophic CardioMyopathy: NIRA-HOCM (NIRA-HOCM)

Hypertrophic Cardiomyopathy

United Kingdom
University of Edinburgh
Sir Jules Thorn Charitable Trust

Active, not recruiting

Early Valve Replacement Guided by Biomarkers of LV Decompensation in Asymptomatic Patients With Severe AS (EVoLVeD)

Aortic Valve Stenosis | Hypertrophy, Left Ventricular

United Kingdom
Newcastle-upon-Tyne Hospitals NHS Trust
Assistance Publique - Hôpitaux de Paris; Azienda Ospedaliero-Universitaria... and other collaborators

Completed

Lifestyle and Pharmacological Interventions in Hypertrophic Cardiomyopathy (SILICOFCM)

Hypertrophic Cardiomyopathy

United Kingdom
University College, London
Inherited Cardiac Diseases Unit, The Heart Hospital, London

Unknown

Morbidity and Mortality in Patients With Hypertrophic Cardiomyopathy: a CALIBER Study (HCM)

Hypertrophic Cardiomyopathy

United Kingdom
NGM Biopharmaceuticals, Inc

Completed

Study of Aldafermin (NGM282) in Participants With Impaired Hepatic Function

Impaired Hepatic Function

United States
Tetraphase Pharmaceuticals, Inc.

Completed

A Phase 1, Open-Label Study to Assess the Single-Dose Pharmacokinetics of Eravacycline in Subjects With Impaired Hepatic Function and Healthy Subjects

Impaired Hepatic Function

United States
East and North Hertfordshire NHS Trust
Royal Brompton & Harefield NHS Foundation Trust

Not yet recruiting

Avr Thrombosis OutcoMe Study (ATOM)

Aortic Stenosis

United Kingdom
Daiichi Sankyo, Inc.

Completed

Study of Pexidartinib in Participants With Moderate Hepatic Impairment Compared With Healthy Participants

Moderate Hepatic Impairment

United States
Alexion

Recruiting

Study of ALXN2050 in Participants With Hepatic Impairment

Healthy | Impaired Hepatic Function

United States
University of Edinburgh

Completed

PET-MRI Imaging in Patients With Symptomatic Carotid Artery Stenosis

Stroke | Carotid Stenosis

United Kingdom
Atea Pharmaceuticals, Inc.

Recruiting

Study of Bemnifosbuvir in Subjects With Normal and Impaired Hepatic Function

Hepatic Impairment | Healthy Volunteer

United States
Barts & The London NHS Trust

Active, not recruiting

Pacemaker Therapy for Drug-refractory Symptoms in Mid-cavity Hypertrophic Cardiomyopathy

Cardiomyopathy, Hypertrophic

United Kingdom
Manchester University NHS Foundation Trust

Completed

A Validation Study of the Dx-pH Probe in Children for the Detection of Extra-oesophageal Reflux

Gastro-oesophageal Reflux

United Kingdom
Sanofi

Completed

Study to Assess the Plasma Concentration of Tolebrutinib Given as a Tablet to Adult Participants With Mild Hepatic Impairment Compared to Participants With Normal Hepatic Function

Hepatic Function Abnormal

United States, Belgium
Alnylam Pharmaceuticals

Recruiting

ELEVATE, a Registry of Patients With Acute Hepatic Porphyria (AHP) (ELEVATE)

Acute Hepatic Porphyria

Belgium, France, Germany, United Kingdom, United States, Italy, Switzerland, Sweden
University of East Anglia
Norfolk and Norwich University Hospitals NHS Foundation Trust; British Medical...

Unknown

Nitrite in Hypertrophic Cardiomyopathy (HCM) Study

Cardiomyopathy, Hypertrophic

United Kingdom
Imperial College London
British Heart Foundation

Recruiting

Electromechanically Optimised Right Ventricular Pacing In Hypertrophic Cardiomyopathy (EMORI-HCM) (EMORI-HCM)

Hypertrophic Cardiomyopathy | Hypertrophic Obstructive Cardiomyopathy

United Kingdom
Eli Lilly and Company
Loxo Oncology, Inc.

Completed

A Study of Effects of Selpercatinib in Hepatically Impaired Participants and Healthy Participants

Healthy | Hepatic Impairment

United States
Hunter Holmes Mcguire Veteran Affairs Medical Center
Instituto Grifols, S.A.; McGuire Research Institute

Completed

HEAL STUDY (Hepatic Encephalopathy and Albumin Study) (HEAL)

Hepatic Encephalopathy | Cirrhosis | Minimal Hepatic Encephalopathy | Covert Hepatic Encephalopathy

United States
Sanofi

Completed

A Study in Adults to Investigate the Impact of Mild, Moderate, and Severe Hepatic Impairment on Pharmacokinetics of Venglustat Compared to Participants With Normal Hepatic Function

Hepatic Function Abnormal

United States, Germany
Imperial College London
University of Oxford; Barts & The London NHS Trust; Medtronic; Imperial College... and other collaborators

Recruiting

Prospective Evaluation Of Exercise-Induced Cardiac Conduction Instability In Predicting Ventricular Fibrillation Events In Hypertrophic Cardiomyopathy (PREDICTVFII)

Hypertrophic Cardiomyopathy

United Kingdom
Barts & The London NHS Trust

Terminated

Paced Dyssynchrony and Myocardial Perfusion IN apiCal Hcm (PINCHcm)

Hypertrophic Cardiomyopathy

United Kingdom
Taiho Oncology, Inc.

Completed

Evaluating Patients With Impaired Hepatic Function

Impaired Hepatic Function

United States
Mitsubishi Tanabe Pharma America Inc.

Completed

Study to Assess Pharmacokinetics, Safety, and Tolerability of MT-7117 in Subjects With Normal and Impaired Hepatic Function

Mild and Moderate Hepatic Impairment

United States
Cardiox Corporation

Withdrawn

Cardiox Liver Function Test Pivotal Trial (LFT-0002)

Liver Failure | Hepatic Failure

United States
Javelin Pharmaceuticals

Completed

Open-Label, Single-Dose Study to Evaluate the Safety and PK of DIC075V in Subjects With Renal Insufficiency and Hepatic Impairment Compared to Healthy Subjects and Evaluate the Safety and Pharmacokinetics of HPβCD When Administered in DIC075V Compared to Sporanox® in Healthy Subjects

Hepatic Insufficiency | Healthy | Renal Insufficiency, Chronic

United States, United Kingdom
Spinal Simplicity LLC
The Leeds Teaching Hospitals NHS Trust

Completed

Minuteman Spinal Fusion Implant Versus Surgical Decompression for Lumbar Spinal Stenosis

Degenerative Disc Disease | Lumbar Spinal Stenosis | Spondylolisthesis

United Kingdom
Principia Biopharma, a Sanofi Company

Completed

A Study to Evaluate the Effect of Mild and Moderate Hepatic Impairment on the Single-Dose Pharmacokinetics of Rilzabrutinib (PRN1008)

Healthy Volunteers | Hepatic Function Abnormal

United States
Indivior Inc.

Completed

Single Dose Pharmacokinetics of Suboxone Study in Hepatic Impaired Subjects

Hepatic Impairment | Hepatic Failure | Chronic Hepatitis C Infection With Hepatic Coma

United States

Clinical Trials on Hepatic Steatosis in United Kingdom

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