Clinical Trials on Hereditary Nonpolyposis in United States

Total 1421 results

National Cancer Institute (NCI)

Completed

Phase I-II Multiple-Dose Safety and Efficacy Study of a Selective Inhibitor of Cyclooxygenase - 2 (SC-58635) in Hereditary Non-Polyposis Colorectal Cancer (HNPCC) Patients and Carriers

Colorectal Neoplasm | Hereditary Nonpolyposis

United States
National Human Genome Research Institute (NHGRI)

Completed

Psychosocial Aspects of Genetic Testing for Hereditary Nonpolyposis Colon Cancer

HNPCC | Hereditary Nonpolyposis Colon Cancer

United States
M.D. Anderson Cancer Center

Recruiting

Registry for Women Who Are At Risk Or May Have Lynch Syndrome

Lynch Syndrome | Hereditary Nonpolyposis Colorectal Cancer

United States
Geisinger Clinic
National Cancer Institute (NCI)

Completed

Trial to Compare eConsent With Standard Consent Among Prospective Biobank Participants

Lynch Syndrome

United States
National Human Genome Research Institute (NHGRI)

Completed

Uncertain Genetic Test Results for Lynch Syndrome

HNPCC

United States
Fox Chase Cancer Center

Recruiting

Atorvastatin ± Aspirin in Lynch Syndrome Syndrome

Lynch Syndrome

United States
Fox Chase Cancer Center
National Cancer Institute (NCI)

Completed

Educational CD-ROM Compared With Standard Informed Consent for Patients With Colorectal Cancer or a Family History of Colorectal Cancer

Colorectal Cancer | Hereditary Non-polyposis Colon Cancer

United States
Vanderbilt University Medical Center
National Cancer Institute (NCI)

Completed

Collecting Information From Patients and Family Members With Hereditary Colorectal Cancer Syndromes or Who Are at High Risk of Developing Colorectal Cancer

Colorectal Cancer | Precancerous Condition | Hereditary Non-polyposis Colon Cancer

United States
M.D. Anderson Cancer Center
National Cancer Institute (NCI)

Completed

Survivorship in Lynch Syndrome Families

Colorectal Cancer

United States
UNC Lineberger Comprehensive Cancer Center
University of North Carolina, Chapel Hill; National Center for Advancing Translational... and other collaborators

Recruiting

Overcoming Barriers to the Uptake of Cascade Screening for Lynch Syndrome: Workbook Feasibility Study

Lynch Syndrome

United States
M.D. Anderson Cancer Center
National Cancer Institute (NCI); National Institutes of Health (NIH)

Recruiting

A Phase IIa Randomized, Double-Blinded Clinical Trial of Naproxen or Aspirin for Cancer Immune Interception in Lynch Syndrome

Colorectal Cancer | Lynch Syndrome | T Cells

United States
Kaiser Permanente
M.D. Anderson Cancer Center; Dana-Farber Cancer Institute; Vanderbilt University and other collaborators

Completed

Integrating Genetic Testing for Lynch Syndrome in a Managed Care Setting (HNPCC)

Lynch Syndrome | Colon Cancer

United States
University of Kansas Medical Center

Active, not recruiting

Omega 3 Fatty Acids in Colorectal Cancer (CRC) Prevention in Patients With Lynch Syndrome (COLYNE)

Colorectal Cancer | Lynch Syndrome

United States
London North West Healthcare NHS Trust

Completed

Magnification Narrow Band Imaging Colonoscopy for Hereditary Non-Polyposis Colorectal Cancer Surveillance

Colorectal Neoplasms, Hereditary Nonpolyposis

United Kingdom
National Cancer Institute (NCI)

Recruiting

Cancer Preventive Vaccine Nous-209 for Lynch Syndrome Patients

Lynch Syndrome

United States, Puerto Rico
Memorial Sloan Kettering Cancer Center
National Cancer Institute (NCI); Albert Einstein College of Medicine

Recruiting

Multi-Organ Screening Recommendations in Patients With Lynch Syndrome

Lynch Syndrome

United States
Mayo Clinic
Exact Sciences Corporation

Recruiting

Collecting Blood and Stool Samples to Detect Colorectal Cancer or Advanced Neoplasia in Lynch Syndrome Patients, CORAL Study

Lynch Syndrome | Colorectal Carcinoma

United States
National Cancer Institute (NCI)

Completed

Naproxen in Preventing DNA Mismatch Repair Deficient Colorectal Cancer in Patients With Lynch Syndrome

Lynch Syndrome

United States
M.D. Anderson Cancer Center
National Cancer Institute (NCI)

Active, not recruiting

Weight Management and Health Behavior Intervention in Lowering Cancer Risk for BRCA Positive and Lynch Syndrome Families

Lynch Syndrome | Hereditary Breast Carcinoma | Hereditary Ovarian Carcinoma

United States
University of Pittsburgh

Completed

Hereditary Colorectal and Associated Tumor Registry Study

Lynch Syndrome | Hereditary Diffuse Gastric Cancer | FAP | Peutz-Jeghers Syndrome | Juvenile Polyposis Syndrome

United States
Memorial Sloan Kettering Cancer Center
Harvard University; Broad Institute

Active, not recruiting

Metagenomic Evaluation of the Gut Microbiome in Patients With Lynch Syndrome and Other Hereditary Colonic Polyposis Syndromes

Lynch Syndrome | Hereditary Colonic Polyposis Syndromes

United States
M.D. Anderson Cancer Center

Unknown

The Molecular Predisposition to Hereditary Nonpolyposis Colon Cancer (HNPCC)

Kidney Cancer | Colorectal Cancer | Bladder Cancer | Skin Cancer | Endometrial Cancer | Uterus Cancer

United States
Imperial College London

Enrolling by invitation

Colonoscopy Check-up in People With Lynch Syndrome

Lynch Syndrome

United Kingdom
Johns Hopkins University
National Human Genome Research Institute (NHGRI)

Completed

Genetic Risk: Whether, When, and How to Tell Adolescents

Huntington Disease | Hereditary Cancer | Hereditary Breast and Ovarian Cancer | Hereditary Non-polyposis Colon Cancer | Hereditary Non-Polyposis Colorectal Cancer Syndrome

United States
National Cancer Institute (NCI)

Recruiting

Testing a Combination of Vaccines for Cancer Prevention in Lynch Syndrome

Lynch Syndrome

United States, Puerto Rico
Joanne Jeter
National Cancer Institute (NCI)

Active, not recruiting

Nivolumab in Preventing Colon Adenomas in Participants With Lynch Syndrome and a History of Partial Colectomy

Lynch Syndrome | Colon Adenoma | Colon Carcinoma | MLH1 Gene Mutation | MSH2 Gene Mutation

United States
M.D. Anderson Cancer Center
National Cancer Institute (NCI)

Completed

Cycling in Preventing Colorectal Cancer in Participants With Lynch Syndrome

High-Frequency Microsatellite Instability | Mismatch Repair Gene Mutation | Mutation-Negative Lynch Syndrome | Mutation-Positive Lynch Syndrome

United States
Ohio State University Comprehensive Cancer Center

Completed

Ohio Colorectal Cancer Prevention Initiative (OCCPI)

Colorectal Cancer | Lynch Syndrome

United States
St George's, University of London

Terminated

Intrauterine Levonorgestrel and Observation or Observation Alone in Preventing Atypical Endometrial Hyperplasia and Endometrial Cancer in Women With Hereditary Non-Polyposis Colorectal Cancer or Lynch Syndrome

Endometrial Cancer | Hereditary Non-polyposis Colon Cancer (hmsh2, hmlh1, hpms1, hpms2)

United Kingdom
University of Pennsylvania
Epigenomics, Inc

Completed

Preliminary Evaluation of Septin9 in Patients With Hereditary Colon Cancer Syndromes (Septin9)

Colorectal Cancer | Lynch Syndrome | Familial Adenomatous Polyposis | Map Syndrome | Hnpcc

United States
RWJ Barnabas Health at Jersey City Medical Center

Unknown

Lynch Syndrome Can be Diagnosed Just From Somatic Mismatch Repair Mutation

Lynch Syndrome | Endometrial Cancer | Somatic Mutation | Cancer Gene Mutation

United States
University of Arizona
Amgen

Completed

Study of TVEC in Patients With Cutaneous Squamous Cell Cancer

Skin Cancer | Squamous Cell Carcinoma | Keratoacanthoma | Cutaneous Tumor | Skin Cancer, Squamous Cell | Lesion Skin

United States
WellSpan Health

Active, not recruiting

Frequency of Endometrial Cancer Precursors Associated With Lynch Syndrome

Endometrial Hyperplasia | Lynch Syndrome | Endometrial Cancer | Microsatellite Instability | Mismatch Repair Deficiency

United States
Geisinger Clinic

Withdrawn

Evaluating the Cologuard Test for Use in Lynch Syndrome

Colorectal Cancer | Lynch Syndrome | Colonic Polyp | Colonic Adenoma

United States
Ohio State University Comprehensive Cancer Center

Active, not recruiting

Universal Endometrial Cancer DNA Sequencing for Detection of Lynch Syndrome and Personalized Care (OPTEC)

Lynch Syndrome | Relatives | Endometrial Carcinoma | Endometrial Adenocarcinoma

United States
Boston University
National Institute on Minority Health and Health Disparities (NIMHD); University... and other collaborators

Recruiting

Scalable Communication Modalities for Returning Genetic Research Results (BWHS RoR)

Lynch Syndrome | Hereditary Breast and Ovarian Cancer

United States
Gynecologic Oncology Group
National Cancer Institute (NCI)

Not yet recruiting

Biomarkers in Samples From Patients With Endometrial Cancer

Lynch Syndrome | Recurrent Uterine Corpus Carcinoma | Stage I Uterine Corpus Cancer | Stage II Uterine Corpus Cancer | Stage III Uterine Corpus Cancer | Stage IV Uterine Corpus Cancer

United States
Kaiser Permanente
Patient-Centered Outcomes Research Institute

Active, not recruiting

Family History Study on Cancer Risk

Breast Cancer | Colorectal Cancer | Ovarian Cancer | Lynch Syndrome | Genetic Predisposition | Family Characteristics

United States
University of Texas Southwestern Medical Center

Recruiting

CHARGE Study: CHoice ARchitecture Genetic tEsting (CHARGE)

Hereditary Cancer

United States
National Eye Institute (NEI)

Completed

Evaluation and Treatment of Patients With Inherited Eye Diseases

Hereditary Eye Disease

United States
National Eye Institute (NEI)

Completed

Screening for Studies on Inherited Eye Diseases

Hereditary Eye Disease

United States
M.D. Anderson Cancer Center

Recruiting

Evaluation of Hereditary Cancer Educational Videos

Hereditary Cancer

United States
University of Utah
University of Witwatersrand, South Africa

Completed

A Novel Mutation of the Spectrin Gene

Hereditary Elliptocytosis (HE) | Hereditary Pyropoikilocytosis (HPP)

United States
Washington University School of Medicine
The Foundation for Barnes-Jewish Hospital

Terminated

Implementation of the Families Accelerating Cascade Testing Toolkit (FACTT) for Hereditary Breast and Ovarian Cancer and Lynch Syndrome

Lynch Syndrome | Hereditary Breast and Ovarian Cancer

United States
Myriad Genetic Laboratories, Inc.
Myriad Genetics, Inc.

Completed

Impact of a Process Intervention on Screening and Testing Outcomes for Common Hereditary Cancer Syndromes

Hereditary Cancer

United States
Duke University
Susan G. Komen Breast Cancer Foundation

Completed

Telemedicine vs. Face-to-Face Cancer Genetic Counseling

Lynch Syndrome | Hereditary Breast and Ovarian Cancer Syndrome

United States
Massachusetts General Hospital

Recruiting

Prostate Cancer Genetic Risk Evaluation and Screening Study (PROGRESS)

Lynch Syndrome | Genetic Predisposition to Disease | Prostate Cancer | BRCA1 Mutation | BRCA2 Mutation | Prostatic Neoplasm | ATM Gene Mutation | MMR Mutation

United States
InheRET, Inc
University of Michigan

Enrolling by invitation

Inherited Risk Evaluation Tool (InheRET): Identifying Patients at Increased Risk for Hereditary Disease

Hereditary Cancer-Predisposing Syndrome

United States
University of Pennsylvania
Fox Chase Cancer Center

Completed

Penn Biobank Return of Research Results Program

Cardiovascular Diseases | Cancer | Hereditary Cancer | Hereditary Cardiac Amyloidosis

United States
National Cancer Institute (NCI)

Active, not recruiting

Combination Chemotherapy With or Without Atezolizumab in Treating Patients With Stage III Colon Cancer and Deficient DNA Mismatch Repair

Lynch Syndrome | Stage III Colon Cancer AJCC v8 | Colon Adenocarcinoma | DNA Repair Disorder

United States, Puerto Rico, Germany

Clinical Trials on Hereditary Nonpolyposis in United States

Sponsors and Collaborators

Medical Conditions

Drug Interventions

CROs by country

CROs in Mongolia

Conditions

Rare Diseases

Drug Interventions

Dietary Supplements

Sponsor/Collaborators

Locations