Clinical Trials on Hereditary Spastic Paraparesis in United Kingdom

Total 1818 results

Massachusetts General Hospital
National Institute of Neurological Disorders and Stroke (NINDS); National Institutes... and other collaborators

Completed

Validation of Biomarkers in Amyotrophic Lateral Sclerosis (ALS) (BIO_ALS-01)

Nervous System Diseases | Amyotrophic Lateral Sclerosis | Primary Lateral Sclerosis | Lou Gehrig's Disease | Hereditary Spastic Paraparesis

United States, Canada
National Institute of Neurological Disorders and...

Completed

Hu Mik-Beta-1 to Treat HTLV-1-Associated Myelopathy/Tropical Spastic Paraparesis

HTLV-1

United States
National Institute of Neurological Disorders and...

Completed

MRI Brain Studies in Patients With HTLV-1 Associated Myelopathy/Tropical Spastic Paraparesis

Tropical Spastic Paraparesis

United States
National Institute of Neurological Disorders and...

Recruiting

Teriflunomide in HTLV-1 Associated Myelopathy/Tropical Spastic Paraparesis

HAM/TSP

United States
National Institute of Neurological Disorders and...

Recruiting

Evaluation of Patients With HAM/TSP

Tropical Spastic Paraparesis | HTLV-I Infection

United States
National Institute of Neurological Disorders and...

Completed

Recombinant Human Interferon Beta-1a (Avonex) for the Treatment of Patients With HTLV-1-Associated Myelopathy (HAM)

Tropical Spastic Paraparesis | Spinal Cord Disease | HTLV-I Infection

United States
National Institute of Neurological Disorders and...

Completed

Assessment of Patients With Multiple Sclerosis (MS)

Multiple Sclerosis | Vasculitis | Tropical Spastic Paraparesis | HTLV-I Infection | Herpesviridae Infection

United States
VA Office of Research and Development
Atlanta VA Medical Center

Recruiting

Biomarkers of Reaction To HIIT Exercise (BReaTHE)

Stroke | Stroke Rehabilitation | Walking, Difficulty | Lower Extremity Weakness, Spastic

United States
Texas Woman's University

Recruiting

Effect of Brain Stimulation on Stepping Performance in Stroke Survivors and Healthy Adults (Gait)

Vascular Accident, Brain | Gait, Hemiplegic | CVA (Cerebrovascular Accident) | Spastic Lower Extremity Weakness

United States
Boston Children's Hospital
CureAP4 Foundation

Recruiting

Registry and Natural History Study for Early Onset Hereditary Spastic Paraplegia (HSP)

Hereditary Spastic Paraplegia | SPG50 | SPG47 | SPG51 | SPG52 | AP4-related Hereditary Spastic Paraplegia | Early Onset Hereditary Spastic Paraplegia | SPG4 | SPG3A | SPG15 | SPG11

United States
Imperial College London
Medical Research Council

Terminated

The HAM Infliximab Study (HAM06)

HTLV-I-associated Myelopathy

United Kingdom
Imperial College London
Medical Research Council; Imperial College Healthcare NHS Trust; University Hospital...

Completed

Ciclosporin in HTLV-1 Associated Myelopathy/ Tropical Spastic Paraparesis (HAM/TSP) (HAM05)

HTLV I Associated Myelopathy

United Kingdom
Imperial College London

Completed

Zidovudine Plus Lamivudine in HTLV-I-associated Myelopathy: a Randomised Trial

HTLV-I-associated Myelopathy

United Kingdom
National Institute of Neurological Disorders and...

Terminated

Disease Natural History and Biomarkers of SPG3A, SPG4A, and SPG31

Hereditary Spastic Paraplegia

United States
National Institute of Neurological Disorders and...

Recruiting

Genetic and Physical Study of Childhood Nerve and Muscle Disorders

Muscular Dystrophies | Inherited Neuromuscular Conditions | Inherited Neuropathies | Muscle Myopathies | Hereditary Spastic Paraplegias

United States
University of California, San Diego
New York University; Heinrich-Heine University, Duesseldorf; Universität Tübingen

Recruiting

Natural History Study of Patients With HPDL Mutations

Genetic Disease | Mitochondrial Encephalomyopathies | Neonatal Encephalopathy | Mutation | Hereditary Spastic Paraplegia | White Matter Disease | Spastic Paraplegia

United States
National Institute of Neurological Disorders and...

Completed

Nuclear Magnetic Spectroscopy Imaging to Evaluate Primary Lateral Sclerosis, Hereditary Spastic Paraplegia and Amyotrophic Lateral Sclerosis

Amyotrophic Lateral Sclerosis | Primary Lateral Sclerosis | Hereditary Spastic Paraplegia

United States
Boston Children's Hospital
Boston Children's Hospital - Children's Rare Disease Cohorts Initiative

Recruiting

Hereditary Spastic Paraplegia Genomic Sequencing Initiative (HSPseq)

Movement Disorders | Neurodegenerative Diseases | Motor Neuron Disease | Spasticity, Muscle | Pediatric Disorder | Hereditary Spastic Paraplegia

United States
National Heart, Lung, and Blood Institute (NHLBI)

Recruiting

Unrelated Umbilical Cord Blood Transplantation for Severe Aplastic Anemia and Hypo-plastic MDS Using CordIn(TM), Umbilical Cord Blood-Derived Ex Vivo Expanded Stem and Progenitor Cells to Expedite Engraftment and Improve Transplant Outcome

Myelodysplastic Syndrome (MDS) | Severe Aplastic Anemia | Hypo-Plastic MDS

United States
King's College Hospital NHS Trust

Recruiting

Autologous Tregs for Aplastic Anaemia (TIARA)

Aplastic Anemia

United Kingdom
University College London Hospitals

Completed

Muscle Structure, Function and Gait in dHMN (GAIT-dHMN)

Distal Hereditary Motor Neuropathy, Type II | Distal Hereditary Motor Neuropathy, Type V | Distal Hereditary Motor Neuronopathy Type I | Distal Hereditary Motor Neuronopathy Type VI

United Kingdom
Takeda

Recruiting

A Study in Adults With Hereditary Angioedema (HAE) Who Currently Receive Icatibant at Home

Hereditary Angioedema (HAE)

United Kingdom
Imperial College London

Completed

Frequency of Common Medical Conditions in People With and Without HHT

Hereditary Hemorrhagic Telangiectasia (HHT)

United Kingdom
University College, London

Recruiting

Hereditary Sensory Neuropathy Serine Trial (SENSE)

Hereditary Sensory Neuropathy Type I

United Kingdom
Takeda

Recruiting

A Study of Lanadelumab in Teenagers and Adults With Hereditary Angioedema (HAE)

Hereditary Angioedema (HAE)

United Kingdom
University of Southampton

Unknown

Femtolaser Assisted Keratoplasty Versus Conventional Keratoplasty

Keratoconus | Fuchs Dystrophy | Corneal Disease

United Kingdom
NHS Greater Glasgow and Clyde
Jean Brown Bequest Fund, Glasgow, UK

Not yet recruiting

3D Telemedicine During COVID-19: Non-clinical Validation

Telemedicine | Surgery, Plastic

United Kingdom
KalVista Pharmaceuticals, Ltd.

Completed

Phase 1 Crossover Study in Healthy Subjects to Evaluate the PK Profile of KVD824 Following Single and Multiple Doses of Modified Release (MR) Formulations

Hereditary Angioedema

United Kingdom
KalVista Pharmaceuticals, Ltd.

Completed

A Single Dose Safety, Tolerability, Pharmacokinetic and Food Effect Study of KVD900 in Healthy Volunteers

Hereditary Angioedema

United Kingdom
BioCryst Pharmaceuticals

Completed

A Relative Bioavailability Study of Two Formulations of BCX7353

Hereditary Angioedema

United Kingdom
BioCryst Pharmaceuticals

Completed

First-in-Human Study to Evaluate the Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of BCX7353 in Healthy Western and Japanese Volunteers

Hereditary Angioedema

United Kingdom
Imperial College London

Completed

Diet and Hereditary Haemorrhagic Telangiectasia

Hereditary Haemorrhagic Telangiectasia (HHT)

United Kingdom
BioCryst Pharmaceuticals

Completed

A Drug-Drug Interaction Study to Evaluate Drug Transporter Interactions

Hereditary Angioedema

United Kingdom
ProQR Therapeutics

Withdrawn

Study With QR-504a to Evaluate Safety, Tolerability & Corneal Endothelium Molecular Biomarker(s) in Subjects With FECD3 (Fuchs Focus)

Corneal Diseases | Fuchs Endothelial Corneal Dystrophy | FECD3 | LRS | Descemet's Membrane Disorder

United Kingdom
NHS Greater Glasgow and Clyde
Jean Brown Bequest Fund, Glasgow

Completed

3D Telemedicine During COVID-19: Cohort Study

Telemedicine | Surgery, Plastic

United Kingdom
KalVista Pharmaceuticals, Ltd.

Completed

A Single and Multiple Doses Safety, Tolerability, Pharmacokinetics and Food Effect Study of KVD824 in Healthy Volunteers

Hereditary Angioedema

United Kingdom
BioCryst Pharmaceuticals

Completed

A Study of the Relative Bioavailability of a New Formulation of BCX4161 and the Effect of Food on BCX4161

Hereditary Angioedema

United Kingdom
BioCryst Pharmaceuticals

Completed

An Open-label Drug-Drug Interaction Study to Evaluate the Effect of BCX7353 on Cytochrome P450 Enzyme Activity Using Probe Substrates

Hereditary Angioedema

United Kingdom
BioCryst Pharmaceuticals

Completed

Study to Determine How BCX4161 is Metabolized and Eliminated by the Body

Hereditary Angioedema

United Kingdom
Imperial College London

Completed

Hereditary Haemorrhagic Telangiectasia Flight Safety Study (Flying and HHT)

Hereditary Haemorrhagic Telangiectasia

United Kingdom
London North West Healthcare NHS Trust

Completed

Magnification Narrow Band Imaging Colonoscopy for Hereditary Non-Polyposis Colorectal Cancer Surveillance

Colorectal Neoplasms, Hereditary Nonpolyposis

United Kingdom
Burke Medical Research Institute
University of Minnesota; Teachers College, Columbia University

Recruiting

tDCS and Bimanual Therapy for Children With Hemiplegic Cerebral Palsy

Cerebral Palsy | Hemiplegic Cerebral Palsy | Spastic Hemiplegic Cerebral Palsy | Spastic Hemiplegia | Spastic Hemiparesis

United States
Motric Bio

Recruiting

Single and Multiple Ascending Dose Study of MTR-601 in Healthy Individuals

Stroke | Multiple Sclerosis | Cerebral Palsy | Spinal Cord Injuries | Dystonia | Muscle Spasticity | Hereditary Spastic Paraplegia | Hypertonia, Muscle

United States
King's College Hospital NHS Trust

Completed

King's Invasive Aspergillosis Study II

Myelodysplastic Syndromes | Leukemia, Myeloid, Acute | Bone Marrow Transplantation | Aplastic Anemia

United Kingdom
Dynasplint Systems, Inc.

Withdrawn

Dynamic Splinting for Plantarflexion in Spastic Hemiplegia

Spastic Hemiplegia

United States
Santhera Pharmaceuticals

Completed

RHODOS Follow-up Single-visit Study (RHODOS-OFU)

Leber's Hereditary Optic Neuropathy

Canada, Germany, United Kingdom
University College, London
Medical Research Council

Recruiting

Transfer of Effector Memory T Cells (Tem) Following Allogeneic Stem Cell Transplantation (ToTem)

Lymphoma | Myelodysplastic Syndromes | Leukemia | Myeloma | Graft Vs Host Disease | Severe Aplastic Anemia | Primary Immune Deficiency

United Kingdom
GenSight Biologics

Completed

RESCUE and REVERSE Long-term Follow-up (RESTORE)

Leber Hereditary Optic Neuropathy

United States, France, Italy, United Kingdom, Germany
Santhera Pharmaceuticals

Completed

Study to Assess Efficacy,Safety and Tolerability of Idebenone in the Treatment of Leber's Hereditary Optic Neuropathy (RHODOS)

Leber's Hereditary Optic Neuropathy

Canada, Germany, United Kingdom
National Institute of Neurological Disorders and...

Completed

Eye-Hand Coordination in Children With Spastic Diplegia

Diplegia, Spastic

United States

Clinical Trials on Hereditary Spastic Paraparesis in United Kingdom

Sponsors and Collaborators

Medical Conditions

Drug Interventions

CROs by country

CROs in Kazakhstan

Conditions

Rare Diseases

Drug Interventions

Dietary Supplements

Sponsor/Collaborators

Locations