Clinical Trials on Hereditary Autoinflammatory Diseases

Total 379296 results

BioCryst Pharmaceuticals

Completed

Study to Evaluate the Efficacy and Safety of BCX7353 as an Oral Treatment for the Prevention of HAE Attacks in Japan (APeX-J)

Hereditary Angioedema, HAE

Japan
Shire

Completed

Efficacy and Safety Study of DX-88 to Treat Acute Attacks of Hereditary Angioedema (HAE)

Hereditary Angioedema (HAE)

United States
Shire

Completed

Long-term Safety and Efficacy Study of DX-2930 (SHP643) to Prevent Acute Angioedema Attacks in Patients With Type I and Type II HAE

Hereditary Angioedema (HAE)

United States, United Kingdom, Germany, Canada, Italy, Jordan, Puerto Rico
Shire

Completed

Study to Evaluate the Clinical Efficacy and Safety of Subcutaneously Administered C1 Esterase Inhibitor for the Prevention of Angioedema Attacks in Adolescents and Adults With Hereditary Angioedema

Hereditary Angioedema (HAE)

Spain, Israel, United States, Hungary, Germany, Canada, Romania
Shire

Completed

CINRYZE for the Treatment of Hereditary Angioedema Attacks in Children Under the Age of 12

Hereditary Angioedema (HAE)

United States, Germany, Hungary
Shire

Completed

Subcutaneous CINRYZE With Recombinant Human Hyaluronidase for Prevention of Angioedema Attacks

Hereditary Angioedema (HAE)

United States, Germany, Spain, Sweden
Shire

Completed

Open-label, Single-arm Study to Assess the Pharmacokinetics, Safety, and Tolerability of a Single Subcutaneous Dose of Icatibant in Healthy Japanese Volunteers

Hereditary Angioedema (HAE)

United States
Shire

Completed

Safety and Efficacy Study of CINRYZE for Prevention of Angioedema Attacks in Children Ages 6-11 With Hereditary Angioedema

Hereditary Angioedema (HAE)

Israel, Germany, Mexico, United States, Romania
Shire

Completed

A Study of Icatibant for Acute Attacks of Hereditary Angioedema in Japanese Participants

Hereditary Angioedema (HAE)

Japan
Shire

Completed

A Double-Blind, Multiple Ascending Dose Study to Assess Safety, Tolerability and Pharmacokinetics of DX-2930 in Hereditary Angioedema Participants

Hereditary Angioedema (HAE)

United States, Jordan, Italy
BioCryst Pharmaceuticals

Completed

Efficacy and Safety of BCX7353 to Prevent Angioedema Attacks in Subjects With Hereditary Angioedema (APeX-1)

Hereditary Angioedema (HAE)

Canada, United Kingdom, Germany, Spain, Australia, Hungary, Italy, Austria, North Macedonia, Denmark, Switzerland
Hôpital Necker-Enfants Malades
European Georges Pompidou Hospital; CLAIROP

Completed

Trial of Befizal® 200 mg for the Treatment of Leber Hereditary Optic Neuropathy (Béfinohl)

Safety Issues | Efficacy, Self

France
Medical University of Vienna

Completed

Assessment of Corneal Graft Attachment in Patients With Fuchs Endothelial Corneal Dystrophy Following DMEK Using Ultra-high Resolution OCT

Fuchs' Endothelial Dystrophy

Austria
Centre Hospitalier Régional Metz-Thionville

Completed

Predictive Factors of Good Results After Primary Descemet's Membrane Endothelial Keratoplasty (DMEK) (GOODRMEK)

Endothelial Corneal Dystrophy
First Affiliated Hospital of Fujian Medical University

Recruiting

PCSK9 Inhibitor Treatment for Patients With SPG5

Hereditary Spastic Paraplegia Type 5

China
Assistance Publique - Hôpitaux de Paris

Completed

Evaluate the Effort Test as a Therapeutic Monitoring Tool in Acute Rhabdomyolyses (EFFORHAB)

Rhabdomyolysis Linked to a Hereditary Disease of Metabolism

France
University of Southampton

Unknown

Femtolaser Assisted Keratoplasty Versus Conventional Keratoplasty

Keratoconus | Fuchs Dystrophy | Corneal Disease

United Kingdom
Rabin Medical Center

Unknown

Ilaris (Canakinumab) in Patient With Periodic Fever, Aphthous Stomatitis, Pharyngitis and Cervical Adenitis (PFAPA)

Periodic Fever

Israel
Chigenovo Co., Ltd

Recruiting

Safety and Efficacy of ZVS101e in Patients With Bietti 's Crystalline Dystrophy

Bietti's Crystalline Dystrophy

China
University Hospital, Essen

Completed

Immunmodulation in Patients With HHT

Hereditary Haemorrhagic Telangiectasia (HHT)

Germany
Oregon Health and Science University

Recruiting

OCT in Diagnosis of Irregular Corneas

Corneal Opacity | Keratoconus | Corneal Dystrophy

United States
NYU Langone Health
Dyax Corp.

Withdrawn

Study to Assess the Tolerability and Safety of Ecallantide in Children and Adolescents With Hereditary Angioedema

Hereditary Angioedema Types I and II

United States
CSL Behring
Parexel

Completed

A Study to Evaluate the Clinical Pharmacology and Safety of C1-esterase Inhibitor Administered by the Subcutaneous Route

Hereditary Angioedema Types I and II

United States, Germany
CSL Behring

Completed

A Study to Evaluate the Long-term Clinical Safety and Efficacy of Subcutaneously Administered C1-esterase Inhibitor in the Prevention of Hereditary Angioedema

Hereditary Angioedema Types I and II

United States, Spain, Germany, Australia, Canada, Czechia, Hungary, Israel, Italy, Romania, United Kingdom
Stanford University
University of Pennsylvania; University of California, Davis; Oregon Health and... and other collaborators

Recruiting

Descemet Endothelial Thickness Comparison Trial II (DETECT II)

Fuchs' Endothelial Dystrophy | Fuchs Dystrophy | Fuchs

United States
Michael D. Straiko, MD
Lions VisionGift Research; Eye Bank Association of America

Recruiting

Ripasudil for Enhanced Corneal Clearing Following Descemet Membrane Endothelial Keratoplasty in Fuchs' Dystrophy

Fuchs Endothelial Dystrophy

United States
Trefoil Therapeutics, Inc.

Completed

TTHX1114(NM141) in Combination With DWEK/DSO

Fuchs' Endothelial Dystrophy | Fuchs Dystrophy | Fuchs

United States
University Eye Hospital, Freiburg

Completed

Eye Drops for Early Morning-Associated Corneal Swelling of the Cornea (EDEMAS)

Fuchs' Endothelial Dystrophy

Germany
Scripps Health
J. Craig Venter Institute

Completed

Biomarker Monitoring in TP53 Mutation Carriers

Li-Fraumeni Syndrome | Hereditary Cancer Syndromes | TP53 Gene Germline Mutation Carrier

United States
Centre Hospitalier Universitaire de Besancon

Completed

Impact of Cataract Surgery on Keratoplasty Graft Survival (IGREC)

Cataract | Keratoconus | Fuchs' Endothelial Dystrophy

France
Beijing Tongren Hospital

Recruiting

Safety Study of rAAV2/8-hCYP4V2 in Patients With Bietti's Crystalline Dystrophy (BCD)

Bietti's Crystalline Dystrophy

China
Johns Hopkins University
National Human Genome Research Institute (NHGRI)

Completed

Genetic Risk: Whether, When, and How to Tell Adolescents

Huntington Disease | Hereditary Cancer | Hereditary Breast and Ovarian Cancer | Hereditary Non-polyposis Colon Cancer | Hereditary Non-Polyposis Colorectal Cancer Syndrome

United States
University Health Network, Toronto

Active, not recruiting

Integrative Sequencing In Germline and Hereditary Tumours (INSIGHT)

Mutation | Hereditary Cancer Syndrome | High-Risk | Germline Mutation

Canada
Kowa Research Institute, Inc.

Recruiting

A Study to Evaluate the Safety and Efficacy of K-321 Eye Drops After Descemetorhexis in Participants With Fuchs Endothelial Corneal Dystrophy (FECD)

Fuchs Endothelial Corneal Dystrophy

United States, Germany, Spain, Canada, United Kingdom, Denmark
Aarhus University Hospital

Completed

Fuchs' Endothelial Dystrophy: Clinical Characteristics, Treatment Outcome, and Pathology

Fuchs' Endothelial Corneal Dystrophy

Denmark
TRB Chemedica AG

Completed

ODM 5 in the Treatment of Corneal Edematous Fuchs' Endothelial Dystrophy

Corneal Edema | Fuchs' Endothelial Dystrophy

Germany
Price Vision Group

Completed

Comparison of Two Steroid Regimens to Prevent Transplant Rejection After Corneal Transplant (DMEK)

Bullous Keratopathy | Fuchs' Dystrophy

United States, Germany
Klinikum Chemnitz gGmbH
German Research Foundation; KKS Netzwerk

Unknown

Comparison of Corneal Grafts Cultured in Serum-free Versus Corneal Grafts Cultured in Serum Supplemented Culture Media (SFM)

Pseudophakic Bullous Keratopathy | Fuch's Endothelial Dystrophy

Germany
University of Illinois at Chicago

Withdrawn

Implementation of Population Breast Cancer Genetic Services in Federally Qualified Health Centers (FQHC) (TestMiGenes)

Hereditary Cancer Syndrome
Federal University of São Paulo
Eye Clinic Day Hospital, São Paulo

Unknown

Corneal Transplantation Guided by OCT RESCAN

Keratoconus | Cornea | Bullous Keratopathy | Corneal Dystrophy
CSL Behring

Completed

A Study to Evaluate the Clinical Efficacy and Safety of Subcutaneously Administered C1-esterase Inhibitor in the Prevention of Hereditary Angioedema

Hereditary Angioedema Types I and II

United States, Spain, Australia, Canada, Czechia, Hungary, Israel, Italy, Romania, United Kingdom
University Hospital, Catania

Unknown

Hereditary AngioEdema, Neurobiology and Psychopathology (HAENP)

Depression | Anxiety | Hereditary AngioEdema

Italy
University College, London

Recruiting

Hereditary Sensory Neuropathy Serine Trial (SENSE)

Hereditary Sensory Neuropathy Type I

United Kingdom
Marian Macsai, MD

Recruiting

Glanatec(R) for Descemet Stripping in Fuch's Endothelial Dystrophy

Fuchs' Endothelial Dystrophy

United States
Cornea Research Foundation of America

Withdrawn

Evaluation of Amphotericin B in Optisol-GS for Prevention of Post-Keratoplasty Fungal Infections.

Fuchs' Endothelial Dystrophy

United States
Vissum, Instituto Oftalmológico de Alicante
Instituto de Salud Carlos III; Universidad Miguel Hernandez de Elche

Completed

Autologous Adipose-Derived Adult Stem Cell Implantation for Corneal Diseases (ADASCs-CT-CD) (ADASCs-CT-CD)

Keratoconus | Treatment | Therapy | Corneal Dystrophy | Ophthalmological Disorder

Spain
Keratoplasty Alliance International

Recruiting

Developing a Nationwide Registry to Track Longitudinal Clinical Outcomes of Corneal Surgery and Disease

Corneal Disease | Corneal Transplant Failure | Endothelial Corneal Dystrophy | Corneal Transplant Rejection

United States
University Health Network, Toronto

Unknown

Comparing Endoglide to Endoserter for DSAEK Graft Insertion

Fuch's Endothelial Dystrophy | Bullous Keratopathy, Unspecified Eye

Canada
Maastricht University Medical Center

Not yet recruiting

The OPTIMISE Study

Intraocular Pressure | Fuchs' Endothelial Dystrophy | Pseudophakic Bullous Keratopathy
Santen Inc.
ActualEyes Inc.

Active, not recruiting

A Multicenter Study Assessing the Efficacy and Safety of STN1010904 Ophthalmic Suspension 0.03% and 0.1% Compared With Vehicle in Subjects With Fuchs Endothelial Corneal Dystrophy (FECD) (PHANTOM)

Fuchs Endothelial Corneal Dystrophy

United States, France, India

Clinical Trials on Hereditary Autoinflammatory Diseases

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