Clinical Trials on High Grade Myelodysplastic Syndrome Lesions

Total 2921 results

Groupe Francophone des Myelodysplasies

Completed

Idarubicin Combined to Azacitidine in Int-2 or High Risk Myelodysplastic Syndromes

High Grade Myelodysplastic Syndrome Lesions

France, Tunisia
University of Colorado, Denver

Active, not recruiting

Omacetaxine + Azacitidine in Untreated Patients With High Grade MDS

High Grade Myelodysplastic Syndromes

United States
Muğla Sıtkı Koçman University

Completed

Evaluation of Thioldisulfide Balance in Cervical Preinvasive Lesions

Oxidative Stress | Low Grade Squamous Intraepithelial Lesion | High-Grade Squamous Intraepithelial Lesions

Turkey
Fred Hutchinson Cancer Center
National Cancer Institute (NCI)

Terminated

HPV Vaccine Therapy in Interrupting Progression in Patients With High-Grade Vulvar or Anal Lesions

High Grade Anal Canal Intraepithelial Neoplasia | High Grade Vulvar Squamous Intraepithelial Lesion

United States
National Cancer Institute (NCI)

Completed

SGN-00101 Vaccine in Treating Human Papillomavirus in Patients Who Have Abnormal Cervical Cells

Cervical Cancer | High-grade Squamous Intraepithelial Lesion | Atypical Squamous Cells of Undetermined Significance | Low-grade Squamous Intraepithelial Lesion

United States
David Finch
Lancashire Teaching Hospitals NHS Foundation Trust

Not yet recruiting

COrSIcA: Disease Measurement

Anal Intraepithelial Neoplasia | Anal High-grade Squamous Intraepithelial Lesion | Anal HSIL
Inovio Pharmaceuticals

Completed

REVEAL 2 Trial (Evaluation of VGX-3100 and Electroporation for the Treatment of Cervical HSIL)

Cervical Dysplasia | Cervical High Grade Squamous Intraepithelial Lesion | HSIL

United States, Spain, Lithuania, Estonia, South Africa, Argentina, Brazil, Finland, Poland, Puerto Rico
National Cancer Institute (NCI)

Terminated

Immunotherapy With E6 T Cell Receptor (TCR) T Cells for Vulvar High-Grade Squamous Intraepithelial Lesions

Human Papillomavirus | HPV-16 | High Grade Squamous Intraepithelial Lesion

United States
University of Witwatersrand, South Africa
Merck Sharp & Dohme LLC

Completed

Randomized, Double Blind Trial of the Quadrivalent HPV Vaccine to Improve Responses to LEEP Treatment of Cervical HSIL

Cervical High Grade Squamous Intraepithelial Lesion
Southwest Oncology Group
National Cancer Institute (NCI)

Withdrawn

S0212 Celecoxib in Treating Patients With High-Grade Squamous Intraepithelial Lesions of the Cervix

Stage 0 Cervical Cancer | High-grade Squamous Intraepithelial Lesion
Millennium Pharmaceuticals, Inc.

Completed

A Phase 2 Trial of MLN8237 in Adult Participants With Acute Myelogenous Leukemia and High-Grade Myelodysplastic Syndrome

Acute Myelogenous Leukemia | High-Grade Myelodysplastic Syndrome

United States
Singapore General Hospital
National Medical Research Council (NMRC), Singapore

Completed

Autologous Cytokine-induced Killer Cell Adoptive Immunotherapy for Acute Myeloid Leukemia and Myelodysplastic Syndrome

Acute Myeloid Leukemia | Myelodysplastic Syndrome, High Grade

Singapore
Sheba Medical Center
Hadassah Medical Organization; Kaplan Medical Center; Tel Aviv Medical Center; Ziv...

Completed

Effect of Deferiprone on Oxidative-Stress and Iron-Overload in Low Risk Transfusion-Dependent MDS Patients

Myelodysplastic Syndrome With Low-grade Lesions | Iron Overload Due to Repeated Red Blood Cell Transfusions

Israel
Hospital Universitari Vall d'Hebron Research Institute

Not yet recruiting

Intraoperative HPV Testing Evaluation

Recurrence | HSIL, High Grade Squamous Intraepithelial Lesions
University Fernando Pessoa

Recruiting

ANAL PRECANCEROUS LESIONS IN HIGH-RISK PATIENTS. (PACCO)

HSIL, High Grade Squamous Intraepithelial Lesions | AIN3 | AIN2

Portugal
Newish Technology (Beijing) Co., Ltd.

Recruiting

NWRD08 DNA Plasmid for HPV-16 and/or HPV-18 Related Cervical HSIL

High-grade Squamous Intraepithelial Lesion (HSIL)

China
Institute of HIV Research and Innovation Foundation...
National Institutes of Health (NIH); amfAR, The Foundation for AIDS Research

Recruiting

Anal HSIL Screening Algorithm (0007/65)

Anal High-grade Squamous Intraepithelial Lesion

Thailand
Brian Jonas
National Cancer Institute (NCI); Celgene; Pharmacyclics LLC.

Completed

Ibrutinib and Lenalidomide in Treating Patients With Myelodysplastic Syndrome

Previously Treated Myelodysplastic Syndrome | Myelodysplastic Syndrome | Therapy-Related Myelodysplastic Syndrome | Secondary Myelodysplastic Syndrome | Refractory High Risk Myelodysplastic Syndrome

United States
Baylor College of Medicine
Medical University of South Carolina; M.D. Anderson Cancer Center; The University... and other collaborators

Active, not recruiting

The Effectiveness of High Resolution Microendoscopy for People Living With HIV

Anal High Grade Squamous Intraepithelial Lesion

United States
Lei Li

Unknown

DNA Methylation for Screening Uterine Cervical Lesions

DNA Methylation | Uterine Cervical Cancer | High Grade Squamous Intraepithelial Lesions | Low Grade Squamous Intraepithelial Lesions

China
Lei Li

Unknown

DNA Methylation for Screening Uterine Cervical Lesions: A Case-control Study

DNA Methylation | Uterine Cervical Cancer | High Grade Squamous Intraepithelial Lesions | Low Grade Squamous Intraepithelial Lesions

China
Inovio Pharmaceuticals

Completed

Evaluation of VGX-3100 and Electroporation Alone or in Combination With Imiquimod for the Treatment of HPV-16 and/or HPV-18 Related Vulvar HSIL (Also Referred as: VIN 2 or VIN 3)

Human Papillomavirus (HPV) | Vulvar Dysplasia | Vulvar Intraepithelial Neoplasia (VIN) | Vulvar High Grade Squamous Intraepithelial Lesion (HSIL) | VIN2 | VIN3 | Pre-cancerous Lesions of the Vulva

United States
M.D. Anderson Cancer Center
National Cancer Institute (NCI)

Active, not recruiting

Guadecitabine in Treating Patients With Higher-Risk Myelodysplastic Syndromes

High Risk Myelodysplastic Syndrome

United States
Inovio Pharmaceuticals

Completed

REVEAL 1 (Evaluation of VGX-3100 and Electroporation for the Treatment of Cervical HSIL) (REVEAL 1)

Cervical Dysplasia | Cervical High Grade Squamous Intraepithelial Lesion | HSIL

United States, Spain, Portugal, Italy, Philippines, Thailand, Slovakia, Lithuania, Estonia, Belgium, South Africa, Germany, Argentina, United Kingdom, Poland, Puerto Rico, Finland, Mexico, Peru
Catharina Ziekenhuis Eindhoven
ZonMw: The Netherlands Organisation for Health Research and Development; Stichting... and other collaborators

Recruiting

Predicting Response In Cervical Intraepithelial Neoplasia to Topical Imiquimod Treatment (PRedICT-TOPIC)

Cervical Intraepithelial Neoplasia | CIN 2/3 | Cervical Intraepithelial Neoplasia Grade 2/3 | Cervical High Grade Squamous Intraepithelial Lesion

Netherlands
GWT-TUD GmbH
Amsterdam UMC, location VUmc; BerGenBio ASA; Groupe Francophone des Myelodysplasies

Completed

Evaluating the Efficacy and Safety of Bemcentinib in Patients With Myelodysplastic Syndromes

Acute Myeloid Leukemia | High-risk Myelodysplastic Syndrome | Low-risk Myelodysplastic Syndrome

Germany, Netherlands, France
Brugmann University Hospital

Completed

A Prolongation of a Clinical Study to Evaluate the Efficacy of an Aqueous Gel Containing 2% (w/w) of Cidofovir, Directly Applied on the Cervix Exhibiting High Grade Squamous Intraepithelial Lesions.

High Grade Cervical Epithelial Neoplasia (CIN2+)

Belgium
Institut de Cancérologie de Lorraine

Recruiting

Evaluation of New Diagnostic Tool Using Fluorescence to Detect High-grade Vulvar Intraepithelial Neoplasia (PhotodiVIN)

Vulvar Intraepithelial Neoplasia | Vulvar High Grade Squamous Intraepithelial Lesion | Differentiated Vulvar Intraepithelial Neoplasia

France
Schrödinger, Inc.

Recruiting

Study of SGR-2921 in Relapsed/Refractory Acute Myeloid Leukemia or Myelodysplastic Syndrome

Acute Myeloid Leukemia | High-Risk and Very High-Risk Myelodysplastic Syndromes

United States
M.D. Anderson Cancer Center
National Cancer Institute (NCI)

Active, not recruiting

Azacitidine and Pembrolizumab in Treating Patients With Myelodysplastic Syndrome

Myelodysplastic Syndrome | High Risk Myelodysplastic Syndrome | IPSS Risk Category Intermediate-1

United States
Central Hospital, Nancy, France
Inserm U954 - N-GERE (Nutrition, Genetics and Exposition to Environmental...

Unknown

High Risk Myelodysplasia Treated by Azacytidine : Genetic and Epigenetic (MYRAGE) (MYRAGE)

High-risk Myelodysplastic Syndromes With Excess Blasts

France
Peking University People's Hospital
Hangzhou Newhorizon Health Technology Co., Ltd.; Hangzhou Mingze Medical Research... and other collaborators

Recruiting

Clinical Evaluation of Detection of High Risk HPV in Urine (Urine-hrHPV)

Cervical Cancer | Cervical Adenocarcinoma | Cervical Squamous Cell Carcinoma | Human Papillomavirus Infection | Human Papilloma Virus | Adenocarcinoma in Situ | High-Grade Squamous Intraepithelial Lesions | Cervical Intraepithelial Neoplasia Grade II | Cervical Intraepithelial Neoplasia, Grade III | Atypical... and other conditions

China
Massachusetts General Hospital
National Cancer Institute (NCI); Dana-Farber Cancer Institute; Damon Runyon Cancer...

Completed

Indocyanine Green Fluorescent Molecular Imaging of the Gastrointestinal Tract

Colorectal Polyps | High Risk Polyposis Syndrome | Distal Colonic Lesions

United States
VIVA Physicians
Prairie Education and Research Cooperative; Lumen Biomedical

Unknown

Safety & Performance Study of Lumen Biomedical's FiberNet Distal Protection System for the Treatment of Renal Artery Stenosis (FORTRESS)

Renal Stenting in the Treatment of Pts w/a High Grade Ostial Atherosclerotic Renal Lesion(s).

United States
Assistance Publique - Hôpitaux de Paris

Unknown

Myelodysplasic Syndromes and Risk Factors for Infection (MYRIFIC)

Infection | Risk Factors | Myelodysplastic Syndrome (MDS) | IPSS High Risk

France
Fujian Maternity and Child Health Hospital

Recruiting

Prognostic Study of HPV Virus Integration in Women With HSIL

HPV Infection | Virus Integration | HSIL, High Grade Squamous Intraepithelial Lesions

China
Barretos Cancer Hospital
Fundação de Amparo à Pesquisa do Estado de São Paulo; Farmoquimica S.A.; Hospital...

Not yet recruiting

Clinical Outcome and Biomarkers for Predicting Immunological Response in Patients Treated With Imiquimod

Biomarkers | HSIL, High-Grade Squamous Intraepithelial Lesions | Vaginal Microbiome
Novartis Pharmaceuticals

Terminated

Phase II Study to Evaluate Overall Response in Patients With Higher Risk Myelodysplastic Syndromes (MDS) Treated With Azacitidine With or Without Deferasirox.

High Risk MDS

United States
Peking University People's Hospital
BeijingNewBiorayTechnologyCo.,Ltd.; Hangzhou Newhorizon Health Technology Co...

Active, not recruiting

Primary Cervical Cancer Screening by Self-sampling HPV Test (PREVENT)

Cervical Cancer | Cervical Adenocarcinoma | Cervical Squamous Cell Carcinoma | Human Papillomavirus Infection | Adenocarcinoma in Situ | Low-Grade Squamous Intraepithelial Lesions | High-Grade Squamous Intraepithelial Lesions | Cervical Intraepithelial Neoplasia Grade II | Cervical Intraepithelial Neoplasia... and other conditions

China
Medtronic - MITG

Completed

A Safety and Tolerability of Circumferential Anal Canal Radiofrequency Ablation For Anal Intraepithelial Neoplasia

Anal Intraepithelial Neoplasia (AIN) | High-grade Squamous Intraepithelial Lesions (HSIL)

United States
Memorial Sloan Kettering Cancer Center
Northwestern University; The City College of New York

Completed

Validation of a Health-Related Symptom Index for Persons Diagnosed With and Either Treated or Monitored for Anal High-Grade Squamous Intraepithelial Lesions (HSIL)

Anal High-Grade Squamous Intraepithelial Lesions

United States
Antiva Biosciences

Completed

Study of Topical ABI-1968 in Subjects With Precancerous Cervical Lesions From Human Papillomavirus (HPV) Infection.

Cervical Cancer | Human Papilloma Virus | HSIL, High Grade Squamous Intraepithelial Lesions | Cervical Dysplasia | HSIL of Cervix | High-Grade Cervical Intraepithelial Neoplasia | HIV Negative | CIN - Cervical Intraepithelial Neoplasia | Cervical Neoplasm

South Africa
AIDS Malignancy Consortium
National Cancer Institute (NCI); University of Arkansas; The Emmes Company, LLC

Active, not recruiting

Imiquimod, Fluorouracil, or Observation in Treating HIV-Positive Patients With High-Grade Anal Squamous Skin Lesions

HIV Infection | Anal Intraepithelial Neoplasia | High-grade Squamous Intraepithelial Lesion

United States, Puerto Rico
Fred Hutchinson Cancer Center
National Cancer Institute (NCI)

Completed

Decitabine With GCLAM for Adults With Newly Diagnosed, Relapsed, or Refractory AML or High-Risk MDS

Previously Treated Myelodysplastic Syndrome | Recurrent Adult Acute Myeloid Leukemia | Untreated Adult Acute Myeloid Leukemia | Refractory Acute Myeloid Leukemia | Recurrent High Risk Myelodysplastic Syndrome | Refractory High Risk Myelodysplastic Syndrome | Mixed Phenotype Acute Leukemia

United States
Massachusetts General Hospital
Dana-Farber Cancer Institute; Beth Israel Deaconess Medical Center; Brigham and...

Terminated

Study of Velcade and Thalidomide in Patients With Myelodysplasia

Myelodysplastic Syndrome

United States
M.D. Anderson Cancer Center
National Cancer Institute (NCI); Celgene

Recruiting

Azacitidine and Enasidenib in Treating Patients With IDH2-Mutant Myelodysplastic Syndrome

Acute Myeloid Leukemia | Chronic Myelomonocytic Leukemia | Myelodysplastic Syndrome With Excess Blasts | IDH2 Gene Mutation | Recurrent High Risk Myelodysplastic Syndrome | Refractory High Risk Myelodysplastic Syndrome | Blasts 20-30 Percent of Bone Marrow Nucleated Cells

United States
Assistance Publique - Hôpitaux de Paris

Recruiting

Papillomavirus Post-THErapeutique (PAPOTHE)

High Grade Intraepithelial

France
M.D. Anderson Cancer Center
National Cancer Institute (NCI)

Recruiting

Cladribine, Idarubicin, Cytarabine, and Quizartinib in Treating Patients With Newly Diagnosed, Relapsed, or Refractory Acute Myeloid Leukemia or High-Risk Myelodysplastic Syndrome

Acute Myeloid Leukemia | Recurrent Acute Myeloid Leukemia | Refractory Acute Myeloid Leukemia | High Risk Myelodysplastic Syndrome | Recurrent Acute Biphenotypic Leukemia | Blasts 20 Percent or More of Bone Marrow Nucleated Cells | Recurrent High Risk Myelodysplastic Syndrome | Refractory High Risk...

United States
Novartis Pharmaceuticals

Active, not recruiting

HDM201 in Combination With MBG453 or Venetoclax in Patients With Acute Myeloid Leukemia (AML) or High-risk Myelodysplastic Syndrome (MDS)

Acute Myeloid Leukemia (AML) | High-risk Myelodysplastic Syndrome (MDS)

Spain, Singapore, Australia, Germany, Italy, Finland, United States
University of Ulm

Terminated

Trial of Intensive Chemotherapy With or Without Volasertib in Patients With Newly Diagnosed High-Risk Myelodysplastic Syndrome (MDS) and Acute Myeloid Leukemia (AML)

Acute Myeloid Leukemia (AML) | High-risk Myelodysplastic Syndrome (MDS)

Germany

Clinical Trials on High Grade Myelodysplastic Syndrome Lesions

Sponsors and Collaborators

Medical Conditions

Drug Interventions

CROs by country

CROs in Bulgaria

Conditions

Rare Diseases

Drug Interventions

Dietary Supplements

Sponsor/Collaborators

Locations