Clinical Trials on Homozygous Familial Hypercholesterolemia

Total 2157 results

University Hospital, Montpellier

Completed

Modeling and Pharmacological Targeting of Genetic Cardiomyopathy in Children Via Cardiomyocytes Derived From Induced Pluripotent Stem Cells (DMDstem) (DMDstem)

Cardiomyopathy, Familial

France
Federico II University

Recruiting

Multicenter Study on the Evaluation of Adherence, Persistence and Efficacy of Treatment With Inclisiran in Italy (CHOLINET)

Hypercholesterolemia

Italy
Valbiotis

Recruiting

Effect of the Food Supplement TOTUM-070 on Lipid Metabolism (HEARTII)

Hypercholesterolemia

Germany
Kowa Company, Ltd.

Recruiting

A Phase III Confirmatory Study of K-877 (Pemafibrate) in Patients With Hypercholesterolemia and Statin Intolerance

Hypercholesterolemia

Japan
Federico II University

Recruiting

Evaluation of Adherence, Persistence and Efficacy of Treatment With PCSK9 Inhibitors in Italy (AT-TARGET-IT)

Hypercholesterolemia

Italy
Assistance Publique Hopitaux De Marseille

Recruiting

Role of A2A Receptor in Hypercholesterolemic Patients (RASCAS)

Hypercholesterolemia

France
Organon and Co

Completed

Coadministration of Ezetimibe and Simvastatin in Patients With Primary Hypercholesterolemia (P05457)

Hypercholesterolemia
Organon and Co

Completed

Ezetimibe (EZ)/Atorvastatin (Ator) (MK-0653C) vs. Ator in Chinese Hypercholesterolemic Participants (MK-0653C-439)

Hypercholesterolemia

China
Organon and Co

Completed

A Study of the Efficacy and Safety of MK-0653H in Japanese Participants With Hypercholesterolemia (MK-0653H-832)

Hypercholesterolemia
Organon and Co

Completed

Ezetimibe/Simvastatin (10 mg/40 mg) vs. the Doubling of Atorvastatin in High Risk Participants (MK-0653A-134 AM1)(COMPLETED)

Hypercholesterolemia
Organon and Co

Completed

A Clinical Trial to Assess the Efficacy and Safety of MK-0653C in Japanese Participants With Hypercholesterolemia (MK-0653C-383)

Hypercholesterolemia
Organon and Co

Completed

An Efficacy and Safety Study of Ezetimibe (MK-0653, SCH 58235) in Addition to Atorvastatin Compared to Placebo in Participants With Primary Hypercholesterolemia (MK-0653-013)

Hypercholesterolemia
Innovent Biologics (Suzhou) Co. Ltd.

Completed

Multiple Ascending Dose Study of PCSK-9 Inhibitor (IBI306) in Chinese Patients With Hypercholesterolemia

Hypercholesterolemia

China
Vaxxinity, Inc.
Novotech (Australia) Pty Limited

Active, not recruiting

A Study to Investigate the Safety, Tolerability, Immunogenicity, and Pharmacodynamics of VXX-401 Administered IM in Adult Participants

Hypercholesterolemia

Australia
HighTide Biopharma Pty Ltd

Completed

A Multiple Ascending Dose Study of HTD1801 in Adults With Hypercholesterolemia

Hypercholesterolemia

Australia
Akeso
AD Pharmaceuticals Co., Ltd.

Completed

A Study of PCSK9 Inhibitor AK102 in Patients With Hypercholesterolemia

Hypercholesterolemia

China
Lescuyer Laboratory
Université d'Auvergne; Hopital Gabriel Montpied; CRNH Auvergne; Clinique Médicale...

Completed

Combined Effect of LIMICOL and Physical Activity on LDL Cholesterol and Muscle Function. (L2012-12)

Hypercholesterolemia

France
Amgen

Completed

Open Label Study of Long Term Evaluation Against LDL-C Trial (OSLER)

Hypercholesterolemia

United States, Denmark, Finland, Czechia, Hungary, South Africa, Spain, Australia, Belgium, Canada, Netherlands, Germany, Sweden, Hong Kong, Japan, Singapore, United Kingdom, Norway
Innovent Biologics (Suzhou) Co. Ltd.

Completed

Safety and Efficacy of IBI306 in Chinese Subjects With Non-familial Hypercholesterolemia

Hypercholesterolemia

China
Sanofi
Regeneron Pharmaceuticals

Completed

Safety, Tolerability, and Effect of Alirocumab in High Cardiovascular Risk Patients With Severe Hypercholesterolemia Not Adequately Controlled With Conventional Lipid-modifying Therapies (ODYSSEY APPRISE)

Hypercholesterolemia

France, Belgium, Austria, Canada, Czechia, Denmark, Finland, Germany, Greece, Hungary, Poland, Romania, Slovakia, Slovenia, Spain, Switzerland
Guangzhou JOYO Pharma Co., Ltd
The First Hospital of Jilin University

Completed

Multiple Ascending Dose Study to Evaluate the Safety, Tolerability of DC371739 Treatment in Hypercholesterolemic

Hypercholesterolemia

China
Organon and Co

Completed

Randomized Parallel Group Trial Of The Efficacy And Safety Of Ezetimibe With A Statin Versus Statin Dose Doubling In Patients With Persistent Primary Hypercholesterolemia (0653-152)(COMPLETED)

Hypercholesterolemia
Organon and Co

Completed

Comparing an Investigational Medication Versus an Approved Medication in Reducing Cholesterol Levels (0653-025)

Hypercholesterolemia
Organon and Co

Completed

A 12 Week Study of MK0653A in Patients Who Have Been Hospitalized for a Possible Heart Problem (0653A-808)

Hypercholesterolemia
Organon and Co
Merck Sharp & Dohme LLC

Completed

Comparison of Ezetimibe Plus Simvastatin Versus Ezetimibe or Simvastatin Alone in Subjects With Primary Hypercholesterolemia (Study P03757)(COMPLETED)

Hypercholesterolemia
Organon and Co

Completed

An Extension Study of An Investigational Drug in Patients With Hypercholesterolemia (0653A-038)(COMPLETED)

Hypercholesterolemia
Organon and Co

Completed

Post-marketing Surveillance of the Safety, Tolerability and Efficacy of Vytorin (Ezetimibe + Simvastatin) Tablet Among Filipino Patients (Study P05647)

Hypercholesterolemia
Organon and Co

Completed

A Study to Evaluate the Effectiveness of Ezetimibe/Atorvastatin 10 mg/20 mg Combination Tablet Compared to Marketed Ezetimibe 10 mg and Atorvastatin 20 mg Tablets in Participants With High Cholesterol (MK-0653C-185 AM1)

Hypercholesterolemia
Organon and Co
Merck Sharp & Dohme LLC

Completed

Comparison of Ezetimibe Added to Ongoing Statin Therapy Versus Doubling the Dose of Statin in the Treatment of Hypercholesterolemia (P04355)

Hypercholesterolemia
Organon and Co

Completed

EZETROL® Re-examination Study (MK0653-175)(COMPLETED)

Hypercholesterolemia
Organon and Co

Completed

Evaluation of the LDL-C Lowering Effects of Ezetimibe Achieved in Co-administration Therapy With Statins in an Indonesian Population (Study P04276)(COMPLETED)

Hypercholesterolemia
Raisio Group

Active, not recruiting

Lipid Lowering Effect of Plant Stanol Ester in a Drinkable Non-dairy Product

Hypercholesterolemia

Finland
University of Roehampton

Completed

The Efficacy of Cholesterol-lowering Probiotic Lactobacillus Plantarum LPLDL® in Hypercholesterolemic Adults. (ProLoChol)

Hypercholesterolemia

United Kingdom
Pfizer's Upjohn has merged with Mylan to form Viatris...

Completed

Bioavailability Study for New Atorvastatin Formulation

Hypercholesterolemia

United States
Pfizer's Upjohn has merged with Mylan to form Viatris...

Completed

Efficacy And Safety Study Of Atorvastatin Versus Simvastatin In Type 2 Diabetic Subjects With Hypercholesterolemia

Hypercholesterolemia

Italy
Amgen

Completed

Goal Achievement After Utilizing an Anti-PCSK9 Antibody in Statin Intolerant Subjects-4 (GAUSS-4)

Hypercholesterolemia

Japan
Manchester University NHS Foundation Trust

Completed

Effect of Tredaptive on Serum Lipoproteins and Inflammatory Markers

Hypercholesterolemia

United Kingdom
Raisio Group

Completed

Lipid-lowering Effect of Plant Stanol Drink

Hypercholesterolemia

Sweden
Civi Biopharma, Inc.

Completed

A First In Human Study to Assess CiVi007 in Subjects With an Elevated LDL-Cholesterol Level

Hypercholesterolemia

United Kingdom
Universitat de Lleida

Completed

Hypocholesterolemic Effect of Fibracep (FIBRACEP)

Hypercholesterolemia

Spain
Esperion Therapeutics, Inc.

Completed

Evaluation of the Efficacy and Safety of Bempedoic Acid (ETC-1002) 180mg, Ezetimibe 10mg, and Atorvastatin 20 mg Triplet Therapy in Patients With Elevated LDL-C

Hypercholesterolemia

United States
Shanghai Junshi Bioscience Co., Ltd.

Completed

A Single Dose Escalation Study of PCSK9 Inhibitor (JS002) in Health Subjects

Hypercholesterolemia

China
Merck Sharp & Dohme LLC

Completed

A Study to Evaluate the Effects of Extended Release (ER) Niacin/Laropiprant, Laropiprant, ER Niacin, and Placebo on Urinary Prostanoid Metabolites in Subjects With High Cholesterol (0524A-075)(COMPLETED)

Hypercholesterolemia
A. Menarini Industrie Farmaceutiche Riunite S.r.l.

Completed

Effect of a Treatment With a Nutraceutical Combination on Sub-optimal LDL Cholesterol Levels (NATCOL)

Hypercholesterolemia

Italy
Sanofi
Regeneron Pharmaceuticals

Completed

Evaluation of Alirocumab Versus Ezetimibe on Top of Statin in Asia in High Cardiovascular Risk Patients With Hypercholesterolemia (ODYSSEY EAST)

Hypercholesterolemia

China, India, Thailand
Eli Lilly and Company

Completed

A Study of LY3015014 in Participants With High Cholesterol

Hypercholesterolemia

Poland, Netherlands, United States, Denmark, Canada, Japan, Czechia, Puerto Rico
Esperion Therapeutics, Inc.
Medpace, Inc.

Completed

Evaluation of ETC-1002 vs Placebo in Patients Receiving Ongoing Statin Therapy

Hypercholesterolemia

United States
Montefarmaco OTC SpA

Completed

Efficacy of a Red Yeast Rice Based Nutraceutical Plus Probiotic in Patients With Moderate Hypercholesterolemia

Hypercholesterolemia

Italy
Arjuna Natural Limited

Unknown

Effect of Indian Gooseberry Extract (AMX160) in Hypercholesterolemia

Hypercholesterolemia

Armenia
Sanofi
Regeneron Pharmaceuticals

Completed

Open Label Study of Long Term Safety Evaluation of Alirocumab (ODYSSEY OLE)

Hypercholesterolemia

United States, Argentina, Austria, Belgium, Bulgaria, Canada, Czechia, Denmark, Finland, France, Germany, Hungary, Israel, Italy, Mexico, Netherlands, Norway, Portugal, Romania, Russian Federation, South Africa, Spain, Sweden, United...

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