Clinical Trials on Injury of Nerve Root of Lumbar and Sacral Spine in United Kingdom

Total 913 results

Numab Therapeutics AG

Recruiting

NM32-2668 in Adult Patients With Selected Advanced Solid Tumors

Renal Cell Carcinoma | Mesothelioma, Malignant | Adenocarcinoma of Lung | Triple Negative Breast Cancer | Endometrial Cancer | Fallopian Tube Carcinoma | Peritoneal Carcinoma | Leiomyosarcoma | Liposarcoma | Ovarian Carcinoma | Adenocarcinoma of the Stomach | Melanoma, Malignant | Adenocarcinoma - Gastroesophageal...

United States
University of Miami
National Institute of Neurological Disorders and Stroke (NINDS); National Institutes...

Active, not recruiting

TRIAL READY (Clinical Trial Readiness)

Amyotrophic Lateral Sclerosis | Primary Lateral Sclerosis | Frontotemporal Dementia | Progressive Muscular Atrophy | ALS-Frontotemporal Dementia

United States
Cytovation AS
Merck Sharp & Dohme LLC

Active, not recruiting

A Study to Evaluate the Safety and Efficacy of CyPep-1 in Combination With Pembrolizumab for the Treatment of Advanced or Metastatic Cancers (Catalyst)

Advanced Breast Cancer | Advanced Melanoma | Advanced Head and Neck Squamous Cell Carcinoma

United States, France, Italy, Spain, Netherlands
SpineX Inc.
Rancho Los Amigos National Rehabilitation Center, Downey, California, United... and other collaborators

Recruiting

Spinal COrd NeuromodulaTor by SpIneX and ScoNE to Treat NeurogeniC BladdEr - SCONE "CONTINENCE" Clinical Study (CONTINENCE)

Stroke | Multiple Sclerosis | Neurogenic Bladder | Spinal Cord Injuries (Complete and Incomplete)

United States, India, Canada
Northwestern University

Completed

Genetics of Familial and Sporadic ALS (ALS)

Amyotrophic Lateral Sclerosis (ALS) | Lou Gehrig's Disease | Primary Lateral Sclerosis (PLS) | Familial Amyotrophic Lateral Sclerosis | ALS With Frontotemporal Dementia (ALS/FTD) | Motor Neuron Disease (MND) | Sporadic ALS (SALS)

United States
Mayo Clinic

Completed

18F-FLT Positron Emission Tomography and Diffusion-Weighted Magnetic Resonance Imaging in Planning Surgery and Radiation Therapy and Measuring Response in Patients With Newly Diagnosed Ewing Sarcoma

Ewing Sarcoma of Bone | Untreated Childhood Supratentorial Primitive Neuroectodermal Tumor | Metastatic Ewing Sarcoma/Peripheral Primitive Neuroectodermal Tumor | Adult Supratentorial Primitive Neuroectodermal Tumor (PNET) | Localized Ewing Sarcoma/Peripheral Primitive Neuroectodermal Tumor and other conditions

United States
Extremity Medical

Recruiting

The KinematX Midcarpal Total Wrist Arthroplasty Registry

Osteoarthritis | Inflammatory Arthritis | Carpal Tunnel Syndrome (CTS) | Post Traumatic Arthritis | Scapholunate Advanced Collapse (SLAC) | Scapholunate Crystalline Advanced Collapse (SCAC) | Scaphoid, Trapezium, and Trapezoid Advanced Collapse (STTAC) | Kienbock's Disease of Adults | Radial Malunion | Ulnar Translocation and other conditions

United States
Gradalis, Inc.

Terminated

A Trial For Participants With Ewing's Sarcoma Treated With Vigil in Combination With Irinotecan and Temozolomide (VITA)

Sarcoma | Neoplasms | Neoplasms, Connective and Soft Tissue | Neoplasms by Histologic Type | Sarcoma, Ewing | Neoplasms, Bone Tissue | Neoplasms, Connective Tissue | Ewing Sarcoma | Rare Diseases | Ewing's Tumor Metastatic | Ewing Family of Tumors | Ewing's Sarcoma Metastatic | Ewing's Tumor Recurrent

United States
National Cancer Institute (NCI)

Suspended

A Study Evaluating Whether Pembrolizumab Alone or in Combination With CMP-001 Improves Efficacy in Patients With Operable Melanoma

Clinical Stage III Cutaneous Melanoma AJCC v8 | Melanoma of Unknown Primary | Pathologic Stage IIIB Cutaneous Melanoma AJCC v8 | Pathologic Stage IIIC Cutaneous Melanoma AJCC v8 | Pathologic Stage IIID Cutaneous Melanoma AJCC v8 | Recurrent Cutaneous Melanoma

United States
AbbVie

Terminated

A Study Evaluating Safety and Pharmacokinetics of ABBV-221 in Subjects With Advanced Solid Tumor Types Likely to Exhibit Elevated Levels of Epidermal Growth Factor Receptor

Glioblastoma Multiforme | Triple Negative Breast Cancer | Non-small Cell Lung Cancer | Head and Neck Squamous Cell Carcinoma | Colorectal Carcinoma

United States, Spain
Ipsen

Terminated

Dysport® Treatment of Urinary Incontinence in Adults Subjects With Neurogenic Detrusor Overactivity (NDO) Due to Spinal Cord Injury or Multiple Sclerosis - Study 1 (CONTENT1)

Overactive Bladder | Urinary Incontinence

United States, Korea, Republic of, Czechia, Netherlands, Romania, Poland, Turkey, Portugal, Canada, Italy
Repertoire Immune Medicines

Terminated

This SCR-103 Protocol Will Permit Sites to Proactively Assess TAA, HLA and HPV-16 Status in Patients With Selected Solid Tumors to Determine Suitability for Repertoire Immune Medicines Treatment Protocols.

Melanoma | Head and Neck Cancer | HPV-Related Malignancy | Melanoma (Skin) | HPV-Related Carcinoma | HPV-Related Cervical Carcinoma | HPV Positive Oropharyngeal Squamous Cell Carcinoma | Lung Cancer, Nonsmall Cell

United States
Sanofi
Pulse Infoframe Ltd.

Recruiting

A Real-world Long-term Safety and Immunogenicity Study of Olipudase Alfa Therapy in Pediatric Patients Less Than 2 Years of Age With Acid Sphingomyelinase Deficiency (ASMD)

Niemann-Pick Diseases | Acid Sphingomyelinase Deficiency

United States
National Cancer Institute (NCI)

Completed

RO4929097, Temozolomide, and Radiation Therapy in Treating Patients With Newly Diagnosed Malignant Glioma

Adult Anaplastic Astrocytoma | Adult Anaplastic Ependymoma | Adult Diffuse Astrocytoma | Adult Ependymoma | Adult Giant Cell Glioblastoma | Adult Glioblastoma | Adult Gliosarcoma | Adult Mixed Glioma | Adult Myxopapillary Ependymoma | Adult Oligodendroglioma | Adult Pilocytic Astrocytoma | Adult Pineal Gland... and other conditions

United States
Cure CMD

Recruiting

Congenital Muscle Disease Study of Patient and Family Reported Medical Information (CMDPROS)

Emery-Dreifuss Muscular Dystrophy | Congenital Myasthenic Syndrome | Limb-Girdle Muscular Dystrophy | Congenital Muscular Dystrophy With ITGA7 (Integrin Alpha-7) Deficiency | Alpha-Dystroglycanopathy (Congenital Muscular Dystrophy and Abnormal Glycosylation of Dystroglycan With Severe Epilepsy) and other conditions

United States
Gregory K. Friedman, MD
Cannonball Kids' Cancer Foundation; Treovir, Inc

Active, not recruiting

HSV G207 in Children With Recurrent or Refractory Cerebellar Brain Tumors

Brain Diseases | Central Nervous System Diseases | Nervous System Diseases | Neoplasms | Neoplasms by Histologic Type | Neoplasms by Site | Neoplasms, Glandular and Epithelial | Neoplasms, Germ Cell and Embryonal | Astrocytoma | Neoplasms, Neuroepithelial | Neuroectodermal Tumors | Neoplasms, Nerve Tissue | Neuroectodermal... and other conditions

United States
Shirley Ryan AbilityLab

Recruiting

Nomad P-KAFO Study

Multiple Sclerosis | Paralysis | Muscular Dystrophy | Spinal Cord Injuries | Cerebrovascular Accident | Post-polio Syndrome

United States
Cyclo Therapeutics, Inc.

Active, not recruiting

Phase 3 Study to Evaluate Intravenous Trappsol(R) Cyclo(TM) in Pediatric and Adult Patients With Niemann-Pick Disease Type C1 (TransportNPC)

Niemann-Pick Disease, Type C1

United States, Taiwan, United Kingdom, Israel, Spain, Brazil, Italy, Australia, Turkey, Saudi Arabia, Argentina, Poland, Germany
National Cancer Institute (NCI)

Recruiting

Using Nivolumab Alone or With Cabozantinib to Prevent Mucosal Melanoma Return After Surgery

Mucosal Melanoma | Anal Melanoma | Bladder Melanoma | Cervical Melanoma | Esophageal Melanoma | Gallbladder Melanoma | Mucosal Melanoma of the Head and Neck | Mucosal Melanoma of the Urinary System | Oral Cavity Mucosal Melanoma | Penile Mucosal Melanoma | Rectal Melanoma | Recurrent Mucosal Melanoma | Sinonasal... and other conditions

United States, Canada
Motric Bio

Recruiting

Single and Multiple Ascending Dose Study of MTR-601 in Healthy Individuals

Stroke | Multiple Sclerosis | Cerebral Palsy | Spinal Cord Injuries | Dystonia | Muscle Spasticity | Hereditary Spastic Paraplegia | Hypertonia, Muscle

United States
DanceStream Projects
Alzheimer's Association

Recruiting

Stories in the Moment: Dance Program for People Living With Dementia

Dementia | Alzheimer Disease | Mild Cognitive Impairment | Lewy Body Disease | Frontotemporal Dementia | Vascular Dementia

United States
Kinto
Alzheimer's Association

Completed

Efficacy Study of Kinto Care Coaching for Dementia Family Caregivers

Dementia | Alzheimer Disease | Lewy Body Disease | Frontotemporal Dementia | Vascular Dementia | Mixed Dementia

United States
Mayo Clinic
National Institute on Aging (NIA)

Enrolling by invitation

Imaging of Brain Amyloid Plaques in the Aging Population

Frontotemporal Dementia | Vascular Dementia | Alzheimer's Disease | Dementia With Lewy Bodies

United States
Arcus Biosciences, Inc.

Completed

A Study to Evaluate the Safety and Tolerability of Immunotherapy Combinations in Participants With Advanced Malignancies

Melanoma | Renal Cell Carcinoma | Breast Cancer | Colorectal Cancer | Ovarian Cancer | Squamous Cell Carcinoma of the Head and Neck | Bladder Cancer | Endometrial Cancer | Non-small Cell Lung Cancer | Castration-resistant Prostate Cancer | Merkel Cell Carcinoma | GastroEsophageal Cancer

United States, Australia
University of Colorado, Denver
National Institute on Aging (NIA)

Completed

Advancing Understanding of Transportation Options (AUTO)

Stroke | Multiple Sclerosis | Glaucoma | Brain Injuries | Macular Degeneration | Arthritis | Chronic Obstructive Pulmonary Disease | Parkinson Disease | Restless Legs Syndrome | Diabetic Retinopathy | Insomnia | Retinitis Pigmentosa | Obstructive Sleep Apnea | Dementia | End Stage Renal Disease | Sleep Apnea | Syncope | Seizures and other conditions

United States
Tufts Medical Center
National Cancer Institute (NCI)

Completed

A Web-Based Stem Cell Transplant Support System or Standard Care in Young Patients Undergoing Stem Cell Transplant and Their Families

Sarcoma | Lymphoma | Myelodysplastic Syndromes | Leukemia | Chronic Myeloproliferative Disorders | Ovarian Cancer | Neuroblastoma | Psychosocial Effects of Cancer and Its Treatment | Myelodysplastic/Myeloproliferative Neoplasms

United States
University of California, Los Angeles
National Institute on Aging (NIA); University of Southern California

Unknown

Early-onset Alzheimer's Disease Phenotypes: Neuropsychology and Neural Networks (EOAD-Subtype)

Alzheimer Disease | Corticobasal Degeneration | Primary Progressive Aphasia | Alzheimer Disease, Early Onset | Alzheimer Disease, Late Onset | Dementia, Alzheimer Type | Logopenic Progressive Aphasia | Visuospatial/Perceptual Abilities | Posterior Cortical Atrophy | Executive Dysfunction | Ideomotor Apraxia

United States
HealthMode Inc.

Completed

Feasibility of Passive Data Collection in Dementia Subjects With Agitation

Dementia | Alzheimer Disease | Frontotemporal Dementia | Vascular Dementia | Lewy Body Dementia | Mixed Dementia

United States
Skulpt, Inc.

Completed

Study of Electrical Impedance Myography (EIM) in ALS

Multiple Sclerosis | Charcot-Marie-Tooth Disease | Motor Neuron Disease | Amyotrophic Lateral Sclerosis

United States
University of Miami
National Institute of Neurological Disorders and Stroke (NINDS); National Institutes... and other collaborators

Recruiting

Clinical Procedures to Support Research in ALS (CAPTURE-ALS)

Amyotrophic Lateral Sclerosis | Primary Lateral Sclerosis | Progressive Muscular Atrophy | ALS-Frontotemporal Dementia

United States
Ashley Hill

Completed

Elucidating the Genetic Basis of the Pleuropulmonary Blastoma (PPB) Familial Cancer Syndrome (PPB)

Sarcoma | Goiter | Pineoblastoma | Wilms Tumor | Medulloepithelioma | Pleuropulmonary Blastoma | Pituitary Tumors | Cystic Nephroma | Sertoli-Leydig Cell Tumor of Ovary | Embryonal Rhabdomyosarcoma of Cervix

United States
University of California, San Francisco
University of Colorado, Denver; National Institute on Aging (NIA); HealthPartners... and other collaborators

Enrolling by invitation

The Care Ecosystem Consortium Effectiveness Study

Dementia | Frontotemporal Dementia | Dementia, Vascular | Dementia With Lewy Bodies | Dementia Alzheimers

United States
National Cancer Institute (NCI)

Completed

Cixutumumab and Doxorubicin Hydrochloride in Treating Patients With Unresectable, Locally Advanced, or Metastatic Soft Tissue Sarcoma

Recurrent Childhood Rhabdomyosarcoma | Recurrent Adult Soft Tissue Sarcoma | Stage III Adult Soft Tissue Sarcoma | Stage IV Adult Soft Tissue Sarcoma | Dermatofibrosarcoma Protuberans | Previously Treated Childhood Rhabdomyosarcoma | Recurrent Childhood Soft Tissue Sarcoma | Adult Rhabdomyosarcoma | Adult Angiosarcoma and other conditions

United States
M.D. Anderson Cancer Center
National Cancer Institute (NCI)

Completed

Thermal Ablation and Spine Stereotactic Radiosurgery in Treating Patients With Spine Metastases at Risk for Compressing the Spinal Cord

Sarcoma | Metastatic Melanoma | Thyroid Gland Carcinoma | Metastatic Malignant Neoplasm of Unknown Primary | Spinal Cord Compression | Stage IV Breast Cancer AJCC v6 and v7 | Malignant Digestive System Neoplasm | Metastatic Malignant Neoplasm in the Spine | Metastatic Kidney Carcinoma | Metastatic Head... and other conditions

United States
Northwestern University
National Cancer Institute (NCI)

Completed

Endoscopic Placement of Metal Stent in Patients With Cancer-Related Bowel Obstruction

Quality of Life | Gastric Cancer | Colorectal Cancer | Small Intestine Cancer | Gastrointestinal Stromal Tumor | Constipation, Impaction, and Bowel Obstruction | Gastrointestinal Carcinoid Tumor

United States
M.D. Anderson Cancer Center
National Cancer Institute (NCI)

Active, not recruiting

Phase II Trial of Nivolumab Plus Ipilimumab in Patients With Renal Medullary Carcinoma

Stage III Renal Cell Cancer AJCC v8 | Stage IV Renal Cell Cancer AJCC v8 | Kidney Medullary Carcinoma | Loss of INI 1 Protein Expression

United States
Emory University
National Cancer Institute (NCI); Merck Sharp & Dohme LLC; National Institutes...

Completed

Pembrolizumab and Stereotactic Radiosurgery for Melanoma or Non-Small Cell Lung Cancer Brain Metastases

Metastatic Melanoma | Stage IV Skin Melanoma | Stage IV Non-Small Cell Lung Cancer | Ocular Melanoma | Melanoma of Unknown Primary | Mucosal Melanoma | Metastatic Malignant Neoplasm in the Brain

United States
City of Hope Medical Center
National Cancer Institute (NCI)

Withdrawn

Whole-Body Radiation Therapy, Systemic Chemotherapy, and High-Dose Chemotherapy Followed By Stem Cell Rescue in Treating Patients With Poor-Risk Ewing Sarcoma

Ewing Sarcoma of Bone | Untreated Childhood Supratentorial Primitive Neuroectodermal Tumor | Recurrent Ewing Sarcoma/Peripheral Primitive Neuroectodermal Tumor | Metastatic Ewing Sarcoma/Peripheral Primitive Neuroectodermal Tumor | Adult Supratentorial Primitive Neuroectodermal Tumor (PNET) and other conditions

United States
University of Southern California

Recruiting

In Situ Immunomodulation With CDX-301, Radiation Therapy, CDX-1140 and Poly-ICLC in Patients w/ Unresectable and Metastatic Solid Tumors

Soft Tissue Sarcoma | Anatomic Stage IV Breast Cancer AJCC v8 | Prognostic Stage IV Breast Cancer AJCC v8 | Metastatic Melanoma | Merkel Cell Carcinoma | Unresectable Melanoma | Unresectable Breast Carcinoma | Bone Sarcoma | Sarcoma,Soft Tissue | Metastatic Breast Carcinoma | Cutaneous Squamous Cell Carcinoma and other conditions

United States
Drexel University
Johns Hopkins University; National Institute on Aging (NIA); University of California...

Active, not recruiting

WeCareAdvisor Study for Caregivers of People Living With Dementia

Dementia | Alzheimer Disease | Frontotemporal Dementia | Vascular Dementia | Dementia With Lewy Bodies | Caregiver Stress Syndrome | Caregiver Burnout

United States
University of California, San Francisco
National Institute of Neurological Disorders and Stroke (NINDS); National Center... and other collaborators

Completed

Advancing Research and Treatment for Frontotemporal Lobar Degeneration (ARTFL) (ARTFL)

Amyotrophic Lateral Sclerosis (ALS) | Progressive Supranuclear Palsy (PSP) | Corticobasal Degeneration (CBD) | FTLD | Frontotemporal Dementia (FTD) | PPA Syndrome | Behavioral Variant Frontotemporal Dementia (bvFTD) | Semantic Variant Primary Progressive Aphasia (svPPA) | Nonfluent Variant Primary Progressive... and other conditions

United States, Canada
University of Massachusetts, Worcester

Enrolling by invitation

Genetic Study of Familial and Sporadic ALS/Motor Neuron Disease, Miyoshi Myopathy and Other Neuromuscular Disorders

Motor Neuron Disease | Amyotrophic Lateral Sclerosis | Muscular Dystrophy | Frontotemporal Dementia | Miyoshi Myopathy | Amyotrophic Lateral Sclerosis, Sporadic | PLS | Lou Gehrigs Disease | Familial Disease | Amyotrophic Lateral Sclerosis With Dementia

United States
Masonic Cancer Center, University of Minnesota

Recruiting

MT2021-08T Cell Receptor Alpha/Beta Depletion PBSC Transplantation for Heme Malignancies

Acute Myeloid Leukemia | Juvenile Myelomonocytic Leukemia | Acute Lymphoblastic Leukemia | AML | Acute Leukemia | Neurofibromatosis 1 | Hematologic Malignancy | Myelodysplasia | Minimal Residual Disease | Chromosome Abnormality | Monosomy 7 | Remission | Somatic Mutation | Cytogenetic Abnormality | TP53 | Fetal Hemoglobin | Intrachromosomal Amplification of Chromosome... and other conditions

United States
Masonic Cancer Center, University of Minnesota

Terminated

Hematopoietic Stem Cell Transplantation (HCT) for Inborn Errors of Metabolism

Sphingolipidoses | Niemann-Pick Disease, Type C | Krabbe Disease | Sly Syndrome | Fucosidosis | Aspartylglucosaminuria | Alpha Mannosidosis | Hurler's Syndrome | Maroteaux-Lamy Syndrome | Wolman's Disease | Niemann-Pick Disease Type B

United States
Incyte Corporation

Completed

A Safety and Tolerability Study of INCAGN02390 in Select Advanced Malignancies

Melanoma | Renal Cell Carcinoma | Cervical Cancer | Stomach Cancer | Small Cell Lung Cancer | Hepatocellular Carcinoma | Gastric Cancer | Esophageal Cancer | Ovarian Cancer | NSCLC | Mesothelioma | Squamous Cell Carcinoma of the Head and Neck | Non-small Cell Lung Cancer | Gastroesophageal Junction Cancer | Urothelial... and other conditions

United States
Masonic Cancer Center, University of Minnesota

Completed

Stem Cell Transplant for Inborn Errors of Metabolism

Niemann-Pick Disease | Wolman Disease | Adrenoleukodystrophy | Batten Disease | Metachromatic Leukodystrophy | GM1 Gangliosidosis | Fucosidosis | Globoid Cell Leukodystrophy | Gaucher's Disease | Tay Sachs Disease | Sandhoff Disease

United States
Eunice Kennedy Shriver National Institute of Child...

Terminated

Combined Intrathecal and Intravenous VTS-270 Therapy for Liver and Neurological Disease Associated With Niemann-Pick Disease, Type C1

Niemann-Pick Disease, Type C1

United States
Vtesse, LLC, a Mallinckrodt Pharmaceuticals Company

Completed

Hydroxypropyl Beta Cyclodextrin for Niemann-Pick Type C1 Disease

Niemann-Pick Disease, Type C1

United States
Cyclo Therapeutics, Inc.

Active, not recruiting

Open-Label Study of Long-Term Safety and Efficacy of Intravenous Trappsol Cyclo (HPβCD) in Niemann-Pick Disease Type C

Niemann-Pick Disease, Type C1

United States
Mayo Clinic
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK); National... and other collaborators

Completed

Longitudinal Study of Cognition With Niemann-Pick Disease, Type C (NPC)

Niemann-Pick Disease, Type C

United States

Clinical Trials on Injury of Nerve Root of Lumbar and Sacral Spine in United Kingdom

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