Clinical Trials on Invasive Fungal Infection in South Africa

Total 3483 results

Pfizer

Completed

An Open-label Study of APX001 for Treatment of Patients With Candidemia/Invasive Candidiasis Caused by Candida Auris (APEX)

Candidemia | Candida Infection | Invasive Candidiases

South Africa
Astellas Pharma Inc
Basilea Pharmaceutica International Ltd

Completed

Isavuconazole (BAL8557) for Primary Treatment of Invasive Aspergillosis

Aspergillosis | Invasive Fungal Infection

Korea, Republic of, Belgium, Australia, United States, Germany, Switzerland, Israel, Canada, Argentina, Chile, Malaysia, Thailand, France, Russian Federation, Hungary, Spain, Brazil, China, India, Egypt, Italy, Turkey, Netherlands, Me... and more
Scynexis, Inc.

Completed

Study to Evaluate the Safety and Efficacy of the Coadministration of Ibrexafungerp (SCY-078) With Voriconazole in Patients With Invasive Pulmonary Aspergillosis (SCYNERGIA)

Invasive Pulmonary Aspergillosis

United States, Belgium, Canada, Germany, South Africa
Cidara Therapeutics Inc.

Completed

Study of Rezafungin Compared to Caspofungin in Subjects With Candidemia and/or Invasive Candidiasis (ReSTORE)

Mycoses | Candidemia | Fungal Infection | Invasive Candidiases

United States, Israel, Spain, Korea, Republic of, Taiwan, Singapore, Thailand, Australia, China, Turkey, Belgium, Germany, France, Argentina, Bulgaria, Colombia, Greece, Italy
Scynexis, Inc.

Completed

Open-Label Study to Evaluate the Efficacy and Safety of Oral Ibrexafungerp (SCY-078) in Patients With Candidiasis Caused by Candida Auris (CARES) (CARES)

Candidemia | Candidiasis, Invasive

Pakistan, India, United States, South Africa
Novartis Pharmaceuticals

Terminated

Efficacy and Safety of Mycograb as Adjunctive Therapy for Cryptococcal Meningitis in Patients With AIDS

Cryptococcal Meningitis

South Africa
Astellas Pharma Inc

Completed

Study of Mycamine® in Children With Fungal Infections to Evaluate Safety and Blood Levels of the Drug

Candidemia | Invasive Candidiasis | Esophageal Candidiasis | Oropharyngeal Candidiasis

United States, South Africa
Mycoses Study Group
Merck Sharp & Dohme LLC

Completed

Randomized Study of Caspofungin Prophylaxis Followed by Pre-emptive Therapy for Invasive Candidiasis in the Intensive Care Unit (ICU) (MSG-01)

Invasive Candidiasis

United States
F2G Biotech GmbH
Iqvia Pty Ltd

Recruiting

Evaluate F901318 Treatment of Invasive Fungal Infections in Patients Lacking Treatment Options (FORMULA-OLS)

Invasive Fungal Infections

United States, Netherlands, Israel, Spain, Korea, Republic of, Belgium, Australia, Germany, France, Brazil, Poland, Egypt, Russian Federation, Thailand, Turkey, United Kingdom, Vietnam
Astellas Pharma Inc
Basilea Pharmaceutica

Completed

Isavuconazole (BAL8557) in the Treatment of Candidemia and Other Invasive Candida Infections

Mycoses | Candidemia | Candidiasis, Invasive

Philippines, New Zealand, United States, Spain, Belgium, Canada, Israel, Malaysia, Mexico, Italy, Australia, Germany, Singapore, Hungary, Brazil, Thailand, China, India, Argentina, France, Russian Federation, Chile, Lebanon, South Africa and more
Astellas Pharma Inc
Basilea Pharmaceutica International Ltd

Completed

Isavuconazole in the Treatment of Renally Impaired Aspergillosis and Rare Fungi (VITAL)

Invasive Fungal Infections | Aspergillosis

Korea, Republic of, United States, Belgium, Israel, Mexico, Canada, Brazil, Chile, Argentina, France, Thailand, Egypt, Australia, Germany, India, Lebanon, Poland, Russian Federation, South Africa
Scynexis, Inc.

Suspended

A Phase 3, Randomized, Double-blind Study for Patients With Invasive Candidiasis Treated With IV Echinocandin Followed by Either Oral Ibrexafungerp or Oral Fluconazole (MARIO)

Candidemia | Candidiasis, Invasive

United States, Korea, Republic of, Greece, Canada, France, Belgium, Germany, Italy, Spain, South Africa, Bulgaria, Israel
Bayside Health
Merck Sharp & Dohme LLC

Unknown

Universal Prophylaxis Versus Pre-emptive Therapy With Posaconazole Post-Lung Transplant (UPPRITE)

Fungal Infection

Australia
University of Minnesota
National Institute of Allergy and Infectious Diseases (NIAID); Makerere University and other collaborators

Completed

Cryptococcal Optimal ART Timing Trial (COAT)

HIV Infections | AIDS | Cryptococcal Meningitis

Uganda, South Africa
Scynexis, Inc.

Completed

Study to Evaluate the Efficacy and Safety of Ibrexafungerp in Patients With Fungal Diseases That Are Refractory to or Intolerant of Standard Antifungal Treatment (FURI)

Coccidioidomycosis | Invasive Pulmonary Aspergillosis | Allergic Bronchopulmonary Aspergillosis | Histoplasmosis | Chronic Pulmonary Aspergillosis | Blastomycosis | Invasive Candidiasis | Recurrent Vulvovaginal Candidiasis | Mucocutaneous Candidiasis | Other Emerging Fungi

United States, Spain, United Kingdom, Austria, Pakistan, South Africa, Germany, Netherlands
Pfizer

Completed

Study Will Evaluate The Safety And Efficacy Of Anidulafungin In Patients With Candidemia Or Invasive Candidiasis

Candidiasis

United States, Korea, Republic of
International Maternal Pediatric Adolescent AIDS...
National Institute of Allergy and Infectious Diseases (NIAID); Comprehensive... and other collaborators

Terminated

Daily Isoniazid to Prevent Tuberculosis in Infants Born to Mothers With HIV

HIV Infection | Tuberculosis | Pneumocystis Jiroveci Pneumonia

Botswana, South Africa
Scynexis, Inc.

Completed

Oral Ibrexafungerp (SCY-078) vs Standard-of-Care Following IV Echinocandin in the Treatment of Invasive Candidiasis

Mycoses | Candidemia | Candidiasis, Invasive

United States, El Salvador, Germany, Guatemala, Honduras
Novartis
Novartis Vaccines

Withdrawn

Antibody Levels Associated With Reduced Risk of Invasive Group B Streptococcus Disease in Infants Aged Less Than 90 Days

Invasive Group B Streptococcus Disease

South Africa
University of Witwatersrand, South Africa
Novartis Vaccines

Completed

GBS Sero-correlate of Protection (V98_28OBTP)

Invasive Group B Streptococcus Disease

South Africa
Mundipharma Research Limited

Recruiting

Rezafungin for Treatment of Pneumocystis Pneumonia in HIV Adults

Pneumocystis Pneumonia

South Africa
Beth Israel Deaconess Medical Center
University of Stellenbosch

Recruiting

Testing Health Workers At Risk to Advance Our Understanding of TB Infection (THWART-TB)

Tuberculosis | Tuberculosis Infection

South Africa
GlaxoSmithKline
Parexel

Completed

Bioequivalence Study Between GR37547 500 Milligrams (mg) Tablet Versus Ciprofloxacin 500 mg Tablet Reference Product in Healthy Adult Subjects

Infections, Bacterial

South Africa
Case Western Reserve University
Thrasher Research Fund

Completed

Diagnosis of Tuberculosis Infection in HIV Co-infected Children (ThrasherIGRA)

HIV Infections | Tuberculosis | Latent Tuberculosis Infection

South Africa
International AIDS Vaccine Initiative
Biofabri, S.L; South African Tuberculosis Vaccine Initiative; Universidad de...

Completed

MTBVAC Study in Adults With and Without Latent Tuberculosis Infection in South Africa (A-050)

Tuberculosis

South Africa
National Institute of Allergy and Infectious Diseases...

Completed

Micronutrients and Enteric Infections in African Children

Enteric Infections

South Africa
Bristol-Myers Squibb

Completed

Safety and Efficacy of Veronate® Versus Placebo in Preventing Nosocomial Staphylococcal Sepsis in Premature Infants

Sepsis | Candidemia | Staphylococcal Infections | Nosocomial Infections

United States, Canada
Shabir Madhi

Recruiting

Surveillance Among Healthcare Workers for SARS-Coronavirus-2 Infection

COVID-19 | SARS-CoV2 Infection

South Africa
Aeras
Statens Serum Institut

Completed

Safety and Immunogenicity Study of AERAS-456 Vaccine for Tuberculosis

Latent Tuberculosis | Latent Tuberculosis Bacteriology and Histology Unknown

South Africa
University of Bern
University of Alabama at Birmingham; University of Southern California; Louisiana... and other collaborators

Active, not recruiting

Genital Tract Infections, the Vaginal Microbiome and Gestational Age at Birth Among Pregnant Women in South Africa

HIV Infections | Premature Birth | Microbial Colonization | Pregnancy; Infection | Bacterial Vaginosis | Trichomonas Vaginitis | Neisseria Gonorrheae Infection | Chlamydia Trachomatis Infection | Mycoplasma Genitalium Infection | Genital Mycoplasma Infection | Vaginal Candida | Sexually Transmitted Infections... and other conditions

South Africa
Centers for Disease Control and Prevention
Johns Hopkins University; Sanofi; University of Stellenbosch; University of Cape... and other collaborators

Recruiting

Tuberculosis Clinical Trials Consortium Study 35

Latent Tuberculosis

South Africa
Archivel Farma S.L.
Parexel

Completed

Clinical Trial to Investigate the Safety, Tolerability, and Immunogenicity of the Novel Antituberculous Vaccine RUTI® Following One Month of Isoniazid Treatment in Subjects With Latent Tuberculosis Infection

Tuberculosis | Latent Tuberculosis Infection

South Africa
Gilead Sciences

Completed

Rollover Study Protocol for Pediatric Patients in South Africa for Continued Access to Emtricitabine

HIV-1 Infection

South Africa
National Institute of Allergy and Infectious Diseases...

Completed

High-Dose Fluconazole for the Treatment of Cryptococcal Meningitis in HIV-Infected Individuals

HIV Infections | Cryptococcal Meningitis

Kenya, Thailand, Uganda, United States, Peru, South Africa, Zimbabwe, India
Professor Francois Venter
University of Cape Town

Completed

The Effect of Rifampicin on the Pharmacokinetics of Intracellular Tenofovir-diphosphate and Tenofovir When Coadministered With Tenofovir Alafenamide Fumarate During the Maintenance Phase of Tuberculosis Treatment in TB/HIV-1 Coinfected Participants (EpiTAF)

Tuberculosis | HIV-1-infection

South Africa
Minervax ApS
European and Developing Countries Clinical Trials Partnership (EDCTP)

Completed

Study of a Group B Streptococcus Vaccine in Pregnant Women Living With HIV and in Pregnant Women Who do Not Have HIV

Group B Streptococcal Infection

South Africa, Uganda
University of Cape Town
London School of Hygiene and Tropical Medicine; Johns Hopkins University; Imperial... and other collaborators

Completed

Isoniazid Plus Antiretroviral Therapy to Prevent Tuberculosis in HIV-infected Persons (HAART-IPT)

HIV Infections | Tuberculosis | Latent Tuberculosis Infection

South Africa
Foundation for Innovative New Diagnostics, Switzerland

Completed

Novel Rapid POC Diagnostics for COVID-19

COVID-19 Respiratory Infection

Georgia, South Africa
ApoPharma

Completed

Antiretroviral Activity and Pharmacokinetics of Deferiprone in Healthy Volunteers and Asymptomatic HIV-infected Subjects

HIV Infection

South Africa
GlaxoSmithKline

Completed

Bioequivalence Study Between SKF101804 Cefixime 200 Milligram (mg)/5 Milliliter (mL) Suspension Versus Cefixime 200 mg/5 mL Suspension Reference Product in Healthy Adult Subjects Under Fasting Conditions

Infections, Bacterial

South Africa
Desmond Tutu HIV Centre
Merck Sharp & Dohme LLC; European and Developing Countries Clinical Trials...

Unknown

Preparing for Adolescent HIV Vaccine Trials in South Africa: (CATSA)

HIV Infections | HIV Infection

South Africa
University of Pretoria

Not yet recruiting

Kefazolin Versus Kefazolin Plus Metronidazole to Reduce Postpartum Infection

Prevention of Postpartum Sepsis

South Africa
National Institute for Communicable Diseases, South...
Bill and Melinda Gates Foundation; Centers for Disease Control and Prevention

Unknown

Effectiveness of Trivalent Inactivated Influenza Maternal Vaccination Among Pregnant Women and Their Newborns in South Africa

Influenza Viral Infections

South Africa
Centers for Disease Control and Prevention
United States Agency for International Development (USAID); Bill and Melinda... and other collaborators

Unknown

Prevention of Perinatal Sepsis (PoPS): Evaluation of Chlorhexidine Wipes of Birth Canal and Newborn

Sepsis | Infant, Newborn, Diseases | Puerperal Infection

South Africa
French National Agency for Research on AIDS and...

Completed

Pharmacokinetics of Rifabutin Combined With Antiretroviral Therapy in Patients With TB/HIV Co-infection in South Africa

HIV Infections | Tuberculosis

South Africa
Centre for the AIDS Programme of Research in South...

Completed

A Study to Compare Three Existing Starting Points of Anti-Retroviral Therapy (ART) Initiation in HIV/Tuberculosis (TB) Co-infected Patients (SAPIT)

HIV Infections | Tuberculosis

South Africa
Professor Francois Venter

Recruiting

ADORE: Efficacy of DORavirine in Adults Living With HIV Experiencing Virological Failure on First-line Efavirenz-based Antiretroviral Therapy With NNRTI Resistance (ADORE)

HIV-1-infection

South Africa
Professor Francois Venter

Completed

ADVANCE Study of DTG + TAF + FTC vs DTG + TDF + FTC and EFV + TDF+FTC in First-line Antiretroviral Therapy (ADVANCE)

HIV-1 Infection

South Africa
University of North Carolina, Chapel Hill
University of Pretoria; SADC Research Centre

Completed

Impact Evaluation of a School-Based Sexuality and HIV Prevention Education Activity in South Africa

HIV Infections | Pregnancy Related | HSV-2 Infection

South Africa
Ottawa Hospital Research Institute
Ontario Lung Association

Withdrawn

A RCT of Prednisone as Adjunctive Therapy for Hospitalized Patients With Pulmonary TB and HIV Co-infection

HIV Infections | Tuberculosis

Canada, South Africa

Clinical Trials on Invasive Fungal Infection in South Africa

Sponsors and Collaborators

Medical Conditions

Drug Interventions

CROs by country

CROs in Oman

Conditions

Rare Diseases

Drug Interventions

Dietary Supplements

Sponsor/Collaborators

Locations