Example: Heart Attack

Clinical Trials on Leber Congenital Amaurosis

Total 28 results

NCT02970266

Completed

Genetic Decryption of Leber Congenital Amaurosis (LCA) in a Large Cohort of Independent Families.

Conditions: Leber Congenital Amaurosis
NCT03140969

Completed

Study to Evaluate QR-110 in Leber's Congenital Amaurosis (LCA) Due to the c.2991+1655A>G Mutation (p.Cys998X) in the CEP290 Gene

Conditions: Leber's Congenital Amaurosis
NCT03920007

Recruiting

Study of Subretinally Injected SAR439483 Administered in Patients With Leber Congenital Amaurosis Caused by Biallelic Mutations in GUCY2D

Conditions: Leber's Congenital Amaurosis
NCT02714816

Recruiting

Natural History Study of Patients With Leber Congenital Amaurosis Associated With Mutations in RPE65

Conditions: Leber Congenital Amaurosis
NCT00516477

Completed

Safety Study in Subjects With Leber Congenital Amaurosis

Conditions: Leber Congenital Amaurosis
NCT00749957

Completed

Phase 1/2 Safety and Efficacy Study of AAV-RPE65 Vector to Treat Leber Congenital Amaurosis

Conditions: Leber Congenital Amaurosis
NCT01208389

Active, not recruiting

Phase 1 Follow-on Study of AAV2-hRPE65v2 Vector in Subjects With Leber Congenital Amaurosis (LCA) 2

Conditions: Leber Congenital Amaurosis
NCT02781480

Completed

Clinical Trial of Gene Therapy for the Treatment of Leber Congenital Amaurosis (LCA)

Conditions: Leber Congenital Amaurosis
NCT00999609

Active, not recruiting

Safety and Efficacy Study in Subjects With Leber Congenital Amaurosis

Conditions: Inherited Retinal Dystrophy Due to RPE65 Mutations; Leber Congenital Amaurosis
NCT00821340

Completed

Clinical Trial of Gene Therapy for Leber Congenital Amaurosis Caused by RPE65 Mutations

Conditions: Leber Congenital Amaurosis
NCT01521793

Completed

Repeated Treatments of QLT091001 in Subjects With Leber Congenital Amaurosis or Retinitis Pigmentosa (Extension of Study RET IRD 01)

Conditions: LCA (Leber Congenital Amaurosis); RP (Retinitis Pigmentosa)
NCT01014052

Completed

Safety/Proof of Concept Study of Oral QLT091001 in Subjects With Leber Congenital Amaurosis (LCA) or Retinitis Pigmentosa (RP) Due to Retinal Pigment Epithelial 65 Protein (RPE65) or Lecithin:Retinol Acyltransferase (LRAT) Mutations

Conditions: LCA (Leber Congenital Amaurosis); RP (Retinitis Pigmentosa)
NCT03566147

Unknown status

Treatment of RP and LCA by Primary RPE Transplantation

Conditions: Leber Congenital Amaurosis, Retinitis Pigmentosa
NCT01496040

Completed

Clinical Gene Therapy Protocol for the Treatment of Retinal Dystrophy Caused by Defects in RPE65

Conditions: Leber Congenital Amaurosis
NCT04525261

Recruiting

Natural History of Patients With Inherited Retinal Diseases Due to Mutations in RPE65 Gene

Conditions: Leber Congenital Amaurosis 2; Retinitis Pigmentosa 20
NCT00643747

Completed

Safety Study of RPE65 Gene Therapy to Treat Leber Congenital Amaurosis

Conditions: Retinal Degeneration
NCT02946879

Recruiting

Long-Term Follow-Up Gene Therapy Study for Leber Congenital Amaurosis OPTIRPE65 (Retinal Dystrophy Associated With Defects in RPE65)

Conditions: Leber Congenital Amaurosis (LCA); Eye Diseases; Eye Diseases, Hereditary; Retinal Diseases
NCT02575430

Completed

Natural History Study in Inherited Retinal Disease Subjects Caused by Mutations in RPE65 or LRAT

Conditions: Leber Congenital Amaurosis (LCA); Retinitis Pigmentosa (RP)
NCT00481546

Active, not recruiting

Phase I Trial of Gene Vector to Patients With Retinal Disease Due to RPE65 Mutations

Conditions: Amaurosis of Leber; Retinal Diseases
NCT03913130

Active, not recruiting

Extension Study to Study PQ-110-001 (NCT03140969)

Conditions: Leber Congenital Amaurosis 10; Blindness; Leber Congenital Amaurosis; Vision Disorders; Sensation Disorders; Neurologic Manifestations; Eye Diseases; Eye Diseases, Hereditary; Eye Disorders Congenital; Retinal Disease
NCT03913143

Active, not recruiting

A Study to Evaluate Efficacy, Safety, Tolerability and Exposure After a Repeat-dose of Sepofarsen (QR-110) in LCA10 (ILLUMINATE)

Conditions: Leber Congenital Amaurosis 10; Blindness; Leber Congenital Amaurosis; Vision Disorders; Sensation Disorders; Neurologic Manifestations; Eye Diseases; Eye Diseases, Hereditary; Eye Disorders Congenital; Retinal Disease
NCT03872479

Recruiting

Single Ascending Dose Study in Participants With LCA10

Conditions: Blindness; Leber Congenital Amaurosis 10; Vision Disorders; Eye Diseases; Eye Diseases, Hereditary; Eye Disorders Congenital; Retinal Disease; Retinal Degeneration
NCT03396042

Recruiting

Natural History Study of CEP290-Related Retinal Degeneration

Conditions: Blindness; Leber Congenital Amaurosis 10; Vision Disorders; Eye Diseases; Eye Diseases, Hereditary; Eye Disorders Congenital; Retinal Disease; Retinal Degeneration
NCT03602820

Active, not recruiting

Long-term Follow-up Study in Subjects Who Received Voretigene Neparvovec-rzyl (AAV2-hRPE65v2)

Conditions: Inherited Retinal Dystrophy Due to RPE65 Mutations
NCT02435940

Recruiting

Inherited Retinal Degenerative Disease Registry

Conditions: Eye Diseases Hereditary; Retinal Disease; Achromatopsia; Bardet-Biedl Syndrome; Bassen-Kornzweig Syndrome; Batten Disease; Best Disease; Choroidal Dystrophy; Choroideremia; Cone Dystrophy; Cone-Rod Dystrophy; Congenital Stationary Night Blindness; Enhanced S-Cone Syndrome; Fundus Albipunctatus; Goldmann-Favre Syndrome; Gyrate Atrophy; Juvenile Macular Degeneration; Kearns-Sayre Syndrome; Leber Congenital Amaurosis; Refsum Syndrome; Retinitis Pigmentosa; Retinitis Punctata Albescens; Retinoschisis; Rod-Cone Dystrophy; Rod Dystrophy; Rod Monochromacy; Stargardt Disease; Usher Syndrome