Clinical Trials on Leber's Hereditary Optic Neuropathy (LHON) in United Kingdom

Total 156 results

Santhera Pharmaceuticals

Completed

Historical Case Record Survey of Visual Acuity Data From Patients With Leber's Hereditary Optic Neuropathy (LHON)

Leber's Hereditary Optic Neuropathy (LHON)

Belgium, Netherlands, France, Germany, Norway, United Kingdom, Italy
Medical College of Wisconsin

Terminated

Near-infrared Light-emitting Diode (NIR-LED) Therapy for Leber's Hereditary Optic Neuropathy (LHON) (LHON)

Leber's Hereditary Optic Neuropathy (LHON)

United States
Santhera Pharmaceuticals

Completed

Study to Assess the Efficacy and Safety of Raxone in LHON Patients (LEROS)

Leber's Hereditary Optic Neuropathy (LHON)

United States, United Kingdom, Spain, Poland, Austria, Belgium, Bulgaria, Germany, Italy, Portugal
Neurophth Therapeutics Inc

Recruiting

Gene Therapy Clinical Trial for the Treatment of Leber's Hereditary Optic Neuropathy Associated With ND1 Mutations

Leber Hereditary Optic Neuropathy (LHON)

China, United States
Neurophth Therapeutics Inc

Active, not recruiting

Gene Therapy Clinical Trial for the Treatment of Leber's Hereditary Optic Neuropathy Associated With ND4 Mutations

Leber Hereditary Optic Neuropathy (LHON)

United States
GenSight Biologics

Completed

RESCUE and REVERSE Long-term Follow-up (RESTORE)

Leber Hereditary Optic Neuropathy

United States, France, Italy, United Kingdom, Germany
GenSight Biologics

Completed

REALITY LHON Registry (REALITY)

Leber Hereditary Optic Neuropathy

United States, France, Italy, Spain, United Kingdom
GenSight Biologics

Active, not recruiting

Efficacy & Safety Study of Bilateral IVT Injection of GS010 in LHON Subjects Due to the ND4 Mutation for up to 1 Year (REFLECT)

Leber Hereditary Optic Neuropathy

Belgium, Spain, United States, France, United Kingdom, Taiwan, Italy
Santhera Pharmaceuticals

Completed

RHODOS Follow-up Single-visit Study (RHODOS-OFU)

Leber's Hereditary Optic Neuropathy

Canada, Germany, United Kingdom
Santhera Pharmaceuticals

Completed

Study to Assess Efficacy,Safety and Tolerability of Idebenone in the Treatment of Leber's Hereditary Optic Neuropathy (RHODOS)

Leber's Hereditary Optic Neuropathy

Canada, Germany, United Kingdom
Byron Lam
National Eye Institute (NEI)

Active, not recruiting

Safety Study of an Adeno-associated Virus Vector for Gene Therapy of Leber's Hereditary Optic Neuropathy (LHON)

Leber's Hereditary Optic Neuropathy

United States
Stealth BioTherapeutics Inc.

Completed

A Study Investigating the Safety, Tolerability, and Efficacy of Elamipretide Topical Ophthalmic Solution for Treatment of Leber's Hereditary Optic Neuropathy

Leber's Hereditary Optic Neuropathy

United States
Edison Pharmaceuticals Inc

No longer available

Emergency Administration of EPI-743 to a Single Patient With Leber's Hereditary Optic Neuropathy [LHON]

Leber's Hereditary Optic Neuropathy

United States
Randy Kardon

Recruiting

New Non-invasive Modalities for Assessing Retinal Structure and Function

Leber Hereditary Optic Neuropathy | Ischemic Optic Neuropathy | Hemianopia | Branch Retinal Artery Occlusion | Acute Zonal Occult Outer Retinopathy

United States
MD Stem Cells

Recruiting

Stem Cell Ophthalmology Treatment Study II (SCOTS2)

Glaucoma | Age-Related Macular Degeneration | Macular Degeneration | Retinitis Pigmentosa | Leber Hereditary Optic Neuropathy | Optic Atrophy | Blindness | Optic Neuropathy | Vision, Low | Retinal Disease | Stargardt Disease | Maculopathy | Retinopathy | Optic Nerve Disease | Nonarteritic Ischemic Optic Neuropathy | Vision... and other conditions

United States, United Arab Emirates
University College London Hospitals

Completed

Muscle Structure, Function and Gait in dHMN (GAIT-dHMN)

Distal Hereditary Motor Neuropathy, Type II | Distal Hereditary Motor Neuropathy, Type V | Distal Hereditary Motor Neuronopathy Type I | Distal Hereditary Motor Neuronopathy Type VI

United Kingdom
Rigshospitalet, Denmark
University of Colorado, Denver; King's College Hospital NHS Trust; Odense University... and other collaborators

Recruiting

NA-AION Risk Factors: New Perspectives (NARROW)

Non-arteritic Ischemic Optic Neuropathy | Optic Disk Drusen

Denmark, United Kingdom, United States, Australia, Canada, France, Iran, Islamic Republic of, Israel, New Zealand
Emory University

Completed

Vision Restoration Therapy (VRT) to Treat Non-Arteritic Anterior Ischemic Optic Neuropathy

Non-Arteritic Anterior Ischemic Optic Neuropathy

United States
Jeffrey L Goldberg

Completed

NT-501 CNTF Implant for Ischemic Optic Neuropathy: Safety, Neuroprotection and Neuroenhancement

Ischemic Optic Neuropathy/Optic Nerve Stroke

United States
Neuro-Ophthalmologic Associates, PC
Acorda Therapeutics

Completed

A New Medicine to Treat Nonarteritic Anterior Ischemic Optic Neuropathy (NAION) (Ampyra)

Non Arteritic Ischemic Optic Neuropathy

United States
University of Colorado, Denver
Genentech, Inc.

Completed

Ranibizumab Therapy for Non-arteritic Ischemic Optic Neuropathy (NAION)

Nonarteritic Anterior Ischemic Optic Neuropathy

United States
Eli Lilly and Company

Completed

A Study to Determine if There is a Possible Association Between NAION and Phosphodiesterase Type 5 (PDE5) Inhibitors

Nonarteritic Anterior Ischemic Optic Neuropathy

United States
Ohio State University

Completed

Safety and Efficacy of Using SightSaver Visual Evoked Potential (VEP) for VEP Monitoring in Prone Spine Surgery (SightSaver)

Ischemic Optic Neuropathy

United States
Regenera Pharma Ltd

Terminated

Efficacy & Safety of RPh201 Treatment in Patients With Previous Nonarteritic Anterior Ischemic Optic Neuropathy (NAION)

Nonarteritic Anterior Ischemic Optic Neuropathy

United States
GenSight Biologics

Completed

Efficacy Study of GS010 for Treatment of Vision Loss From 7 Months to 1 Year From Onset in LHON Due to the ND4 Mutation (REVERSE) (REVERSE)

Optic, Atrophy, Hereditary, Leber

United Kingdom, United States, Germany, Italy, France
GenSight Biologics

Completed

Efficacy Study of GS010 for the Treatment of Vision Loss up to 6 Months From Onset in LHON Due to the ND4 Mutation (RESCUE)

Optic, Atrophy, Hereditary, Leber

United Kingdom, United States, France, Germany, Italy
Quark Pharmaceuticals

Terminated

Phase 2/3, Randomized, Double-Masked, Sham-Controlled Trial of QPI-1007 in Subjects With Acute Nonarteritic Anterior Ischemic Optic Neuropathy (NAION)

Non Arteritic Anterior Ischemic Optic Neuropathy

United States, Australia, Germany, China, India, Italy, Singapore, Israel
Wills Eye
United States Department of Defense

Completed

Electric Stimulation of the Eye to Improve Vision After Trauma (TES)

Trauma | Multiple Sclerosis (MS) | Non-arteritic Anterior Ischemic Optic Neuropathy (NAION)

United States
National Eye Institute (NEI)

Unknown

Ischemic Optic Neuropathy Decompression Trial Followup (IONDT Followup)

Ischemic Optic Neuropathy

United States
University of Colorado, Denver

Terminated

Choroidal Thickness in Optic Neuropathy

Optic Nerve Disorders

United States
Quark Pharmaceuticals

Completed

Safety Study of a Single IVT Injection of QPI-1007 in Chronic Optic Nerve Atrophy and Recent Onset NAION Patients

Optic Atrophy | Non-arteritic Anterior Ischemic Optic Neuropathy

United States, Israel
NGoggle
National Eye Institute (NEI); Duke University

Enrolling by invitation

Assessment of Visual Function With a Portable Brain-computer Interface

Glaucoma | Retinal Degeneration | Age Related Macular Degeneration | Optic Neuropathy

United States
Pfizer's Upjohn has merged with Mylan to form Viatris...

Completed

A Study to Assess Whether PDE5 Inhibitors Increase the Chance of Triggering the Onset of Acute NAION

Optic Neuropathy, Ischemic

United States, Spain, Germany, Italy, France, United Kingdom
University College, London

Recruiting

Hereditary Sensory Neuropathy Serine Trial (SENSE)

Hereditary Sensory Neuropathy Type I

United Kingdom
Applied Therapeutics, Inc.

Active, not recruiting

Pharmacodynamic EffIcacy and Clinical Benefit of AT 007 in Patients With Sorbitol Dehydrogenase (SORD) Deficiency (INSPIRE)

Hereditary Neuropathy Caused by SORD Deficiency

United States, United Kingdom, Czechia, Italy
Stanford University

Recruiting

Hyperbaric Oxygen Therapy for Optic Neuropathies (HBOT)

Glaucoma | Optic Neuropathy

United States
Bayer

Terminated

PDE5 Inhibitor Use and Non-arteritic Anterior Ischemic Optic Neuropathy (NAION)

Anterior Ischemic Optic Neuropathy

United States, Australia, Canada
ProQR Therapeutics

Completed

Study to Evaluate QR-110 in Leber's Congenital Amaurosis (LCA) Due to the c.2991+1655A>G Mutation (p.Cys998X) in the CEP290 Gene

Leber's Congenital Amaurosis

United States, Belgium
University of Miami
National Eye Institute (NEI)

Completed

BCI and Evaluation of Visual and Task Performance in Subjects With Eye Diseases

Glaucoma | Macular Degeneration | Retinal Degeneration | Optic Neuropathy | Glaucoma Suspect | Visual Pathway Disorder

United States
St George's, University of London
University College London Hospitals

Unknown

Effect of Orthoses and Underfoot Vibration on Balance in Neuropathy

Peripheral Neuropathy | CMT - Charcot-Marie-Tooth Disease | Hereditary Peripheral Neuropathy | CMT1A

United Kingdom
University of Iowa
University of South Florida; National Institute of Neurological Disorders and... and other collaborators

Completed

Disability Severity Scale (DSI) and Hereditary Motor and Sensory Neuropathy Overall Disability Scale (HMSN-R-ODS) (DSI and HMSN)

Charcot Marie Tooth Disease | Inherited Peripheral Neuropathy

United States, United Kingdom
University College, London
Moorfields Eye Hospital NHS Foundation Trust; Targeted Genetics Corporation

Completed

Safety Study of RPE65 Gene Therapy to Treat Leber Congenital Amaurosis

Retinal Degeneration

United Kingdom
Massachusetts General Hospital

Completed

L-Serine Supplementation in Hereditary Sensory Neuropathy Type 1

Hereditary Sensory and Autonomic Neuropathy Type I

United States
Wills Eye

Completed

Comparing Rates of Glaucoma in Professional Wind Versus Non-Wind Instrument Players

Glaucoma | Intraocular Pressure | Optic Neuropathy

United States
University of Miami

Terminated

Biomechanics of Optic Neuropathy

Optic Neuropathy

United States
MeiraGTx UK II Ltd
Syne Qua Non Limited

Completed

Long-Term Follow-Up Gene Therapy Study for Leber Congenital Amaurosis OPTIRPE65 (Retinal Dystrophy Associated With Defects in RPE65)

Eye Diseases | Retinal Diseases | Eye Diseases, Hereditary | Leber Congenital Amaurosis (LCA)

United States, United Kingdom
Massachusetts General Hospital

Active, not recruiting

High Frequency Impulse Therapy for Neuropathic Pain in NMOSD

Neuromyelitis Optica

United States
NYU Langone Health

Completed

Proprioception and Sensorimotor Control in Hereditary Sensory and Autonomic Neuropathy

Atunomic Neuropathy

United States
Nova Southeastern University

Recruiting

A More Engaging Visual Field Test to Increase Use and Reliability in Pediatrics

Glaucoma, Suspect | Optic Nerve Hypoplasia and Abnormalities of the Central Nervous System | Congenital Coloboma of the Optic Nerve | Optic Nerve Head Pits, Bilateral Congenital

United States
Great Ormond Street Hospital for Children NHS Foundation...
AstraZeneca

Completed

Intermittent Dosing Of Selumetinib In Childhood NF1 Associated Tumours (INSPECT)

Neurofibromatosis Type 1 | Optic Nerve Glioma | Plexiform Neurofibroma

United Kingdom

Clinical Trials on Leber's Hereditary Optic Neuropathy (LHON) in United Kingdom

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