Clinical Trials on Lipoproteins, VLDL

Total 114 results

Otsuka Pharmaceutical Co., Ltd.

Completed

A Confirmatory Trial of ETC-1002 in Patients With Hyper-LDL Cholesterolemia

Hyper-low-density Lipoprotein (LDL) Cholesterolemia

Japan
Otsuka Pharmaceutical Co., Ltd.

Active, not recruiting

A Long-term Trial of ETC-1002 in Patients With Hyper-LDL Cholesterolemia

Hyper-low-density Lipoprotein (LDL) Cholesterolemia

Japan
Jordan Collaborating Cardiology Group
The Cardiovascular Academy Group of the JCS; The Jordan Cardiac Society (JCS); Istishari Hospital Department of Clinical Research

Terminated

Cardiovascular Risk Categories and Attaining LDL-C Targets in Middle Eastern Adults Aged 30-55 Years of Age (CREATE)

Atherosclerotic Cardiovascular Risk | Low-density-lipoprotein (LDL) Cholesterol

Jordan
Nina Hermans
University Hospital, Antwerp

Recruiting

Extracts of Amla, Walnut Leaf, Red Yeast Rice and Olive in Cardiovascular Prevention (AmWaRO)

Low-Density-Lipoprotein-Type [LDL] Hyperlipoproteinemia

Belgium
Wihuri Research Institute
Karolinska Institutet; University of Helsinki; Minerva Foundation Institute for...

Unknown

The Effect of E-EPA on Circulating LDL and Plasma Lipid Metabolism (EPA&LDL)

Cardiovascular Diseases | Atherosclerosis | Low-density Lipoproteins Aggregation Susceptibility | Low-density Lipoprotein Lipid Composition

Finland
S.LAB (SOLOWAYS)
Center of New Medical Technologies; Triangel Scientific

Completed

Evaluating the Impact of Omega-3 Fatty Acid Supplementation (Soloways™) on Lipid Profiles in Adults With PPARG Polymorphisms (SOLIPARG)

LDL Hyperlipoproteinemia | Low-Density-Lipoprotein-Type [LDL] Hyperlipoproteinemia | Triglyceride Storage Type I or II Disease

Russian Federation
University of Connecticut
American Egg Board

Recruiting

Investigating Age-dependent Effects of Egg Intake on HDL and Immune Profiles

Inflammatory Response | Lipoproteins

United States
Jubilee Mission Medical College and Research Institute
Christian Medical College, Vellore, India

Active, not recruiting

Effect of a Customised Lifestyle Medicine Strategy on Lowering Blood Lipid Levels in Indian Physicians (CLIP)

Hypertension | BMI | Cholesterol, Elevated | Lifestyle Risk Reduction | LDL Hyperlipoproteinemia | HbA1C | Lipoprotein(A)

India
Ionis Pharmaceuticals, Inc.
Akcea Therapeutics

Completed

Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of IONIS APO(a)-LRx in Healthy Volunteers With Elevated Lipoprotein(a)

Elevated Lipoprotein(a)

Canada
University of Aarhus
University of Copenhagen; Hvidovre University Hospital; Arla Foods

Recruiting

A Randomized Controlled Trial of Effects of DAIry PROtein Products on Liver Disease Severity and Metabolism in Patients With Non-Alcoholic Fatty Liver Disease. (DAIPRO-NAFLD)

Metabolic Syndrome | Weight Loss | Non-Alcoholic Fatty Liver Disease | Whey | Caseins | Diet, High Protein | Lipoproteins, VLDL

Denmark
Pamukkale University
Bakirkoy Dr. Sadi Konuk Research and Training Hospital

Completed

The Effect of Tele-Nursing Based Motivational Interviewing in Individuals With Type 2 Diabetes:RCT

Type2 Diabetes | Self Efficacy | Self Management | Cholesterol; Lipidosis | High Density Lipoprotein Deficiency | Motivational Interview | Tele-nursing | LDL - Low Density Lipoprotein Receptor Disorder

Turkey
Ionis Pharmaceuticals, Inc.

Completed

Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of ISIS-APO(a)Rx in Participants With High Lipoprotein(a)

Elevated Lipoprotein(a)

Netherlands, United Kingdom, Denmark, Germany, Canada
National Heart, Lung, and Blood Institute (NHLBI)

Completed

Comparison of EPA and DHA-Rich Fish Oils on Lipoprotein Metabolism In Adults

Proteomics | Lipoprotein Metabolism | PCSK9

United States
University of Texas Southwestern Medical Center
National Heart, Lung, and Blood Institute (NHLBI)

Recruiting

Extreme Lipids Repository

Lipoprotein Disorder

United States
Eli Lilly and Company

Active, not recruiting

A Study of LY3819469 in Participants With Elevated Lipoprotein(a) [Lp(a)]

Lipoprotein Disorder

United States, Spain, China, Japan, Germany, Argentina, Romania, Netherlands, Mexico, Denmark
Syneos Health
SynerK Pharmatech (Suzhou) Limited

Recruiting

Dose Escalation of SNK-396 in Participants With Elevated Low-Density Lipoprotein Cholesterol

Elevated Low-Density Lipoprotein Cholesterol

Australia
Amgen

Completed

A Study to Evaluate the Pharmacokinetics, Pharmacodynamics, Safety and Tolerability of Olpasiran in Chinese Participants With Elevated Serum Lipoprotein(a)

Elevated Serum Lipoprotein(a)

Hong Kong
National Heart, Lung, and Blood Institute (NHLBI)

Completed

Effect of Fish Oil Enriched In Omega-11 Fatty Acid On Lipoprotein Metabolism In Adults

Proteomics | Lipoprotein Metabolism | PCSK9

United States
Charite University, Berlin, Germany

Unknown

Evaluation of the Effect of NICOtinic Acid (Niacin) on Elevated Lipoprotein(a) Levels (NICOLa Study) (NICOLa)

Elevated Lipoprotein(a) Levels

Germany
Akcea Therapeutics

Completed

Drug-drug Interaction Study to Evaluate the Effect of ISIS 681257 on Warfarin

Cardiovascular Diseases | Elevated Lipoprotein(a)

Canada
Akcea Therapeutics

Completed

Drug-drug Interaction Study to Evaluate the Effect of ISIS 681257 on Clopidogrel

Cardiovascular Diseases | Elevated Lipoprotein(a)

Canada
Yonsei University
Daewoong Pharmaceutical Co. LTD.

Recruiting

Effect of Early Initiation of Evolocumab on Lipid Profiles Changes in Patients With ACS Undergoing PCI (C-STAR)

Low-Density-Lipoprotein-Type [LDL] Hyperlipoproteinemia

Korea, Republic of
Novartis Pharmaceuticals

Completed

Adherence and Persistence to Inclisiran Among Early Users in Germany

High Levels of Low-density Lipoprotein Cholesterol

Switzerland
InQpharm Group

Completed

Benefit of IQP-AS-118 on Blood Pressure and LDL-cholesterol

Blood Pressure | Low Density Lipoprotein Cholesterol Level

Germany
Novartis Pharmaceuticals

Completed

Lipoprotein(a) in Patients With Cardiovascular Disease (CVD)

Cardiovascular Disease and Lipoprotein(a)

China, Germany, United States, Colombia, South Africa, Italy, Spain, Belgium, Egypt, Hungary, Taiwan, Turkey, Japan, Netherlands, Australia, Austria, Canada, Czechia, France, Israel, Switzerland, United Kingdom, Korea, Republic of, Th... and more
National Heart, Lung, and Blood Institute (NHLBI)

Active, not recruiting

Evaluation of Lipoproteins

Evaluation of Plasma Lipoproteins

United States
Eli Lilly and Company

Completed

A Study of LY3473329 in Adult Participants With Elevated Lipoprotein(a) at High Risk for Cardiovascular Events (KRAKEN)

Lipoprotein Disorder

Australia, China, Hungary, Brazil, Japan, Germany, Netherlands, United States
Alnylam Pharmaceuticals

Completed

Trial to Evaluate Safety and Tolerability of ALN-PCS02 in Subjects With Elevated LDL-Cholesterol (LDL-C)

Elevated LDL-Cholesterol (LDL-C)

United Kingdom
Texas A&M University

Completed

Ground Beef and Cardiovascular Disease

Lipoprotein Metabolism Disorder
Amsterdam Molecular Therapeutics
International Antiviral Therapy Evaluation Center

Unknown

Safety and Efficacy in LPL-Deficient Subjects of AMT-011, an Adeno-Associated Viral Vector Expressing Human Lipoprotein Lipase [S447X]

Familial Lipoprotein Lipase Deficiency

Canada
Amsterdam Molecular Therapeutics
The Clinical Trial Company

Completed

Efficacy and Safety of Human Lipoprotein Lipase (LPL)[S447X] Expressed by an Adeno-Associated Viral Vector in LPL-deficient Subjects

Familial Lipoprotein Lipase Deficiency

Canada
Silence Therapeutics plc

Active, not recruiting

Evaluate SLN360 in Participants With Elevated Lipoprotein(a) at High Risk of Atherosclerotic Cardiovascular Disease Events

Cardiovascular Diseases | Atherosclerosis | Lipoprotein(a)

Australia, Czechia, Denmark, Netherlands, Slovakia, South Africa, United Kingdom
Supplement Formulators, Inc.

Terminated

To Assess the Efficacy and Safety of the Cardio Formulation in Reducing Oxidized LDL

Oxidized Low Density Lipoprotein

United States
LIB Therapeutics LLC
Medpace, Inc.

Completed

Study to Evaluate Efficacy and Safety of LIB003 in Patients on Lipid-Lowering Therapy Needing Additional LDL-C Reduction

LDL Cholesterol

United States
Universidad de Granada
University of Copenhagen; University of Oxford; Harvard University; University... and other collaborators

Recruiting

Cardiovascular Risk Prevention With a Mediterranean Dietary Pattern Reduced in Saturated Fat (CADIMED)

LDL Cholesterol

Spain
Uppsala University
Dalarna County Council, Sweden

Completed

Effectiveness of Written Dietary Advice on Lipoproteins - a Pragmatic Randomized Controlled Trial (MYDICLIN)

Cholesterol, LDL

Sweden
Unity Health Toronto

Unknown

Effect of Viscous Soluble Fibers on Serum Cholesterol Levels (CHOL-META)

LDL Cholesterol

Canada
University of Texas Southwestern Medical Center
Merck Sharp & Dohme LLC; Donald W. Reynolds Foundation

Completed

Comparison of Efficacy and Safety of Ezetimibe or Statin Monotherapy to Co-Administration of Both

Cholesterol, LDL

United States
Ferrer Internacional S.A.

Terminated

Pharmacodynamic Clinical Trial of Cardiovascular Polypill on LDL Cholesterol

Elevated LDL Cholesterol

Spain
Akcea Therapeutics
Ionis Pharmaceuticals, Inc.

Completed

Phase 2 Study of ISIS 681257 (AKCEA-APO(a)-LRx) in Participants With Hyperlipoproteinemia(a) and Cardiovascular Disease

Cardiovascular Disease | Elevated Lipoprotein(a)

United States, Canada, Denmark, Germany, Netherlands
Ferrer Internacional S.A.

Terminated

A Pharmacodynamic Study to Evaluate the Effect of a Fixed Dose Combination Pill on Low Density Lipoprotein (LDL) Cholesterol

Elevated LDL Cholesterol

United States
Danone Japan

Completed

"A Clinical Study for Evaluating the Effect of a Plant Sterol-enriched Fermented Dairy Product on Blood Lipoprotein Profile in Japanese Adults"

Subjects With High LDL-Cholesterol

Japan
Wake Forest University Health Sciences

Completed

Habitual Diet and Avocado Trial (HAT)

Cardiovascular Diseases | Diabetes | Metabolic Syndrome | Liver Fat | Cardiovascular Risk Factor | Diet Habit | Dietary Modification | High Cholesterol | Triglycerides High | Low-density-lipoprotein-type | HDL Cholesterol, Low Serum | High Blood Sugar | Intra-abdominal Fat | High Density Lipoprotein Deficiency

United States
Haisco Pharmaceutical Group Co., Ltd.

Completed

Ascending Single-Dose and Multiple-Dose Study to Evaluate HSK31679 in Healthy Subjects and Subjects With Elevated LDL-C

Healthy | Elevated LDL-C

China
Biosearch S.A.

Completed

Evaluation of a Probiotic on LDL-cholesterol Levels

Cardiovascular Diseases | LDL-cholesterol

Spain
University Rovira i Virgili
Universitat de Lleida; Ministerio de Ciencia e Innovación, Spain

Unknown

Red-fleshed Apple as a Novel Anthocyanin-biofortified Food to Improve Cardiometabolic Risk Factors. (AppleCor)

High LDL-cholesterol Levels

Spain
Texas A&M University

Completed

Impact of Beef's Unique Food Matrix on Human Health

Cholesterol, LDL | Cholesterol, HDL | Research Subjects

United States
Yonsei University

Completed

The Effectiveness of Plant Stanols as Ester on Change in Blood Cholesterol Level

LDL-cholesterol Level 130-159mg/dL
LIB Therapeutics LLC
Medpace, Inc.

Active, not recruiting

Study of Efficacy and Safety of LIB003 in Patient With CVD on Statins Requiring Additional LDL-C Reduction (LIBerate-CVD)

Cardiovascular Diseases | Hyper-LDL-cholesterolemia

United States
Novartis Pharmaceuticals

Active, not recruiting

Assessing the Impact of Lipoprotein (a) Lowering With Pelacarsen (TQJ230) on Major Cardiovascular Events in Patients With CVD (Lp(a)HORIZON)

Cardiovascular Disease and Lipoprotein(a)

United States, China, Germany, South Africa, Italy, Spain, Belgium, Czechia, Hungary, Japan, Taiwan, Netherlands, Australia, Austria, Canada, France, Israel, Switzerland, United Kingdom, Korea, Republic of, Argentina, Denmark, Greece, Romani... and more

Clinical Trials on Lipoproteins, VLDL

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