Clinical Trials on Metabolic Disease in South Africa

Total 18899 results

University of Cape Town
University of Stellenbosch; University of KwaZulu

Recruiting

South African Paediatric Surgical Outcomes Study 2 (SAPSOS2)

Iron Deficiency Anemia | Anaemia | Iron | Prospective Studies | Paediatric Surgery | Interventional Studies

South Africa
Alvotech Swiss AG

Completed

AVT03 With Xgeva in Healthy Male Subjects

This is a Phase I Study Conducted in Healthy Volunteers

United Kingdom, South Africa, Poland
North-West University, South Africa
GlaxoSmithKline; Novartis; Pfizer; Boehringer Ingelheim; Medical Research Council; Medical... and other collaborators

Active, not recruiting

The African-PREDICT Study (PREDICT)

Cardiovascular Diseases | Hypertension | Health Risk Behaviors | Arterial Stiffness | Young | Renin Hypertension

South Africa
North-West University, South Africa
Medical Research Council, South Africa; National Research Foundation of South... and other collaborators

Completed

Effect of African Leafy Vegetables on Nutritional Status of South African School Children. (ALV)

Malnutrition | Vitamin A Status | Iron Status | Zinc Status

South Africa
Sanofi

Completed

Immunogenicity and Safety of Pentaxim in South African Infants

Pertussis | Tetanus | Diphtheria | Poliomyelitis | Haemophilus Infections

South Africa
Pfizer

Completed

Study To Evaluate The Effect Of Torcetrapib/Atorvastatin In Patients With Genetic High Cholesterol Disorder

Hypercholesterolemia, Familial

Canada, United States, South Africa
University of Cape Town

Completed

The Impact of Obesity on Cardiac Function in Pregnancy (CFOP)

Obesity | Pregnancy

South Africa
International Maternal Pediatric Adolescent AIDS...
Eunice Kennedy Shriver National Institute of Child Health and Human Development... and other collaborators

Completed

TASK-002: Bioequivalence of Bedaquiline 400mg Administered in Crushed Form Compared to Tablet Form in Healthy Male and Female Adults Under Fed Conditions (BDQ Crush Study)

Tuberculosis

South Africa
North-West University, South Africa
Medical Research Council, South Africa; National Research Foundation of South...

Active, not recruiting

Exercise, Arterial Modulation and Nutrition in Youth South Africa Study (ExAMIN-Youth)

Hypertension | Childhood Obesity | Retinal Artery Stenosis

South Africa
University of Virginia
University of Venda

Active, not recruiting

Effectiveness of Point-of-use Water Treatment Technologies to Prevent Stunting Among Children in South Africa

Environmental Exposure | Diarrhoea;Infectious;Presumed | Diarrhea, Infantile | Diarrhea Tropical | Enteropathy | Malnutrition, Child

South Africa
DePuy International

Terminated

A Single Centre Study to Assess the Long-term Performance of the DePuy ASR™ System in Primary Hip Resurfacing Surgery

Osteoarthritis | Rheumatoid Arthritis | Avascular Necrosis | Post-traumatic Arthritis | Congenital Hip Dysplasia | Slipped Capital Femoral Epiphysis | Collagen Disorders | Nonunion of Femoral Fractures

South Africa
Columbia University
Eunice Kennedy Shriver National Institute of Child Health and Human Development... and other collaborators

Recruiting

Obesogenic Origins of Maternal and Child Metabolic Health Involving Dolutegravir (ORCHID)

Obesity | HIV | Maternal Obesity During Childbirth | Maternal Obesity Complicating Pregnancy | Obesity, Infant

South Africa
Arrowhead Pharmaceuticals

Active, not recruiting

Study of ARO-ANG3 in Participants With Homozygous Familial Hypercholesterolemia (HOFH) (Gateway)

Homozygous Familial Hypercholesterolemia

Australia, Canada, United States, South Africa
University of California, Los Angeles

Active, not recruiting

Neighborhood Alcohol & HIV Prevention in South African Townships (Philani)

Nutrition Disorders | HIV | Fetal Alcohol Syndrome

South Africa
Sanofi Pasteur, a Sanofi Company

Completed

DTaP-IPV-HB-PRP-T Combined Vaccine as a Primary Series and a Second Year of Life Booster in HIV-Exposed Infected and Uninfected Infants

Hepatitis B | Pertussis | Tetanus | Diphtheria | Polio | Human Immunodeficiency Virus Infection

South Africa
Yaounde Central Hospital
University of Exeter; University of Yaounde 1; MRC/UVRI & LSHTM Uganda Research...

Recruiting

Characteristics of Young-onset Diabetes in Sub-Saharan Africa (YODA) Study (YODA)

Type 1 Diabetes | Diabetes, Autoimmune

Tanzania, Cameroon, South Africa, Uganda
Immtech Pharmaceuticals, Inc

Terminated

Randomized, Double-Blind Phase 1 Safety and Tolerability Study of Pafuramidine Maleate (DB289) in Healthy Subjects

Healthy

South Africa
Eli Lilly and Company

Completed

Lispro Mid Mixture (MM) Intensive Mixture Therapy With Progressive Dose-Titration of Lispro Low Mixture (LM) or Biphasic Insulin Aspart 30/70 (S019) (S019)

Diabetes Mellitus, Type 2

Croatia, Poland, Romania, South Africa, Turkey
GlaxoSmithKline

Completed

Parkinson's Disease Patient Study On Absorption, Distribution, Metabolism And Excretion Of Ropinirole

Parkinson Disease

Germany, South Africa
Cycle Pharmaceuticals Ltd.
Parexel

Completed

Assessment of Intra-subject Variability in the Bioavailability of Chlorpromazine Hydrochloride

Acute Intermittent Porphyria | Anti-Psychotic | Management of Manifestations of Psychotic Disorders | Treatment of Schizophrenia | Control Nausea and Vomiting | Relief of Restlessness and Apprehension Before Surgery | Adjunct in the Treatment of Tetanus | Control Manifestations of the Manic Type... and other conditions

South Africa
Sanofi

Completed

Antibody Persistence in Healthy Children After Primary and Booster DTaP-IPV-Hep B-PRP-T Vaccine or Control Vaccine

Hepatitis B | Whooping Cough | Tetanus | Diphtheria | Poliomyelitis

South Africa
Abbott Products
Quintiles, Inc.

Completed

A Safety PK/PD Study of SLV337 in Patients With Type 2 Diabetes

Type 2 Diabetes

Bulgaria, Poland, South Africa
Genzyme, a Sanofi Company

Completed

Extension Study of Long-term Safety and Efficacy of Myozyme in Patients With Pompe Disease Who Were Previously Enrolled in Genzyme Sponsored Enzyme Replacement Therapy (ERT) Studies

Glycogen Storage Disease Type II | Pompe Disease Infantile-Onset

United States, France, South Africa
GlaxoSmithKline

Completed

Study to Asses DTPw-HBV/Hib at 15-18 Months (m) and Mencevax™ ACW at 24 to 30 m in Primed Subjects

Infections, Meningococcal

South Africa
Alvotech Swiss AG

Completed

AVT03 With Prolia in Healthy Male Subjects

Healthy Male Subjects

South Africa, Australia, New Zealand
Novartis Pharmaceuticals

Terminated

Efficacy and Safety of Mycograb as Adjunctive Therapy for Cryptococcal Meningitis in Patients With AIDS

Cryptococcal Meningitis

South Africa
Eli Lilly and Company

Completed

Safety, Tolerability, and Effect of LY2405319 After Multiple Injections in Subjects With Type 2 Diabetes

Type 2 Diabetes

India, Mexico, New Zealand, South Africa
LIB Therapeutics LLC
Medpace, Inc.

Completed

Study to Assess the Efficacy and Safety of LIB003 in HeFH Patients on Oral Lipid Therapy Needing Further LDL-C Reduction (LIBerate-FH)

Heterozygous Familial Hypercholesterolemia

United States, Israel, Norway, South Africa, Turkey
Novo Nordisk A/S

Completed

Safety of Insulin Detemir Produced by a New Process as Measured by Antibody Formation in Subjects With Type 1 Diabetes

Diabetes | Diabetes Mellitus, Type 1

Germany, South Africa, Russian Federation, Former Serbia and Montenegro, North Macedonia
Penn State University
National Institute on Drug Abuse (NIDA)

Completed

Adolescent Drug and HIV Prevention in South Africa

Substance-Related Disorders | Sexually Transmitted Diseases

South Africa
Novo Nordisk A/S

Completed

A Survey on Low Blod Sugar Among Insulin-treated Patients With Diabetes

Diabetes Mellitus, Type 2 | Diabetes | Diabetes Mellitus, Type 1

Turkey, Egypt, Philippines, United Arab Emirates, Bangladesh, Colombia, Singapore, South Africa
French National Agency for Research on AIDS and...

Completed

Pharmacokinetics of Rifabutin Combined With Antiretroviral Therapy in Patients With TB/HIV Co-infection in South Africa

HIV Infections | Tuberculosis

South Africa
GlaxoSmithKline

Completed

A Study of the Pharmacokinetics of Albiglutide in Normal and Renally Impaired Subjects.

Diabetes Mellitus, Type 2

United States, South Africa
Sanofi

Completed

Evaluation of the Blood Levels of the Drug (Lixisenatide), the Plasma Glucose Levels and Safety in Paediatric and Adult Patients With Type 2 Diabetes

Type 2 Diabetes Mellitus

South Africa, United States, Mexico, United Kingdom
Aegerion Pharmaceuticals, Inc.

Completed

Long Term, Follow-on Study of Lomitapide in Patients With Homozygous Familial Hypercholesterolemia

Familial Hypercholesterolemia

United States, Canada, Italy, South Africa
Sanofi

Completed

Efficacy and Safety Study of New Ambroxol Hardboiled Lozenges in Acute Pharyngitis (DELICIOUS)

Pharyngitis

South Africa
Sanofi

Terminated

Evaluation of Safety and Efficacy of AVE5530 as add-on to Ongoing High Doses of Statins in Patients With Primary Severe Hypercholesterolemia

Hypercholesterolemia

United States, France, Canada, Russian Federation, Ukraine, Netherlands, Bulgaria, Belgium, Czech Republic, Israel, Slovakia, Australia, South Africa
Pfizer

Completed

Plant Cell Expressed Recombinant Human Glucocerebrosidase Extension Trial

Gaucher Disease

Chile, United Kingdom, Canada, Spain, Israel, United States, Australia, South Africa
GlaxoSmithKline

Completed

Study to Determine the Bioequivalence of Two Fixed Dose Combination (FDC) Tablet Formulations of Amlodipine and Losartan FDC5/50 and FDC5/100 Under Fasting Conditions

Hypertension

South Africa
Bial - Portela C S.A.

Completed

An Open-label, Multiple-dose, Single-centre Study, Investigating the Pharmacokinetics of BIA 2-093

Epilepsy

South Africa
International Partnership for Microbicides, Inc.

Completed

Relative Bioavailability Trial of Dapivirine Ring-004 and Ring-008

HIV Infections

South Africa
Emory University
National Institute of Mental Health (NIMH); University of KwaZulu

Recruiting

Support for Adolescents Living With HIV in South Africa (InTSHA VIP)

HIV | Human Immunodeficiency Virus

South Africa
Catalyst Biosciences

Completed

Study of Next-Generation Recombinant Factor IX Variant in Adult Subjects With Hemophilia B

Hemophilia B

South Africa
Bial - Portela C S.A.

Completed

An Open-label, Single-dose, Single-centre Study, Investigating the Pharmacokinetics of BIA 2-093

Epilepsy

South Africa
University of California, Los Angeles
University of Stellenbosch; The ELMA Foundation; Philani Maternal Child Health...

Completed

Evaluation of a Home-based Community Health Worker Program in Rural Eastern Cape, South Africa

Depression | HIV Infections | Alcohol Drinking | Alcohol; Harmful Use | HIV/AIDS | Depressive Symptoms | Child Development | Alcohol Use Disorder | Stunting | Child Nutrition Disorders | Child Malnutrition | Birth Weight Less Than 10Th Percentile

South Africa
University of Witwatersrand, South Africa

Completed

Comparison Of Trabeculectomy Versus The Ex-PRESS Miniature Glaucoma Device In The Same Patient: A Prospective Randomized Study (XVT-USF)

Glaucoma

South Africa
The Wistar Institute

Completed

Anti-HIV Treatment Interruptions in HIV Infected Adults in South Africa

HIV Infections

South Africa
Johns Hopkins Bloomberg School of Public Health
United States Agency for International Development (USAID); University of KwaZulu and other collaborators

Completed

Safety and Efficacy of Zinc Supplementation in HIV-1-Infected Children in South Africa

HIV Infections

South Africa
University of Witwatersrand, South Africa

Unknown

A Comparison of Immediate Treatment of CIN1 With Cryotherapy and 12 Month Cytology Follow up in HIV Seropositive Women

Cervical Dysplasia

South Africa
GRI Bio, Inc.

Terminated

Trial to Examine the Effect of Two Doses of GRI-0621 in Patients With Chronic Liver Disease (GRI-201)

Chronic Liver Disease

South Africa

Clinical Trials on Metabolic Disease in South Africa

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