Clinical Trials on Metastatic Colorectal Carcinoma

Total 35576 results

Rottapharm Biotech
Agenus Inc.

Active, not recruiting

A Phase Ib/IIa Study of CR6086 in Combination With Balstilimab in pMMR-MSS Metastatic Colorectal Cancer Patients

Solid Tumor | Metastatic Microsatellite-stable Colorectal Cancer | Mismatch Repair Protein Proficient | Refractory Metastatic Colorectal Cancer

Italy
Sirtex Medical

Recruiting

Observational SIR-Spheres Study for the Treatment of Unresectable Liver Tumors (SIRtain Registry) (SIRtain)

Unresectable Hepatocellular Carcinoma (HCC) | Liver Metastases From Colorectal Cancer (mCRC)

Spain, United Kingdom, France
National Cancer Institute (NCI)

Recruiting

Hepatic Artery Infusion Pump Chemotherapy With Floxuridine and Dexamethasone in Combination With Systemic Chemotherapy for Patients With Colorectal Cancer Metastatic to the Liver

Colorectal Cancer | Liver Metastases | Colorectal Carcinoma | Colorectal Adenocarcinoma | Colorectal Cancer With Hepatic Metastases

United States
Genentech, Inc.

Completed

A Study of Vismodegib (GDC-0449) in Patients Treated With Vismodegib in a Previous Genentech-sponsored Phase I or II Cancer Study

Metastatic Colorectal Cancer | Ovarian Cancer | Basal Cell Carcinoma

United States
Cancer Institute and Hospital, Chinese Academy...

Unknown

A Phase I/II Study of XELOXIRI and Bevacizumab as First-line Treatment in Metastatic Colorectal Cancer

Colorectal Cancer | Metastatic Cancer | Colorectal Adenocarcinoma

China
Royal Surrey County Hospital NHS Foundation Trust

Completed

Feasibility Study of a 4 Stage Bowel Obstruction Cancer Diet (BOUNCED)

Metastatic Colorectal Cancer | Colorectal Neoplasms | Colorectal Cancer | Ovarian Cancer | Colorectal Cancer Metastatic | Peritoneal Carcinomatosis | Colorectal Carcinoma | Colorectal Adenocarcinoma | Ovarian Neoplasm | Bowel Obstruction | Metastatic Ovary Cancer

United Kingdom
Academic and Community Cancer Research United
National Cancer Institute (NCI)

Active, not recruiting

Pemigatinib for the Treatment of Metastatic or Unresectable Colorectal Cancer Harboring FGFR Alterations

Metastatic Colorectal Carcinoma | Stage IV Colorectal Cancer AJCC v8 | Stage IVA Colorectal Cancer AJCC v8 | Stage IVB Colorectal Cancer AJCC v8 | Stage IVC Colorectal Cancer AJCC v8 | Stage III Colorectal Cancer AJCC v8 | Stage IIIA Colorectal Cancer AJCC v8 | Stage IIIB Colorectal Cancer AJCC v8 | Stage IIIC Colorectal Cancer AJCC v8 and other conditions

United States
Hospital Sirio-Libanes

Completed

Exploratory Study to Determine Tissue Alterations of Advanced Hepatocellular Carcinoma Induced by Electromagnetic Waves of Low Energy Amplitude Modulated to Specific Frequencies During Imaging Study by MRI

Primary or Metastatic Tumor in the Liver Parenchyma

Brazil
Fondazione IRCCS Istituto Nazionale dei Tumori,...
Istituto Di Ricerche Farmacologiche Mario Negri; Gruppo Oncologico del Nord-Ovest

Recruiting

Improving Outcome of Selected Patients With Non-resectable Hepatic Metastases From Colo-rectal Cancer With Liver Transplantation (COLT)

Neoplasms | Colorectal Cancer Metastatic | Liver Metastases | Liver Neoplasm

Italy
The University of Hong Kong

Unknown

Circulating Tumor Cells in mCRC for Liver Resection

Metastatic Colorectal Cancer | Circulating Tumor Cell

Hong Kong
Clinica Universidad de Navarra, Universidad de...

Unknown

Study With Dendritic Cell Immunotherapy in Resected Hepatic Metastasis of Colorectal Carcinoma

Colorectal Carcinoma | Hepatic Metastasis

Spain
M.D. Anderson Cancer Center
National Cancer Institute (NCI)

Active, not recruiting

LY3214996 and Cetuximab Alone or in Combination With Abemaciclib for the Treatment of Unresectable or Metastatic Colorectal Cancer

Recurrent Colorectal Carcinoma | Metastatic Colon Adenocarcinoma | Metastatic Colorectal Carcinoma | Metastatic Rectal Adenocarcinoma | Stage III Colon Cancer AJCC v8 | Stage III Rectal Cancer AJCC v8 | Stage IIIA Colon Cancer AJCC v8 | Stage IIIA Rectal Cancer AJCC v8 | Stage IIIB Colon Cancer AJCC v8 and other conditions

United States
Centre Hospitalier Universitaire de Besancon
Bayer

Completed

Regorafenib in Combination With Metronomic Chemotherapies, and Low-dose Aspirin in Metastatic Colorectal Cancer (REPROGRAM-01)

Metastatic Cancer | Colo-rectal Cancer

France
European Organisation for Research and Treatment...

Withdrawn

Nintedanib Plus mFOLFOX6 for Previously Untreated Metastatic Esophagogastric Adenocarcinoma (MEGAN) (MEGAN)

Metastatic Disease | Esophagogastric Adenocarcinoma | No Previous Chemotherapy for Metastatic Esophagogastric Cancer
M.D. Anderson Cancer Center
National Cancer Institute (NCI)

Active, not recruiting

Panitumumab With or Without Trametinib in Treating Patients With Stage IV Colorectal Cancer

EGFR NP_005219.2:p.S492R | KRAS Gene Mutation | MAP2K1 Gene Mutation | Metastatic Colorectal Adenocarcinoma | Refractory Colorectal Adenocarcinoma | Stage IV Colorectal Cancer AJCC v7 | Stage IVA Colorectal Cancer AJCC v7 | Stage IVB Colorectal Cancer AJCC v7

United States
City of Hope Medical Center
National Cancer Institute (NCI)

Completed

Trametinib and Trifluridine and Tipiracil Hydrochloride in Treating Patients With Colon or Rectal Cancer That is Advanced, Metastatic, or Cannot Be Removed by Surgery

Stage IV Colorectal Cancer AJCC v7 | Stage IVA Colorectal Cancer AJCC v7 | Stage IVB Colorectal Cancer AJCC v7 | Metastatic Colorectal Carcinoma | Stage III Colon Cancer AJCC v7 | Stage III Rectal Cancer AJCC v7 | Stage IIIA Colon Cancer AJCC v7 | Stage IIIA Rectal Cancer AJCC v7 | Stage IIIB Colon... and other conditions

United States
National Cancer Institute (NCI)

Active, not recruiting

Cisplatin and Gemcitabine Hydrochloride With or Without Berzosertib in Treating Patients With Metastatic Urothelial Cancer

Metastatic Bladder Urothelial Carcinoma | Metastatic Ureter Urothelial Carcinoma | Stage IV Bladder Urothelial Carcinoma AJCC v7 | Metastatic Renal Pelvis and Ureter Urothelial Carcinoma

United States
Amgen
Roche-Genentech

Completed

Study of Talimogene Laherparepvec With Atezolizumab for Triple Negative Breast Cancer and Colorectal Cancer With Liver Metastases

Metastatic Colorectal Cancer | Metastatic Triple Negative Breast Cancer

United States, Belgium, Spain, Australia, Switzerland, Germany
Changhai Hospital

Recruiting

Anti-CEA CAR-T Cells to Treat Colorectal Liver Metastases

Colorectal Cancer | Metastatic Liver Cancer

China
GERCOR - Multidisciplinary Oncology Cooperative...

Completed

Combination Chemotherapy in Treating Patients With Colorectal Cancer and Resectable Metastases (MIROX)

Colorectal Cancer | Chemotherapy | Metastatic Cancer

France
Jules Bordet Institute

Completed

Phase 1 Study Testing the Combination of Aflibercept and Capecitabine in Metastatic Digestive and Breast Cancers (MOMENTUM1)

Metastatic Colorectal Cancers | Metastatic Gastric Cancers | Metastatic Oesophageal Cancers | Metastatic Pancreatic Cancers | Metastatic Biliary Cancers | Metastatic Breast Cancers

Belgium
Assiut University

Completed

Metastatic Left Colon and Rectal Cancer Treatment With Anti_EGFR Targeted Therapy (EGFR)

Metastatic Colorectal Adenocarcinoma
National Cancer Institute (NCI)

Active, not recruiting

Testing the Combination of XL184 (Cabozantinib), Nivolumab, and Ipilimumab for Poorly Differentiated Neuroendocrine Tumors

Metastatic Neuroendocrine Neoplasm | Metastatic Neuroendocrine Carcinoma | Metastatic Large Cell Neuroendocrine Carcinoma | Metastatic Small Cell Neuroendocrine Carcinoma

United States, Canada
Pharmacyclics LLC.

Completed

Study to Evaluate Ibrutinib Combination Therapy in Patients With Selected Gastrointestinal and Genitourinary Tumors

Metastatic Renal Cell Carcinoma | Metastatic Colorectal Adenocarcinoma | Advanced Gastric Adenocarcinoma | Advanced Urothelial Carcinoma

United States, Korea, Republic of, Spain, United Kingdom
Chloe Atreya, MD, PhD
Merck Sharp & Dohme LLC; MedPacto, Inc.

Recruiting

Preoperative Immunotherapy (Pembrolizumab) for Patients With Colorectal Cancer and Resectable Hepatic Metastases

Metastatic Malignant Neoplasm in the Liver | Stage IV Colorectal Cancer AJCC v8 | Stage IVA Colorectal Cancer AJCC v8 | Stage IVB Colorectal Cancer AJCC v8 | Stage IVC Colorectal Cancer AJCC v8

United States
Novartis Pharmaceuticals

Terminated

Study of Safety and Efficacy of INC280 and Cetuximab, in Adult c-MET Positive mCRC and HNSCC Patients After Progression on Cetuximab or Panitumumab Therapy

Metastatic Colorectal Cancer | Squamous Cell Carcinoma of Head and Neck (SCCHN)

France, Belgium, Spain, Germany, Italy, Canada, United States
Eastern Cooperative Oncology Group
National Cancer Institute (NCI)

Completed

Gemcitabine in Treating Patients With Metastatic Cancer of Unknown Primary

Pain | Carcinoma of Unknown Primary

United States
Dana-Farber Cancer Institute
American Cancer Society, Inc.

Not yet recruiting

Exercise for Gut Microbiome in Patients With Young-Onset Colorectal Cancer Undergoing Chemotherapy: The COURAGE Trial

Metastatic Colorectal Cancer | Colorectal Cancer | Metastatic Colon Cancer

United States
Memorial Sloan Kettering Cancer Center
Washington University School of Medicine; The Cleveland Clinic; Oregon Health... and other collaborators

Withdrawn

Study of Chemotherapy With or Without Hepatic Arterial Infusion for Patients With Unresectable Metastatic Colorectal Cancer to the Liver

Colorectal Adenocarcinoma Metastatic to the Liver

United States
Holy Stone Healthcare Co., Ltd

Completed

First-in-human Study of CA102N Monotherapy and CA102N Combined With Trifluridine/Tipiracil (LONSURF) in Subjects With Advanced Solid Tumors

Advanced or Metastatic Solid Tumors | Advanced or Metastatic Colorectal Cancer (mCRC)

United States
Array Biopharma, now a wholly owned subsidiary...

Completed

A Study of ARRY-438162 (MEK162) in Patients With Advanced Cancer

Metastatic Colorectal Cancer | Advanced Solid Tumors | Advanced or Metastatic Biliary Cancer

United States
M.D. Anderson Cancer Center
National Cancer Institute (NCI)

Recruiting

Personalized Peptide Vaccine in Treating Patients With Advanced Pancreatic Cancer or Colorectal Cancer

Stage IV Pancreatic Cancer AJCC v6 and v7 | Metastatic Colorectal Adenocarcinoma | Stage IV Colorectal Cancer AJCC v7 | Stage IVA Colorectal Cancer AJCC v7 | Stage IVB Colorectal Cancer AJCC v7 | Metastatic Pancreatic Ductal Adenocarcinoma

United States
European Organisation for Research and Treatment...
European Society of Surgical Oncology

Completed

A Prospective Colorectal Liver Metastasis Database With an Integrated Quality Assurance Program (CLIMB)

Colorectal Carcinoma | Liver Metastasis

France, Sweden, Italy, Denmark, Germany, Spain, Netherlands, Serbia, Austria, Switzerland, Belgium, United Kingdom
Association pour la Recherche sur le Temps Biologique...
Pfizer; Merck Serono International SA; Gustave Roussy, Cancer Campus, Grand Paris and other collaborators

Unknown

Optimal Control of Liver Metastases From Colorectal Cancer With Cetuximab and Hepatic Artery Infusion of Chemotherapy (OPTILIV)

Metastatic Colorectal Cancer | Liver Metastases | Hepatic Lesions

France, Italy, Belgium, Portugal
UMC Utrecht

Not yet recruiting

FAPI Molecular Imaging for Diagnosis of the CMS4 Unfavorable Colorectal Cancer Subtype (FoCus)

Metastatic Colorectal Cancer | Metastatic Cancer to Liver
Harbin Medical University

Not yet recruiting

A Trial of Camrelizumab Combined With Microwave Ablation and Chemotherapy in the Treatment of Colorectal Cancer Liver Metastasis/Pulmonary Metastasis

Lung Metastases | Colorectal Cancer Metastatic | Liver Metastases
Jena University Hospital
University Hospital Tuebingen

Recruiting

Living Donor Liver Transplantation With Two Stage Hepatectomy for Patients With Isolated, Irresectable Colorectal Liver Metastases (LIVERT(W)OHEAL)

Colorectal Cancer Metastatic | Liver Metastases

Germany
National Cancer Center, Korea

Unknown

Phase II Study of Irinotecan,Oxaliplatin Plus TS-1 in Untreated Metastatic Colorectal Cancer (TIROX2)

Colorecal Neoplasms | Secondary

Korea, Republic of
Hospital Maciel
University of Adelaide

Completed

Chemotherapy and Tumor Clearance in Hepatic Resections for Colorectal Liver Metastases.

Colorectal Cancer Metastatic | Liver Metastases
AstraZeneca

Completed

A Phase 1 Clinical Study of AZD4635 in Patients With Advanced Solid Malignancies

Advanced Solid Malignancies | Non-Small Cell Lung Cancer (NSCLC) | Metastatic Castrate-Resistant Prostate Carcinoma (mCRPC) | Colorectal Carcinoma (CRC)

United States
Hoffmann-La Roche

Completed

A Study of Bevacizumab (Avastin) in Combination With Chemotherapy in Participants With Metastatic Cancer of the Colon or Rectum.

Colorectal Cancer

Brazil
Hoffmann-La Roche

Completed

An Observational Study of Avastin (Bevacizumab) in Patients With Metastatic Cancer of the Colon or Rectum

Colorectal Cancer

Montenegro
AHS Cancer Control Alberta
Cross Cancer Institute

Withdrawn

A Trial of Glutamine to Prevent Oxaliplatin Neurotoxicity and a Pharmacokinetic Analysis of Oxaliplatin

Colorectal Cancer | Metastasis | Colorectal Tumors | Colorectal Carcinoma | Neoplasms, Colorectal
CCTU- Cancer Theme
Sanofi; National Institute for Health Research, United Kingdom; Stand Up To Cancer and other collaborators

Completed

To Assess the Safety of Continuous IV Administration of Plerixafor in Patients With Advanced Pancreatic, Ovarian and Colorectal Cancers (CAM-PLEX)

Colorectal Cancer Metastatic | Ovarian Serous Adenocarcinoma | Pancreatic Adenocarcinoma Metastatic

United Kingdom
Centre Oscar Lambret
Roche Pharma AG

Completed

Study About Preventive Treatment of Folliculitis Induced by Epidermal Growth Factor Receptor Inhibitors (DIPROCOL)

Metastatic Colorectal Cancer | Non-Small-Cell Lung Carcinoma

France
Hoffmann-La Roche

Completed

A Study of Bevacizumab (Avastin) in Combination With Chemotherapy in Participants With Metastatic Cancer of the Colon or Rectum

Colorectal Cancer

Taiwan
Hoffmann-La Roche

Completed

OBELIX Study: A Study of Avastin (Bevacizumab) in Combination With XELOX in Patients With Metastatic Cancer of the Colon or Rectum.

Colorectal Cancer

Italy
Eli Lilly and Company

Completed

A Study of Prexasertib (LY2606368) in Combination With Ralimetinib in Participants With Advanced or Metastatic Cancer

Colorectal Cancer | Metastatic Cancer | Non-small Cell Lung Cancer | Advanced Cancer

United States, Germany
Amgen

Completed

SPIRITT - Second-Line Panitumumab Irinotecan Treatment Trial

Cancer | Metastatic Colorectal Cancer | Colorectal Cancer | Rectal Cancer | Metastatic Cancer | Colon Cancer
Sirtex Medical

Completed

FOLFOX Plus SIR-SPHERES MICROSPHERES Versus FOLFOX Alone in Patients With Liver Mets From Primary Colorectal Cancer (SIRFLOX)

Colorectal Cancer | Liver Metastases | Colorectal Carcinoma

United States, Israel, Australia, Belgium, New Zealand, Spain, Germany, Switzerland, Italy, France, Poland

Clinical Trials on Metastatic Colorectal Carcinoma

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