Clinical Trials on Metastatic Esophageal Adenocarcinoma in Ireland

Total 597 results

Cancer Trials Ireland

Completed

A Phase II Trial of Epirubicin, Oxaliplatin and Capecitabine (EOX) Versus Docetaxel and Oxaliplatin (ElTax) in the Treatment of Advanced Gastro-oesophageal Cancer (ELECT)

Gastro Oesophageal Cancer

Ireland
Alliance for Clinical Trials in Oncology
National Cancer Institute (NCI)

Recruiting

mFOLFIRINOX Versus mFOLFOX With or Without Nivolumab for the Treatment of Advanced, Unresectable, or Metastatic HER2 Negative Esophageal, Gastroesophageal Junction, and Gastric Adenocarcinoma

Clinical Stage III Gastric Cancer AJCC v8 | Clinical Stage III Gastroesophageal Junction Adenocarcinoma AJCC v8 | Clinical Stage IV Gastric Cancer AJCC v8 | Clinical Stage IV Gastroesophageal Junction Adenocarcinoma AJCC v8 | Metastatic Gastric Adenocarcinoma | Metastatic Gastroesophageal Junction... and other conditions

United States, Puerto Rico
Cancer Trials Ireland
Southampton Clinical Trials Unit; Region H Rigshospitalet; Centre Hospitalier...

Completed

NEOadjuvant Trial in Adenocarcinoma of the oEsophagus and oesophagoGastric Junction International Study (Neo-AEGIS)

Oesophageal Cancer | Adenocarcinoma of the Oesophagus | Adenocarcinoma of the Oesophago-gastric Junction | Oesophageal Tumours | Junctional Tumours

Ireland, United Kingdom, Denmark, France, Sweden
Reckitt Benckiser Healthcare (UK) Limited

Completed

Clinical Investigation to Assess the Acid Neutralisation Activity of a Calcite Chewing Gum

Esophagitis | Gastro Oesophageal Reflux Disease

Ireland
St. James's Hospital, Ireland

Unknown

Classification of Adenocarcinoma of the Esophagogastric Junction

Barrett Esophagus | Siewert Type II Adenocarcinoma of Esophagogastric Junction | Oesophagus Cancer | Siewert Type I Adenocarcinoma of Esophagogastric Junction | Siewert Type III Adenocarcinoma of Esophagogastric Junction

Ireland
St. James's Hospital, Ireland
Karolinska Institutet; St Mary's Hospital, Paddington, London

Completed

European iNvestigation of SUrveillance After Resection for Esophageal Cancer (ENSURE)

Esophageal Cancer | Chemoradiation | Chemotherapy | Surgery | Metastatic Cancer | Radiation | Recurrent Esophageal Cancer

Sweden, Ireland, United Kingdom
Roger Williams Medical Center

Suspended

Phase II/Pilot Study of 2nd Generation Anti-CEA Designer T Cells in Adenocarcinomas

Metastatic Cancers

United States
Weill Medical College of Cornell University
Merck Sharp & Dohme LLC

Active, not recruiting

Study of Pembrolizumab in Locally Advanced Esophageal Adenocarcinoma

Esophageal Adenocarcinoma

United States
Brown University
AstraZeneca

Recruiting

Adjuvant Trastuzumab Deruxtecan (Enhertu) & Nivolumab For Patients Who Are Disease Free After Completion of Trimodality Treatment For HER-2+ Cancers of Esophagus & Gastroesophageal Junction

Esophageal Cancer | Esophageal Adenocarcinoma | HER-2 Protein Overexpression | Gastroesophageal-junction Cancer

United States
King's College Hospital NHS Trust
King's College London; Cardiff University; Guy's and St Thomas' NHS Foundation... and other collaborators

Recruiting

Beta-blockers for Oesophageal Varices (BOPPP)

Cirrhoses, Liver | Oesophageal Varices

United Kingdom
St. James's Hospital, Ireland

Completed

Neoadjuvant Therapy for Esophageal Cancer and Cardiopulmonary Physiology

Pneumonia | Adenocarcinoma | Respiratory Failure | Esophageal Cancer | Pulmonary Fibrosis | Surgery | Chemotherapy Effect | Radiation Toxicity | Squamous Cell Carcinoma | Radiation Pneumonitis | Radiation Fibrosis

Ireland
National Cancer Institute (NCI)

Suspended

Nivolumab and Ipilimumab in Treating Patients With Esophageal and Gastroesophageal Junction Adenocarcinoma Undergoing Surgery

Esophageal Adenocarcinoma | Clinical Stage III Gastroesophageal Junction Adenocarcinoma AJCC v8 | Gastroesophageal Junction Adenocarcinoma | Clinical Stage II Esophageal Adenocarcinoma AJCC v8 | Clinical Stage III Esophageal Adenocarcinoma AJCC v8 | Clinical Stage IVA Esophageal Adenocarcinoma... and other conditions

United States
EMD Serono Research & Development Institute, Inc.
Merck KGaA, Darmstadt, Germany

Completed

Avelumab in First-Line Maintenance Gastric Cancer (JAVELIN Gastric 100)

Unresectable, Locally Advanced or Metastatic, Adenocarcinoma of the Stomach, or of the Gastro Esophageal Junction

United States, Spain, Italy, Australia, Russian Federation, Taiwan, Korea, Republic of, Thailand, Canada, Turkey, Germany, Romania, United Kingdom, Hungary, Brazil, France, Japan
St. James's Hospital, Ireland

Completed

The Predictive Value of CT-PET in Esophageal Cancer

Esophageal Neoplasms

Ireland
University of Dublin, Trinity College
Abbott

Unknown

Trial of Enteral Nutrition Enriched With Eicosapentaenoic Acid (EPA) in Upper Gastrointestinal Cancer Surgery

Esophageal Cancer

Ireland
Vedanta Biosciences, Inc.
Bristol-Myers Squibb

Completed

Study of VE800 and Nivolumab in Patients With Selected Types of Advanced or Metastatic Cancer (ConsortiumIO)

Melanoma | Gastric Cancer | Colorectal Cancer | Metastatic Cancer | Gastroesophageal Junction Adenocarcinoma

United States
National Cancer Institute (NCI)
NRG Oncology

Completed

Radiation Therapy, Paclitaxel, and Carboplatin With or Without Trastuzumab in Treating Patients With Esophageal Cancer

Esophageal Adenocarcinoma | Gastroesophageal Junction Adenocarcinoma | Stage IIA Esophageal Cancer AJCC v7 | Stage IIB Esophageal Cancer AJCC v7 | Stage IIIA Esophageal Cancer AJCC v7 | Stage IIIB Esophageal Cancer AJCC v7 | Stage IB Esophageal Cancer AJCC v7

United States
University of Dublin, Trinity College
University College Dublin

Completed

Rehabilitative Strategies Following Oesophageal Cancer (ReStOre)

Esophageal Cancer

Ireland
Cancer Trials Ireland

Recruiting

Dose-Painted Intensity Modulated Radiotherapy Pancreas (DP-IMRT Pancreas)

Pancreatic Adenocarcinoma

Ireland
Cancer Trials Ireland

Completed

Sorafenib. ICORG 06-41, V4

Gastric Cancer | Esophageal Cancer

Ireland
Universitaire Ziekenhuizen KU Leuven

Unknown

Metachronic Brain Metastases After Esophagectomy for Esophageal Cancer (METABREC) (METABREC)

Esophageal Neoplasms | Brain Metastases | Esophagectomy

United States, France, Netherlands, Sweden, Belgium, Ireland
Astellas Pharma Global Development, Inc.

Active, not recruiting

A Study of Zolbetuximab (IMAB362) Plus CAPOX Compared With Placebo Plus CAPOX as First-line Treatment of Subjects With Claudin (CLDN) 18.2-Positive, HER2-Negative, Locally Advanced Unresectable or Metastatic Gastric or Gastroesophageal Junction (GEJ) Adenocarcinoma (GLOW)

Locally Advanced Unresectable Gastroesophageal Junction (GEJ) Adenocarcinoma or Cancer | Locally Advanced Unresectable Gastric Adenocarcinoma or Cancer | Metastatic Gastric Adenocarcinoma or Cancer | Metastatic Gastroesophageal Junction (GEJ) Adenocarcinoma

United States, Korea, Republic of, China, Spain, Taiwan, Japan, Argentina, Canada, Croatia, Greece, Ireland, Malaysia, Netherlands, Portugal, Romania, Thailand, Turkey, United Kingdom
British Columbia Cancer Agency
The Alfred; London Regional Cancer Program, Canada; Tom Baker Cancer Centre; Cancer... and other collaborators

Recruiting

Stereotactic Ablative Radiotherapy for Comprehensive Treatment of Oligometastatic (1-3 Metastases) Cancer (SABR-COMET-3)

Metastatic Tumors

Canada, Australia, United Kingdom, Ireland
St. James's Hospital, Ireland
University College Dublin; University of Dublin, Trinity College

Completed

Longitudinal Assessment of Gut Hormone Secretion Following Upper Gastrointestinal Surgery for Cancer

Stomach Neoplasms | Malnutrition | Esophageal Neoplasms | Weight Loss

Ireland
University of Dublin, Trinity College
Health Research Board, Ireland

Completed

ReStOre@Home: Feasibility Study of a 12-week Multidisciplinary Telehealth Rehabilitation Programme for Survivors of Upper Gastrointestinal (UGI) Cancer (ReStOre@Home)

Gastric Cancer | Oesophageal Cancer

Ireland
Astellas Pharma Global Development, Inc.

Active, not recruiting

A Phase 3 Efficacy, Safety and Tolerability Study of Zolbetuximab (Experimental Drug) Plus mFOLFOX6 Chemotherapy Compared to Placebo Plus mFOLFOX6 as Treatment for Gastric and Gastroesophageal Junction (GEJ) Cancer (Spotlight)

Locally Advanced Unresectable Gastroesophageal Junction (GEJ) Adenocarcinoma or Cancer | Locally Advanced Unresectable Gastric Adenocarcinoma or Cancer | Metastatic Gastric Adenocarcinoma or Cancer | Metastatic Gastroesophageal Junction (GEJ) Adenocarcinoma

United States, Australia, Belgium, Brazil, Canada, Chile, China, Colombia, France, Germany, Israel, Italy, Japan, Korea, Republic of, Mexico, Peru, Poland, Spain, Taiwan, United Kingdom
AO Innovation Translation Center
AO Foundation, AO Spine

Recruiting

Metastatic Tumor Research and Outcomes Network (MTRON)

Metastatic Spine Tumor

United States, Canada, Hungary, Australia, Germany, Italy, Japan, Netherlands, Singapore, Switzerland
Cancer Trials Ireland
University College Cork

Active, not recruiting

Dose Escalation Study of Lithium With Oxaliplatin and Capecitabine in Advanced Oesophago-Gastric or Colorectal Cancer (Lithium)

Colorectal Neoplasms | Esophageal Neoplasms | Stomach Neoplasm

Ireland
Coombe Women and Infants University Hospital

Completed

An Evaluation of a Liberal Hydration Regimen Before Elective Caesarean Section Using Beside Gastric Ultrasound

Aspiration; Gastric Contents, Anesthesia

Ireland
University College Dublin

Recruiting

Unintentional Weight Loss After Oesophagectomy (UWL)

Oesophageal Cancer

Ireland
Lawson Health Research Institute
VU University of Amsterdam; London Regional Cancer Program, Canada

Active, not recruiting

Stereotactic Ablative Radiotherapy for Comprehensive Treatment of Oligometastatic Tumors (SABR-COMET) (SABR-COMET)

Metastatic Tumors

Canada, Australia, Netherlands, United Kingdom
Jazz Pharmaceuticals
BeiGene, Ltd.

Recruiting

A Study of Zanidatamab in Combination With Chemotherapy Plus or Minus Tislelizumab in Patients With HER2-positive Advanced or Metastatic Gastric and Esophageal Cancers (HERIZON-GEA-01)

Gastroesophageal Adenocarcinoma | Esophageal Adenocarcinoma | Gastric Neoplasms

Korea, Republic of, Belgium, Netherlands, Spain, Japan, China, Germany, United Kingdom, Malaysia, Taiwan, Portugal, France, Italy, Australia, Turkey, Thailand, Argentina, Mexico, Ireland, Estonia, Serbia, Romania, Canada, Singapore, Poland and more
St. James's Hospital, Ireland
Göteborg University; University College Dublin; University of Dublin, Trinity...

Completed

Food Intake and Gut Hormones in Patients Who Have Undergone Upper Gastrointestinal Surgery for Cancer

Stomach Neoplasms | Malnutrition | Esophageal Neoplasms | Weight Loss

Ireland, Sweden
Imperial College London
University College Dublin; St. James's Hospital, Ireland

Terminated

Resection of the Esophagus and Subsequent Weight Loss (REWARD)

Esophageal Cancer | Weight Gain | Eating Behavior | Food Reward

Ireland
Brown University
University of Maryland Greenebaum Cancer Center

Completed

Neoadjuvant Paclitaxel Poliglumex, Cisplatin and Radiation for Esophageal Cancer: A Phase II Trial (CTI#X64001)

Esophageal Cancer

United States
Lucid Diagnostics, Inc.

Recruiting

Efficacy of EsoGuard Assay on Esophageal Surface Cells Collected With EsoCheck vs EGD for the Diagnosis of BE or EAC (ESOGUARDBE2)

Barrett Esophagus | Esophageal Adenocarcinoma | Barrett's Esophagus Without Dysplasia | Barretts Esophagus With Dysplasia

United States, Netherlands
Southwest Oncology Group
National Cancer Institute (NCI)

Completed

S1201: Combination Chemo for Patients W/Advanced or Metastatic Esophageal, Gastric, or Gastroesophageal Junction Cancer

Gastric Cancer | Esophageal Cancer | Adenocarcinoma of the Gastroesophageal Junction

United States
Daiichi Sankyo
AstraZeneca

Recruiting

Trastuzumab Deruxtecan for Subjects With HER2-Positive Gastric Cancer or Gastro-Esophageal Junction Adenocarcinoma After Progression on or After a Trastuzumab-Containing Regimen (DESTINY-Gastric04)

Gastroesophageal Junction Adenocarcinoma | Gastric Cancer, Adenocarcinoma

Italy, Hong Kong, Belgium, Korea, Republic of, France, United Kingdom, Spain, China, Ireland, Brazil, Japan, Singapore, Israel, Russian Federation, Argentina, Chile, Hungary, Poland, Portugal, Taiwan, Turkey, Ukraine, Germany, Romania
Merck Sharp & Dohme LLC
Eisai Inc.

Active, not recruiting

Efficacy and Safety of Lenvatinib (E7080/MK-7902) Plus Pembrolizumab (MK-3475) Plus Chemotherapy in Participants With Advanced/Metastatic Gastroesophageal Adenocarcinoma (MK-7902-015/E7080-G000-321/LEAP-015) (LEAP-015)

Advanced/Metastatic Gastroesophageal Adenocarcinoma

China, Japan, Poland, Hong Kong, Korea, Republic of, Canada, United States, Argentina, Australia, Belgium, Chile, Colombia, Costa Rica, France, Germany, Guatemala, Ireland, Israel, Italy, Russian Federation, Spain, Taiwan, Turkey, United...
University of Dublin, Trinity College
St Vincent's University Hospital, Ireland; Health Research Board, Ireland; St... and other collaborators

Recruiting

Rehabilitation Strategies Following Oesophagogastric and Hepatopancreaticobiliary Cancer (RESTORE II)

Gastric Cancer | Pancreatic Cancer | Liver Cancer | Oesophageal Cancer

Ireland
Brown University
Bristol-Myers Squibb

Completed

Cetuximab, Paclitaxel, Carboplatin & Radiation for Esoph, Gastroesoph & Gastric Cancer

Gastric Cancer | Esophageal Cancer

United States
Novartis Pharmaceuticals

Completed

A Descriptive Study of Baseline Characteristics, Clinical Outcomes, and Treatment Patterns of HR+/HER2- Advanced or Metastatic Breast Cancer Patients Treated With Alpelisib Plus Fulvestrant Who Have Received Fulvestrant in Any Prior Line of Therapy

HR+/HER2- Advanced or Metastatic Breast Cancer

Ireland
Cancer Trials Ireland

Terminated

Plasma Biomarkers P-DAC, V1

Pancreatic Ductal Adenocarcinoma

Ireland
St. James's Hospital, Ireland

Unknown

Obesity and Liver Function in Oesophageal Cancer

Obesity | Liver Function

Ireland
American College of Radiology Imaging Network
National Cancer Institute (NCI)

Completed

Radiofrequency Ablation in Treating Patients With Bone Metastases (ACRIN-6661)

Pain | Unspecified Adult Solid Tumor, Protocol Specific | Metastatic Cancer

United States
Amgen
Zai Lab (China only)

Recruiting

Bemarituzumab or Placebo Plus Chemotherapy in Gastric Cancers With Fibroblast Growth Factor Receptor 2b (FGFR2b) Overexpression (FORTITUDE-101)

Gastric Cancer | Gastroesophageal Junction Adenocarcinoma

Canada, Japan, United States, Korea, Republic of, China, Italy, Australia, Sweden, Spain, Taiwan, France, Belgium, Denmark, Thailand, Turkey, Czechia, Bulgaria, Brazil, Norway, Mexico, Poland, Estonia, Israel, Greece, Romania, Chile, Peru, Po... and more
Cancer Trials Ireland

Completed

Biomarkers of Response to Taxotere in HRPC. ICORG 08-08, V2

Prostate Cancer | Metastatic Cancer

Ireland
St. James's Hospital, Ireland
Göteborg University; University College Dublin; University of Dublin, Trinity...

Completed

The Effect of Satiety Gut Hormone Modulation on Appetitive Drive After Upper Gastrointestinal Surgery

Stomach Neoplasms | Pancreatic Neoplasms | Malnutrition | Esophageal Neoplasms | Weight Loss | Duodenal Neoplasms

Ireland, Sweden
Mayo Clinic
National Cancer Institute (NCI)

Completed

Percutaneous Cryoablation in Treating Patients With Painful Bone Metastases

Pain | Unspecified Adult Solid Tumor, Protocol Specific | Metastatic Cancer

United States
howard safran
The Miriam Hospital; Rhode Island Hospital

Terminated

Advanced Non-Small Cell Lung Cancer Progressing After at Least One Prior Therapy For Metastatic Disease

NSCLC | Lung Cancer | Metastatic Lung Cancer | Non-small Cell Lung Cancer

United States

Clinical Trials on Metastatic Esophageal Adenocarcinoma in Ireland

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