Clinical Trials on Mitochondrial Neurogastrointestingal Encephalopathy

Total 919 results

University Hospitals Bristol and Weston NHS Foundation...
University of Bristol

Completed

Xenon and Cooling Therapy in Babies at High Risk of Brain Injury Following Poor Condition at Birth (CoolXenon2)

Hypoxic Ischaemic Encephalopathy

United Kingdom
University College Cork
Karolinska Institutet

Completed

BiHiVE2 Study. The Investigation and Validation of Predictive Biomarkers in Hypoxic-ischaemic Encephalopathy. (BiHiVE2)

Asphyxia | Hypoxic Ischaemic Encephalopathy (HIE)

Sweden, Ireland
Medical University of South Carolina
National Institute of Neurological Disorders and Stroke (NINDS); Carlos III... and other collaborators

Completed

NVD in Hypothermic HIE Neonates

HIE - Perinatal Hypoxic - Ischemic Encephalopathy
Virginia Commonwealth University
National Center for Complementary and Integrative Health (NCCIH)

Completed

Probiotic Lactobacillus GG (LGG) in Patients With Minimal Hepatic Encephalopathy

Minimal Hepatic Encephalopathy

United States
University of Florida
National Center for Complementary and Integrative Health (NCCIH); Office of...

Completed

Resveratrol to Enhance Vitality and Vigor in Elders (REVIVE)

Physical Function | Mitochondrial Function

United States
Mayo Clinic
Astellas Pharma Inc; Casimir, LLC

Completed

Genomic Profiling of Mitochondrial Disease - Imaging Analysis for Precise Mitochondrial Medicine

Mitochondrial Diseases | Mitochondrial Myopathies | Kearns-Sayre Syndrome | Mitochondrial DNA Mutation | Chronic Progressive External Ophthalmoplegia With Myopathy

United States
MaineHealth

Completed

OMT to Improve Feeding After Hypothermia

Neonatal Encephalopathy | Feeding; Difficult, Newborn

United States
Kenneth Myers, MD

Completed

Memantine for Epileptic Encephalopathy

Epileptic Encephalopathy, Childhood-Onset

Canada
University Hospital, Lille
Ministry of Health, France

Completed

Effect Of The System In The Enriched Fat Metabolism Of The Child Reached Mitochondrial Cytopathy (MITOX)

Mitochondrial Cytopathies Disorders

France
University Hospital of Ferrara
AUSL Romagna Rimini

Recruiting

Use of Melatonin for Neuroprotection in Asphyxiated Newborns (MELPRO)

Hypoxic-Ischemic Encephalopathy | Cell Damage | Asphyxia Perinatal

Italy, Holy See (Vatican City State)
Tepecik Training and Research Hospital

Completed

Cerebral Oxymetry and Neurological Outcome in Therapeutic Hypothermia

Cardiac Arrest | Hypoxic-Ischemic Encephalopathy | Post-Cardiorespiratory Arrest Coma

Turkey
Assistance Publique - Hôpitaux de Paris

Completed

Efficacy of Erythropoietin to Improve Survival and Neurological Outcome in Hypoxic Ischemic Encephalopathy (Neurepo)

Hypoxic Ischemic Encephalopathy

France
University Children's Hospital, Zurich

Completed

Magnetic Resonance Imaging and Spectroscopy Biomarkers of Neonatal Hypoxic Ischemic Encephalopathy

Hypoxic Ischemic Encephalopathy

Switzerland
Ludwig-Maximilians - University of Munich
Technical University of Munich; Deutsches Herzzentrum Muenchen; University Hospital... and other collaborators

Completed

Study for the Improvement of Long-Term Outcome Prediction in Patients in Coma After Cardiac Arrest (HOPE)

Anoxic-Ischemic Encephalopathy

Germany
Stanford University
Inspiration Healthcare

Completed

California Transport Cooling Trial (CTCT)

Hypoxic Ischemic Encephalopathy

United States
University of Edinburgh
NHS Lothian; Prism Training and Consultancy; Simpsons Special Care Babies

Recruiting

Investigating Cerebral Oxygenation in the Newborn (ICON)

Neonatal Encephalopathy | Premature Infant Disease | Hypoxic Ischemic Encephalopathy of Newborn

United Kingdom
University of Utah
Thrasher Research Fund

Completed

Darbe Administration in Newborns Undergoing Cooling for Encephalopathy (DANCE)

Hypoxic Ischemic Encephalopathy

United States
Robertson, Nicola, M.D.
Thayyil, Sudhin

Unknown

Whole Body Cooling Using Phase Changing Material

Hypoxic Ischemic Encephalopathy

India
University of California, San Francisco
National Institute of Neurological Disorders and Stroke (NINDS)

Recruiting

Neonatal Seizure Registry, GEnetics of Post-Neonatal Epilepsy (NSR-GENE)

Stroke | Epilepsy | Hypoxic-Ischemic Encephalopathy | Neonatal Seizure | Intracranial Hemorrhage | Gene Abnormality

United States
Khondrion BV

Not yet recruiting

KHENERFIN Study: A Trial to Evaluate the Efficacy and Safety of Sonlicromanol in Primary Mitochondrial Diseases (KH176-301)

Mitochondrial Diseases | Mitochondrial DNA tRNALeu(UUR) m.3243A<G Mutation | Maternally Inherited Diabetes and Deafness (MIDD) | Mitochondrial Encephalomyopathy, Lactic Acidosis and Stroke-like Episodes (MELAS)
Ocera Therapeutics

Completed

AST-120 Used to Treat Mild Hepatic Encephalopathy (ASTUTE)

Mild Hepatic Encephalopathy

United States
University of Catania

Completed

Acetyl-L-Carnitine In Severe Hepatic Encephalopathy

Hepatic Encephalopathy (Grade 3 of the West Haven Grading Scale)

Italy
Radboud University Medical Center

Unknown

Cerebral Bloodflow and Carbondioxide Reactivity During Mild Therapeutic Hypothermia in Patients After Cardiac Arrest

Cardiac Arrest | Post-Anoxic Encephalopathy

Netherlands
Medical College of Wisconsin
National Center for Research Resources (NCRR)

Completed

Effect of Yogurt on Minimal Hepatic Encephalopathy

Cirrhosis | Minimal Hepatic Encephalopathy

United States
Yungjin Pharm. Co., Ltd.

Completed

Safety, Tolerability and Pharmacokinetic Study of KL1333 in Healthy Male Volunteers

MELAS Syndrome | Mitochondrial Respiratory Chain Deficiencies

Korea, Republic of
Boston Children's Hospital

Not yet recruiting

A Safety and Feasibility Trial Protocol of Metformin in Infants After Perinatal Brain Injury

Hypoxic-Ischemic Encephalopathy | Infant Development | Neurodevelopment | HIE
University of Southern California
Eunice Kennedy Shriver National Institute of Child Health and Human Development... and other collaborators

Recruiting

Therapeutic Intervention Supporting Development From NICU to 6 Months for Infants Post Hypoxic-Ischemic Encephalopathy

Cerebral Palsy | Hypoxic-Ischemic Encephalopathy

United States
Imperial College London
University College London Hospitals; Guy's and St Thomas' NHS Foundation Trust

Completed

Neuroprotective Effects of Hypothermia Combined With Inhaled Xenon Following Perinatal Asphyxia (TOBYXe)

Hypoxic Ischaemic Encephalopathy

United Kingdom
McGill University Health Centre/Research Institute...
Wayne State University; Brown University; Imperial College London; Ohio State University and other collaborators

Completed

Prospective Research in Infants With Mild Encephalopathy (PRIME)

Brain Injury | Hypoxic-Ischemic Encephalopathy | Neonatal Seizure

Canada, United States, Thailand, United Kingdom
Children's Hospital of Chongqing Medical University
Chongqing Science and Technology Commission

Completed

Clinical Trial of a New Rectum Cooling System on Patients of Hypoxic-ischemic Brain Damage

Hypoxic-Ischemic Encephalopathy

China
Biofortis, Merieux NutriSciences

Recruiting

Phytochemicals on "Metabolic Aging" in Older Overweight Adults

Mitochondrial Functions

United States
Neurocrine Biosciences

Enrolling by invitation

Extension Study to Evaluate NBI-827104 in Pediatric Participants With Epileptic Encephalopathy With Continuous Spike-and-Wave During Sleep (Steamboat 2)

Epileptic Encephalopathy | Continuous Spike and Wave During Sleep

United States, Denmark, Spain, Switzerland, United Kingdom
Medical University of Vienna
Bodychillz Ltd

Withdrawn

Prehospital Non-invasive Cooling of Comatose Patients After Cardiac Arrest

Cardiac Arrest | Postresuscitation Encephalopathy

Austria
Liaocheng People's Hospital

Unknown

Treatment of Human Cord Blood Mononuclear Cell for Delayed Encephalopathy After Carbon Monoxide Poisoning

Delayed Encephalopathy After Carbon Monoxide Poisoning

China
University Hospital Tuebingen

Recruiting

Mitochondrial Diseases - Long-read Genome and Transcriptome Sequencing in Cases Unresolved After Short-read Genomics

Rare Diseases | Genetic Predisposition

Germany
The University of Texas Health Science Center,...

Completed

Ketones & Mitochondrial Heteroplasmy

Mitochondrial Diseases | MELAS Syndrome

United States
Haseki Training and Research Hospital

Recruiting

Monitoring After Cardiac Arrest: Electroencephalogram and Cerebral Oximetry in Predicting Outcome

Cardiac Arrest | Hypoxic-Ischemic Encephalopathy | EEG With Periodic Abnormalities

Turkey
Xuanwu Hospital, Beijing

Not yet recruiting

tDCS and rTMS in Patients With Early Disorders of Consciousness

Stroke | Disorder of Consciousness | Ischemic-hypoxic Encephalopathy
Shahid Beheshti University of Medical Sciences

Completed

MLC901 in Hypoxic-ischemic Brain Injury Patients; A Double-blind, Randomized Placebo-controlled Trial

Hypoxic Ischaemic Encephalopathy Due to Cardiac Arrest

Iran, Islamic Republic of
Concordia University, Montreal

Completed

Boosting Performance: The Power of Cranberry Supplementation

Blood Flow | Oxygen Consumption | Mitochondria | Aerobic Capacity

Canada
Imperial College London

Completed

Brain Muscle Axis During Treatment of Hepatic Encephalopathy With L-ornithine L-aspartate

Hepatic Encephalopathy | Cirrhosis | Minimal Hepatic Encephalopathy

United Kingdom
University Hospital, Basel, Switzerland

Completed

Septic Encephalopathy and Late Cognitive Dysfunction

Sepsis | Severe Sepsis

Switzerland
Ocera Therapeutics, Inc.

Completed

Phase 2B Efficacy/Safety of Ornithine Phenylacetate in Hospitalized Cirrhotic Patients With Hepatic Encephalopathy (STOP-HE) (STOP-HE)

Hepatic Encephalopathy | Acute Episode of Overt Hepatic Encephalopathy

Belgium, Germany, Italy, Spain, United States, France, Austria, Russian Federation, Czechia, Australia, Hungary, Israel, Netherlands, Bulgaria, Estonia, Denmark, New Zealand
Drexel University

Completed

Pharmacokinetics of Ampicillin in Neonates With Moderate to Severe Hypoxic-Ischemic Encephalopathy

Hypothermia

United States
University of Mississippi Medical Center

Terminated

Eclampsia and Posterior Reversible Encephalopathy Syndrome (PRES): (PRESIDEX)

Eclampsia

United States
University of Texas Southwestern Medical Center

Completed

Efficacy Study of Polyethylene Glycol 3350-electrolyte Solution (GoLYTELY®) Versus Lactulose in Patients With Hepatic Encephalopathy. (PSE)

Hepatic Encephalopathy | Cirrhosis | Portosystemic Encephalopathy | PSE

United States
Indiana University

Terminated

Study of Lactulose in Children With Chronic Liver Disease (MHE)

Minimal Hepatic Encephalopathy

United States
University of Saskatchewan

Active, not recruiting

Cannabidiol in Children With Refractory Epileptic Encephalopathy (CARE-E)

Epileptic Encephalopathy

Canada
Drexel University

Unknown

Does Clinical Treatment of Mitochondrial Dysfunction Impact Autism Spectrum Disorder (ASD)? (MitoASD)

Mitochondrial Diseases | Autism Spectrum Disorders

United States
Thayyil, Sudhin
Wayne State University

Active, not recruiting

Optimising the Duration of Cooling in Mild Encephalopathy (COMET)

Neonatal Encephalopathy | Magnetic Resonance Spectroscopy | Hypothermia Neonatal

United Kingdom, United States, Italy

Clinical Trials on Mitochondrial Neurogastrointestingal Encephalopathy

Sponsors and Collaborators

Medical Conditions

Drug Interventions

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CROs in Uruguay

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Rare Diseases

Drug Interventions

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