Boosting Performance: The Power of Cranberry Supplementation

Effect of a Cranberry Extract on Muscle Oxygenation and Mitochondrial Health in University Students

Cranberry is a fruit native to North America that is widely grown in Quebec and has been shown to have the highest antioxidant capacity among the most commonly eaten fruits. Consequently, consuming cranberries prior to exercising may help to improve exercise endurance by preventing accumulation of reactive oxygen species. For aerobic endurance, in order to maintain a certain pace for a long duration, runners need to effectively neutralize reactive oxygen species. Although it is not the only component involved in running, offsetting reactive oxygen species should improve running performance.

To test this, we plan to investigate the effects, both acute and chronic, of a cranberry extract on the oxygen consumption in 18-35 year old males and females.

The present research project will contribute to expand our knowledge of how cranberry extract can exert a positive effect, and thus improve aerobic performance or even every day life. This project can benefit a wide range of the population, from sedentary individuals and older adults to elite athletes by providing an all-natural supplement alternative.

Study Overview

• Status: Completed
• Conditions: Blood Flow; Oxygen Consumption; Mitochondria; Aerobic Capacity
• Intervention / Treatment: Dietary supplement: Cranberry extract

Detailed Description

Each participant will be involved in the study for a period of 5 weeks, during which they will commit to 3 visits:

The first visit (on week 1) will be to obtain baseline measurements. During the second visit (on week 2), acute effects of the cranberry extract will be evaluated by giving a single high dose to the participants 1 hour before the trial events. The third visit (on week 5) will be to evaluate the chronic effects of the cranberry extract after 4 weeks of daily consumption. We will use the following instruments to gather data:

• Questionnaires (height, weight, dietary patterns, to determine training level, past injuries, single or multisport athlete etc.)
• Continuous wavelength NIRS will be used to measure oxygen levels in the quadriceps using portable Moxy monitors. For this test the subjects will be wearing the portable and convenient oxygen monitors taped firmly on the appropriate muscles. NIRS is a non-invasive method and measures the level of oxygenation in the muscle tissues by sending near-infrared light through the skin, which travels through the muscle fibers and is then recovered and returned to the surface of the skin and into the back of the sensor. As light moves through the skin layers (skin, fat and muscle), it scatters, and it identifies the oxygenated and the deoxygenated blood cells due to their colors. The blood cells identified are hemoglobin and myoglobin cells.

For the actual test, the quadriceps will be activated using electrical twitch stimulation at either 4 or 6Hz for 30 s at a current level that produce vigorous but submaximal contractions. During the contraction, the NIRS will be used in combination with short duration ischemic cuff periods (200 mmHg) applied by a Hokanson rapid cuff inflator. By repeating 5 second occlusion followed by 5 second deflation 6 times, at the same time as we activate the muscle, we will be able to determine muscle metabolism (mitochondrial oxygen consumption) by using the rate constant of the recovery from high to low metabolic rate.

• Skinfold measurement of the placement area for the Moxy oxygen monitors to determine if the light can penetrate subcutaneous tissues (has to be <15mm)

• Study Type: Interventional
• Enrollment (Actual): 21
• Phase: Not Applicable

Contacts and Locations

Study Locations

• Canada
  • Quebec
    • Montréal, Quebec, Canada, H4B 1R6
      • Concordia University

Participation Criteria

Eligibility Criteria

• Ages Eligible for Study: Adult
• Accepts Healthy Volunteers: Yes

Description

Inclusion Criteria:

• recreationally active, healthy and between the ages of 18-35.

Exclusion Criteria:

• smoker; use of ergogenic substances or any kind or drugs that could alter the cardiovascular responses; resting BP higher than 140/90 mm Hg; and cardiovascular or metabolic disease (especially hypertension and diabetes)

Study Plan

How is the study designed?

Design Details

• Primary Purpose: Basic Science
• Allocation: Non-Randomized
• Interventional Model: Single Group Assignment
• Masking: Single

Number of Arms

2

Arms and Interventions

Participant Group / Arm	Intervention / Treatment
Experimental: Cranberry extract	Dietary supplement: Cranberry extract; polyphenol PAC-1
Active Comparator: Baseline	Dietary supplement: Cranberry extract; polyphenol PAC-1

What is the study measuring?

Primary Outcome Measures

Outcome Measure	Time Frame
Oxygen consumption	20 minutes

Secondary Outcome Measures

Outcome Measure	Time Frame
Blood flow	20 minutes

Collaborators and Investigators

• Sponsor: Concordia University, Montreal

Study record dates

Study Major Dates

• Study Start (Actual): March 1, 2023
• Primary Completion (Actual): June 30, 2023
• Study Completion (Actual): June 30, 2023

Study Registration Dates

• First Submitted: December 15, 2023
• First Submitted That Met QC Criteria: December 15, 2023
• First Posted (Estimated): January 1, 2024

Study Record Updates

• Last Update Posted (Estimated): January 1, 2024
• Last Update Submitted That Met QC Criteria: December 15, 2023
• Last Verified: December 1, 2023

More Information

Terms related to this study

• Other Study ID Numbers: 30017882

Plan for Individual participant data (IPD)

• Plan to Share Individual Participant Data (IPD)?: NO

Drug and device information, study documents

• Studies a U.S. FDA-regulated drug product: No
• Studies a U.S. FDA-regulated device product: No