Clinical Trials on Monogenic Disorders

Total 144116 results

Apteeus

Enrolling by invitation

Development of In Vitro Functional Assays From Primary Cells of Patients With Monogenic Diseases (OPERANDO)

Monogenic Disorders

France
University Hospital, Montpellier
ABM Industries

Unknown

NIPD of CFTC by WGA Coupled to Mini-exome Sequencing (DIAFEXOME)

Monogenic Diseases

France
Kunling Shen
Shengjing Hospital; Xinhua Hospital, Shanghai Jiao Tong University School of... and other collaborators

Recruiting

Registry Study on Respiratory Monogenic Diseases in Chinese Children

Monogenic Diseases

China
Assistance Publique - Hôpitaux de Paris

Not yet recruiting

Real-life Evaluation of WEGOVY (Semaglutide) Treatment in Adults With Monogenic Obesity (ObGeSema) (ObGeSema)

Monogenic Obesity

France
University Hospital, Bordeaux

Not yet recruiting

Genetic Research of Monogenic Obesity in a Pediatric Cohort With Severe and Early Onset Obesity (OBEGENE)

Monogenic Obesity

France
Chinese Academy of Medical Sciences, Fuwai Hospital

Unknown

Genetic Testing of Monogenic Hypertension in Chinese Population

Monogenic Hypertension

China
University Hospital, Bordeaux

Not yet recruiting

Genetic Research of Monogenic Obesity in a Pediatric Cohort With Severe and Early Onset Obesity (GENOBE) (GENOBE)

Monogenic Obesity | Non Syndromic Obesity

France
University of Chicago

Completed

Incretin Regulation of Insulin Secretion in Monogenic Diabetes

Monogenic Diabetes

United States
Joslin Diabetes Center

Enrolling by invitation

Oral Hypoglycemic Therapy for Monogenic Variant Carriers of the Joslin Medalist Study

Type 1 Diabetes | Monogenic Diabetes

United States
Assistance Publique - Hôpitaux de Paris

Completed

Predisposition Genes in Monogenic Diabetes (DIAMONO) (DIAMONO)

Non Autoimmune Monogenic Diabetes
Children's Hospital of Fudan University

Recruiting

Monogenic Lupus in Childhood Onset Systemic Lupus Erythematosus

Systemic Lupus Erythematosus | Monogenic Lupus

China
United Arab Emirates University

Not yet recruiting

Identifying Maturity-onset Diabetes of the Young in Emirati Patients

Maturity-onset Diabetes of the Young | MODY | Monogenic Diabetes
AHEPA University Hospital

Unknown

Molecular Pathways Involved in the Pathogenesis and Behavior of Mesenchymal Phosphaturic Tumors Causing Oncogenic Osteomalacia

Tumor Induced Oncogenic Osteomalacia

Greece
National Institute of Dental and Craniofacial Research...

Completed

Catheterization to Locate Mesenchymal Tumors in Patients With Tumor-Induced Osteomalacia or Oncogenic Osteomalacia

Neoplasms | Osteomalacia

United States
Regeneron Pharmaceuticals

Available

Expanded Access to REGN4461 for Patients With Lipodystrophy or Monogenic Obesity With Complications of Leptin Deficiency or Deficient Leptin Signaling

Partial Lipodystrophy | Generalized Lipodystrophy | Monogenic Obesity Due to LEP or LEPR Loss of Function
CASI Pharmaceuticals, Inc.

Completed

A Phase 1 Study of MKC-1 in Patients With Refractory Hematologic Malignancies

Myelodysplasia | Hematological Malignancies | Agnogenic Myeloid Metaplasia

Canada
Peking Union Medical College Hospital

Unknown

68Ga-DOTATATE PET/CT in Oncogenic Osteomalacia

Oncogenic Osteomalacia | Mesenchymal Tumor

China
National Institute of Dental and Craniofacial Research...

Terminated

BGJ398 for the Treatment of Tumor-Induced Osteomalacia

Oncogenic Osteomalacia | Tumor-Induced Osteomalacia

United States
Dana-Farber Cancer Institute
Massachusetts General Hospital; Novartis; Brigham and Women's Hospital

Completed

A Study of Gleevec in Patients With Idiopathic Myelofibrosis or Chronic Myelomonocytic Leukemia (CMML)

Myelofibrosis | Chronic Myelomonocytic Leukemia | Myeloid Metaplasia | Agnogenic Myeloid Metaplasia

United States
M.D. Anderson Cancer Center
Novartis

Completed

PTK 787 and Gleevec in Patients With AML, AMM, and CML-BP

Acute Myelogenous Leukemia | Chronic Myelogenous Leukemia | Agnogenic Myeloid Metaplasia

United States
Guang Ning

Recruiting

China Diabetes Registry by Metabolic Management Center (CDR-MMC)

Type 2 Diabetes Mellitus | Type1 Diabetes Mellitus | Monogenetic Diabetes | Pancreatogenic Diabetes | Drug-Induced Diabetes Mellitus | Other Forms of Diabetes Mellitus

China
M.D. Anderson Cancer Center
Novartis

Completed

RAD001 in Relapsed or Refractory AML, ALL, CML in Blastic-Phase, Agnogenic Myeloid Metaplasia, CLL, T-Cell Leukemia, or Mantle Cell Lymphoma

Leukemia | Myelofibrosis | Mantle Cell Lymphoma

United States
M.D. Anderson Cancer Center
Bristol-Myers Squibb

Completed

Dasatinib as Therapy for Myeloproliferative Disorders (MPDs)

Acute Myeloid Leukemia | Myelodysplastic Syndromes | Polycythemia Vera | Myelofibrosis | Leukemia, Myelomonocytic, Chronic | Hypereosinophilic Syndrome | Mastocytosis | Agnogenic Myeloid Metaplasia

United States
McGill University Health Centre/Research Institute...

Recruiting

Monogenic Diabetes Misdiagnosed as Type 1 (ADDAM)

Diabetes Mellitus, Type 1 | Wolfram Syndrome | Neonatal Diabetes | Monogenic Diabetes | Maturity-onset Diabetes in the Young (MODY) | Wolcott-Rallison Syndrome | Mitochondrial Diabetes

Canada
Johns Hopkins University
Massachusetts General Hospital; Washington University School of Medicine; Emory... and other collaborators

Completed

Answer ALS: Individualized Initiative for ALS Discovery (AnswerALS)

Motor Neuron Disease | Amyotrophic Lateral Sclerosis | Primary Lateral Sclerosis | Progressive Muscular Atrophy | Healthy Controls | Flail Arm ALS | Monomelic Amyotrophy | Asymptomatic ALS Gene Carriers

United States
University of Michigan

Completed

Sleep-Disordered Breathing and PAP in Perinatal Depression

Major Depressive Disorder | Sleep-disordered Breathing

United States
University Hospital, Montpellier

Recruiting

Evaluation of a Parent/Child Cognitive-Behaviorial Therapy Program in ADHD Children With Emotional Dysregulation Profile (DP-KID)

Attention Deficit Disorder With Hyperactivity | Attention-Deficit-Disordered Children

France
Adams Clinical

Recruiting

Triage Survey for Psychiatry Research Eligibility (TRIAGE-Psych)

Generalized Anxiety Disorder | Major Depressive Disorder | Borderline Personality Disorder

United States
Academisch Medisch Centrum - Universiteit van Amsterdam...

Recruiting

Imagery Rescripting as a Stand-alone Treatment for OCD and BDD.

Obsessive-Compulsive Disorder | Anxiety Disorders | Body Dysmorphic Disorders

Netherlands
Weill Medical College of Cornell University

Completed

The Influence of the Menstrual Cycle on Lithium and Sertraline Blood Levels

Schizoaffective Disorder | Obsessive-Compulsive Disorder | Major Depressive Disorder | Posttraumatic Stress Disorder | Social Anxiety Disorder | Panic Disorder | Premenstrual Dysphoric Disorder | Dysthymic Disorder | Cyclothymic Disorder | Bipolar Affective Disorders

United States
Sheba Medical Center

Recruiting

Development of a Model for Digital Monitoring of the Mental State of the Hospitalized Patient

Personality Disorders | Depressive Disorder | Mood Disorders | Schizophrenia | Schizoaffective Disorder | Anxiety Disorders | Bipolar Disorder | Severe Mental Disorder | Psychotic Episode

Israel
Nova Scotia Health Authority

Terminated

Cognitive Behavioral Therapy Group for Older Adults Delivered by Telethealth

Generalized Anxiety Disorder | Major Depressive Disorder | Social Anxiety Disorder | Panic Disorder

Canada
King's College London
Innovate UK; Juniver

Recruiting

Efficacy of Juniver, a Digital Self-help Intervention, on Symptoms of Eating Disorders: A Randomised Controlled Trial

Anorexia Nervosa | Feeding and Eating Disorders | Binge-Eating Disorder | Bulimia Nervosa | Binge Eating | Eating Disorders | Disordered Eating

United Kingdom
Laureate Institute for Brain Research, Inc.
National Center for Complementary and Integrative Health (NCCIH)

Active, not recruiting

Floatation-REST (Reduced Environmental Stimulation Therapy) for Anxiety and Depression

Generalized Anxiety Disorder | Major Depressive Disorder | Posttraumatic Stress Disorder | Social Anxiety Disorder | Panic Disorder | Agoraphobia

United States
Johns Hopkins University
Once Upon a Time Foundation

Completed

Electronic Communication Augmented Mental Health Care

Depressive Disorder | Anxiety Disorders | Bipolar Affective Disorder

United States
Samsung Medical Center

Unknown

The Development of Skin Adhesive Patches for the Monitoring and Prediction of Mental Disorders

Major Depressive Disorder, Anxiety Disorder

Korea, Republic of
Medical University of Gdansk

Enrolling by invitation

Observation of Ketamine Treatment Safety and Tolerability in Adult Psychiatry Clinic Medical University of Gdańsk Inpatients (KetGD)

Obsessive-Compulsive Disorder | Anxiety Disorders | Somatoform Disorders | Post Traumatic Stress Disorder | Major Depressive Disorder | Dissociative Disorder

Poland
Vivantes Netzwerk für Gesundheit GmbH
Medizinische Hochschule Brandenburg Theodor Fontane; Vivantes Klinikum am Urban and other collaborators

Active, not recruiting

Implementation, Efficacy and Costs of Inpatient Equivalent Home-Treatment in German Mental Health Care (AKtiV)

Personality Disorders | Anxiety Disorders | Addiction | Schizo Affective Disorder | Mental Disorder | Eating Disorders

Germany
Laureate Institute for Brain Research, Inc.

Completed

Examining the Effects of Reduced Environmental Stimulation on Anxiety

Generalized Anxiety Disorder | Major Depressive Disorder | Social Anxiety Disorder | Panic Disorder | Agoraphobia | PostTraumatic Stress Disorder

United States
Centre Hospitalier Intercommunal Creteil
University of Paris 5 - Rene Descartes

Terminated

School Withdrawal in Adolescents (DESCOL)

Depression | Obsessive-Compulsive Disorder | Anxiety Disorders | Somatoform Disorders | Emotional Disorder | Behavior Disorders | Neurotic Disorders

France
Columbia University

Not yet recruiting

Self-Distancing for Pediatric Anxiety and OCD

Obsessive-Compulsive Disorder | Anxiety Disorders

United States
National Institute of Mental Health (NIMH)
University of Oregon; University of Maryland; University of Minnesota

Recruiting

Study of Neuro-Cognitive Correlates of Pediatric Anxiety Disorders

Anxiety Disorders | Major Depressive Disorder

United States
GlaxoSmithKline

Completed

To Investigate Effects GSK561679 on Part of the Body's System That Controls the Balance of Many of the Hormones.

Depressive Disorder and Anxiety Disorders

United Kingdom
GlaxoSmithKline

Completed

First Study in Humans With GSK206136 (NSB101909)

Depressive Disorder and Anxiety Disorders

United Kingdom
GlaxoSmithKline

Completed

Emotional Processing in Healthy Volunteers in the Presence of an Investigational Anxiolytic

Depressive Disorder and Anxiety Disorders

United Kingdom
Stanford University

Recruiting

Caloric Vestibular Stimulation for Modulation of Insight in Obsessive-Compulsive Spectrum Disorders

Obsessive-Compulsive Disorder | Body Dysmorphic Disorders | Illness Anxiety Disorder

United States
Brain and Cognition Discovery Foundation

Enrolling by invitation

Chart Review of Patients Undergoing Ketamine Infusions

Obsessive-Compulsive Disorder | Bipolar Disorder | Post Traumatic Stress Disorder | Major Depressive Disorder

Canada
GlaxoSmithKline

Completed

First Study in Humans With GSK424887

Depressive Disorder and Anxiety Disorders

United Kingdom
GlaxoSmithKline

Completed

PET (Positron Emission Tomography)/Public Speaking Study With A Combination Of 2 Medications In Social Anxiety Patients

Depressive Disorder and Anxiety Disorders

Sweden
Temple University
National Institute on Disability, Independent Living, and Rehabilitation...

Recruiting

Getting Out of the House: Using Behavioral Activation to Increase Community Participation

Schizophrenia | Bipolar Disorder | Major Depressive Disorder | Schizo Affective Disorder

United States

Clinical Trials on Monogenic Disorders

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