Clinical Trials on Muscular Atrophy, Progressive

Total 52564 results

Biogen

Completed

A Study to Assess the Efficacy and Safety of Nusinersen (ISIS 396443) in Participants With Later-onset Spinal Muscular Atrophy (SMA) (CHERISH)

Spinal Muscular Atrophy

United States, Germany, Spain, Canada, France, Hong Kong, Italy, Japan, Korea, Republic of, Sweden
Biogen

Completed

An Open-label Safety and Tolerability Study of Nusinersen (ISIS 396443) in Participants With Spinal Muscular Atrophy (SMA) Who Previously Participated in ISIS 396443-CS2 (NCT01703988) or ISIS 396443-CS10 (NCT01780246)

Spinal Muscular Atrophy

United States
Hospices Civils de Lyon

Unknown

Responsiveness and Validation Study of MFM-20 in SMA Patients Treated With Nusinersen (RetroNusiMFM)

Spinal Muscular Atrophy

France
Genentech, Inc.

Approved for marketing

An Expanded Access Program for Risdiplam in Participants With Spinal Muscular Atrophy (SMA)

Muscular Atrophy, Spinal

United States
University Hospital, Rouen
Society GENOMIC VISION

Terminated

Identification of a Biomarker Associated With Cis-duplication of the SMN1 Gene (BADGES)

Spinal Muscular Atrophy

France
Hoffmann-La Roche

Completed

A Study to Investigate the Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of Risdiplam (RO7034067) Given by Mouth in Healthy Volunteers

Spinal Muscular Atrophy

Netherlands
University of Utah
Abbott; Families of Spinal Muscular Atrophy

Completed

Valproic Acid in Ambulant Adults With Spinal Muscular Atrophy (VALIANTSMA)

Spinal Muscular Atrophy

United States
Rigshospitalet, Denmark

Completed

Aerobic Training in Patients With Spinal Muscular Atrophy Type III

Spinal Muscular Atrophy

Denmark
HealthCore-NERI
The Spinal Muscular Atrophy Foundation

Completed

A Pilot Study of Biomarkers for Spinal Muscular Atrophy (BforSMA)

Spinal Muscular Atrophy

United States, Canada
Centro Universitário Augusto Motta

Completed

Spinal Muscular Atrophy and Cardiac Autonomic Function

Spinal Muscular Atrophy
Peking University First Hospital

Recruiting

Treatment of Atrophic Gastritis After HP Eradication With Modified Liujunzi Decoction Based on Syndrome Differentiation

Chronic Atrophic Gastritis

China
St. Mary's University, Twickenham

Unknown

Effect of Neuromuscular Electrical Stimulation Combined With Blood Flow Restriction on Muscular and Cardiovascular Function

Muscle Weakness | Muscle Atrophy
Universal Skincare Institute
Lavish Beauty

Completed

Straberi Microneedling For Atrophic Acne (SAA)

Atrophic Acne Scar

United States
Ho Chi Minh City Hospital of Dermato-Venereology

Completed

Simultaneous Versus Sequential Fractional CO2 Laser and Subcision Combination for Post-acne Atrophic Scars: A Split-face Comparative Study.

Atrophic Acne Scar

Vietnam
Alexandria University

Completed

Lateralization of the Inferior Alveolar Nerve After Repositioning of the Bone Window Versus Sticky Bone Augmentation

Posterior Atrophic Mandible | Inferior Alveolar Nerve | Nerve Lateralization

Egypt
Suneva Medical, Inc.
ethica Clinical Research Inc.

Completed

The Use of Bellafill for Atrophic Acne Scar Correction in the Full Facial Area

Atrophic Acne Scarring

United States
Elastagen Pty Ltd

Completed

A Study to Evaluate the Efficacy of ELAPR002f in Females and Males With Atrophic Acne Scars

Atrophic Acne Scar

United Kingdom
King's College London
University of Nottingham

Recruiting

Beta-lactoglobulin, Immobilisation and Muscle Protein Synthesis

Muscle Atrophy

United Kingdom
Massachusetts General Hospital

Withdrawn

Strategies to Reduce Organic Muscle Atrophy in the Intensive Care Unit (STROMA-ICU)

Muscle Atrophy
McMaster University
Axcella Health, Inc

Completed

Effects of Amino Acid Formulation on Healthy Men Undergoing Unilateral Knee Immobilization

Muscle Atrophy

Canada
McMaster University

Withdrawn

The Effects of 17β-estradiol on Skeletal Muscle

Muscle Atrophy

Canada
Paulista University

Completed

Effectiveness of the Kinesio Taping® in Muscle Activation (EKTAQRIH)

Muscle Atrophy

Brazil
Baltimore VA Medical Center

Active, not recruiting

Muscle Atrophy, Physical Performance and Glucose Tolerance Post Stroke

Stroke

United States
Ain Shams University

Unknown

National Registry for Egyptian Pediatric Neuromuscular Diseases

Muscular Dystrophy | Polyneuropathies | Spinal Muscular Atrophy | Muscle Diseases | Myasthenic Syndromes

Egypt
Pixium Vision SA
Pixium Vision LLC acts as sponosor in the US on behalf of Pixium Vision SA

Active, not recruiting

PRIMA US-Feasibility Study in Atrophic Dry AMD (PRIMA-FS-US)

Dry Age-related Macular Degeneration

United States
University Hospital, Ghent
Nobel Biocare

Completed

Immediate Load of Dental Implants, Placed in Atrophic Upper and/or Lower Jaw of Partial or Complete Edentate Patients, According to Flapless Technique

Dental Implants

Belgium
Cairo University

Unknown

Reconstruction of Atrophic Maxillary Ridges Using Mandibular Blocks With and Without Coverage Using Collagen Membrane

Bone Augmentation

Egypt
GeneCradle Inc

Recruiting

Evaluation of Safety and Efficacy of Gene Therapy Drug in the Treatment of Spinal Muscular Atrophy (SMA) Type 2 Patients

SMA II

China
Charitable Foundation Children with Spinal Muscular...

Withdrawn

Study of Feasibility to Reliably Measure Functional Abilities' Changes in Nonambulant Neuromuscular Patients Without Trial Site Visiting

Spinal Muscular Atrophy | Neuromuscular Disorders

Ukraine
Chinese University of Hong Kong

Recruiting

Efficacy and Safety of Using Granules Dendrobii for the Treatment of Chronic Atrophic Gastritis

Atrophic Gastritis

Hong Kong
Fayoum University

Recruiting

Estrogen and Platelet Rich Plasma in Treatment of Atrophic Vaginitis

Atrophic Vaginitis | Postmenopausal Atrophic Vaginitis

Egypt
University of Saskatchewan

Recruiting

Milk Versus a Pea-based Beverage for Bone and Muscle Health in Young Athletes

Muscle Atrophy

Canada
Robert Westermann

Withdrawn

Ultrasound for Rectus Femoris Measurement

Muscle Atrophy | ACL Tear | Quadriceps Muscle Atrophy | Muscle Atrophy, Proximal

United States
University of Oxford
Oxford Brookes University; Oxford University Hospitals NHS Trust; Scholar Rock... and other collaborators

Not yet recruiting

Acceptability, Feasibility, Safety and Efficacy of a Optimized Rehabilitation Program for Treated Patients With Spinal Muscular Atrophy (SMA) (ACE SMA) (ACE SMA)

Spinal Muscular Atrophy

United Kingdom
McGill University Health Centre/Research Institute...

Not yet recruiting

A Registry Based Randomized-Controlled Trial of an Upper Limb Exergaming Intervention for Children and Adolescents With Spinal Muscular Atrophy (INFORM SMA)

Spinal Muscular Atrophy
Rigshospitalet, Denmark

Recruiting

High-intensity Interval Training in Patients With Spinal Muscular Atrophy

Spinal Muscular Atrophy

Denmark
National Taiwan University Hospital

Not yet recruiting

Motor Function and Activity of Daily Life in Spinal Muscular Atrophy

Spinal Muscular Atrophy

Taiwan
Fondazione Policlinico Universitario Agostino Gemelli...
IRCCS Eugenio Medea; Azienda Ospedaliera Universitaria Policlinico "G. Martino... and other collaborators

Not yet recruiting

Development of a Multidisciplinary Network for Clinical and Laboratory Research for SMA

Spinal Muscular Atrophy
Hoffmann-La Roche

Recruiting

A Study Evaluating the Effectiveness and Safety of Risdiplam Administered in Pediatric Patients With Spinal Muscular Atrophy Who Experienced a Plateau or Decline in Function After Gene Therapy (HINALEA 2)

Muscular Atrophy, Spinal

United States
GeneCradle Inc

Recruiting

Evaluation of Safety and Efficacy of Gene Therapy Drug in the Treatment of Spinal Muscular Atrophy (SMA) Type 1 Patients

Spinal Muscular Atrophy

China
Fondazione Policlinico Universitario Agostino Gemelli...
University of Milan; Ospedale Pediatrico Bambino Gesù

Recruiting

Personalized Medicine for SMA: a Translational Project

Spinal Muscular Atrophy

Italy
University of Castilla-La Mancha

Recruiting

Spinal Muscular Atrophy on Wheels, Using Power Mobility (SMAPmob)

Spinal Muscular Atrophy

Spain
University of Oxford
Hoffmann-La Roche; Oxford University Hospitals NHS Trust; Novartis Gene Therapies

Recruiting

Newborn Screening for Spinal Muscular Atrophy (SMA-NBS)

Muscular Atrophy, Spinal

United Kingdom
Genentech, Inc.

Recruiting

Long-Term Follow-Up Study of Risdiplam in Participants With Spinal Muscular Atrophy (SMA) (WeSMA)

Spinal Muscular Atrophy

United States, Puerto Rico
Bakri Elsheikh
Genentech, Inc.

Recruiting

Investigating NMJ Defects in SMA Following Central and Peripheral SMN Restoration

Spinal Muscular Atrophy

United States
Biogen

Recruiting

Pediatric Spinal Muscular Atrophy (SMA) China Registry

Muscular Atrophy, Spinal

China
Great Ormond Street Hospital for Children NHS Foundation...

Recruiting

Improving Standards of Care and Translational Research in Spinal Muscular Atrophy (SMA) (SMA-REACH)

Spinal Muscular Atrophy

United Kingdom
Kaohsiung Medical University Chung-Ho Memorial...
The Chinese Foundation of Health; Taipei Institute of Pathology

Recruiting

Neonatal Spinal Muscular Atrophy (SMA) Screening (SMA)

Spinal Muscular Atrophy

Taiwan
Biogen

Active, not recruiting

A Study of Multiple Doses of Nusinersen (ISIS 396443) Delivered to Infants With Genetically Diagnosed and Presymptomatic Spinal Muscular Atrophy (NURTURE)

Spinal Muscular Atrophy

United States, Taiwan, Israel, Australia, Qatar, United Kingdom, Turkey, Italy, Germany, Argentina, Canada
Hospital Israelita Albert Einstein
Biogen

Active, not recruiting

Longitudinal Data Collection in Pediatric and Adult Patients With Spinal Muscular Atrophy in Latin America (RegistrAME)

Spinal Muscular Atrophy

Brazil, Argentina, Chile, Colombia, Mexico, Uruguay

Clinical Trials on Muscular Atrophy, Progressive

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