Milk Versus a Pea-based Beverage for Bone and Muscle Health in Young Athletes

Milk Versus a Pea-based Beverage for Increasing Muscle Mass and Bone Mineral Density During Resistance Training in Adolescent Boys and Girls

Canada's Food Guide places an increased emphasis on plant-based proteins; however, Canadians who consume a plant-based diet may be compromised because of intake of lower-quality protein. Consumption of high-quality protein is important during growth and development, especially in highly active individuals. The study will compare milk (i.e. high quality protein) to a pea-based beverage (i.e. lower quality plant-based protein) in adolescent boys and girls who are engaged in resistance-training programs as part of their athletic training. One-hundred and fourteen adolescent boys and girls (12-17y of age) will be divided into groups that consume milk, a pea-beverage, or a carbohydrate (sugar) beverage after resistance training sessions performed three times per week for six months. It is predicted that the group consuming milk will have greater increases in muscle mass, strength, and bone density, and greater reductions in fat mass compared to the groups consuming a pea-based or carbohydrate beverages.

Study Overview

• Status: Recruiting
• Conditions: Muscle Atrophy
• Intervention / Treatment: Dietary supplement: Nutritional supplementation during a 6 month resistance training program; Dietary supplement: Nutritional supplementation during a 6 month resistance training program; Dietary supplement: Nutritional supplementation during a 6 month resistance training program

Detailed Description

Milk protein is important especially for very active people and in the context of plant-based diets, which are lower in protein quality. The purpose of the study is to compare the effectiveness of milk supplementation to pea-beverage supplementation during resistance training programs for increasing lean tissue mass in adolescent boys and girls. Secondary and tertiary outcomes include fat mass, bone mineral density, and muscular strength. It is hypothesized that milk supplementation during resistance training will be more effective than plant-based proteins (i.e. pea-beverage) for increasing muscle mass, reducing fat mass, and improving bone mineral outcomes in adolescent boys and girls. One-hundred and fourteen boys and girls (aged 12-17y) who are currently enrolled in resistance training programs (3 times per week for 6 months) as part of their competitive athletic programs will be stratified by sex and maturity status before being randomized to three groups: 1) 1% chocolate milk supplementation; 2) pea-based beverage; 3) carbohydrate beverage (placebo control). Beverages will be consumed during recovery from each resistance training session (i.e. 250 ml immediately after training and 250 ml one hour later to optimize post-exercise protein synthesis) over the six-month intervention. It is anticipated that milk supplementation will be more effective than plant-based protein supplementation.

• Study Type: Interventional
• Enrollment (Anticipated): 114
• Phase: Not Applicable

Contacts and Locations

Study Locations

• Canada
  • Saskatchewan
    • Saskatoon, Saskatchewan, Canada, S7N5B2
      • Recruiting
      • University of Saskatchewan

Participation Criteria

Eligibility Criteria

• Ages Eligible for Study: 12 years to 17 years (Child)
• Accepts Healthy Volunteers: No
• Genders Eligible for Study: All

Description

Inclusion Criteria:

• Currently participating in a resistance-training program 3 times per week
• Female participants must have reached menarche

Exclusion Criteria:

• Have taken any nutritional supplement (e.g., protein, creatine, amino acids) within the past month
• Currently taking anabolic steroids or oral corticosteroids
• Allergies to dairy, almonds, cashews, or peas

Study Plan

How is the study designed?

Design Details

• Primary Purpose: Other
• Allocation: Randomized
• Interventional Model: Parallel Assignment
• Masking: Quadruple

Number of Arms

3

Arms and Interventions

Participant Group / Arm	Intervention / Treatment
Experimental: 1% chocolate milk; 250 ml of 1% chocolate milk consumed immediately after resistance training sessions + 250 ml of chocolate milk consumed 1 hour after resistance training sessions	Dietary supplement: Nutritional supplementation during a 6 month resistance training program; 1% chocolate milk; Dietary supplement: Nutritional supplementation during a 6 month resistance training program; Pea-based beverage; Dietary supplement: Nutritional supplementation during a 6 month resistance training program; Maltodextrin placebo
Active Comparator: Pea-based beverage; 250 ml of pea beverage consumed immediately after resistance training sessions + 250 ml of pea beverage consumed 1 hour after resistance training sessions	Dietary supplement: Nutritional supplementation during a 6 month resistance training program; 1% chocolate milk; Dietary supplement: Nutritional supplementation during a 6 month resistance training program; Pea-based beverage; Dietary supplement: Nutritional supplementation during a 6 month resistance training program; Maltodextrin placebo
Placebo Comparator: Placebo: Low protein plant-based beverage; 250 ml of placebo beverage consumed immediately after resistance training sessions + 250 ml of placebo beverage consumed 1 hour after resistance training sessions	Dietary supplement: Nutritional supplementation during a 6 month resistance training program; 1% chocolate milk; Dietary supplement: Nutritional supplementation during a 6 month resistance training program; Pea-based beverage; Dietary supplement: Nutritional supplementation during a 6 month resistance training program; Maltodextrin placebo

What is the study measuring?

Primary Outcome Measures

Outcome Measure	Measure Description	Time Frame
Change in lean tissue mass (kg)	Lean tissue mass measured by dual energy X-ray absorptiometry	6 months

Secondary Outcome Measures

Outcome Measure	Measure Description	Time Frame
Change in fat mass (kg)	Fat mass measured by dual energy X-ray absorptiometry	6 months
Change in lumbar spine bone mineral density (g/cm-squared)	Lumbar spine bone mineral density measured by dual energy X-ray absorptiometry	6 months
Change in hip bone mineral density (g/cm-squared)	Hip bone mineral density measured by dual energy X-ray absorptiometry	6 months
Change in bench press strength (kg)	Bench press strength predicted from resistance lifted for 6-10 repetitions	6 months
Change in squat strength (kg)	Squat strength predicted from resistance lifted for 6-10 repetitions	6 months
Change in cross-sectional moment of inertia at the hip (cm to the power of 4)	Cross-sectional moment of inertia measured by dual energy X-ray absorptiometry	6 months
Change in section modulus at the hip (cm to the power of 3)	Section modulus measured by dual energy X-ray absorptiometry	6 months
Change in cross-sectional area at the hip (cm-squared)	Cross-sectional area measured by dual energy X-ray absorptiometry	6 months
Change in cortical thickness at the hip (cm)	Cortical thickness measured by dual energy X-ray absorptiometry	6 months
Change in buckling ratio at the hip (no units)	Buckling ratio measured by dual energy X-ray absorptiometry	6 months

Collaborators and Investigators

• Sponsor: University of Saskatchewan

Study record dates

Study Major Dates

• Study Start (Actual): May 24, 2022
• Primary Completion (Anticipated): June 30, 2023
• Study Completion (Anticipated): August 31, 2023

Study Registration Dates

• First Submitted: May 14, 2022
• First Submitted That Met QC Criteria: May 14, 2022
• First Posted (Actual): May 19, 2022

Study Record Updates

• Last Update Posted (Actual): November 30, 2022
• Last Update Submitted That Met QC Criteria: November 25, 2022
• Last Verified: November 1, 2022

More Information

Terms related to this study

• Additional Relevant MeSH Terms: Nervous System Diseases; Neurologic Manifestations; Neuromuscular Manifestations; Pathological Conditions, Anatomical; Atrophy; Muscular Atrophy
• Other Study ID Numbers: 3228

Plan for Individual participant data (IPD)

• Plan to Share Individual Participant Data (IPD)?: No

Drug and device information, study documents

• Studies a U.S. FDA-regulated drug product: No
• Studies a U.S. FDA-regulated device product: No