Clinical Trials on Neonatal Sepsis in South Africa

Total 112 results

University of Stellenbosch
Fogarty International Center of the National Institute of Health

Unknown

Neonatal Bacterial Colonization Study

Prematurity | Bloodstream Infection | Neonatal SEPSIS | Very Low Birth Weight Baby

South Africa
Drugs for Neglected Diseases
Universiteit Antwerpen; PENTA Foundation; St George's, University of London

Completed

NeoAMR Observational Study in Neonatal Sepsis

Neonatal SEPSIS

Bangladesh, Uganda, Thailand, South Africa, Italy, Greece, India, Brazil, China, Kenya, Vietnam
University of Stellenbosch
Stanford University

Completed

Transcutaneous Screening for Risk of Severe Hyperbilirubinemia in South African Newborns

Hyperbilirubinemia | Neonatal Jaundice

South Africa
University of Pretoria

Completed

Efficacy of Using a Closing Pack to Reduce Postpartum Sepsis

Prevention of Postpartum Sepsis

South Africa
University of Pretoria

Not yet recruiting

Kefazolin Versus Kefazolin Plus Metronidazole to Reduce Postpartum Infection

Prevention of Postpartum Sepsis

South Africa
Cardiff and Vale University Health Board
Cardiff University

Recruiting

nSeP: Detecting Neonatal Sepsis by Immune-Metabolic Network Analysis (nSeP)

Sepsis

United Kingdom
University of KwaZulu
Bristol-Myers Squibb

Completed

Prophylactic Intrapartum Antibiotics and Immunological Markers for Postpartum Morbidity in HIV Positive Women

Puerperal Sepsis

South Africa
University of Athens

Recruiting

Vitamin C, Steroids, and Thiamine, and Cerebral Autoregulation and Functional Outcome in Septic Shock (CORVICTES-ΥΜ)

Septic Shock

Greece
University of Witwatersrand, South Africa

Completed

Epidemiology of Congenital Cytomegalovirus in a High HIV Prevalence Setting, South Africa

Neurodevelopmental Disorders | Hearing Loss | Immunogenicity | Stillbirth | Neonatal Death | Cytomegalovirus Congenital

South Africa
University of Witwatersrand, South Africa

Terminated

Safety And Efficacy Of Topical Platelet Rich Plasma And Thrombin Coagulum

Stasis Ulcer

South Africa
Basilea Pharmaceutica

Completed

An Open-label Study of APX001 for Treatment of Patients With Candidemia/Invasive Candidiasis Caused by Candida Auris (APEX)

Candidemia | Candida Infection | Invasive Candidiases

South Africa
Centers for Disease Control and Prevention
United States Agency for International Development (USAID); Bill and Melinda... and other collaborators

Unknown

Prevention of Perinatal Sepsis (PoPS): Evaluation of Chlorhexidine Wipes of Birth Canal and Newborn

Sepsis | Infant, Newborn, Diseases | Puerperal Infection

South Africa
University of Athens
Naval Hospital, Athens; General Hospital of Nikaia "Saint Panteleimon"

Recruiting

Vitamin C, Hydrocortisone and Thiamine for Septic Shock (CORVICTES)

Shock, Septic

Greece
Wollo University
Jimma University

Recruiting

Mobile Health Intervention to Improve Neonatal Care Practice (NCP)

Neonatal Care

Ethiopia
AstraZeneca

Completed

A Study to Compare the Efficacy and Safety of 2 Dosing Regimens of IV Infusions of AZD9773 (CytoFab™) With Placebo in Adult Patients With Severe Sepsis and/or Septic Shock

Septic Shock | Severe Sepsis

Czech Republic, France, Spain, Finland, Canada, Australia, Belgium
The George Institute for Global Health, Australia

Completed

Days Alive and Out of Hospital for Patients With Sepsis

Sepsis | Septic Shock

Australia
The George Institute

Completed

Fludrocortisone Dose Response Relationship in Septic Shock - FluDReSS (FluDReSS)

Septic Shock | Critically Ill

Australia
The George Institute
National Health and Medical Research Council, Australia; Australian and New...

Completed

ADjunctive coRticosteroid trEatment iN criticAlly ilL Patients With Septic Shock (ADRENAL)

Septic Shock

Australia, Denmark, Saudi Arabia, New Zealand, United Kingdom
Australian and New Zealand Intensive Care Research...

Recruiting

Australasian Resuscitation In Sepsis Evaluation: FLUid or Vasopressors In Emergency Department Sepsis (ARISE FLUIDS)

Shock, Septic

Australia
State University of New York at Buffalo
United States Agency for International Development (USAID); Save the Children; Unilever R...

Withdrawn

Intervention Study to Improve Maternal Handwashing

Infection | Neonatal

Kenya
Spectral Diagnostics (US) Inc.

Recruiting

Safety and Efficacy of Polymyxin B Hemoperfusion (PMX) for Endotoxemic Septic Shock in a Randomized, Open-Label Study (TIGRIS)

Septic Shock | Endotoxemia

United States
Eli Lilly and Company

Completed

Efficacy and Safety of Drotrecogin Alfa (Activated) in Adult Patients With Septic Shock

Sepsis

Italy, United Kingdom, United States, Germany, Spain, Belgium, France, Australia, Czech Republic, Netherlands, Canada, Mexico, New Zealand, Finland, Portugal, Brazil, India, Switzerland
Universitas Sriwijaya
Indonesia University

Completed

Resuscitation Failure, Oxidative Stress, and Necroptosis as Mortality Predictor in Septic Patient

Sepsis

Indonesia
PMD Solutions
Hospital of South West Jutland

Completed

Can Respiratory Rate Predict the Risk of Deterioration of Septic Patients

Sepsis

Denmark
Pediatrix

Completed

Amino Acid and Acylcarnitine Profiles in Premature Neonates

Prematurity | Parenteral Nutrition | Neonatal Screening

United States
Massachusetts General Hospital

Completed

Crystalloid Liberal or Vasopressors Early Resuscitation in Sepsis (CLOVERS)

Septic Shock

United States
Spark Biomedical, Inc.
Medical University of South Carolina; University of Texas Southwestern Medical...

Recruiting

Neurostimulation to Improve NOWS Outcomes (SPROUT)

Neonatal Abstinence Syndrome | Neonatal Opioid Withdrawal Syndrome

United States
Scynexis, Inc.

Completed

Open-Label Study to Evaluate the Efficacy and Safety of Oral Ibrexafungerp (SCY-078) in Patients With Candidiasis Caused by Candida Auris (CARES) (CARES)

Candidemia | Candidiasis, Invasive

Pakistan, India, United States, South Africa
The University of Queensland
Australasian Society for Infectious Diseases; International Society of Chemotherapy and other collaborators

Terminated

RCT Meropenem vs Piperacillin-Tazobactam for Definitive Treatment of BSI's Due to Ceftriaxone Non-susceptible Escherichia Coli and Klebsiella Spp. (MERINO)

Bloodstream Infections

Australia, Singapore, South Africa, Italy, Saudi Arabia, Canada, Lebanon, New Zealand, Turkey
The George Institute
Sunnybrook Health Sciences Centre; Imperial College London

Completed

Selective Decontamination of the Digestive Tract in Intensive Care Unit Patients (SuDDICU)

Sepsis | Critical Illness | Septic Shock | Ventilator Associated Pneumonia

Australia, Canada, United Kingdom
Astellas Pharma Inc

Completed

Study of Mycamine® in Children With Fungal Infections to Evaluate Safety and Blood Levels of the Drug

Candidemia | Invasive Candidiasis | Esophageal Candidiasis | Oropharyngeal Candidiasis

United States, South Africa
Belinda Howe
Australian and New Zealand Intensive Care Society Clinical Trials Group; Australasian...

Unknown

Australasian Resuscitation In Sepsis Evaluation Randomised Controlled Trial (ARISE)

Severe Sepsis

New Zealand, Australia, Finland, Ireland, Hong Kong
University of Virginia
National Institutes of Health (NIH); Medical Predictive Science Corporation

Completed

Impact of Heart Rate Characteristics Monitoring in Neonates (HeRO)

Sepsis

United States
Spark Biomedical, Inc.
Medical University of South Carolina

Completed

tAN to Mitigate Withdrawal Behaviors in Neonates

Neonatal Abstinence Syndrome

United States
Leiden University Medical Center
Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA); Sanquin...

Recruiting

PRedicting OutcomeS in Preterm nEonates With thromboCyTopenia (PROSPECT) (PROSPECT)

Intraventricular Hemorrhage | Neonatal Thrombocytopenia | Platelet Transfusion

Netherlands, Sweden
InfaCare Pharmaceuticals Corporation, a Mallinckrodt...

Completed

Stannsoporfin With Light Therapy for Newborn Babies With Jaundice (JASMINE_204)

Hyperbilirubinemia, Neonatal | Jaundice, Neonatal

United States
Medical University of South Carolina
National Institute on Minority Health and Health Disparities (NIMHD)

Completed

Critical Care Excellence in Sepsis and Trauma (CREST)

Sepsis | Trauma

United States
Eisai Inc.

Completed

ACCESS: A Controlled Comparison of Eritoran Tetrasodium and Placebo in Patients With Severe Sepsis

Severe Sepsis

United States, France, Poland, United Kingdom, Germany, Hong Kong, Taiwan, Spain, Switzerland, Argentina, Belgium, Israel, South Africa, Japan, Canada, Netherlands, Korea, Republic of, Australia, Chile, Brazil, Austria, Italy, Czechia, Portug...
Murdoch Childrens Research Institute
University of Otago; Sydney Children's Hospitals Network; Royal Children's Hospital and other collaborators

Completed

Improving Dosing of Vancomycin in Young Infants With Infections (VANCAPP)

Sepsis | Bacteremia | Infection

Australia
Murdoch Childrens Research Institute
Royal Children's Hospital; Royal Hospital For Women

Completed

RCT of Continuous Versus Intermittent Infusion of Vancomycin in Neonates

Sepsis | Bacteremia | Infection

Australia
The University of Queensland

Completed

Trial of Meropenem Versus Piperacillin-Tazobactam on Mortality and Clinial Response (MERINO II)

Bloodstream Infections

Singapore, Australia
MicroPhage, Inc.

Terminated

Study of the Performance of the KeyPath MRSA/MSSA Blood Culture Test - BTA

Bacteremia

United States
Medical University of South Carolina
Baxter Healthcare Corporation

Completed

Hemofilter Life Span, ECLS and/or CRRT

Kidney Diseases | Renal Insufficiency | Renal Failure | Acute Injury of Kidney | Neonatal Renal Disorder (Disorder)

United States
Eli Lilly and Company

Completed

Evaluate Protein C Levels in Severe Sepsis Patients on Drotrecogin Alfa (Activated)

Severe Sepsis

United States, Belgium, Spain, France, Finland, Germany, Canada, United Kingdom, Puerto Rico
Mednax Center for Research, Education, Quality...

Completed

Dose Comparison of Amino Acids on Growth in Premature Neonates

Malnutrition

United States
South West Sydney Local Health District

Recruiting

Capnodynamic Monitoring of Cardiorespiratory Function in Critically Ill Patients (PROFICIENT)

Sepsis | Acute Respiratory Infection | Postoperative Respiratory Distress

Australia
Brno University Hospital
Masaryk University

Active, not recruiting

Perioperative Analgesia in Neonates Who Underwent Primary Cleft Lip Repair Surgery

Perioperative Analgesia in Neonates

Czechia
T. John Winhusen, PhD
National Institute on Drug Abuse (NIDA); The Emmes Company, LLC

Active, not recruiting

Medication Treatment for Opioid Use Disorder in Expectant Mothers (MOMs)

Pregnancy Related | Opioid-Related Disorders | Substance Abuse | Drug Abuse | Drug Addiction | Neonatal Abstinence Syndrome | Drug Abuse in Pregnancy | Neonatal Opioid Withdrawal Syndrome

United States
Nationwide Children's Hospital
Eunice Kennedy Shriver National Institute of Child Health and Human Development...

Recruiting

GM-CSF for Reversal of Immunoparalysis in Pediatric Sepsis-induced MODS (GRACE-2)

Pediatric Sepsis-induced Multiple Organ Dysfunction Syndrome

United States
Advancing Clinical Trials in Neonatal Opioid Withdrawal...
National Institutes of Health (NIH)

Active, not recruiting

Eating, Sleeping, Consoling for Neonatal Withdrawal (ESC-NOW): a Function-Based Assessment and Management Approach ((ESC-NOW))

Neonatal Opiate Withdrawal Syndrome

United States

Clinical Trials on Neonatal Sepsis in South Africa

Sponsors and Collaborators

Medical Conditions

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CROs in Kazakhstan

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