Clinical Trials on Neoplasms, Hepatic

Total 109948 results

Pfizer

Completed

Single-Dose PK and Safety Study of GBT440 in Subjects With Hepatic Impairment

Hepatic Impairment

United States
CSPC ZhongQi Pharmaceutical Technology Co., Ltd.

Completed

A Study to Evaluate the Pharmacokinetics and Safety of DBPR108 in Subjects With Hepatic Impairment

Hepatic Impairment

China
Concert Pharmaceuticals

Completed

Study to Assess the Effect of Hepatic Impairment on the Pharmacokinetics of CTP-543

Hepatic Impairment

United States
Janssen Research & Development, LLC

Terminated

A Study of JNJ-53718678 in Participants With Hepatic Impairment

Hepatic Impairment

United States
Novartis Pharmaceuticals

Completed

Pharmacokinetics of BAF312 in Patients With Hepatic Impairment

Hepatic Impairment

Hungary, Russian Federation
Sichuan Haisco Pharmaceutical Group Co., Ltd
The First Hospital of Jilin University

Completed

Safety and Pharmacokinetics/Pharmacodynamics of HSK3486 in Patients With Hepatic Impairment

Hepatic Impairment

China
Novartis Pharmaceuticals

Completed

INC280 in Healthy Subjects With Impaired Hepatic Function and Subjects With Normal Hepatic Function

Hepatic Impairment

United States
Novartis Pharmaceuticals

Completed

A Trial to Evaluate the Pharmacokinetics of ABL001 in Healthy and Hepatic Impaired Subjects

Hepatic Impairment

United States
Novartis Pharmaceuticals

Completed

A Study to Evaluate the Pharmacokinetics of AFQ056 in Subjects With Hepatic Impairment Compared to Healthy Subjects

Hepatic Impairment

Germany, United States, Hungary
Novartis Pharmaceuticals

Terminated

Pharmacokinetics of Dabrafenib in Subjects With Hepatic Impairment

Hepatic Impairment

United States
Janssen Sciences Ireland UC

Completed

A Study to Evaluate the Effect of Hepatic Impairment on JNJ-73763989

Hepatic Impairment

Germany
Celgene

Completed

A Study to Assess the Pharmacokinetics of Enasidenib (CC-90007) in Subjects With Moderate and Severe Hepatic Impairment.

Hepatic Impairment

United States
Idorsia Pharmaceuticals Ltd.

Completed

A Study to Evaluate the Pharmacokinetics of ACT-541468 in Subjects With Mild, Moderate, and Severe Hepatic Impairment

Hepatic Impairment

Switzerland
Pfizer

Completed

A Hepatic Impairment Study for PF-04965842.

Hepatic Impairment

United States
MedDay Pharmaceuticals SA
Eurofins Optimed

Terminated

HI Study to Assess and Compare the Pharmacokinetic Parameters of MD1003 in Hepatic Impaired Patients and Healthy Subjects

Healthy Volunteers | Hepatic Impairment of Moderate Child Pugh Category

France, Hungary
Akebia Therapeutics

Completed

A Single Dose Study of Oral Vadadustat in Subjects With Normal and Impaired Hepatic Function

Hepatic Impairment

United States
Hoffmann-La Roche

Completed

Effect of Hepatic Impairment on the Pharmacokinetics of Alectinib

Hepatic Impairment

Czechia, Slovakia
H. Lundbeck A/S

Completed

Study Investigating the Pharmacokinetic Properties of the Drug Lu AF35700 in Subjects With Liver Impairment and in Healthy Subjects

Hepatic Impairment

Germany
Agios Pharmaceuticals, Inc.

Completed

A Study of AG-120 (Ivosidenib) in Subjects With Mild or Moderate Hepatic Impairment or Normal Hepatic Function

Hepatic Impairment

United States
Allergan

Completed

Impact of Severe Hepatic Impairment on Pharmacokinetics of Cenicriviroc and Its Metabolites

Hepatic Impairment

United States
PTC Therapeutics

Completed

A Single Dose Evaluation of the Effects of Moderate Hepatic Impairment on Deflazacort Pharmacokinetics

Hepatic Impairment

United States
Bristol-Myers Squibb

Withdrawn

A Study to Evaluate the Pharmacokinetics of BMS-986141 in Participants With Hepatic Impairment Compared to Healthy Participants

Hepatic Impairment

United States
Trius Therapeutics LLC

Completed

A PK and Safety Study in Subjects With Hepatic Impairment

Hepatic Impairment

United States
Alkermes, Inc.

Completed

Pharmacokinetics and Safety of ALKS 5461 in Healthy Subjects and Subjects With Hepatic Impairment and Normal Hepatic Function

Hepatic Impairment

United States
Wockhardt

Completed

Pharmacokinetics of WCK 2349 In Patients With Hepatic Impairment

Hepatic Impairment

United States
ApoPharma

Completed

An Open-label, Non-randomized, Parallel Group Study in Subjects With Mild and Moderate Hepatic Insufficiency and Healthy Volunteers

Hepatic Impairment

United States
Vanda Pharmaceuticals

Completed

Pharmacokinetics of Tasimelteon in Subjects With Mild or Moderate Hepatic Impairment

Hepatic Impairment

United States
AVEO Pharmaceuticals, Inc.

Completed

A Single-Dose Study of Tivozanib in Subjects With Hepatic Impairment and Normal Hepatic Function

Hepatic Impairment

United States
Novartis Pharmaceuticals

Completed

Single-dose Iloperidone Pharmacokinetics in Patients With Mild or Moderate Liver Disease, Compared to Healthy Volunteers

Hepatic Impairment

United States
Chonbuk National University Hospital

Completed

A Human Trial to Evaluate the Efficacy and Safety of Fermented Turmeric in Subjects Showing Mild Hepatic Injury

Mild Hepatic Injury

Korea, Republic of
Movetis

Completed

Evaluation of Prucalopride in Subjects With Moderate and Severe Hepatic Impairment (HI)

Hepatic Impairment

Russian Federation
VIVUS LLC
Covance; Sentrx

Completed

A Study to Evaluate the Pharmacokinetics of VI-0521 in Subjects With Hepatic Impairment

Hepatic Impairment

United States
Ocera Therapeutics, Inc.

Completed

Phase 2B Efficacy/Safety of Ornithine Phenylacetate in Hospitalized Cirrhotic Patients With Hepatic Encephalopathy (STOP-HE) (STOP-HE)

Hepatic Encephalopathy | Acute Episode of Overt Hepatic Encephalopathy

Belgium, Germany, Italy, Spain, United States, France, Austria, Russian Federation, Czechia, Australia, Hungary, Israel, Netherlands, Bulgaria, Estonia, Denmark, New Zealand
Indiana University

Terminated

Study of Lactulose in Children With Chronic Liver Disease (MHE)

Minimal Hepatic Encephalopathy

United States
University of Bern

Completed

Impact of Microparticles on Postoperative Complications in Surgical Patients

Colorectal Neoplasms | Pancreatic Neoplasms | Neoplasm, Hepatic

Switzerland
Bayer

Completed

Study of Copanlisib in Hepatic or Renal Impairment

Hepatic Insufficiency, Renal Insufficiency

Germany, Romania
David Minor, MD
University of Chicago; Jefferson Medical College of Thomas Jefferson University and other collaborators

Active, not recruiting

Yttrium90, Ipilimumab, & Nivolumab for Uveal Melanoma With Liver Metastases

Uveal Melanoma | Hepatic Metastases

United States
Karolinska Institutet

Unknown

Multiple Arterial Phase Computed Tomography Examination to Improve Detection of Tumors in the Liver and Pancreas

Pancreatic Cancer | Computed Tomography | Hepatic Cancer | Contrast Media | Imaging

Sweden
Association pour la Recherche sur le Temps Biologique...
Pfizer; Merck Serono International SA; Gustave Roussy, Cancer Campus, Grand Paris and other collaborators

Unknown

Optimal Control of Liver Metastases From Colorectal Cancer With Cetuximab and Hepatic Artery Infusion of Chemotherapy (OPTILIV)

Metastatic Colorectal Cancer | Liver Metastases | Hepatic Lesions

France, Italy, Belgium, Portugal
Association pour la Recherche en Medecine Interne

Not yet recruiting

Prevalence of Acute Hepatic Porphyria (PHA)

Acute Hepatic Porphyria
Alnylam Pharmaceuticals

Recruiting

ELEVATE, a Registry of Patients With Acute Hepatic Porphyria (AHP) (ELEVATE)

Acute Hepatic Porphyria

Belgium, France, Germany, United Kingdom, United States, Italy, Switzerland, Sweden
National Institute of Diabetes and Digestive and...
Ann & Robert H Lurie Children's Hospital of Chicago

Recruiting

TReatment for ImmUne Mediated PathopHysiology (TRIUMPH)

Hepatic Encephalopathy | Acute Liver Failure | Fulminant Hepatic Failure | Acute Liver Injury | Immune Dysregulation

United States
Zhejiang University

Recruiting

LISH Trial for the Hepatic Flexure and Proximal Transverse Colon Cancer

Hepatic Flexure Colon Cancer | Proximal Transverse Colon Cancer

China
Zhejiang University

Completed

Laparoscopic IIeocecus-Sparing Right Hemicolectomy for Cancer of the Hepatic Flexure and Proximal Transverse Colon (LISH)

Hepatic Flexure Colon Cancer | Proximal Transverse Colon Cancer

China
Alnylam Pharmaceuticals

Approved for marketing

Expanded Access Protocol of Givosiran for Patients With Acute Hepatic Porphyria

Acute Hepatic Porphyria
National Cancer Institute (NCI)

Recruiting

Hepatic Artery Infusion Pump Chemotherapy With Floxuridine and Dexamethasone in Combination With Systemic Chemotherapy for Patients With Colorectal Cancer Metastatic to the Liver

Colorectal Cancer | Liver Metastases | Colorectal Carcinoma | Colorectal Adenocarcinoma | Colorectal Cancer With Hepatic Metastases

United States
Genta Incorporated

Terminated

Pharmacokinetics of G3139 in Subjects With Advanced Melanoma, Including Those With Normal Hepatic Function and Those With Moderate Hepatic Impairment

Advanced Melanoma and Normal or Impaired | Hepatic Function
Federation Francophone de Cancerologie Digestive

Completed

Everolimus After (Chemo)Embolization for Liver Metastases From Digestive Endocrine Tumors (EVACEL)

Neuroendocrine Tumors | Hepatic Metastases | Metastases

France
Idorsia Pharmaceuticals Ltd.

Recruiting

A Study to Investigate the Effect of Hepatic Impairment on the Pharmacokinetics of a Single Dose of Cenerimod

Healthy | Hepatic Impairment

Portugal, Hungary
Mitsubishi Tanabe Pharma America

Completed

Pharmacokinetics Study of MCI-186 in Subjects With Mild or Moderate Hepatic Impairment

Healthy | Hepatic Impairment

Japan

Clinical Trials on Neoplasms, Hepatic

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Rare Diseases

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