Clinical Trials on Noninflammatory Degenerative Joint Disease in South Africa

Total 1059 results

Eli Lilly and Company

Completed

A Study in Participants With Moderate to Severe Rheumatoid Arthritis (RA-BEGIN)

Rheumatoid Arthritis

United States, Argentina, India, Korea, Republic of, Puerto Rico, Italy, Belgium, Canada, Japan, Mexico, Russian Federation, United Kingdom, Germany, Portugal, Greece, South Africa, Brazil, Austria, Sweden
Gilead Sciences
Galapagos NV

Completed

Filgotinib in Combination With Methotrexate in Adults With Moderately to Severely Active Rheumatoid Arthritis Who Have an Inadequate Response to Methotrexate (FINCH 1)

Rheumatoid Arthritis

United States, Italy, Poland, Ukraine, Belgium, Hong Kong, Taiwan, Spain, Israel, Bulgaria, India, Serbia, South Africa, Korea, Republic of, Japan, Russian Federation, Argentina, Germany, New Zealand, Thailand, Hungary, Netherlands, Slovaki... and more
Novartis

Completed

Long-term Efficacy, Safety and Tolerability of ACZ885 in Patients With Rheumatoid Arthritis

Rheumatoid Arthritis

Russian Federation, Switzerland, Germany, United States, Belgium, Italy, Netherlands, Spain, Turkey
Horizon Pharma Ireland, Ltd., Dublin Ireland

Completed

Study to Assess the Safety and Efficacy of Modified-Release Prednisone (Lodotra®) Therapy in Patients With Active Rheumatoid Arthritis (CAPRA-2)

Rheumatoid Arthritis

United States, Germany, Hungary, Canada, Poland, United Kingdom
Vertex Pharmaceuticals Incorporated

Completed

A 12-week Study of 4 Doses of VX-509 in Subjects With Active Rheumatoid Arthritis

Rheumatoid Arthritis

Poland, Belgium, Romania, Serbia, United States, Puerto Rico, Germany, Hungary, Russian Federation, Croatia
Rigel Pharmaceuticals

Completed

Efficacy and Safety Study of R935788 Tablets to Treat Rheumatoid Arthritis (Taski-3) (Taski-3)

Rheumatoid Arthritis

Belgium, United States, Colombia, France, Germany, Italy, Peru
NicOx

Completed

Efficacy and Safety Study of Naproxcinod in Subjects With Osteoarthritis of the Knee

Osteoarthritis

United States
Amgen

Completed

Study to Assess the Injection Site Pain Associated With a New Etanercept Formulation in Adults With Rheumatoid Arthritis or Psoriatic Arthritis

Arthritis, Rheumatoid; Arthritis, Psoriatic

United States, Puerto Rico
UCB Biopharma SRL

Completed

A Study to Evaluate the Long-Term Safety and Efficacy of Bimekizumab in Subjects With Psoriatic Arthritis (BE ACTIVE 2)

Psoriatic Arthritis

United States, Czechia, Germany, Hungary, Poland, Russian Federation
Novartis Pharmaceuticals

Completed

16-week Efficacy and 2-year Safety, Tolerability and Efficacy of Secukinumab in Participants With Active Ankylosing Spondylitis (MEASURE4)

Spondylitis, Ankylosing

Germany, Austria, Denmark, United States, Australia, Netherlands, Poland, Italy, Bulgaria, Spain, Russian Federation, United Kingdom, Greece, Czechia, Canada, Norway, Slovakia, Switzerland, Finland
Arthrosi Therapeutics

Active, not recruiting

Phase 2 to Assess Efficacy and Safety in AR882 Alone or in Combination With Allopurinol in Patients With Tophaceous Gout

Hyperuricemia | Gout | Arthritis, Gouty | Gout Chronic

United States, New Zealand
Opal Rheumatology Ltd.
Merck Sharp & Dohme LLC

Unknown

Investigating the Utilisation and Effectiveness of Originator and Biosimilar Anti-TNF Agents

Rheumatoid Arthritis | Psoriatic Arthritis | Ankylosing Spondylitis

Australia
Pacira Pharmaceuticals, Inc

Completed

Study of FX006 vs Normal Saline in Patients With Osteoarthritis of the Knee

Osteoarthritis of the Knee

United States, Canada
UCB Biopharma S.P.R.L.

Completed

A Study to Evaluate the Dose Response Based on the Efficacy, Safety and Tolerability of Bimekizumab in Subjects With Active Psoriatic Arthritis Which is a Type of Inflammatory Arthritis (BE ACTIVE)

Psoriatic Arthritis

United States, Czechia, Germany, Hungary, Poland, Russian Federation
Incyte Corporation

Completed

INCB028050 Compared to Background Therapy in Patients With Active Rheumatoid Arthritis (RA) With Inadequate Response to Disease Modifying Anti-Rheumatic Drugs

Rheumatoid Arthritis

United States, Czechia
Bristol-Myers Squibb

Completed

A Phase III Study of Abatacept (BMS-188667) in Patients With Active Rheumatoid Arthritis and Inadequate Response to Methotrexate

Rheumatoid Arthritis

United States
Genentech, Inc.

Completed

A Study to Evaluate the Efficacy and Safety of MLTA3698A in Combination With a Disease-Modifying Anti-Rheumatic Drug (DMARD) Compared With Adalimumab in Combination With a DMARD in Patients With Active Rheumatoid Arthritis

Rheumatoid Arthritis

Poland, United States, Germany, Hungary, Bulgaria, Mexico, Peru, Chile, Romania, Spain
Hoffmann-La Roche

Completed

Extension Study Evaluating the Safety and Efficacy of Subcutaneous Tocilizumab (RoActemra/Actemra) Administration in Systemic and Polyarticular-Course Juvenile Idiopathic Arthritis

Juvenile Idiopathic Arthritis

United States, Canada, United Kingdom, Brazil, Germany, Italy, Russian Federation, Spain, Australia, France, Mexico, Argentina
Novartis Pharmaceuticals

Completed

Efficacy at 24 Weeks With Long Term Safety, Tolerability and Efficacy up to 5 Years of Secukinumab in Patients of Active Psoriatic Arthritis (FUTURE 2)

Psoriatic Arthritis

Germany, United Kingdom, Belgium, United States, Australia, Thailand, Russian Federation, Czechia, Canada, Poland, Puerto Rico
Boehringer Ingelheim

Completed

A Multi-Center Trial to Compare Three Doses of Meloxicam and Placebo in Patients With Rheumatoid Arthritis

Arthritis, Rheumatoid

Korea, Republic of, United States, Taiwan, Canada, Italy, Ukraine, Russian Federation, Germany, Australia, Argentina, Belgium, Brazil, France, Hungary
Hoffmann-La Roche

Completed

A Study Of Tocilizumab in Patients With Moderate to Severe Active Rheumatoid Arthritis Who Have an Inadequate Response to or Are Unable to Tolerate Biologic and Non-Biologic Disease-modifying Antirheumatic Drugs (DMARDs)

Rheumatoid Arthritis

United States
Hoffmann-La Roche

Completed

A Study of Tocilizumab and Methotrexate Treatment Strategies (Adding Tocilizumab to Methotrexate Versus Switching to Tocilizumab) in Patients With Active Rheumatoid Arthritis With Inadequate Response to Prior Methotrexate Treatment

Rheumatoid Arthritis

Germany, Norway, Spain, France, Sweden, United States, Estonia, United Kingdom, Greece, Russian Federation, Italy, Denmark, Netherlands, Thailand, Latvia, Croatia, Serbia, Israel, Brazil, Romania
GlaxoSmithKline
Iqvia Pty Ltd

Terminated

Efficacy and Safety of GSK3196165 Versus Placebo and Tofacitinib in Participants With Moderately to Severely Active Rheumatoid Arthritis Who Have an Inadequate Response to Conventional Synthetic (cs)/Biologic (b) Disease Modifying Anti-rheumatic Drugs (DMARDs) (contRAst 2)

Arthritis, Rheumatoid

United States, Australia, Germany, Japan, Korea, Republic of, Poland, Bulgaria, Estonia, Hungary, Mexico, Russian Federation, Spain, Thailand, Colombia, China, Argentina, United Kingdom, France
AbbVie

Active, not recruiting

A Study Comparing Upadacitinib (ABT-494) to Placebo and to Adalimumab in Adults With Rheumatoid Arthritis Who Are on a Stable Dose of Methotrexate and Who Have an Inadequate Response to Methotrexate (SELECT-COMPARE)

Rheumatoid Arthritis

United States, Argentina, Australia, Austria, Belarus, Belgium, Bosnia and Herzegovina, Brazil, Bulgaria, Canada, Chile, Colombia, Croatia, Czechia, Denmark, Estonia, France, Germany, Greece, Hong Kong, Hungary, Ireland, Israel, Italy, ... and more
Eli Lilly and Company

Terminated

An Open Label Study for Participants With Rheumatoid Arthritis

Rheumatoid Arthritis

Argentina, Germany, India, Korea, Republic of, United States, Hungary, Taiwan, Bulgaria, France, Russian Federation, Spain, Ukraine, Colombia, Mexico, Poland, Japan, Croatia, Greece, New Zealand, Romania, South Africa, Australia, Br... and more
Regeneron Pharmaceuticals
Teva Pharmaceutical Industries, Ltd.

Completed

Study to Determine the Safety and the Efficacy of Fasinumab Compared to Placebo and Nonsteroidal Anti-inflammatory Drugs (NSAIDs) for Treatment of Adults With Pain From Osteoarthritis of the Knee or Hip (FACT OA2)

Osteoarthritis, Knee | Osteoarthritis, Hip

United States
Sanofi
Regeneron Pharmaceuticals

Completed

Long Term Evaluation of Sarilumab in Rheumatoid Arthritis Patients (SARIL-RA-EXTEND)

Rheumatoid Arthritis

United States, Argentina, Australia, Austria, Belarus, Belgium, Brazil, Canada, Chile, Colombia, Czechia, Ecuador, Estonia, Finland, Germany, Greece, Guatemala, Hungary, Israel, Italy, Korea, Republic of, Lithuania, Malaysia, Mexico, Ne... and more
Amgen

Completed

Study to Assess if ABP 798 is Safe & Effective in Treating Moderate to Severe Rheumatoid Arthritis (RA) Compared to Rituximab

Arthritis, Rheumatoid

United States, Germany, Bulgaria, Hungary, Poland, Estonia
Eli Lilly and Company
Incyte Corporation

Completed

A Study in Participants With Rheumatoid Arthritis on Background Methotrexate Therapy

Arthritis, Rheumatoid

Hungary, Romania, United States, Czechia, Croatia, Poland, Ukraine, Mexico, India
Biotest
AbbVie

Terminated

Study to Investigate the Safety and Efficacy of Tregalizumab in Subjects (MTX-IR) With Active Rheumatoid Arthritis (986)

Rheumatoid Arthritis

United States, Bulgaria, Canada, Czechia, Estonia, Germany, Hungary, Lithuania, Mexico, Poland, Russian Federation, Serbia, Slovakia, Ukraine
Abbott

Completed

Study of Human Anti-TNF Monoclonal Antibody D2E7 in Subjects With Active Rheumatoid Arthritis

Rheumatoid Arthritis

United States
Sandoz
Hexal AG

Completed

GP2013 Treatment in Patients With Active Rheumatoid Arthritis, Previously Treated With Rituxan® or MabThera® (ASSIST-RT)

Rheumatoid Arthritis

United States, Germany, Poland, Hungary
Novartis Pharmaceuticals

Completed

Efficacy, Safety and Tolerability of AIN457 in Patients With Rheumatoid Arthritis (RA) Taking Methotrexate (MTX)

Rheumatoid Arthritis

Hungary, Belgium, Germany, United States, Czech Republic, Korea, Republic of, Russian Federation, Taiwan, Poland, Slovakia, Japan
Ardea Biosciences, Inc.

Completed

Combination Treatment Study in Subjects With Tophaceous Gout With Lesinurad and Febuxostat (CRYSTAL)

Tophaceous Gout

Poland, United States, Canada, Australia, New Zealand, Switzerland
AbbVie

Completed

A Study of Subjects With Psoriatic Arthritis to Investigate the Effectiveness of Adalimumab Introduction Compared With Methotrexate Dose Escalation (CONTROL) (CONTROL)

Psoriatic Arthritis

United States, Australia, Brazil, Bulgaria, Canada, Colombia, Czechia, Germany, Italy, Poland, Puerto Rico, Qatar, Spain, United Kingdom
Pfizer

Completed

Long-Term Effectiveness And Safety Of CP-690,550 For The Treatment Of Rheumatoid Arthritis

Arthritis, Rheumatoid

United States, Spain, Korea, Republic of, Taiwan, China, France, Belgium, Denmark, Bulgaria, Czechia, Hungary, India, Slovakia, Croatia, Turkey, Mexico, Canada, Germany, Argentina, Poland, Puerto Rico, Malaysia, Brazil, Australia, Romania, United Kingdom and more
University of Alabama at Birmingham
Oregon Health and Science University

Completed

Safety and Effectiveness of Live Zoster Vaccine in Anti-Tumor Necrosis Factor (TNF) Users (VERVE Trial)

Arthritis | Rheumatoid Arthritis | Psoriasis | Crohn's Disease | Inflammatory Arthritis | Psoriatic Arthritis | Ankylosing Spondylitis | Enteropathic Arthritis

United States
Sanford Health
National Ataxia Foundation; Beyond Batten Disease Foundation; Pitt Hopkins Research... and other collaborators

Recruiting

Rare Disease Patient Registry & Natural History Study - Coordination of Rare Diseases at Sanford (CoRDS)

Mitochondrial Diseases | Retinitis Pigmentosa | Myasthenia Gravis | Eosinophilic Gastroenteritis | Multiple System Atrophy | Leiomyosarcoma | Leukodystrophy | Anal Fistula | Spinocerebellar Ataxia Type 3 | Friedreich Ataxia | Kennedy Disease | Lyme Disease | Hemophagocytic Lymphohistiocytosis | Spinocerebellar Ataxia... and other conditions

United States, Australia
Arthrosi Therapeutics

Recruiting

Phase 3 Evaluation of Efficacy and Safety of AR882 in Gout Patients

Hyperuricemia | Gout | Arthritis, Gouty | Gout Chronic

United States, Australia, New Zealand
Mallinckrodt

Completed

Safety and Effectiveness of Acthar Gel in Participants With Rheumatoid Arthritis

Arthritis, Rheumatoid

United States, Puerto Rico, Mexico, Peru, Argentina
University of Southern California
National Institute on Aging (NIA); Alzheimer's Therapeutic Research Institute; Alzheimer's Association

Completed

Longitudinal Evaluation of Amyloid Risk and Neurodegeneration - the LEARN Study (LEARN)

Cognition Disorders

United States
Pfizer

Completed

Study of CP-690,550 Versus Placebo In Rheumatoid Arthritis Patients On Background Methotrexate With Inadequate Response To Tumor Necrosis Factor (TNF) Inhibitors

Arthritis, Rheumatoid

Australia, United States, Austria, Germany, Ireland, Brazil, Spain, Taiwan, Belgium, Canada, France, Italy, Korea, Republic of, Puerto Rico
UCB BIOSCIENCES GmbH

Completed

Multicenter Study Evaluating Certolizumab Pegol Compared to Placebo in Subjects With axSpA Without X-ray Evidence of AS (C-AXSPAND)

Axial Spondyloarthritis | Nonradiographic Axial Spondyloarthritis | Nr-axSpA

United States, Australia, Bulgaria, Canada, Czechia, Hungary, Poland, Russian Federation, Taiwan
AbbVie

Completed

A Study to Compare Upadacitinib (ABT-494) to Placebo in Adults With Rheumatoid Arthritis on Stable Dose of Conventional Synthetic Disease-Modifying Antirheumatic Drugs (csDMARDs) With an Inadequate Response or Intolerance to Biologic DMARDs (SELECT-BEYOND)

Rheumatoid Arthritis

United States, Australia, Austria, Belgium, Canada, Czechia, Estonia, Finland, France, Germany, Greece, Hungary, Ireland, Israel, Korea, Republic of, Latvia, New Zealand, Poland, Portugal, Puerto Rico, Russian Federation, Slovakia, ... and more
Genentech, Inc.

Terminated

A Study to Evaluate Ocrelizumab in Combination With Methotrexate Compared With Infliximab Plus Methotrexate in Patients With Active Rheumatoid Arthritis Currently Responding Inadequately to Etanercept or Adalimumab

Rheumatoid Arthritis

United States
UCB Pharma

Completed

Open Label Long-Term Safety Study of Certolizumab Pegol (CZP) for Patients With Rheumatoid Arthritis

Rheumatoid Arthritis

United States, United Kingdom, Belgium, Germany, Austria, Ireland, Czechia
AstraZeneca

Completed

A 6-month Randomised, Double-blind, Open Arm Comparator, Phase IIb, With AZD9056, in Patients With Rheumatoid Arthritis (RA)

Rheumatoid Arthritis

United States, Mexico, Poland, Romania, Canada, Argentina, Australia, Slovakia, France, Czech Republic, Belgium, Russian Federation
LG Chem

Recruiting

Tigulixostat, Phase 3 Study, Placebo Controlled in Gout Patients (EURELIA1)

Hyperuricemia | Gout | Gout Flare | Tophi

United States
Regeneron Pharmaceuticals

Completed

Study of REGN475 in Patients With Pain Due to Osteoarthritis of the Knee or Hip

Osteoarthritis, Knee | Osteoarthritis, Hip

United States
Ventyx Biosciences, Inc

Terminated

VTX958 Versus Placebo for the Treatment of Active Psoriatic Arthritis (Tranquility-PsA)

Psoriatic Arthritis

United States, Bulgaria, Czechia, Germany, Hungary, Poland, Spain

Clinical Trials on Noninflammatory Degenerative Joint Disease in South Africa

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