Clinical Trials on Oesophageal Adenocarcinoma

Total 13520 results

MedImmune LLC

Completed

A Study to Evaluate the Safety and Tolerability of MEDI-565 in Adults With Gastrointestinal Adenocarcinomas

Gastrointestinal Adenocarcinomas

United States
Academisch Medisch Centrum - Universiteit van Amsterdam...

Completed

Chemoradiation and Panitumumab for Esophageal Cancer

Adenocarcinoma | Esophageal Cancer | Squamous Cell Carcinoma | Gastro-esophageal Junction Cancer

Netherlands
Betta Pharmaceuticals Co., Ltd.

Completed

Second-line Treatment With Icotinib in Esophageal Carcinoma Patients With EGFR Overexpression (IHC 3+) or Positive FISH

Esophageal Carcinoma | Adenocarcinoma of the Gastroesophageal Junction

China
University of Nottingham

Completed

The Accuracy and Acceptability of Magnet Assisted Capsule Endoscopy in the Diagnosis of Esophageal Pathology: a Pilot Study (MACE)

Oesophageal Varices | Barrett's Oesophagus

United Kingdom
Janssen-Cilag Pty Ltd

Completed

A Study to Compare the Number of Patients With Gastro-Oesophageal Reflux Disease (GORD) Achieving Heartburn and Regurgitation Symptom Resolution After Treatment With Either Rabeprazole Sodium 20mg, Esomeprazole 20mg or Esomeprazole 40mg

Gastro-oesophageal Reflux

Australia
Memorial Sloan Kettering Cancer Center

Active, not recruiting

Evaluate Mesothelin as a Biomarker for the Clinical Management of Esophageal Adenocarcinoma (EAC)

Adenocarcinoma | Esophageal Cancer

United States
Memorial Sloan Kettering Cancer Center

Terminated

A Single-Arm Pilot Study of Adjuvant Pembrolizumab Plus Trastuzumab in HER2+ Esophagogastric Tumors With Persistent Circulating Tumor DNA Following Curative Resection

Gastric Cancer | Esophageal Cancer | Esophageal Neoplasms | Gastroesophageal Junction Cancer | Gastric Tumor | Gastroesophageal Junction Adenocarcinoma | GastroEsophageal Cancer | Esophageal Tumor | Esophagogastric Tumors | Gastroesophageal Junction Tumor

United States
Changhai Hospital
Shanghai Municipal Science and Technology Commission

Completed

Esophageal cAncer Screening Trial (EAST)

Esophageal Cancer | Esophageal Squamous Cell Carcinoma | Gastroesophageal Junction Adenocarcinoma

China
Washington University School of Medicine

Terminated

Proton Beam Therapy to Treat Esophageal Cancer

Esophageal Squamous Cell Carcinoma | Adenocarcinoma Of Esophagus

United States
GERCOR - Multidisciplinary Oncology Cooperative...

Not yet recruiting

POP-UP: a Single-arm, Two-cohort Study: Trimodal Prehab for Upper GI and Pancreatic Cancer (POP-UP)

Esophageal Cancer | Pancreatic Ductal Adenocarcinoma
Vrije Universiteit Brussel

Completed

Influence of Intrapulmonary Percussive Ventilation (IPV) on Gastro-oesophageal Reflux (GOR).

Gastro-oesophageal Reflux

Belgium
Vrije Universiteit Brussel

Completed

Influence of IPV on GOR in Infants From 0 to 12 Months.

Gastro-oesophageal Reflux

Belgium
Great Ormond Street Hospital for Children NHS Foundation...
National Institute for Health Research, United Kingdom

Recruiting

Swallowing, Feeding and Eating in Children Born With Oesophageal Atresia/Trache-oesophageal Fistula (OA/TOF) (SaFE)

Esophageal Atresia With Tracheoesophageal Fistula

United Kingdom
AHS Cancer Control Alberta

Recruiting

A Study Involving Neoadjuvant Chemoradiotherapy With Hypofractionated Radiotherapy in Patients With Esophageal and Gastroesophageal Junction Adenocarcinoma

Esophageal Cancer

Canada
Merck Sharp & Dohme LLC

Active, not recruiting

Pembrolizumab/Placebo Plus Trastuzumab Plus Chemotherapy in Human Epidermal Growth Factor Receptor 2 Positive (HER2+) Advanced Gastric or Gastroesophageal Junction (GEJ) Adenocarcinoma (MK-3475-811/KEYNOTE-811)

Gastric Neoplasms | Gastroesophageal Junction Adenocarcinoma

United States, Australia, Brazil, Chile, China, France, Germany, Guatemala, Ireland, Israel, Italy, Japan, Korea, Republic of, New Zealand, Poland, Russian Federation, Spain, Turkey, Ukraine, United Kingdom
Merck Sharp & Dohme LLC

Terminated

Efficacy and Safety Study of Pembrolizumab (MK-3475) Versus Paclitaxel in Asian Participants With Advanced Gastric or Gastroesophageal Junction Adenocarcinoma Who Progressed After First-line Therapy With Platinum and Fluoropyrimidine (MK-3475-063/KEYNOTE-063)

Gastric Neoplasms | Gastroesophageal Junction Adenocarcinoma

China, Korea, Republic of, Malaysia, Taiwan
Krankenhaus Nordwest

Completed

Oxaliplatin and 5-Fluorouracil With or Without Docetaxel in Elderly Patients (>65 y) With Stomach and Esophagus Cancer

Gastric Cancer | Adenocarcinoma of the Esophagogastric Junction

Germany
King's College Hospital NHS Trust
King's College London; Cardiff University; Brighton and Sussex University Hospitals...

Recruiting

Beta-blockers or Placebo for Primary Prophylaxis (BOPPP) of Oesophageal Varices Trial. (BOPPP)

Portal Hypertension | Cirrhosis, Liver | Variceal Hemorrhage | Varices, Esophageal

United Kingdom
M.D. Anderson Cancer Center
National Cancer Institute (NCI)

Terminated

CD8+ T Cell Therapy and Pembrolizumab in Treating Patients With Metastatic Gastrointestinal Tumors

Metastatic Pancreatic Adenocarcinoma | Stage IV Pancreatic Cancer AJCC v6 and v7 | Stage IV Colorectal Cancer AJCC v7 | Stage IVA Colorectal Cancer AJCC v7 | Stage IVB Colorectal Cancer AJCC v7 | Colorectal Adenocarcinoma | Metastatic Colorectal Carcinoma | Metastatic Cholangiocarcinoma | Metastatic... and other conditions

United States
Dana-Farber Cancer Institute
Merck Sharp & Dohme LLC

Completed

Pembrolizumab in Refractory Advanced Esophageal Cancer

Esophageal Cancer | Adenocarcinoma Esophagus | Squamous Cell Esophagus Cancer

United States
Shanghai Junshi Bioscience Co., Ltd.

Recruiting

A Study to Evaluate the Efficacy and Safety of Toripalimab Injection in the Treatment of Recurrent or Metastatic Gastric or Gastroesophageal Junction Adenocarcinoma Who Have Failed at Least Two Prior Lines of Therapy and Are Positive Specific Markers

Recurrent or Metastatic Gastric or Gastroesophageal Junction Adenocarcinoma Who Have Failed at Least Two Prior Lines of Therapy

China
EMD Serono Research & Development Institute, Inc.
Merck KGaA, Darmstadt, Germany

Completed

Avelumab in Third-Line Gastric Cancer (JAVELIN Gastric 300)

Unresectable, Recurrent, Locally Advanced or Metastatic Gastric or Gastroesophageal Junction Adenocarcinoma | Gastric Cancer Third Line

Spain, Italy, Australia, Korea, Republic of, Belgium, France, Poland, United States, Czechia, Germany
Case Western Reserve University
Johns Hopkins University; Mayo Clinic; University of Pennsylvania; Washington University... and other collaborators

Recruiting

Genetic Determinants of Barrett's Esophagus and Esophageal Adenocarcinoma (FBE)

Barrett's Esophagus | Esophageal Neoplasm

United States
Alliance for Clinical Trials in Oncology
National Cancer Institute (NCI)

Completed

Irinotecan in Treating Patients With Advanced Cancer of the Stomach

Gastric Cancer | Esophageal Cancer

United States, Canada
University of Aarhus
Aarhus University Hospital

Recruiting

Thromboprophylaxis in Oesophageal Cancer Patients (TOP-RCT)

Thrombosis | Esophageal Neoplasms | Thromboembolism

Denmark
Vrije Universiteit Brussel

Completed

Influence of Airway Clearance Techniques on GOR in Infants

Gastro-oesophageal Reflux

Belgium
Xiaofeng Chen

Recruiting

XELOX Combined With Fruquintinib and Sintilimab Regimen Conversion Therapy for Gastric Cancer/Gastroesophageal Junction Adenocarcinoma Only With Liver and/or Retroperitoneal Lymph Node Metastasis, a Prospective Single-arm, Multicenter Study

Gastric Cancer/Gastroesophageal Junction Adenocarcinoma

China
The Leeds Teaching Hospitals NHS Trust
The Leeds Teaching Hospitals Charitable Foundation

Unknown

Evaluation of 4D-contrast Enhanced PET-CT in Tumour Volume Definition

Lung Carcinoma | Pancreatic Carcinoma | Lower Oesophageal Carcinoma

United Kingdom
EMD Serono Research & Development Institute, Inc.
Merck KGaA, Darmstadt, Germany

Completed

Avelumab in First-Line Maintenance Gastric Cancer (JAVELIN Gastric 100)

Unresectable, Locally Advanced or Metastatic, Adenocarcinoma of the Stomach, or of the Gastro Esophageal Junction

United States, Spain, Italy, Australia, Russian Federation, Taiwan, Korea, Republic of, Thailand, Canada, Turkey, Germany, Romania, United Kingdom, Hungary, Brazil, France, Japan
Stanford University

Terminated

Phase I Dose Escalation of Stereotactic Radiosurgical Boost for Locally Advanced Esophageal Cancer

Adenocarcinoma | Carcinoma, Squamous Cell | Esophageal Cancer | Esophageal Neoplasms

United States
Mayo Clinic

Recruiting

Assessment of a Minimally Invasive Collection Device for Molecular Analysis of Esophageal Samples (SOS4C)

Barrett Esophagus | Esophageal Adenocarcinoma | Barrett's Esophagus Without Dysplasia | Barretts Esophagus With Dysplasia

United States
Ochsner Health System
The University of Queensland

Unknown

Microbiome Involvement With Barrett's Esophagus and Progression to Esophageal Adenocarcinoma

Esophageal Cancer | Barrett Esophagus

United States
Seagen Inc.

Recruiting

Tucatinib Plus Trastuzumab and Oxaliplatin-based Chemotherapy or Pembrolizumab-containing Combinations for HER2+ Gastrointestinal Cancers

Gastric Adenocarcinoma | Cholangiocarcinoma | Esophageal Adenocarcinoma | Colorectal Carcinoma | Gallbladder Carcinoma | GEJ Adenocarcinoma

United States, Japan
Karolinska University Hospital
Ullevaal University Hospital; Oslo University Hospital; Sahlgrenska University... and other collaborators

Completed

Neoadjuvant Chemotherapy Versus Radiochemotherapy for Cancer of the Esophagus or Cardia (NeoRes)

Carcinoma, Squamous Cell | Adenocarcinoma of the Esophagus and Gastric Cardia

Sweden
Federation Francophone de Cancerologie Digestive
Shire

Active, not recruiting

Nal-iri/lv5-fu Versus Paclitaxel as Second Line Therapy in Patients With Metastatic Oesophageal Squamous Cell Carcinoma (OESIRI)

Squamous Cell Carcinoma

France
National Cancer Institute (NCI)

Not yet recruiting

Testing the Combination of the Anticancer Drugs Trastuzumab Deruxtecan (DS-8201a) and Azenosertib (ZN-c3) in Patients With Stomach or Other Solid Tumors

Locally Advanced Malignant Solid Neoplasm | Unresectable Malignant Solid Neoplasm | Metastatic Malignant Solid Neoplasm | Clinical Stage III Gastric Cancer AJCC v8 | Clinical Stage III Gastroesophageal Junction Adenocarcinoma AJCC v8 | Clinical Stage IV Gastric Cancer AJCC v8 | Clinical Stage... and other conditions
National Cancer Institute (NCI)

Recruiting

Testing Immunotherapy (Atezolizumab) With or Without Chemotherapy in Locoregional MSI-H/dMMR Gastric and Gastroesophageal Junction (GEJ) Cancer

Gastric Adenocarcinoma | Clinical Stage III Gastric Cancer AJCC v8 | Clinical Stage III Gastroesophageal Junction Adenocarcinoma AJCC v8 | Gastroesophageal Junction Adenocarcinoma | Clinical Stage I Gastric Cancer AJCC v8 | Clinical Stage II Gastric Cancer AJCC v8 | Clinical Stage IVA Gastric... and other conditions

United States
Organon and Co
World Health Information Science Consultants, LLC

Completed

Observational Study of Incidence Rates of Esophageal Cancer in Women Taking Medications for the Prevention or Treatment of Osteoporosis (MK-0217A-352)

Adenocarcinoma | Esophageal Cancer | Squamous Cell Carcinoma
National Taiwan University Hospital

Unknown

PLA for HCC and Esophageal ca Serum

Hepatocellular Carcinoma | Esophageal Cancer

Taiwan
Memorial Sloan Kettering Cancer Center
Genentech, Inc.; Weill Medical College of Cornell University

Completed

Pre-operative Chemotherapy Plus Bevacizumab With Early Salvage Therapy Based on PET Assessment of Response in Patients With Locally Advanced But Resectable Gastric and GEJ Adenocarcinoma

Gastric Cancer | Esophageal Cancer

United States
M.D. Anderson Cancer Center
National Cancer Institute (NCI)

Active, not recruiting

Pembrolizumab and Chemoradiotherapy for the Treatment of Unresectable Gastroesophageal Cancer

Clinical Stage III Gastroesophageal Junction Adenocarcinoma AJCC v8 | Clinical Stage IV Gastroesophageal Junction Adenocarcinoma AJCC v8 | Unresectable Gastroesophageal Junction Adenocarcinoma | Locally Advanced Gastroesophageal Junction Adenocarcinoma | Postneoadjuvant Therapy Stage III... and other conditions

United States
University of North Carolina, Chapel Hill
Interpace Diagnostics Corporation

Completed

Utility Of Mutational Load As A Predictor For Endoscopic Treatment Response In Barrett's Esophagus

Barretts Esophagus With Dysplasia | Intramucosal Adenocarcinoma

United States
Universitätsklinikum Hamburg-Eppendorf

Recruiting

Neoplastic Barrett Esophagus: Endoscopic Piecemeal vs. En Bloc Resection (BEEPER)

Barrett Esophagus | Barrett Adenocarcinoma | Esophagus Neoplasm

United States, Germany
Lucid Diagnostics, Inc.

Recruiting

CLUE: CLinical Utility Study of EsoGuard (PR-0410)

Barrett Esophagus | Barretts Esophagus With Dysplasia | Esophagus Adenocarcinoma

United States
Shadia Jalal, MD
GlaxoSmithKline; Indiana University School of Medicine

Terminated

A Study Evaluating Safety and Efficacy of Niraparib in Patients With Previously Treated Metastatic Esophageal/Gastroesophageal Junction/Proximal Gastric Adenocarcinoma

Adenocarcinoma | Gastric Cancer | Esophageal Cancer

United States
Columbia University

Completed

Trial to Assess the Effects of an Antimicrobial Mouthwash on the Esophageal Microbiome (Mouthwash)

Barrett's Esophagus | Esophageal Adenocarcinoma | Reflux Esophagitis

United States
VA Office of Research and Development
VA Palo Alto Health Care System; VA Puget Sound Health Care System; Michael E... and other collaborators

Not yet recruiting

A Phase II Trial to Evaluate the Effect of Itraconazole on Pathologic Complete Response Rates in Resectable Esophageal Cancer

Esophageal Adenocarcinoma | Esophageal Squamous Cell Carcinoma | Gastroesophageal Junction Carcinoma

United States
Midwest Biomedical Research Foundation
Kansas City Veteran Affairs Medical Center

Recruiting

Progression of Gastroesophageal Reflux Disease and Barrett's Esophagus and the Creation of a Barrett's Registry

Gastroesophageal Reflux Disease | Barrett's Esophagus | Esophageal Adenocarcinoma

United States
BioNTech SE

Terminated

Safety, Pharmacokinetics, Pharmacodynamics, and Preliminary Efficacy Trial of BNT141 in Patients With Unresectable or Metastatic CLDN18.2-positive Gastric, Pancreatic, Ovarian and Biliary Tract Tumors

Gastric Cancer | Pancreatic Cancer | Solid Tumor | Metastatic Cancer | Cholangiocarcinoma | Esophageal Adenocarcinoma | Biliary Tract Cancer | Gastroesophageal Junction Adenocarcinoma

United States, Canada
Groupe Hospitalier Paris Saint Joseph

Withdrawn

Retrospective Analysis of the Expression of the Neurotensin Receptor by Metastatic Lung Adenocarcinomas (NTS)

Metastatic Lung Adenocarcinomas

Clinical Trials on Oesophageal Adenocarcinoma

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