Clinical Trials on Organic Cation Transporter 1

Total 745 results

David Garcia Cinca
Fundacion Clinic per a la Recerca Biomédica

Unknown

Study With Dual Therapy Including Lamivudine (300 mg QD) Plus Raltegravir (1200 mg QD) in Virologically Suppressed HIV-1 Infected Patients Experiencing Inconvenience, Toxicity, Negative Impact on Co-morbidities or Risk of Drug-drug Interactions With Their Current Regimen (RALAM-II)

HIV Infections | HIV Seropositivity | HIV-1-infection

Spain
Alessandro Doria
University of Colorado, Denver; University Health Network, Toronto; University... and other collaborators

Not yet recruiting

Sotagliflozin to Slow Kidney Function Decline in Persons With Type 1 Diabetes and Diabetic Kidney Disease (SUGARNSALT)

Heart Failure | Diabetic Nephropathies | Kidney Failure, Chronic | Diabetes Mellitus Type 1

Canada, United States
University Hospital, Ghent
KU Leuven; Universitair Ziekenhuis Brussel; Vrije Universiteit Brussel; Centre... and other collaborators

Not yet recruiting

Immuno-virological Evaluation of Persons Living With HIV (PLWH)

HIV Seropositivity | HIV-1-infection

Belgium
Calmy Alexandra

Completed

Evaluation of a Simplified Strategy for the Long-term Management of HIV Infection (Simpl'HIV) (Simpl'HIV)

Antiretroviral Therapy | HIV-1-infection | Maintenance Therapy

Switzerland
Peter Rossing

Completed

PeRsOnalising Treatment Of Diabetic Nephropathy: (PROTON)

Diabetes Complications | Diabetes Mellitus, Type 1 | Diabetic Nephropathies

Denmark
Kyowa Kirin, Inc.
Kyowa Kirin Co., Ltd.

Completed

Study of KRN23 in Adults With X-linked Hypophosphatemia (XLH)

X-linked Hypophosphatemia

United States, Korea, Republic of, Japan, Ireland, United Kingdom, France, Italy
Kyowa Kirin Pharmaceutical Development Ltd

Completed

Study of the Anti-FGF23 Antibody, Burosumab, in Adults With XLH

X-linked Hypophosphatemia

United Kingdom, France, Ireland, Italy
Rocket Pharmaceuticals Inc.

Unknown

A Clinical Trial to Evaluate the Safety of RP-L102 in Pediatric Subjects With Fanconi Anemia Subtype A

Fanconi Anemia Complementation Group A

United States
Children's Hospital Medical Center, Cincinnati
Amgen

Completed

Pilot Study of Etanercept (Enbrel) in Children With Fanconi Anemia

Fanconi Anemia

United States
Rocket Pharmaceuticals Inc.

Enrolling by invitation

Long-Term Follow-up of Subjects With Fanconi Anaemia Subtype A Treated With ex Vivo Gene Therapy

Fanconi Anemia | Fanconi Anemia Complementation Group A

Spain
Kyowa Hakko Kirin Pharma, Inc.

Completed

A Study of KRN23 in X-linked Hypophosphatemia

X-linked Hypophosphatemia

United States
Turku University Hospital

Not yet recruiting

Noninvasive Evaluation of Fetal Hyperinsulinemia With Ultrasound Radiomics

Diabetes Mellitus, Type 1 | Pregnancy in Diabetic

Finland
Gilead Sciences

Completed

Study to Evaluate the Safety and Efficacy of Teropavimab and Zinlirvimab in Combination With Lenacapavir (GS-6207) in Virologically Suppressed Adults With HIV-1 Infection

HIV-1 Infection

United States
Shanghai Public Health Clinical Center

Completed

Zadaxin and HIV-positive Patients With Immune Reconstitution Disorder

HIV-1-infection

China
AbbVie

Terminated

A Study to Assess Effectiveness and Safety of Fixed Dose Combination of Lopinavir/Ritonavir (LPV/r) in Human Immunodeficiency Virus Type 1 (HIV-1) Infected Patients After Switching From Kaletra in the Routine Clinical Settings of Russian Federation (COPI)

HIV-1 Infection

Russian Federation
Luis Montaner
National Institute of Allergy and Infectious Diseases (NIAID); University of... and other collaborators

Unknown

Peg-Interferon Alpha 2b Combined With Two Intravenous Broadly HIV-1 Neutralizing Antibodies 3BNC117 and 10-1074 (BEAT-2) (BEAT-2)

HIV/AIDS | HIV | HIV-1 Infection

United States
AIDS Healthcare Foundation
HIV Immunotherapeutics Institute

Completed

Study of Pentasa® for Reducing Residual Systemic Immune Activation in Treated HIV Infection

HIV-1-infection | Gut Inflammation

United States
ANRS, Emerging Infectious Diseases
ViiV Healthcare

Completed

A Trial Evaluating Maintenance Therapy With Lamivudine (Epivir®) and Dolutegravir (Tivicay®) in Human Immunodeficiency Virus 1 (HIV-1) Infected Patients Virologically Suppressed With Triple Highly Active Antiretroviral Therapy (HAART) (ANRS 167 Lamidol)

HIV-1 Infection

France
Gilead Sciences

Completed

Ritonavir-Boosted GS-9137 vs. Ritonavir-Boosted Protease Inhibitor(s) in Combination With Background ART.

HIV | Human Immunodeficiency Virus | HIV-1

United States, Puerto Rico
Kyowa Kirin Co., Ltd.

Active, not recruiting

Study to Assess the Safety, Pharmacokinetics and Efficacy of KRN23 in Adult Chinese Patients With XLH

X-linked Hypophosphatemia (XLH)

China
Kyowa Kirin Co., Ltd.

Completed

A Study of KRN23 in Adult and Pediatric Patients With X-linked Hypophosphatemic Rickets/Osteomalacia

XLH

Japan, Korea, Republic of
National Center for Research Resources (NCRR)
University of California, San Diego

Completed

Evaluation of Fanconi Syndrome and Cystinosis

Fanconi Syndrome | Cystinosis
Lei Li

Recruiting

Tislelizumab and Radiotherapy for Recurrent Cervical Cancer

Recurrent Cervical Carcinoma | Radiotherapy | Immunotherapy | Survival Outcomes | Immune Checkpoint Inhibitors | Objective Response Rate | Metastatic Cervical Carcinoma | Tislelizumab | Persistent Cervical Carcinoma | Anti-programmed Cell Death Receptor 1

China
Carmel Medical Center

Recruiting

Decrease Type II Diabetes in Gestational Diabetes Population

Diabetes Mellitus, Type 2 | Diabetes Mellitus, Type 1 | Impaired Glucose Tolerance | Gestational Diabetes | Breastfeeding

Israel
University of Alabama at Birmingham
National Institute of Mental Health (NIMH); Washington University School of... and other collaborators

Completed

Reaching 90 90 90 in Adolescents in Zambia: Using All Our SKILLZ (SKILLZ)

HIV Infections | Pregnancy Related | Mental Health Wellness 1 | STI

Zambia
Ain Shams University
Ahram Canadian University

Completed

The Impact of Sitagliptin as an Add on Therapy With Closed Loop Control in Adolescents With Diabetic Nephropathy

Type 1 Diabetic Nephropathy

Egypt
Janssen Scientific Affairs, LLC

Completed

A Study to Evaluate the Efficacy and Safety of (D/C/F/TAF) Once Daily Fixed Dose Combination (FDC) Regimen in Newly Diagnosed, Antiretroviral Treatment-naive Human Immunodeficiency Virus Type 1 (HIV-1) Infected Participants Receiving Care in a Test and Treat Model of Care

HIV-1

United States
Central Hospital, Nancy, France

Unknown

Intracavernous Injection of Autologous Mesenchymal Stem Cells in the Treatment of Erectile Dysfunction Resistant to Oral Treatment in Patients With Type I Diabetes (MESERIC)

Diabetes Mellitus, Type 1 | Erectile Dysfunction | Stem Cells
Kyowa Kirin Co., Ltd.

Active, not recruiting

Study to Assess the Safety, Pharmacokinetics and Efficacy of KRN23 in Pediatric Chinese Patients With XLH

X-linked Hypophosphatemia (XLH)

China
Kyowa Kirin Pharmaceutical Development Ltd

Active, not recruiting

Registry for Patients With X-Linked Hypophosphatemia (XLH Registry)

X-Linked Hypophosphatemia

Spain, Italy, United Kingdom, France, Belgium, Denmark, Germany, Hungary, Portugal, Norway, Switzerland, Israel, Netherlands, Czechia, Bulgaria, Sweden, Slovenia, Ireland, Latvia, Slovakia
Children's Mercy Hospital Kansas City

Withdrawn

Calcimimetics in Hypophosphatemic Rickets (CHR)

Familial Hypophosphatemic Rickets

United States
Instituto Nacional de Cardiologia Ignacio Chavez
EchoNous Inc.

Recruiting

Ultrasound Guided Diuretic Therapy in Type 1 Cardiorenal Syndrome (NEEDED)

Cardiorenal Syndrome Type 1

Mexico
Chulalongkorn University

Not yet recruiting

The Treatment Effects of Empagliflozin on Renal Outcomes in Cardiorenal Syndrome Type 1 (TREAT-CRS)

Empagliflozin in Cardiorenal Syndrome Type 1

Thailand
Sun Yat-sen University

Recruiting

Treating Muscle-invasive Bladder Cancer With A Non-surgical Method Consisting of Anti-PD-1 Therapy and Chemoradiation (BCIRT-01)

Muscle-Invasive Bladder Carcinoma | Radiotherapy | Programmed Cell Death Protein 1 Inhibitor

China
Lei Li

Recruiting

PD-1 Antibody and Radiotherapy for Recurrent Cervical Cancer

Recurrent Cervical Carcinoma | Radiotherapy | Immune Checkpoint Inhibitors | Overall Survival | Anti-programmed Death-1 Antibody | Metastatic Cervical Carcinoma | Persistent Advanced Cervical Carcinoma | Objective Remission Rate | Progression-free Survival | Severe Adverse Events

China
University of Pennsylvania
National Institute of Drug Abuse; The Wistar Institute; Ho Chi Minh City CDC; Institute...

Recruiting

Anti-retroviral Therapy, Medications for Opioid Use Disorder, Opioids and HIV Infection - Study 1 (AMOHI-1)

Inflammation | Opioid-use Disorder | HIV-1-infection | Immune Activation | Buprenorphine | Methadone | Naltrexone | Antiretroviral Treatment

United States, Vietnam
AbbVie

Completed

A Study to Evaluate the Safety, Pharmacokinetics and Pharmacodynamics of ABBV-181 (Budigalimab) in Adult Participants With Human Immunodeficiency Virus (HIV)-1

HIV Infection | HIV-1 | Human Immunodeficiency Virus (HIV)

United States, Australia, Canada, Puerto Rico
Pregistry
Harvard School of Public Health (HSPH)

Completed

Health and Wellbeing of Pregnant and Post-Partum Women During the COVID-19 Pandemic

Depression | COVID-19 | Pregnancy Complications | Anxiety | Mental Health Wellness 1 | Coronavirus | Ptsd

United States
Fatma ketenci gencer

Completed

Hepassocin Levels in Patients With Polycystic Ovary Syndrome

Obesity | Polycystic Ovary Syndrome | Insulin Resistance | Hepassocin (Hepatocyte-derived Fibrinogen-related Protein 1)

Turkey
Hospices Civils de Lyon

Completed

IDENTIFICATION OF A MULTI-ANALYTE PROFILE FOR PRIMARY HYPEROXALURIA AND COMPARISON WITH HEALTHY SIBLINGS AND IDIOPATHIC HYPERCALCIURIA (PH1)

Idiopathic Hypercalciuria | Primary Hyperoxaluria Type 1

France
Merck Sharp & Dohme LLC

Completed

A Study to Assess the Efficacy of Raltegravir (Isentress®), Administered in Combination With Other Antiretroviral Drugs as Treatment for Adults and Older Adults Infected With the Human Immunodeficiency Virus 1 (HIV-1)(MK-0518-145) (Wirksamkeit Von Isentress® Unter Praxisbedingungen) (WIP)

HIV-1 Infection
PENTA Foundation
Medical Research Council; ANRS, Emerging Infectious Diseases

Completed

KONCERT A Kaletra ONCE Daily Randomised Trial of the Pharmacokinetics, Safety and Efficacy of Twice-daily Versus Once-daily Lopinavir/Ritonavir Tablets Dosed by Weight as Part of Combination Antiretroviral Therapy in Human Immunodeficiency Virus-1 (HIV-1) Infected Children (PENTA 18) (KONCERT)

Antiretroviral Therapy in HIV-1 Infected Children

Netherlands, Germany, United Kingdom, Ireland, Thailand
Tibotec Pharmaceuticals, Ireland

Completed

A Study With TMC125 in Human Immunodeficiency Virus (HIV) Type 1 Infected Patients, Who Were Treated With TMC125 Arm in a Sponsor-Selected TMC125 Study

Human Immunodeficiency Virus Type 1
Shanghai Jiao Tong University School of Medicine

Completed

Adiponectin in Obese Women With T2DN and Effects by RAS Blocker

Diabetic Nephropathy | Type 2 Diabetes | Obese | Glucose Metabolism | Angiotensin II Type 1 Receptor Blockers
Janssen R&D Ireland

Completed

Study to Evaluate Efficacy and Safety of Darunavir/Cobicistat/Emtricitabine/Tenofovir Alafenamide (D/C/F/TAF) Regimen Versus Boosted Protease Inhibitor (bPI) Along With Emtricitabine/Tenofovir Disoproxil Fumarate (FTC/TDF) Regimen in Virologically-Suppressed, HIV-1 Infected Participants

Human Immunodeficiency Virus Type 1

United States, France, United Kingdom, Belgium, Spain, Switzerland, Sweden, Canada, Puerto Rico, Poland
University Hospital, Ghent

Completed

The Hysteroscopic Morcellator (HM). (HM)

Large Intrauterine Polyps | Smaller Type 0 and 1 Myomas | Residual Placental Tissue

Belgium, Netherlands
The University of Texas Medical Branch, Galveston

Completed

Adipose Tissue Function After Pancreas Transplantation

Diabetes Mellitus, Type 2 | Diabetes Mellitus, Type 1 | End Stage Renal Disease

United States
Janssen Infectious Diseases BVBA

Completed

A Study to Evaluate the Pharmacokinetic Effects of Different Storage Conditions for a Long-Acting Nanosuspension of Rilpivirine on Pharmacokinetics

Human Immunodeficiency Virus Type 1

Belgium
ViiV Healthcare
Pfizer

Withdrawn

Maraviroc Compassionate Use

Human Immunodeficiency Virus Type 1
Janssen-Cilag S.p.A.

Completed

A Study to Compare Brachial Artery Reactivity and Cardiovascular Risk of a Treatment Simplification by Darunavir/Ritonavir (DRV/r) 800/100 mg Versus a Triple Combination Therapy Containing DRV/r in HIV-1 Infected Patients (MONARCH)

Human Immunodeficiency Virus 1

Clinical Trials on Organic Cation Transporter 1

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