Clinical Trials on Paralyses, Familial Periodic

Total 3013 results

Ionis Pharmaceuticals, Inc.

Completed

Extension Study Assessing Long Term Safety and Efficacy of IONIS-TTR Rx in Familial Amyloid Polyneuropathy (FAP)

Amyloidosis | Familial Amyloid Polyneuropathy | FAP | TTR | Transthyretin

United States, Spain, Argentina, Brazil, France, Germany, Italy, Portugal, United Kingdom
Ionis Pharmaceuticals, Inc.

Completed

Efficacy and Safety of Inotersen in Familial Amyloid Polyneuropathy

Amyloidosis | Familial Amyloid Polyneuropathy | FAP | TTR | Transthyretin

New Zealand, United States, Spain, Argentina, Brazil, France, Germany, Italy, Portugal, United Kingdom
Novartis Pharmaceuticals

Terminated

Extension to a Randomized, Double-blind, Placebo Controlled Study of LCQ908 in Subjects With Familial Chylomicronemia Syndrome.

Familial Chylomicronemia Syndrome (FCS) (HLP Type I)

South Africa, Germany, United Kingdom, France, United States, Canada, Netherlands
Association pour le Développement et l'Organisation...

Completed

Assesment of New Devices for the Diagnostic Evaluation of Diaphragmatic Dysfunction (DYSDIA)

Healthy Volunteers | Diaphragmatic Paralysis

France
Istanbul Medipol University Hospital

Active, not recruiting

EEG Results of Deep TMS in Patients With OCD

Obsessive-Compulsive Disorder | EEG With Periodic Abnormalities

Turkey
ResMed

Completed

Comparison of Modified With Conventional Adaptive Servoventilation Processes

Cheyne-Stokes Respiration | Periodic Breathing

Germany
Instituto de Investigación Sanitaria Aragón
Hospital Miguel Servet

Completed

Diaphragmatic Paralysis Comparison Between Local Anesthetic Volumen Doses After Interscalene Block (REDOLEV-2019)

Brachial Plexus Block | Diaphragmatic Paralysis

Spain
Centre Hospitalier Universitaire de Nice

Withdrawn

Effect of Psyllium (Plantago Ovata) on Digestive Disorders in Familial Amyloidosis (Psyllium)

Familial Amyloidosis

France
Assistance Publique Hopitaux De Marseille

Completed

Expanding the Biomarkers in Familial Amyloid Neuropathy: MRI and Motor Unit Estimation by Electrophysiological Study

Amyloid Neuropathies | Transthyretin Amyloidosis

France
Nantes University Hospital
Pfizer

Completed

Assessment of the Prevalence of TTR Amyloid Neuropathy in a Population of Patients With Neuropathy of Unknown Aetiology (PRE-TRANS)

Transthyretin Amyloidosis | Familial Amyloid Neuropathy

France
University of Manitoba

Completed

Pulmonary Function Changes and Diaphragmatic Paralysis Following Ultrasound Guided Supraclavicular Brachial Plexus Blockade: The Effects of Decreased Local Anesthetic Volume

Lung Function | Diaphragmatic Function

Canada
University of Illinois at Chicago

Withdrawn

Digoxin for Congenital Erythrocytosis Due to Up-Regulated Hypoxia Sensing

VHL Gene Mutation | Polycythemia; Familial | Erythrocytosis; Familial | HIF-2alpha Erythrocytosis | PHD2 Erythrocytosis | Chuvash Erythrocytosis
Spaulding Rehabilitation Hospital

Completed

FES-Rowing: Preventing the Secondary Conditions of Paralysis Through Vigorous Exercise

Paralysis, Legs

United States
National Institute of Allergy and Infectious Diseases...

Recruiting

Evaluating the Genetics and Immunology of Periodic Fever, Aphthous Stomatitis, Pharyngitis, and Cervical Adenitis (PFAPA) Syndrome and Other Tonsil Disorders

Obstructive Sleep Apnea | Sleep Disordered Breathing | Tonsillitis | Periodic Fever, Aphthous Stomatitis, Pharyngitis, And Cervical Adenitis (Pfapa) | Tonsil Disorder

United States
Capital Medical University
Peking University First Hospital; The First Affiliated Hospital of Anhui Medical... and other collaborators

Recruiting

The Chinese Familial Alzheimer's Network (CFAN)

Alzheimer Disease | Familial Alzheimer Disease (FAD)

China
Rabin Medical Center

Unknown

Ilaris (Canakinumab) in Patient With Periodic Fever, Aphthous Stomatitis, Pharyngitis and Cervical Adenitis (PFAPA)

Periodic Fever

Israel
Advanced Reconstructive Surgery Alliance

Active, not recruiting

A Chart Review to Evaluate the Safety and Efficacy of Phrenic Nerve Reconstruction for the Treatment of Diaphragmatic Paralysis

Diaphragm Issues | Diaphragmatic Paralysis | Breath Shortness | Diaphragm; Paralysis, Due to Accidental Section of Phrenic Nerve During Procedure

United States
University Hospital, Montpellier
PhyMedExp Inserm U1046

Terminated

Anatomopathology of the Subscapularis and Infraspinatus Muscles in Children With Brachial Plexus Obstetric Paralysis (POPB)

Brachial Obstetrical Palsy

France
Pfizer

Completed

An Extension of Study Fx-005 Evaluating Long-Term Safety And Clinical Outcomes Of Fx-1006A In Patients With Transthyretin Amyloid Polyneuropathy

Familial Amyloid Polyneuropathy | ATTR-PN

Sweden, Brazil, Germany, Argentina, France, Portugal
University Hospital, Basel, Switzerland

Completed

Effects of FXR Activation on Hepatic Lipid and Glucose Metabolism

Metabolic Syndrome | Familial Combined Hyperlipidemia | Familial Hypertriglyceridemia

Switzerland
KU Leuven

Completed

Effects of Inspiratory Muscle Training on Exertional Breathlessness in Patients With Unilateral Diaphragm Paralysis

Diaphragmatic Paralysis

Belgium
Pak Emirates Military Hospital

Completed

A Novel Approach for VC Lateralization, With Prolene Suture Stabilized Over Prolene Mesh

Paralysis of Vocal Cords or Larynx | Bilateral Vocal Cord Paralysis

Pakistan
Imperial College London

Unknown

The Cyclocapnic Method for Measurement of Chemosensitivity

Heart Failure | Periodic Breathing

United Kingdom
Clinique Medipole Garonne

Completed

Diaphragmatic Paralysis in Arthroscopic Shoulder Surgery

Hypoxia | Analgesia | Dyspnea

France
University Hospital, Montpellier

Completed

Modeling and Pharmacological Targeting of Genetic Cardiomyopathy in Children Via Cardiomyocytes Derived From Induced Pluripotent Stem Cells (DMDstem) (DMDstem)

Cardiomyopathy, Familial

France
Kyoto University
Osaka University; Mie University; Tokushima University; Tokyo Metropolitan Geriatric... and other collaborators

Completed

Repurposing Bromocriptine for Abeta Metabolism in Alzheimer's Disease (REBRAnD)

Familial Alzheimer Disease (FAD) | PSEN1 Mutation

Japan
South Valley University

Completed

Clinical and Sonographic Diaphragm Evaluation Post-plication

Diaphragmatic Plication | Unilateral Diaphragmatic Paralysis | Diaphragm Ultrasonography
Seoul National University Hospital

Completed

Intraoperative Lung Ultrasound in Pediatric Patients (LUS)

Ultrasonography | Lung | Pediatrics | Cardiac Surgical Procedures | Perioperative Period

Korea, Republic of
Centre d'Investigation Clinique et Technologique...

Unknown

Regional Distribution of Ventilation to Assess Respiratory Muscle Dysfunction (DREM)

Respiratory Failure | Neuromuscular Disorder | Diaphragmatic Paralysis

France
Amgen

Completed

Reduction of Low-Density Lipoprotein Cholesterol (LDL-C) With PCSK9 Inhibition in Heterozygous Familial Hypercholesterolemia Disorder Study (RUTHERFORD)

Hypercholesterolemia, Familial
Institute of Health Information and Statistics...
Centre of Cardiovascular and Transplantation Surgery, Czech Republic; The Central... and other collaborators

Recruiting

Pilot Project of Familial Hypercholesterolemia Screening in Newborns in the Czech Republic (CzeCH-IN)

Familial Hypercholesterolaemia

Czechia
Vanderbilt University Medical Center

Recruiting

Mechanisms of Familial Pulmonary Fibrosis

Idiopathic Pulmonary Fibrosis | Familial Pulmonary Fibrosis | Familial Interstitial Pneumonia

United States
Fundación Hipercolesterolemia Familiar
Instituto de Salud Carlos III; Fundación Centro Nacional de Investigaciones...

Recruiting

The Spanish Familial Hypercholesterolaemia Cohort Study (SAFEHEART)

Familial Hypercholesterolaemia

Spain
Kastle Therapeutics, LLC

Completed

A Study of the Safety and Efficacy of Two Different Regimens of Mipomersen in Patients With Familial Hypercholesterolemia and Inadequately Controlled Low-Density Lipoprotein Cholesterol (FOCUS FH)

Hypercholesterolemia | Heterozygous Familial

United States, Italy, Poland, Ukraine, United Kingdom, Germany, Hong Kong, Taiwan, Spain, Argentina, Belgium, Israel, Malaysia, South Africa, Turkey, Netherlands, Korea, Republic of, Canada, New Zealand, Russian Federation, Brazil, Austral... and more
Kastle Therapeutics, LLC
Ionis Pharmaceuticals, Inc.

Completed

Dose-escalating Safety Study of ISIS 301012 in Homozygous Familial Hypercholesterolemia Subjects on Lipid Lowering Therapy

Hypercholesterolemia, Familial

United States, Netherlands
Poitiers University Hospital

Recruiting

Efficacy of Oral Corticosteroid Therapy in Recurrent Paralyzes After Thyroidectomy

Recurrent Paralysis of Vocal Cords

France
Pamukkale University

Recruiting

Client-Centered Breastfeeding Support: Effects on Primipara Mothers in a Randomized Trial Breastfeeding Self-Efficacy, Attitudes, and Problems in Primiparous Mothers: A Randomized Controlled Trial

Breastfeeding Self-Efficacy Attitude to Health Postpartum Period Primiparity

Turkey
Pamukkale University

Not yet recruiting

The Effect of Digital Storytelling Applied to Children in Preoperative Period

Child | Preoperative Period
Central Hospital, Nancy, France

Not yet recruiting

Hospitalizations in Neonatal Period and Early Discharge of Maternity

Hospitalization | Neonatal Period | Early Maternity Discharge | Risk Factor Readmission
Mahidol University

Completed

Ketamine Combination With Spinal Morphine for Post Thoracic Surgery Pain : A Randomized Control Study

Pain | Postoperative Period

Thailand
Seoul National University Hospital

Completed

Effects of Recruitment Maneuver in Patients Undergoing Robotic Assisted Radical Prostatectomy

Effects of Recruitment Maneuver During Intraoperative and Postoperative Period

Korea, Republic of
Nemours Children's Clinic

Completed

TAPB vs. Caudal for Lower Abdominal Surgery in Children: A Double-Blinded Randomized Controlled Trial

Anesthesia, Recovery Period

United States
Novartis Pharmaceuticals

Recruiting

Specified Drug-use Survey of Leqvio for s.c. Injection.

Hypercholesterolaemia | Familial Hypercholesterolaemia

Japan
Amgen

Completed

Safety, Tolerability and Efficacy of Evolocumab (AMG 145) in Children With Inherited Elevated Low-density Lipoprotein Cholesterol (Familial Hypercholesterolemia) (HAUSER-OLE)

Familial Hypercholesterolemia

Canada, Italy, Norway, Belgium, United States, Turkey, Australia, Austria, South Africa, Poland, Switzerland, Spain, Portugal, Slovenia, Brazil, Russian Federation, Hungary, United Kingdom, Colombia, Czechia, Netherlands, Greece, Ma...
Regeneron Pharmaceuticals

Completed

Evaluate the Long-Term Safety and Efficacy of Evinacumab in Patients With Homozygous Familial Hypercholesterolemia

Homozygous Familial Hypercholesterolemia

United States, Netherlands, South Africa, Australia, Austria, Canada, Czechia, France, Greece, Italy, Japan, Ukraine
Shanghai Junshi Bioscience Co., Ltd.

Completed

A Study to Evaluate the Efficacy and Safety of JS002 in Patients With Heterozygous Familial Hypercholesterolemia (HeFH).

Heterozygous Familial Hypercholesterolemia

China
Mirum Pharmaceuticals, Inc.

Completed

Open Label Study to Evaluate Efficacy and Long Term Safety of LUM001 (Maralixibat) in the Treatment of Cholestatic Liver Disease in Patients With Progressive Familial Intrahepatic Cholestasis (INDIGO)

Progressive Familial Intrahepatic Cholestasis (PFIC)

United States, United Kingdom, Poland, France
Daniel Gaudet
Ultragenyx Pharmaceutical Inc

Active, not recruiting

Safety and Effectiveness of Evinacumab for the Treatment of Homozygous Familial Hypercholesterolemia

Homozygous Familial Hypercholesterolemia

Canada
Innovent Biologics (Suzhou) Co. Ltd.

Completed

Safety and Efficacy of IBI306 in HeFH Patients

Heterozygous Familial Hypercholesterolemia

China
Amryt Pharma

Active, not recruiting

Efficacy and Safety of Lomitapide in Paediatric Patients With Homozygous Familial Hypercholesterolaemia (HoFH)

Homozygous Familial Hypercholesterolaemia (HoFH)

Germany, Israel, Italy, Saudi Arabia, Spain, Tunisia

Clinical Trials on Paralyses, Familial Periodic

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