The Chinese Familial Alzheimer's Network

A Multi-center Longitudinal Cohort Study of Familial Alzheimer's Disease in China

Sponsors

Lead Sponsor: Capital Medical University

Collaborator: Beijing Tiantan Hospital
Beijing Chao Yang Hospital
Fu Xing Hospital, Capital Medical University
Peking Union Medical College Hospital
Peking University First Hospital
Peking University Third Hospital
Chinese PLA General Hospital
China-Japan Friendship Hospital
Beijing Geriatric Hospital
The First Affiliated Hospital of Dalian Medical University
Fujian Medical University Union Hospital
Guangzhou Psychiatric Hospital
Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University
First Affiliated Hospital of Guangxi Medical University
The Affiliated Hospital Of Guizhou Medical University
Handan Central Hospital
Hebei General Hospital
First Hospital of Shijiazhuang City
Tangshan Worker's Hospital
Henan Provincial People's Hospital
Kaifeng Central Hospital
People's Hospital of Zhengzhou University
First Affiliated Hospital of Harbin Medical University
Tongji Hospital
People's Hospital Affiliated Hubei Medical University
Wuhan University Zhongnan Hospital
The Third Xiangya Hospital of Central South University
Xiangya Hospital of Central South University
The First Hospital of Jilin University
China-Japan Union Hospital, Jilin University
Subei People's Hospital of Jiangsu
Nantong University Affiliated Hospital
Mineral General Hospital, Xuzhou
Jiangxi Provincial People's Hopital
Anshan Central Hospital
The Affiliated Zhongshan Hospital of Dalian University
First Hospital of China Medical University
Baotou Central Hospital
General Hospital of Ningxia Medical University
The People's Hospital of Ningxia
The Affiliated Hospital of Qingdao University
The 960th Hospital of PLA
Qilu Hospital of Shandong University
Qilu Hospital of Shandong University (Qingdao)
Shandong Provincial Hospital
Qingdao Municipal Hospital
The First Affiliated Hospital of Shanxi Medical University
Tang-Du Hospital
First Affiliated Hospital Xi'an Jiaotong University
Ruijin Hospital
RenJi Hospital
Shanghai Changzheng Hospital
Affiliated Hospital of North Sichuan Medical College
Tianjin Huanhu Hospital
Tianjin Medical University General Hospital
Traditional Chinese Medicine Hospital of Xinjiang Autonomous Region
Ningbo Medical Center Lihuili Hospital
First Affiliated Hospital of Wenzhou Medical University
First Affiliated Hospital of Zhejiang University
Shao Yifu Hospital of Zhejiang Medical University
Zhejiang Provincial People's Hospital
Daping Hospital and the Research Institute of Surgery of the Third Military Medical University
The Second Affiliated Hospital of Chongqing Medical University
The First Affiliated Hospital of Anhui Medical University
People's Hospital of Chongqing
Dongfang Hospital Beijing University of Chinese Medicine
Zigong First People's Hospital

Source Capital Medical University
Brief Summary

This research will establish and continuously improve the FAD research network in conjunction with multi-center institutions nationwide. By collecting information on the family's demography, genetics, neuropsychology, neuroimaging, biomarkers and other information, we can understand the current FAD population in China, clarify the genetic characteristics, pathogenesis, disease characteristics and diagnosis and treatment status of AD in China; which will lay the foundation for ameliorating clinical diagnosis and treatment, establishing a Chinese FAD clinical database and an international cooperative research platform. 1. To set up a multi-center, nationwide FAD research network and database platform in China 2. To clarify the epidemiological characteristics of FAD in China. 3. To clarify the genetic characteristics of FAD in China. 4. To clarify the clinical characteristics and disease development laws of FAD. 5. To discover and verify the early diagnosis biomarkers of AD. 6. To establish a genetic counseling model.

Detailed Description

1. The network and database include ADAD cohort of the known mutations of PSEN1, PSEN2 and APP (mutation carriers and noncarriers; pre-symptomatic and symptomatic) and unknown mutations cohort. 2. Conduct a comprehensive FAD epidemiological survey in China to clarify the impact of different nationalities, regions, gender, age, living environment (rural/urban), education level, etc. on the occurrence and development of the disease. 3. This project is to discover new FAD mutation sites,pathogenic genes, to protective genes, to explore the pathogenic and protective mechanism, to analyze the disease development laws of families with different sizes of FAD in China, and to clarify the frequency distribution of mutant genes in the Chinese FAD population. 4. The project will collect and regularly follow-up the samples (blood, urine and saliva etc.) and data (neuropsychology, imaging etc.) in the cohort. Emphasis is placed on the occurrence and development of asymptomatic mutant gene carriers from asymptomatic to symptomatic periods. 5. In the FAD family cohort, we will screen high-sensitivity and high-specificity body fluid markers suitable for Chinese people, verify in the SAD cohort, and establish a prediction model of body fluid markers for AD occurrence and disease progression; use structural MRI, dual tracer 18F-FDG PET and 11C-PIB PET multimodal imaging technology, dynamically monitor the dynamic evolution of imaging biomarkers such as brain structure, glucose metabolism and Aβ deposition at various stages of AD progression. 6. We will combine with the genetic characteristics of Chinese FAD to analyze the impact of lifestyle, physical exercise, nootropic drugs, cognitive training, etc. on the disease progression of FAD patients or asymptomatic mutant gene carriers, to establish a genetic counseling model.

Overall Status Recruiting
Start Date 2005-01-10
Completion Date 2038-01-01
Primary Completion Date 2038-01-01
Study Type Observational [Patient Registry]
Primary Outcome
Measure Time Frame
The prevalence of gene mutations in familial Alzheimer's disease in China. An Average of 1 year
The development patterns of genetic, biofluid, imaging, and neuropsychological markers of FAD. An Average of 3 to 10 years
Secondary Outcome
Measure Time Frame
Changes of neuropsychological function in pedigree members at different stage of cognitive impairment in familial Alzheimer's disease in China. An Average of 1 year
Changes of brain structure in pedigree members at different stage of cognitive impairment in familial Alzheimer's disease in China. An Average of 1 year
Changes of brain glucose metabolism in pedigree members at different stage of cognitive impairment in familial Alzheimer's disease in China. An Average of 1 year
Changes of brain amyloid deposition in pedigree members at different stage of cognitive impairment in familial Alzheimer's disease in China. An Average of 1 year
Changes of brain tau deposition in pedigree members at different stage of cognitive impairment in familial Alzheimer's disease in China. An Average of 1 year
Changes of humoral biomarkers in pedigree members at different stage of cognitive impairment in familial Alzheimer's disease in China. Each biomarker with time frame of average 1 year
The effective non-pharmacologic treatment(NPT) intervention An Average of 1 year
Enrollment 40000
Condition
Eligibility

Sampling Method:

Non-Probability Sample

Criteria:

Familial Alzheimer's disease group Inclusion criteria: 1. Written informed consent obtained from the participant or a legal guardian prior to any study-related procedures; 2. At least two first-degree relatives in a family have AD (clinically or by testing),and at least 3 out of 2 generations are patients; 3. At least one family member with normal cognitive function (the age should be greater than the average age of onset of the family); 4. Pedigrees carrying FAD pathogenic genes (APP/PSEN1/PSEN2); 5. People in this family >18 years old can be recruited; 6. Participant is cognitively normal or demented but not reaching bedridden level; 7. Participants are able to provide two reliable informants who can provide clinical information; 8. Dementia is diagnosed according to the criteria described by the Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition, Text Revision (DSM-IV-R ); 9. The diagnosis of AD is made using the National Institute of Neurologic and Communicative Disorders and Stroke and the Alzheimer's Disease and Related Disorders Association (NINCDS-ADRDA ) or National Institute on Aging and the Alzheimer's Association (NIA-AA) criteria ; 10. The diagnosis of MCI is made according to Petersen criteria and the classification is according to the method of Lopez et al. Exclusion criteria: 1. Dementia caused by other factors such as depression, other psychiatric illnesses, thyroid dysfunction, encephalitis, multiple sclerosis, brain trauma, brain tumor, syphilis, acquired immunodeficiency syndrome (AIDS), Creutzfeldt-Jakob disease and other types of dementias such as vascular dementia (VaD), frontotemporal dementia (FTD), dementia with Lewy bodies (DLB), and Parkinson's dementia (PDD); 2. MRI and laboratory tests do not support or rule out a diagnosis of AD; 3. Severe circulatory, respiratory, urinary, digestive, hematopoietic diseases (such as unstable angina, uncontrollable asthma, active gastric bleeding) and cancer; 4. Participant has severe psychiatric illness or severe dementia that would interfere in completing initial and follow-up clinical assessments; 5. Participant has a history of alcoholism or drug abuse; 6. Pregnant or lactating women; 7. No reliable informant; 8. Lumbar puncture exclusion criteria:coagulation disorders or platelet counts < 100,000 cells/μL, lumbar surgery within the last 6 months prior to lumbar puncture that interferes with anatomy of the inter-vertebral spaces, History of chronic or repeated CSF leakage following previous LP(s); 9. MRI Exclusion Criteria: electronic and magnetic metal implants such as pacemakers, artificial heart valve, metal prosthesis, metal joint, etc.; metallic foreign body in the eye; aneurysm clips in the brain. Normal control group Inclusion criteria: 1. Aged 18 (inclusive) or above; 2. Normal MMSE and MoCA evaluations. MMSE>19 points for illiteracy, >24 points for those educated less than 7 years, >27 points for those educated equal to or more than 7 years. MoCA>13 points for illiteracy, >19 points for those educated less than 7 years, >24 points for those educated equal to or more than 7 years. Exclusion criteria: 1. Subjects with abnormal MMSE or MoCA scores; 2. Subjects with a history of cerebral infarction, traumatic brain injury or related manifestations in MRI; 3. Other neurological diseases that can cause brain dysfunction (such as depression, brain tumor, Parkinson's disease, metabolic encephalopathy, encephalitis, multiple sclerosis, epilepsy, brain trauma, normal intracranial pressure hydrocephalus, etc.); 4. Other systemic diseases that can cause cognitive impairment (such as liver, renal and thyroid insufficiency, severe anemia, folic acid or vitamin B12 deficiency, syphilis, HIV infection, alcohol and drug abuse, etc.); 5. Mental and neurodevelopmental retardation; 6. Suffering from a disease that cannot be combined with a cognitive examination; 7. Contraindications to MRI; 8. Refuse to draw blood; 9. Refuse to sign the informed consent at baseline.

Gender:

All

Minimum Age:

18 Years

Maximum Age:

N/A

Healthy Volunteers:

Accepts Healthy Volunteers

Overall Official
Last Name Role Affiliation
Jianping Jia, Doctor Study Chair Xuanwu Hospital of Capital Medical University
Overall Contact

Last Name: Jianping Jia, Doctor

Phone: +8610-83199449

Email: [email protected]

Location
Facility: Status: Contact:
The First Affiliated Hospital of Anhui Medical University | Hefei, Anhui, China Recruiting Yanghua Tian, Doctor [email protected]
Beijing Geriatric Hospital | Changping, Beijing, China Recruiting Jihui Lv [email protected]
Beijing Chao Yang Hospital | Chaoyang, Beijing, China Recruiting Yue Wang, Doctor [email protected]
China-Japan Friendship Hospital | Chaoyang, Beijing, China Recruiting Dantao Peng [email protected]
Dongfang Hospital Affiliated to Beijing University of Chinese Medicine | Fengtai, Beijing, China Recruiting Lanxiang Jin, Doctor [email protected]
Chinese PLA General Hospital | Haidian, Beijing, China Recruiting Jianjun Jia, Doctor [email protected]
Fu Xing Hospital, Capital Medical University | Haidian, Beijing, China Recruiting Fang Li, Doctor [email protected]
Peking University Third Hospital | Haidian, Beijing, China Recruiting Weizhong Xiao [email protected]
Peking Union Medical College Hospital | Xicheng, Beijing, China Recruiting Jing Gao, Doctor [email protected]
Peking University First Hospital | Xicheng, Beijing, China Recruiting Zhirong Jia [email protected]
Daping Hospital and the Research Institute of Surgery of the Third Military Medical University | Yuzhong, Chongqing, China Recruiting Yanjiang Wang
The Second Affiliated Hospital of Chongqing Medical University | Yuzhong, Chongqing, China Recruiting Yangmei Chen [email protected]
Fujian Medical University Union Hospital | Fujian, Guangdong, China Recruiting Qinyong Ye [email protected]
Guangzhou Psychiatric Hospital | Guangzhou, Guangdong, China Recruiting Mouni Tang, Doctor [email protected]
Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University | Zhongshan, Guangdong, China Recruiting Jun Liu, Doctor [email protected]
First Affiliated Hospital of Guangxi Medical University | Nanning, Guangxi, China Recruiting Shengliang Liang [email protected]
The Affiliated Hospital Of Guizhou Medical University | Guiyang, Guizhou, China Recruiting Lan Chu, Doctor [email protected]
Handan Central Hospital | Handan, Hebei, China Recruiting Minchen Kan, Doctor [email protected]
First Hospital of Shijiazhuang City | Shijiazhuang, Hebei, China Recruiting Huiying Zhao [email protected]
Tangshan Worker's Hospital | Tangshan, Hebei, China Recruiting Yongqiu Li, Doctor [email protected]
Hebei General Hospital | Zhijiazhuang, Hebei, China Recruiting Peiyuan Lv, Doctor [email protected]
First Affiliated Hospital of Harbin Medical University | Haerbin, Heilongjiang, China Recruiting Shurong Duan, Doctor [email protected]
Kaifeng Central Hospital | Kaifeng, Henan, China Recruiting Huanrong Yu, Doctor [email protected]
Henan Provincial People's Hospital | Zhengzhou, Henan, China Recruiting Jiewen Zhang, Doctor [email protected]
People's Hospital of Zhengzhou | Zhengzhou, Henan, China Recruiting Shuling Zhang, Doctor
People's Hospital Affiliated Hubei Medical University | Wuhan, Hubei, China Recruiting Jianjun Zhang, Doctor [email protected]
Tongji Hospital | Wuhan, Hubei, China Recruiting Min Zhang [email protected]
The Third Xiangya Hospital of Central South University | Wuhan, Hunan, China Recruiting Lu Shen [email protected]
Wuhan University Zhongnan Hospital | Wuhan, Hunan, China Recruiting Hanxing Liu [email protected]
Xiangya Hospital of Central South University | Wuhan, Hunan, China Recruiting Qiuyun Tu, Doctor [email protected]
Nantong University Affiliated Hospital | Nantong, Jiangsu, China Recruiting Maohong Cao, Doctor [email protected]
Subei People's Hospital of Jiangsu | Subei, Jiangsu, China Recruiting Jun Xu, Doctor [email protected]
Mineral General Hospital, Xuzhou | Xuzhou, Jiangsu, China Recruiting Liangqun Rong, Doctor [email protected]
Jiangxi Provincial People's Hospital | Nanchang, Jiangxi, China Recruiting Kunnan Zhang, Doctor [email protected]
China-Japan friendship Hospital of Jilin university | Changchun, Jilin, China Recruiting Qin Zhao, Doctor [email protected]
The First Hospital of Jilin University | Changchun, Jilin, China Recruiting Li Sun, Doctor [email protected]
Changda Hospital, Anshan | Anshan, Liaoning, China Recruiting Xiu Han, Doctor [email protected]
Affiliated Zhongshan hospital of Dalian university | Dalian, Liaoning, China Recruiting Qiang Ma, Doctor [email protected]
The First Affiliated Hospital of Dalian Medical University | Dalian, Liaoning, China Recruiting Cui Wang, Doctor [email protected]
First Hospital of China Medical University | Shenyang, Liaoning, China Recruiting Yunpeng Cao, Doctor [email protected]
Baotou Central Hospital | Baotou, Nei Monggol, China Recruiting Furu Liang, Doctor [email protected]
General Hospital of Ningxia Medical University | Yinchuan, Ningxia, China Recruiting Qin Zhang, Doctor [email protected]
The People's Hospital of Ningxia | Yinchuan, Ningxia, China Recruiting Yongying Gao, Doctor [email protected]
Qilu Hospital of Shandong University | Jinan, Shandong, China Recruiting Peiyan Shan, Doctor [email protected]
Shandong Provincial Hospital | Jining, Shandong, China Recruiting Yifeng Du, Doctor [email protected]
Qilu Hospital of Shandong University (Qingdao) | Qingdao, Shandong, China Recruiting Bin Liang, Doctor [email protected]
QingDao Municipal Hospital | Qingdao, Shandong, China Recruiting Lan Tan, Doctor [email protected]
The Affiliated Hospital of Qingdao University | Qingdao, Shandong, China Recruiting Jinping Sun, Doctor [email protected]
The 88th Hospital of PLA | Tai'an, Shandong, China Recruiting Jintao Zhang, Doctor [email protected]
Shanghai Changzheng Hospital | Huangpu, Shanghai, China Recruiting Jianhua Zhuang, Doctor [email protected]
Ruijin Hospital | Luwan, Shanghai, China Recruiting Gang Wang, Doctor [email protected]
RenJi Hospital | Putong, Shanghai, China Recruiting Qun Xu, Doctor [email protected]
The First Affiliated Hospital of Shanxi Medical University | Taiyuan, Shanxi, China Recruiting Yuling Tian, Doctor [email protected]
First Affiliated Hospital Xi'an Jiaotong University | Xi'an, Shanxi, China Recruiting Qiumin Qu, Doctor [email protected]
Tang-Du Hospital | Xi'an, Shanxi, China Recruiting Wei Zhang, Doctor [email protected]
Affiliated Hospital of North Sichuan Medical College | Nanchong, Sichuan, China Recruiting Ying Ma, Doctor [email protected]
Zigong First People's Hospital | Zigong, Sichuan, China Recruiting Xiaoya Xu, Doctor [email protected]
Tianjin Medical University General Hospital | Heping, Tianjin, China Recruiting Nan Zhang, Doctor [email protected]
Tianjin Huanhu Hospital | Jinnan, Tianjin, China Recruiting Yuying Zhou, Doctor [email protected]
Traditional Chinese Medicine Hospital of Xinjiang Autonomous Region | Urumqi, Xinjiang, China Recruiting Xinling Meng [email protected]
First Affiliated Hospital of Zhejiang University | Hangzhou, Zhejiang, China Recruiting Benyan Luo, Doctor [email protected]
Shao Yifu Hospital of Zhejiang Medical University | Hangzhou, Zhejiang, China Recruiting Peilin Lu, Doctor [email protected]
Zhejiang Provincial People's Hospital | Hangzhou, Zhejiang, China Recruiting Enyan Yu [email protected]
Ningbo City Medical Treatment Center Lihuili Hospital | Ningbo, Zhejiang, China Recruiting Guomin Xie, Doctor [email protected]
First Affiliated Hospital of Wenzhou Medical Univeristy | Wenzhou, Zhejiang, China Recruiting Zhen Wang [email protected]
Location Countries

China

Verification Date

2021-04-01

Responsible Party

Type: Principal Investigator

Investigator Affiliation: Capital Medical University

Investigator Full Name: Jianping Jia

Investigator Title: Chief Director

Keywords
Has Expanded Access No
Condition Browse
Arm Group

Label: Familial Alzheimer's disease group

Description: Familial Alzheimer's disease with the known mutation presenilin1 (PSEN1), presenilin2 (PSEN2) and amyloid precursor protein (APP) including mutation carriers and noncarriers, presymptomatic and symptomatic.

Label: Normal control group

Description: Normal cognitive control people

Acronym CFAN
Patient Data Undecided
Study Design Info

Observational Model: Cohort

Time Perspective: Prospective

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