Clinical Trials on Paroxysmal AF

Total 518 results

Biosense Webster, Inc.

Completed

CARTO® 3 System and Real Time Intracardiac Ultrasound (IUAF)

Atrial Fibrillation | Paroxysmal AF

United States
University Hospital, Clermont-Ferrand
Groupama foundation; Biochemistry Lab University Hospital Clermont-Ferrand

Recruiting

Predictive Properties of Myocardial Fibrosis Biomarkers on the Outcome of Atrial Fibrillation Ablation (PROFIB-AF)

Women and Men Over 18 Years Old | AF Ablation (ECS recommendation2020&ACS2014) Either for Paroxysmal AF Unresponsive to Anti-arrhythmic Treatment Either for Persisting Symptomatic AF | Able to Give His Non Opposition to Participate to the Study

France
Avidhrt Inc.
Michigan State University; ASCENSION SACRED HEART; Spring Arbor University

Not yet recruiting

Avidhrt Clinical Equivalence Study

Equivalence of ECG Electrode Type Signal Quality for AF and Non AF Users
Assiut University

Unknown

Demographic Outcomes, and Health Care Resources in Newly Diagnosed Non Valvular AF Patients

Non Valvular AF ,AF

Egypt
Boston Scientific Corporation

Recruiting

Watchman FLX Pro CT Pilot Study

Non-valvular Atrial Fibrillation (AF)

Denmark
Erasmus Medical Center

Unknown

Contact-Force-Sensing-Based Radiofrequency Catheter Ablation in Paroxysmal Supraventricular Tachycardias (COBRA-PATH)

Tachycardia, Supraventricular | Tachycardia; Paroxysmal, Supraventricular

Netherlands
Bayer

Completed

Study to Gather Information About the Proper Dosing of the Oral FXIa Inhibitor BAY 2433334 and to Compare the Safety of the Study Drug to Apixaban, a Non-vitamin K Oral Anticoagulant (NOAC) in Patients With Irregular Heartbeat (Atrial Fibrillation) That Can Lead to Heart-related Complications. (PACIFIC-AF)

Atrial Fibrillation (AF)

Spain, Belgium, Latvia, Italy, Switzerland, Canada, Austria, Japan, Czechia, Hungary, Netherlands, Sweden, France, United Kingdom
University Hospital, Basel, Switzerland
Boston Scientific Corporation

Completed

Characterization of Left Atrial Substrate by Comparison of Bipolar Voltage Maps With Standard Focal 4.5 mm Tip Electrode, 1 mm Ring Electrode, and Microelectrode Catheters Using InTEllaMap Orion and IntellaNav MIFI O (CHAZESubstrate)

Atrial Fibrillation (AF)

Switzerland
Anthos Therapeutics, Inc.
Laboratory Corporation of America; The TIMI Study Group

Active, not recruiting

Safety and Tolerability of Abelacimab (MAA868) vs. Rivaroxaban in Patients With Atrial Fibrillation (AZALEA-TIMI 71)

Stroke | Atrial Fibrillation (AF)

United States, Canada, Czechia, Hungary, Korea, Republic of, Poland, Taiwan
Assiut University

Not yet recruiting

the Role of Ivabradine in Causing AF in Patients With Chronic Coronary Syndrome

AF - Atrial Fibrillation
The First Affiliated Hospital of Xiamen University

Recruiting

Pulmonary Vein Isolation (PVI) Combined With Renal Denervation (RDN) in Atrial Fibrillation (AF) and Hypertension (HTN)

AF - Atrial Fibrillation | HTN-Hypertension

China
Apellis Pharmaceuticals, Inc.

Recruiting

A Study of Pegcetacoplan in Pediatric Patients With Paroxysmal Nocturnal Hemoglobinuria (PNH)

Paroxysmal Nocturnal Hemoglobinuria (PNH) | Paroxysmal Hemoglobinuria

Malaysia, United States, Czechia, France, Netherlands, Serbia, Spain, Thailand, United Kingdom
Anthos Therapeutics, Inc.

Recruiting

Study to evaLuate the effIcacy and Safety of abeLacimab in High-risk Patients With Atrial Fibrillation Who Have Been Deemed Unsuitable for Oral antiCoagulation (LILAC-TIMI 76) (LILAC-TIMI 76)

Atrial Fibrillation (AF)

United States, Canada, Israel, Japan, China, Brazil, Chile, United Kingdom, Bulgaria, Germany, Hungary, Italy, Poland, Romania, Spain, Czechia, Latvia, Mexico
Northwestern University
Cardiovascular Institute of the South Clinical Research Corporation

Enrolling by invitation

KardiaMobile ECG Monitoring Effects on Health Care Utilization and Patient Experience With Atrial Fibrillation

Atrial Fibrillation (AF)

United States
University Hospital, Basel, Switzerland

Completed

Accuracy of Cardiac Wearables Devices to Detect Atrial Fibrillation

Atrial Fibrillation (AF)

Switzerland
Maria Cecilia Hospital

Completed

Antral Lesions Characterization of a New Cryoballoon Ablation System in Terms of Local Impedance Drop (CryoLID)

Atrial Fibrillation (AF)

Italy
Ain Shams University

Completed

Predictors of Postoperative Atrial Fibrillation After Coronary Artery Bypass Grafting: A Prospective Cohort Study

AF - Atrial Fibrillation

Egypt
University Hospital, Toulouse

Completed

Medical and Surgical Hybrid Treatment of Atrial Fibrillation. (HT2AF)

Atrial Fibrillation (AF)

France
Novartis Pharmaceuticals

Completed

Proof of Concept Study to Assess the Efficacy, Safety and Pharmacokinetics of LFG316 in Patients With Paroxysmal Nocturnal Hemoglobinuria

Paroxysmal Nocturnal Hemoglobinuria PNH

Lithuania, Japan, Czechia
Ra Pharmaceuticals

Completed

Phase 2 Safety and Efficacy Study of Zilucoplan (RA101495) to Treat PNH Patients Who Have an Inadequate Response to Eculizumab

Paroxysmal Nocturnal Hemoglobinuria (PNH)

United States
Alexion Pharmaceuticals
Achillion, a wholly owned subsidiary of Alexion

Completed

Study of Danicopan in Participants With Paroxysmal Nocturnal Hemoglobinuria (PNH)

Paroxysmal Nocturnal Hemoglobinuria (PNH)

United Kingdom, New Zealand, Korea, Republic of, Italy
AKARI Therapeutics

Completed

Treating Paroxysmal Nocturnal Haemoglobinuria Patients With rVA576 (CAPSTONE)

Paroxysmal Nocturnal Hemoglobinuria (PNH)

Kazakhstan, Lithuania, Sri Lanka
Alexion Pharmaceuticals

Terminated

Safety and Pharmacokinetics of TT30 in Subjects With Paroxysmal Nocturnal Hemoglobinuria (PNH)

Paroxysmal Nocturnal Hemoglobinuria (PNH)

United States, Czech Republic, Italy, Poland, United Kingdom
Vivek Reddy

Recruiting

LS-PersAFone: Pulsed Field Ablation for Long-Standing Persistent Atrial Fibrillation (LS-PersAFone)

Long-standing Persistent AF

United States
Biosense Webster, Inc.

Active, not recruiting

A Study of Multi-electrode Circular Irreversible Electroporation (IRE) Catheter and Multi-Channel IRE Generator in Paroxysmal Atrial Fibrillation (AF) (AFIRE)

Refractory Paroxysmal Atrial Fibrillation

China
Boston Scientific Corporation

Completed

Clinical Evaluation of the Blazer Open-Irrigated Ablation Catheter for the Treatment of Paroxysmal Atrial Fibrillation (ZERO-AF)

Paroxysmal Atrial Fibrillation (PAF)

United States, Spain, Germany, Australia, United Kingdom, Sweden, Czechia, France, Portugal
National Heart, Lung, and Blood Institute (NHLBI)

Completed

Transfer of GPI-Linked Proteins to Transfused Patients With Paroxysmal Nocturnal Hemoglobinuria

Paroxysmal Hemoglobinuria

United States
Alexion

Completed

ALXN1210 Versus Eculizumab in Adult Participants With Paroxysmal Nocturnal Hemoglobinuria (PNH) Currently Treated With Eculizumab

Paroxysmal Nocturnal Hemoglobinuria (PNH)

United States, Korea, Republic of, Canada, France, Germany, Spain, United Kingdom, Japan, Australia, Italy, Netherlands
Ra Pharmaceuticals

Completed

Phase 2 Safety and Efficacy Study of Zilucoplan (RA101495) to Treat PNH Patients

Paroxysmal Nocturnal Hemoglobinuria (PNH)

United Kingdom, Australia, Canada, Denmark, Finland, Germany, Hungary, New Zealand
Alnylam Pharmaceuticals

Completed

A Phase 1/2 Study of an Investigational Drug, ALN-CC5, in Healthy Adult Volunteers and Patients With PNH

Paroxysmal Nocturnal Hemoglobinuria (PNH)

Spain, United Kingdom
King's College Hospital NHS Trust

Completed

Study of Global Coagulation Tests in Patients With Paroxysmal Nocturnal Haemoglobinuria

Paroxysmal Nocturnal Haemoglobinuria

United Kingdom
Alexion Pharmaceuticals

Completed

Extension Study of Eculizumab in Patients With Transfusion Dependent Paroxysmal Nocturnal Hemoglobinuria (PNH)

Paroxysmal Hemoglobinuria, Nocturnal

United States, Australia, Belgium, Canada, Germany, Italy, Spain, Sweden, United Kingdom, France, Ireland, Netherlands
National Heart, Lung, and Blood Institute (NHLBI)

Completed

Eculizumab to Treat Paroxysmal Nocturnal Hemoglobinuria

Paroxysmal Hemoglobinuria, Nocturnal

United States
Hospital Clinic of Barcelona

Completed

Benefit of Left Atrial Roof Ablation in Paroxysmal Atrial Fibrillation

Drug-refractory Paroxysmal Atrial Fibrillation

Spain
Medtronic Cardiac Rhythm and Heart Failure

Completed

Sustained Treatment of Paroxysmal Atrial Fibrillation Post-Approval Study (STOP AF PAS) (STOP AF PAS)

Paroxysmal Atrial Fibrillation (PAF)

United States, Canada
Charite University, Berlin, Germany
German Federal Ministry of Education and Research

Terminated

Mesh Ablator Versus Cryoballoon Pulmonary Vein Ablation of Symptomatic Paroxysmal Atrial Fibrillation (MACPAF)

Symptomatic Paroxysmal Atrial Fibrillation

Germany
Alexion

Active, not recruiting

Study of the Oral Factor D (FD) Inhibitor ALXN2050 in PNH Patients as Monotherapy

Paroxysmal Nocturnal Hemoglobinuria (PNH)

United Kingdom, Italy, Canada, Korea, Republic of, New Zealand, Spain, Turkey
Alexion

Completed

ALXN1210 (Ravulizumab) Versus Eculizumab in Complement Inhibitor Treatment-Naïve Adult Participants With Paroxysmal Nocturnal Hemoglobinuria (PNH)

Paroxysmal Nocturnal Hemoglobinuria (PNH)

Belgium, France, Italy, Japan, Spain, Taiwan, United Kingdom, United States, Canada, Czechia, Germany, Sweden, Singapore, Korea, Republic of, Russian Federation, Austria, Poland, Argentina, Australia, Brazil, Estonia, Malaysia, Mexico, Thaila... and more
Apellis Pharmaceuticals, Inc.

Completed

A Phase I Study to Assess the Safety of Pegcetacoplan (APL-2) as an Add-On to Standard of Care in Subjects With PNH

Paroxysmal Nocturnal Hemoglobinuria (PNH)

United States
Biosense Webster, Inc.

Completed

THERMOCOOL® SMARTTOUCH™ Catheter for the Treatment of Symptomatic Paroxysmal Atrial Fibrillation CONTINUED ACCESS

Drug Refractory Symptomatic Paroxysmal Atrial Fibrillation

United States
Biosense Webster, Inc.

Recruiting

A Study of the THERMOCOOL SMARTTOUCH Surround Flow (SF) Catheter With the TRUPULSE Generator for Treatment of Drug Refractory Symptomatic PAF (SMARTPULSE PAF)

Drug Refractory Paroxysmal Atrial Fibrillation

United States
Assistance Publique - Hôpitaux de Paris

Unknown

Benefit/Risk in Real Life of New Oral Anticoagulants and Vitamin K Antagonists in Patients Aged 75 Years and Over Suffering From Non Valvular Atrial Fibrillation (nv AF) (Presage-Aco)

Non Valvular Atrial Fibrillation (nv AF)
AO GENERIUM

Completed

Efficacy and Safety of Elizaria® vs. Soliris® in Patients With PNH

Paroxysmal Nocturnal Hemoglobinuria | Marchiafava-Micheli Syndrome | Paroxysmal Hemoglobinuria

Russian Federation
Asklepios proresearch
Atrial Fibrillation Network; Medtronic Bakken Research

Recruiting

From the Emergency Department Directly to Ablation of Atrial Fibrillation Study (EMERGE Cryo)

Atrial Fibrillation (AF)

Germany
CARE Pharma Shanghai Ltd.

Completed

Natural History Study of Adult Patients With Paroxysmal Nocturnal Hemoglobinuria of High-risk Hemolysis in China

Paroxysmal Nocturnal Hemoglobinuria, Natural History Study

China
Cardiovascular Innovation and Research Institute
Valley View Hospital

Recruiting

Cardiovascular Innovation & Research Institute 's NEXUS Registry, the Whole is Greater Than the Parts.

Coronary Artery Disease | Atrial Fibrillation (AF)

United States
Sidney Kimmel Comprehensive Cancer Center at Johns...

Completed

Study of High Dose Cyclophosphamide in Patients With Severe Aplastic Anemia and Paroxysmal Nocturnal Hemoglobinuria

Aplastic Anemia | Paroxysmal Hemoglobinuria, Nocturnal

United States
TriVirum, Inc.

Completed

Clinical Performance of the AFGen1 Device Over a 7-day Period

Atrial Fibrillation | Arrhythmias, Cardiac | Paroxysmal Atrial Fibrillation | Afib | Irregular Heart Beat | Arrhythmia Atrial | Arrhythmias Paroxysmal

United States
Medtronic Cardiac Rhythm and Heart Failure
Medtronic Atrial Fibrillation Solutions

Completed

Catheter Cryoablation Versus Antiarrhythmic Drug as First-Line Therapy of Paroxysmal Atrial Fibrillation

Symptomatic Paroxysmal Atrial Fibrillation Without Clinically Significant Heart Diseases

Netherlands, Australia, France, Norway, Germany, Croatia, Italy, Argentina, Belgium
Longbio Pharma

Recruiting

A Study of Single and Multiple Doses of LP-005 in Healthy Adult Participants

Paroxysmal Nocturnal Hemoglobinuria (PNH)

China

Clinical Trials on Paroxysmal AF

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