Clinical Trials on Pediatric Disorders

Total 146772 results

Methodist Health System

Enrolling by invitation

Renal Autotransplantation; Case Series

Renal Tumor | Loin Pain-Hematuria Syndrome | Renal Vascular Disease | Nutcracker Syndrome, Renal | Pelvic Trauma | Congestion, Venous

United States
University Health Network, Toronto
Princess Margaret Hospital, Canada

Terminated

Intraperitoneal (IP) Cisplatin Given With Paclitaxel to Treat Epithelial Ovarian Cancer (OVHM-01)

Epithelial Ovarian Cancer

Canada
Ain Shams University

Active, not recruiting

The Epigenetic Regulatory Role of P-element Induced Wimpy Testis (Piwi) Interacting RNA-823 (piR-823) in Ovarian Cancer Progression

Ovarian Cancer

Egypt
Alexion Pharmaceuticals, Inc.

Completed

Study of Ravulizumab in Children and Adolescents With Atypical Hemolytic Uremic Syndrome (aHUS)

Atypical Hemolytic Uremic Syndrome (aHUS)

Italy, United States, Korea, Republic of, Spain, Germany, Belgium, United Kingdom
Memorial Sloan Kettering Cancer Center

Active, not recruiting

Using Advanced Imaging Studies to Develop a Profile of High-grade Serous Ovarian Cancer

Ovarian Cancer | High Grade Ovarian Serous

United States
Bispebjerg Hospital
Rigshospitalet, Denmark; Steno Diabetes Center Copenhagen; The Novo Nordisk Foundation...

Enrolling by invitation

Twenty-year Follow-up of the Inter99 Cohort

Cardiovascular Diseases | Obesity | Type 2 Diabetes | Birth Weight | Coronary Heart Disease | Acute Myocardial Infarction

Denmark
Sanofi

Active, not recruiting

Safety and Efficacy of Eliglustat With or Without Imiglucerase in Pediatric Patients With Gaucher Disease (GD) Type 1 and Type 3 (ELIKIDS)

Gaucher's Disease Type III | Gaucher's Disease Type I

Canada, Argentina, France, Italy, Japan, Russian Federation, Spain, Sweden, Turkey, United Kingdom
University of Pennsylvania
National Heart, Lung, and Blood Institute (NHLBI)

Completed

Implementation of Nudges to Promote Utilization of Low Tidal Volume Ventilation (INPUT) Study (INPUT)

Critical Illness | Acute Respiratory Distress Syndrome | ARDS | Acute Respiratory Failure

United States
Hospital do Coracao
Brazilian Research In Intensive Care Network

Terminated

Two Different Ventilatory Strategies in Acute Respiratory Distress Syndrome Due to Community-acquired Pneumonia (STAMINA)

Acute Respiratory Distress Syndrome | Community-acquired Pneumonia

Brazil
Karolinska Institutet
Skane University Hospital

Active, not recruiting

The IPLA-OVCA Trial, Intra-Peritoneal Local Anaesthetics in Ovarian Cancer (IPLA-OVCA)

Advanced Ovarian Cancer

Sweden
Emory University
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)

Completed

Study to Determine the Efficacy of Real-time CGM in Preventing Hypoglycemia Among Insulin-treated Patients With DM2 on Hemodialysis, Compared to Standard of Care (POC BG)

Type 2 Diabetes | End-Stage Renal Disease

United States
Oregon Health and Science University

Active, not recruiting

Effect of Abdominal Wall Injections on Abdominal Pain

Anterior Cutaneous Nerve Entrapment Syndrome

United States
Ohio State University Comprehensive Cancer Center

Completed

Testing a Cognitive Behavioral Model for Reducing Dyspnea in Patients With Lung Cancer

Lung Non-Small Cell Carcinoma | Lung Small Cell Carcinoma

United States
Shanghai Fosun Pharmaceutical Industrial Development...

Active, not recruiting

Study to Evaluate the Safety, Tolerability, PK Characteristics and Anti-tumor Activity of FCN-159 in Adult and Pediatric Participants With Neurofibromatosis Type 1

Neurofibromatosis 1 | NF1 | Plexiform Neurofibroma

United States, China, Spain
Stanford University
Pfizer

Completed

Paxlovid for Treatment of Long Covid (STOP-PASC)

Long COVID | Post-acute Sequelae of SARS-CoV-2 Infection

United States
Nobias Therapeutics, Inc.

Completed

NB-001 in Children and Adolescents With 22q11 Deletion Syndrome

22q11 Deletion Syndrome

United States, Canada
Ohio State University

Terminated

Soy Modulation of Immune Activation, LDL- Levels, and Lowering Inflammation by Pretzel Isoflavone Dietary Intervention (SMALLLIPIDS)

Hypercholesterolemia | Human Immunodeficiency Virus (HIV) Infection

United States
National Cancer Institute (NCI)

Completed

Testing the Addition of an Anti-cancer Drug, Entinostat, to the Usual Chemotherapy and Immunotherapy Treatment (Atezolizumab, Carboplatin and Etoposide) for Previously Untreated Aggressive Lung Cancer That Has Spread

Malignant Solid Neoplasm | Extensive Stage Lung Small Cell Carcinoma | Metastatic Malignant Neoplasm in the Brain

United States
Universiti Kebangsaan Malaysia Medical Centre

Completed

Effect of Intravenous Lignocaine Infusion on Intraoperative End Tidal Desflurane Concentration Requirements

Ovarian Cysts | Appendicitis | Cholelithiases

Malaysia
University of Nebraska

Terminated

Using Sitagliptin as a Treatment to Prevent New Onset Diabetes After Kidney Transplantation

End Stage Renal Disease | Type 2 Diabetes

United States
Hoffmann-La Roche

Completed

A Clinical Study of Cobimetinib Administered in Combination With Niraparib, With or Without Atezolizumab to Patients With Advanced Platinum-sensitive Ovarian Cancer

OVARIAN CANCER

Italy, Spain, United States
Shire
Takeda Development Center Americas, Inc.

Active, not recruiting

An Efficacy and Safety Study of HGT-1110 in Participants With Metachromatic Leukodystrophy

Metachromatic Leukodystrophy (MLD)

Denmark, Germany, Japan, Australia, France, Brazil, Czechia
Poitiers University Hospital
Baxter Healthcare Corporation

Active, not recruiting

Effect of Medium Cut-Off Hemodialysis on Protein Energy Wasting: The EMCOPEW Study (EMCOPEW)

End Stage Renal Disease (ESRD)

France
The University of Queensland
National Health and Medical Research Council, Australia

Completed

Ataxia-telangiectasia: Treating Mitochondrial Dysfunction With a Novel Form of Anaplerosis (A-TC7)

Ataxia Telangiectasia

Australia
University of Calgary
Alberta Health services

Completed

Treatment of Hypoxemic Respiratory Failure and ARDS With Protection, Paralysis, and Proning (TheraPPP) Pathway (TheraPPP)

Acute Respiratory Distress Syndrome | ARDS, Human | Hypoxemic Respiratory Failure

Canada
National Organization for Rare Disorders
Food and Drug Administration (FDA)

Active, not recruiting

The Natural History of Metachromatic Leukodystrophy Study (HOME Study)

Metachromatic Leukodystrophy

United States
Martina Bebin
National Institute of Neurological Disorders and Stroke (NINDS)

Completed

Preventing Epilepsy Using Vigabatrin In Infants With Tuberous Sclerosis Complex

Tuberous Sclerosis Complex

United States
Mayo Clinic
Regenerative Medicine Minnesota

Terminated

Patient-Derived Stem Cell Therapy for Diabetic Kidney Disease

Diabetes Mellitus, Type 2 | Diabetes Mellitus, Type 1 | Diabetic Kidney Disease | Diabetic Nephropathies | Chronic Kidney Disease | Kidney Failure | Diabetic Nephropathy Type 2 | Kidney Insufficiency

United States
Pontificia Universidad Catolica de Chile

Completed

Impact of Decreasing Respiratory Rate on Lung Injury Biomarkers in ARDS Patients

Acute Respiratory Distress Syndrome | Ventilator-Induced Lung Injury | Respiration, Artificial

Chile
Maastricht University
TNO; Netherlands Instititute for Health Services Research; University of Twente

Completed

Effectiveness and Implementation of the Assessment of Burden of Chronic Conditions (ABCC)-Tool

Heart Failure | Diabetes Mellitus, Type 2 | Chronic Obstructive Pulmonary Disease | Asthma

Netherlands
Northwell Health

Completed

Pilot Phase I/II Study of Amino Acid Leucine in Treatment of Patients With Transfusion-Dependent Diamond Blackfan Anemia (LeucineDBA)

Pure Red Cell Aplasia | Diamond Blackfan Anemia | Blackfan Diamond Syndrome | DBA | Congenital Hypoplastic Anemia

United States
Boston Medical Center
Emory University

Completed

Global Impact of the COVID 19 Pandemic on Stroke Care, Cerebral Venous Thrombosis, and Subarachnoid Hemorrhage

Stroke

United States
University of Geneva, Switzerland

Completed

Effects of Methylphenidate on Brain and Cognition in 22q11 Deletion Syndrome

22q11.2 Deletion Syndrome

Switzerland
AstraZeneca
Quotient Sciences

Completed

A Randomised, Open-Label Study to Evaluate the Relative and Absolute Bioavailability of Cotadutide in Healthy Subjects

Chronic Kidney Disease | Type 2 Diabetes Mellitus (T2DM) | Non-alcoholic Steatohepatitis

United Kingdom
Washington University School of Medicine

Active, not recruiting

Spinraza in Adult Spinal Muscular Atrophy (SAS)

Spinal Muscular Atrophy | Spinal Muscular Atrophy Type 3 | Spinal Muscular Atrophy Type II

United States, Canada
Chimerix

Terminated

Dociparstat for the Treatment of Severe COVID-19 in Adults at High Risk of Respiratory Failure

Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) | Acute Lung Injury | Coronavirus Disease 2019 (COVID-19)

United States
Hanmi Pharmaceutical Company Limited

Completed

An Observational Study to Evaluate the Incidence of MACCE According to Time Interval of Taking Medication in Patients With Acute Coronary Syndrome or Cerebral Infarction Who Received DAPT for the Secondary Prevention and Esomezol Cap for the Prevention of Gastrointestinal Bleeding

Acute Coronary Syndrome or B Cerebral Infarction Requiring DAPT(Clopidogrel + Aspirin) for at Least 6 Months

Korea, Republic of
University of Cambridge
Imperial College London; Cambridge University Hospitals NHS Foundation Trust; Wellcome Trust and other collaborators

Active, not recruiting

PET Imaging of Giant Cell and Takayasu Arteritis (PITA)

Giant Cell Arteritis | Takayasu Arteritis

United Kingdom
AstraZeneca
Merck Sharp & Dohme LLC; Myriad Genetic Laboratories, Inc.

Completed

Olaparib Treatment in Relapsed Germline Breast Cancer Susceptibility Gene (BRCA) Mutated Ovarian Cancer Patients Who Have Progressed at Least 6 Months After Last Platinum Treatment and Have Received at Least 2 Prior Platinum Treatments (SOLO3)

Relapsed Ovarian Cancer, BRCA Mutation, Platinum Sensitivity

United States, Italy, Spain, Belgium, Poland, Canada, Korea, Republic of, Brazil, Czechia, Hungary, Israel, Argentina, Mexico
Corcept Therapeutics

Active, not recruiting

Study of Relacorilant in Combination With Nab-Paclitaxel for Patients With Recurrent Platinum-Resistant Ovarian, Fallopian Tube, or Primary Peritoneal Cancer

Recurrent Fallopian Tube Carcinoma | Recurrent Primary Peritoneal Carcinoma | Recurrent Ovarian Cancer

United States, Belgium, Canada, Italy, Spain
Heidelberg Engineering GmbH

Completed

Repeatability of Static & Dynamic Composite Confocal Microscopy for Assessment of the Corneal Nerve Fiber Plexus in Early Diabetic Polyneuropathy

Normal Eyes of Subjects Without Diabetes Mellitus | Subjects With Diabetes Mellitus Type 2 Without Coexisting DPN | Subjects With Diabetes Mellitus Type 2 With Coexisting Early to Moderate DPN
University of Utah
University of British Columbia; Children's Hospital Medical Center, Cincinnati and other collaborators

Terminated

Vitamin D Supplementation for Adults With Neurofibromatosis Type 1 (NF1) (VitDBoneNF1)

Neurofibromatosis Type 1 (NF1)

United States, Canada
Far Eastern Memorial Hospital

Active, not recruiting

The Life Style Patterns and the Development Trend of Chronic Diseases in Healthy and Sub-healthy Groups Were Analyzed by Using Data-mining Techniques

Metabolic Syndrome | Chronic Disease | Chronic Kidney Disease Stage 5 | Chronic Kidney Disease Stage 3 | Chronic Kidney Disease Stage 4 | Chronic Kidney Disease Stage 2 | Chronic Kidney Disease Stage 1

Taiwan
Università degli Studi di Ferrara

Completed

PEEP-induced Changed in RRI as Physiological Background of Ventilator-induced Kidney Injury (PRE-VIKI)

Acute Kidney Injury | Respiratory Distress Syndrome, Adult | Respiration, Artificial

Italy
Ankara Training and Research Hospital

Completed

The Impact of the COVID-19 Pandemic on Testicular Cancer

COVID-19 | Testicular Cancer

Turkey
Dana-Farber Cancer Institute
Brigham and Women's Hospital

Completed

GM-CSF Vaccinations After Allogeneic Blood Stem Cell Transplantation in Patients With Advanced Myeloid Malignancies

Refractory Acute Myeloid Leukemia | Myelodysplastic Syndrome RAEB-I or RAEB-II | Refractory CML Myeloid Blast Crisis

United States
Institut National de la Santé Et de la Recherche...
Assistance Publique - Hôpitaux de Paris; European Leukodystrophy Association

Active, not recruiting

Intracerebral Gene Therapy for Children With Early Onset Forms of Metachromatic Leukodystrophy (TG-MLD)

Metachromatic Leukodystrophy

France
Selcuk University

Completed

Carpal Tunnel Syndrome in Patients With Psoriatic Arthritis; Ultrasonography and Magnetic Resonance Imaging Findings

Carpal Tunnel Syndrome | Psoriatic Arthritis

Turkey
Selcuk University

Completed

Carpal Tunnel Syndrome in Patients With Psoriatic Arthritis

Carpal Tunnel Syndrome | Psoriatic Arthritis

Turkey
Can Tho Stroke International Services Hospital

Completed

Rescue Intracranial Stenting in Acute Ischemic Stroke (RISIS)

Ischemic Stroke | Intracranial Hemorrhages | Stroke, Ischemic | Stent Stenosis | Acute Stroke | Cerebral Ischemia | Intracranial Atherosclerosis | Stent Occlusion | Thrombotic Stroke, Acute

Vietnam

Clinical Trials on Pediatric Disorders

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CROs in Cote d'Ivoire

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