Clinical Trials on Pharmacokinetic Variables

Total 819 results

AstraZeneca

Completed

A Single Ascending Dose Study To Assess The Safety, Tolerability, Pharmacokinetics And Pharmacodynamics Of AZD9567.

Rheumatoid Arthritis | Healthy Subjects | Pharmacokinetics | Pharmacodynamics | Tolerability | Safety

Germany
Astellas Pharma Europe B.V.
Medivation, Inc.

Completed

Drug-drug Interaction Study With MDV3100 and a Cocktail of Substrates

Castration Resistant Prostate Cancer (CRPC) | Pharmacokinetics of MDV3100

South Africa
Azienda Socio Sanitaria Territoriale degli Spedali...
University of Pisa; University of Turin, Italy; Università degli Studi di Brescia

Unknown

Ceftobiprole's Cerebrospinal Fluid Penetration in Patients With External Ventricular Derivation (CEFTO-EVD) (CEFTO-EVD)

Pharmacokinetics | Cerebrospinal Fluid | Cerebral Ventriculitis | Cephalosporins

Italy
CSL Behring

Completed

Efficacy and Safety of Vivaglobin® in Previously Untreated Patients With Primary Immunodeficiency

Common Variable Immunodeficiency | Agammaglobulinemia

Canada, Germany, Italy, Spain
CSL Behring

Completed

Safety and Efficacy of Intravenous Immunoglobulin IgPro10 in Patients With Primary Immunodeficiencies (PID)

Common Variable Immunodeficiency | Agammaglobulinemia | IgG Deficiency

United States
Tabula Rasa HealthCare

Enrolling by invitation

Pharmacist-led Pharmacogenomic Clinical Service Within the Program of All-inclusive Care for the Elderly

Pain | Pain, Acute | Elderly | Opioid Use | Pain, Chronic | Pharmacogenetic Testing

United States
Amphastar Pharmaceuticals, Inc.

Completed

Study of Drug Exposure in Systemic Circulation of Primatene Mist by Oral Inhalation, Versus Epinephrine Injection by Intramuscular Injection and ProAir by Oral Inhalation in Healthy Individuals

Asthma | Pharmacokinetics | Anaphylaxis | Epinephrine | Albuterol

United States
Eye & ENT Hospital of Fudan University

Completed

A Study of Dexmedetomidine Pharmacokinetics for Preoperative Sedation

Anxiety | Emergence Delirium | Pharmacokinetics | Preoperative Care

China
Université Libre de Bruxelles

Unknown

Serratus Anterior Plane Block: Post-operative Analgesia in Video-assisted Thoracic Surgery (Serrathos)

Thoracic Surgery | Post-operative Pain | Regional Anesthesia | Post-operative Chronic Pain | Pharmacokinetic Analysis | Serratus Anterior Plane Block

Belgium
Jan Lycke

Completed

Teriflunomide Concentration in Serum and Cerebrospinal Fluid From Patients With Multiple Sclerosis

Multiple Sclerosis, Pharmacokinetics

Sweden
Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University
Sun Yat-sen University

Recruiting

Study on Umorestat Hydrogen Sulfate Capsule in Patients With Locally Advanced/Metastatic Pancreatic Cancer

Pancreatic Cancer | Pharmacokinetics | Gene Polymorphisms

China
Chulalongkorn University

Completed

Citrate Pharmacokinetics in Critically Ill Liver Failure Patients Receiving CRRT (Citrate PK)

Liver Failure, Acute | Continuous Renal Replacement Therapy | Regional Citrate Anticoagulation | Pharmacokinetic | Liver Failure, Acute on Chronic | Citrate Toxicity

Thailand
National Cancer Institute (NCI)

Recruiting

Pilot Trial of Allogeneic Blood or Marrow Transplantation for Primary Immunodeficiencies

Immune System Diseases | Lymphoproliferative Disorders | Common Variable Immunodeficiency | Primary T-cell Immunodeficiency Disorders | Autoimmune Lymphoproliferative

United States
CSL Behring

Completed

Efficacy and Safety of Intravenous Immunoglobulin IgPro10 in Patients With Primary Immunodeficiencies (PID)

Common Variable Immunodeficiency | Agammaglobulinemia | IgG Deficiency
CSL Behring

Completed

Efficacy and Safety of Intravenous Immunoglobulin IVIG-F10 in Patients With Primary Immunodeficiencies (PID)

Common Variable Immunodeficiency | Agammaglobulinemia | IgG Deficiency
Johns Hopkins University
National Institute on Drug Abuse (NIDA); University of Florida

Recruiting

Direct Observation Study of Kratom Product Effects Among Regular Consumers

Kratom Withdrawal Symptoms | Kratom Pharmacokinetics | Kratom Pharmacodynamics

United States
Centre Hospitalier Universitaire, Amiens

Completed

Pharmacokinetics and Pleural Fluid Penetration of Amoxicillin and Clavulanic Acid in Patients With Pleural Infections (PK-plèvre)

Pleural Infection | Empyema | Community-acquired Pneumonia | Pharmacokinetic | Amoxicillin

France
Imperial College London

Recruiting

Routinely Collected Clinical Data and Evaluation of Antimicrobial Target Attainment (DATATDM)

Pharmacokinetics | Drug-Related Side Effects and Adverse Reactions | Infections, Bacterial | Drug Monitoring

United Kingdom
Astellas Pharma Inc
Astellas Pharma Europe B.V.

Completed

A Study to Evaluate the Pharmacokinetics, Safety and Tolerability of Mirabegron OCAS (Oral Controlled Absorption System) in Pediatric Subjects With Neurogenic Detrusor Overactivity or Overactive Bladder

Overactive Bladder | Pharmacokinetics of Mirabegron | Neurogenic Detrusor Overactivity

Belgium, Denmark, Norway, Poland, Serbia
Universidad Peruana Cayetano Heredia

Completed

Pharmacokinetics of Diammine Silver Fluoride

Fluoride and Silver Pharmacokinetics of DSF Applied Topically to Teeth of Adults. Erythema, Bleeding, White Changes, Ulceration and Pigmentation Were Assessed

Peru
University of South Florida
Johns Hopkins University; Baylor College of Medicine; Boston Children's Hospital and other collaborators

Completed

Construction of a Health-related Quality of Life (HR-QOL) Questionnaire for Patients With Primary Antibody Deficiency Disease (HR-QOLPIDD)

Immune Deficiency, Antibody
Melbourne Health
Merck Sharp & Dohme LLC

Recruiting

Posaconazole Pharmacokinetics in Patients Receiving Chemotherapy or Stem Cell Transplants (POPULAR)

Fungal Infection | Pharmacokinetics | Invasive Aspergillosis | Prophylaxis | Invasive Candidiases | Posaconazole | Invasive Mycosis

Australia
Boehringer Ingelheim

Completed

Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of Multiple Rising Oral Doses of BI 201335 as Softgel Capsule in Naive Hepatitis C Virus (HCV) Patients

Hepatitis C | Pharmacokinetics

Japan
American University of Beirut Medical Center

Completed

μ-opioid Receptor Polymorphism and Opioid Analgesia

Pharmacogenetic and Duration of Labor Fentanyl Analgesia

Lebanon
Sharon Hillier
National Cancer Institute (NCI)

Completed

Safety and Acceptability of Q GRFT Nasal Spray for COVID-19 Prophylaxis

COVID-19 | Pharmacokinetics | Safety

United States
Federal University of São Paulo
CSL Behring

Completed

Specific IgG Antibody in Patients With Primary Antibody Deficiencies Treated With Subcutaneous Immunoglobulin

Common Variable Immunodeficiency | Agammaglobulinemia

Brazil
Ove Andersen
University of Copenhagen; Glostrup University Hospital, Copenhagen; University... and other collaborators

Recruiting

Sativex® and Gentamicin for Optimized Pharmagological Treatment in Older Patients (CanPan) (CanPan)

Anorexia | Malnutrition | Aging | Pharmacokinetics | Cannabis | Renal Function | Emergency Service, Hospital

Denmark
Emmaus Medical, Inc.

Completed

Pharmacokinetics and Safety of Endari (L-glutamine) in Sickle Cell Disease Patients

Sickle Cell Disease | Pharmacokinetics

United States
AstraZeneca

Completed

Effects of Administration of Fostamatinib on Blood Concentrations of Pioglitazone in Healthy Subjects

Rheumatoid Arthritis | Healthy Volunteers | Pharmacokinetics | Drug-drug Interaction | Pioglitazone | Amount of Pioglitazone in Blood

United States
The Affiliated Nanjing Drum Tower Hospital of Nanjing...

Not yet recruiting

Population Pharmacokinetics/Pharmacodynamics of Carbapenems in Febrile Neutropenia Patients

Febrile Neutropenia | Pharmacokinetics | Pharmacodynamic | Carbapenems
Astellas Pharma Global Development, Inc.

Completed

A Study to Investigate the Effect of Severe Renal Impairment on Gilteritinib Compared to Healthy Participants With Normal Renal Function

Renal Impaired | Gilteritinib | Normal Renal Function | Pharmacokinetics of ASP2215

United States, Bulgaria
Universitaire Ziekenhuizen KU Leuven

Active, not recruiting

Association of Cefepime Trough Levels With Clinical Efficacy and Neurotoxicity in Patients With Febrile Neutropenia

Pharmacokinetics | Pharmacodynamics | Cefepime

Belgium
Universitaire Ziekenhuizen KU Leuven
KU Leuven

Completed

Optimization of PK/PD Target Attainment for Ceftriaxone in Critically Ill Patients With Community-acquired Pneumonia.

Critical Illness | Pharmacokinetics

Belgium
Bio Products Laboratory

Completed

Pharmacokinetics (PK) and Safety of Subgam-VF in Primary Immunodeficiency Diseases (SCIG03)

Common Variable Immunodeficiency | Primary Immune Deficiency Disorders | X-linked Agammaglobulinaemia | Hyperimmunoglobulin M Syndrome

United States
Stockton University
Nova Southeastern University

Completed

The Impact of Exercise on Stress, Fatigue, and Quality of Life in Individuals With Primary Immunodeficiency Disease

Common Variable Immunodeficiency | Hypergammaglobulinemia | Primary Immune Deficiency Disorder | Specific Antibody Deficiency

United States
Université Catholique de Louvain

Recruiting

Population Pharmacokinetics and Pharmacodynamics of Beta-lactams of Interest in Adult Patients From Intensive Care Units (Pop-PK/PD)

Pharmacokinetics | Infection | Infection, Bacterial | Anti-Bacterial Agents | Drug Monitoring | Infections, Respiratory

Belgium
Astellas Pharma Inc

Completed

Examination of Plasma Concentrations and Safety in Chronic Kidney Disease Patients Undergoing Hemodialysis

Patients on Stable Chronic Maintenance Dialysis Who Are Receiving Hemodialysis Therapy | Pharmacodynamics of ASP7991 | Pharmacokinetics of ASP7991

Japan
Beijing Children's Hospital

Unknown

Pharmacokinetic (PK)Research on Chinese Children of Hemophilia (PK)

Pharmacokinetics

China
CHU de Reims

Recruiting

Bronchiectasis Prevalence in Patients With Primary Humoral Immunodefiency in Champagne-Ardenne Region, France (PREDDICHA)

Primary Immunodeficiency | Common Variable Immunodeficiency | Igg Subclass Deficiency | Selective IgM Deficiency

France
Texas Tech University Health Sciences Center
University of Texas Southwestern Medical Center; National Center for Research...

Completed

Effect of Weight and/or Obesity on Sulfamethoxazole and Trimethoprim Concentrations

Obesity | Tuberculosis | Pharmacokinetics | MRSA | PCP

United States
Paul M. Tulkens

Recruiting

Plasma Protein Binding and PK/PD of Total and Unbound Temocillin Non-ICU Patients (TEMODELTA)

Pharmacokinetics | Infection | Infections, Bacterial | Drug Monitoring | Antibacterial Agents | Temocillin

Belgium
University Hospital, Ghent
University Ghent

Completed

Renal Function Assessment in Critically Ill Children (IOHEXOL)

Acute Kidney Injury | Pharmacokinetics | Renal Function | Augmented Renal Clearance | Iohexol | Critically Ill Children

Belgium
AstraZeneca

Completed

Investigating Safety, Tolerability and Efficacy of AZD5363 in Prostate Cancer. (PYRUS)

Metastatic Castrate-Resistant Prostate Cancer (mCRPC), | Efficacy, | Safety and Tolerability, | Pharmacokinetics, | Pharmacodynamics, | Tumour Response.

United Kingdom, United States
Astellas Pharma Inc
Agensys, Inc.

Completed

A First in Man Study to Determine the Safety at Various Dose Levels of AGS-16M8F in Advanced Kidney Cancer

Renal Cell Carcinoma | Pharmacokinetics of AGS-16M8F

United States
Medical University of Vienna

Completed

The Effect of Desflurane Versus Sevoflurane on Postoperative Recovery (RAPID)

Postoperative Delirium | Postoperative Recovery | Difference in Pharmakokinetics of Volatile Anesthetics

Austria
Food and Drug Administration (FDA)
Spaulding Clinical Research LLC

Completed

CiPA Phase 1 ECG Biomarker Validation Study

Pharmacokinetics | Pharmacodynamics | Drug-induced QT Prolongation

United States
Food and Drug Administration (FDA)
Spaulding Clinical Research LLC

Completed

Ability of Late Sodium or Calcium Current Block to Balance the ECG Effects of Potassium Current Block

Pharmacokinetics | Pharmacodynamics | Drug-induced QT Prolongation
National Heart, Lung, and Blood Institute (NHLBI)

Recruiting

Natural History of Bronchiectasis

Bronchiectasis | Common Variable Immunodeficiency | Cystic Fibrosis | Autoimmune Disease

United States
Astellas Pharma Global Development, Inc.

Terminated

A Study to Evaluate Mirabegron in Pediatric Participants From 5 to Less Than 18 Years of Age With Overactive Bladder (OAB) (Dolphin)

Pharmacokinetics of Mirabegron | Overactive Bladder (OAB)

Korea, Republic of, Russian Federation, Turkey
Tibotec Pharmaceuticals, Ireland

Completed

TMC435350-TiDP16-C105: Phase I, 3-way Crossover, Drug-drug Interaction Between TMC435350 and Rifampin After Multiple Dosing.

Hepatitis C | Tuberculosis | Pharmacokinetics | HCV | Rifampin

Clinical Trials on Pharmacokinetic Variables

Sponsors and Collaborators

Medical Conditions

Drug Interventions

CROs by country

CROs in Czech Republic

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Rare Diseases

Drug Interventions

Dietary Supplements

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