Clinical Trials on Primary Immune Deficiency

Total 104087 results

Ottawa Hospital Research Institute
Octapharma

Unknown

Safety, Tolerability, Patient Satisfaction and Cost of 16.5% Subcutaneous Immunoglobulin (Cutaquig®) Treatment

Primary Immunodeficiency Disease | Secondary Immunodeficiency

Canada
Fondazione Telethon

Completed

Evaluating the Effectiveness of STRIMVELIS Risk Minimization Measures (RMMs)

Severe Combined Immunodeficiency Due to ADA Deficiency

Italy
University of California, Los Angeles
Great Ormond Street Hospital for Children NHS Foundation Trust

Enrolling by invitation

An Observational LTFU Study for Patients Previously Treated With Autologous ex Vivo Gene Therapy for ADA-SCID

Adenosine Deaminase Deficiency | Severe Combined Immunodeficiency (SCID)

United States, United Kingdom
Bio Products Laboratory

Completed

Pharmacokinetics (PK) and Safety of Subgam-VF in Primary Immunodeficiency Diseases (SCIG03)

Common Variable Immunodeficiency | Primary Immune Deficiency Disorders | X-linked Agammaglobulinaemia | Hyperimmunoglobulin M Syndrome

United States
Regina Elena Cancer Institute

Completed

Approaches and Metrics in Fraily Patients During COVID-19 Era (COMETA)

Frailty | Oncology | Immune Deficiency

Italy
Pfizer

Completed

Azithromycin in the Treatment of Cryptosporidiosis in Patients With Acquired Immune Deficiency Syndrome (AIDS): A Randomized, Multi-Center, Placebo-Controlled, Double-Blind Study

HIV Infections | Cryptosporidiosis

United States
University of North Carolina, Chapel Hill
The Hospital for Sick Children; Washington University School of Medicine; McGill... and other collaborators

Recruiting

Defining the Genetic Etiology of Suppurative Lung Disease in Children and Adults

Primary Ciliary Dyskinesia | Kartagener Syndrome | Primary Immune Deficiency

United States, Canada
Bio Products Laboratory

Completed

A Study to Find Out How Safe and Effective Gammaplex® is in Young People With Primary Immunodeficiency

Common Variable Immunodeficiency | Wiskott-Aldrich Syndrome | X-linked Agammaglobulinemia | Primary Immune Deficiency Disorders | Hyper-IgM Syndrome

United States, Chile, Israel
CSL Behring

Completed

Efficacy and Safety of Intravenous Immunoglobulin IgPro10 in Patients With Primary Immunodeficiencies (PID)

Common Variable Immunodeficiency | Agammaglobulinemia | IgG Deficiency
CSL Behring

Completed

Efficacy and Safety of Intravenous Immunoglobulin IVIG-F10 in Patients With Primary Immunodeficiencies (PID)

Common Variable Immunodeficiency | Agammaglobulinemia | IgG Deficiency
Leiden University Medical Center
ZonMw: The Netherlands Organisation for Health Research and Development; Horizon...

Recruiting

Phase I/II Clinical Trial Stem Cell Gene Therapy in RAG1-Deficient SCID (RAG1-SCID)

Severe Combined Immunodeficiency Due to RAG1 Deficiency

Spain, Netherlands, Italy, Poland, Australia, Turkey, United Kingdom
University of California, Los Angeles
Orchard Therapeutics; California Institute for Regenerative Medicine (CIRM)

Completed

Efficacy and Safety of the Cryopreserved Formulation of OTL-101 in Subjects With ADA-SCID

Severe Combined Immunodeficiency Due to ADA Deficiency

United States
Great Ormond Street Hospital for Children NHS Foundation...
Orchard Therapeutics

Completed

Lentiviral (LV) Gene Therapy for Adenosine Deaminase (ADA) Deficiency

Adenosine Deaminase Deficiency | Severe Combined Immunodeficiencies (SCID)

United Kingdom
University of North Carolina, Chapel Hill
The Hospital for Sick Children; Washington University School of Medicine; McGill... and other collaborators

Recruiting

Characterizing the Upper Airway Manifestations in Primary Ciliary Dyskinesia and Primary Immunodeficiencies

Primary Ciliary Dyskinesia | Kartagener Syndrome | Primary Immune Deficiency

United States, Canada
Fondazione Telethon

Active, not recruiting

Methodology Study of Retroviral Insertion Site Analysis in Strimvelis Gene Therapy

Severe Combined Immunodeficiency Due to ADA Deficiency

Italy
Great Ormond Street Hospital for Children NHS Foundation...
Orchard Therapeutics

Completed

Efficacy and Safety of the Cryopreserved Formulation of OTL-101 in Subjects With ADA-SCID

Severe Combined Immunodeficiency Due to ADA Deficiency

United Kingdom
University of California, Los Angeles

Withdrawn

A Clinical Study to Enable Process Validation of Commercial Grade OTL-101

Severe Combined Immunodeficiency Due to ADA Deficiency

United States
Columbia University
Clínica de Familia La Romana, Dominican Republic

Recruiting

WiseApp for Spanish Speakers Living With HIV

HIV Infections | Sexually Transmitted Diseases, Viral | Acquired Immune Deficiency Syndrome

United States, Dominican Republic
CSL Behring

Completed

Safety and Efficacy of Intravenous Immunoglobulin IgPro10 in Patients With Primary Immunodeficiencies (PID)

Common Variable Immunodeficiency | Agammaglobulinemia | IgG Deficiency

United States
Qu Biologics Inc.
The National Research Council of Canada Industrial Research Assistance Program

Active, not recruiting

Assessment of QBKPN Site-Specific Immunomodulator Efficacy in Improving Innate Immune Function & Reducing Respiratory Tract Infection Morbidity in Older Adults (RESILIENCE)

Immune Deficiency

Canada
PATH

Not yet recruiting

Developing a Screening Tool for Primary Immunodeficiency Disease (PID) in Pakistan

Primary Immunodeficiency Diseases

Pakistan
Octapharma
Premier Research Group plc

Completed

A Study of NewGam, Human Immunoglobulin 10%, in Patients With Primary Immunodeficiency Diseases

Primary Immunodeficiency Diseases

United States
Kedrion S.p.A.

Recruiting

Clinical Assessment of Pharmacokinetics, Efficacy, and Safety of 10% IVIg in Pediatric PID Patients (KIDCARES10) (KIDCARES10)

Primary Immunodeficiency Disease

Italy, United States, Portugal, Hungary, Russian Federation, Slovakia
National Institute of Allergy and Infectious Diseases...

Recruiting

The Mechanistic Biology of Primary Immunodeficiency Disorders

Primary Immunodeficiency Disorders

United States
National Institute of Allergy and Infectious Diseases...
University of Pittsburgh; PPD

Completed

Bilateral Orthotopic Lung Transplant - Bone Marrow Transplant (BOLT-BMT)

Primary Immunodeficiency | PID

United States
Kedrion S.p.A.

Completed

Clinical Assessment of Pharmacokinetics, Efficacy, and Safety of 10% IVIg in PID Patients (CARES10)

Primary Immunodeficiency Disease

United States
University of the Punjab
The National HIV/AIDS Programme

Completed

High-Dose Vitamin D3 Supplementation in the Treatment of Human Immune Deficiency Virus Patients Trial (HDVDS-HIVT)

HIV-1-infection | Hypovitaminosis D

Pakistan
Michele Staton
National Institute on Drug Abuse (NIDA)

Completed

Brief Intervention for Rural Women at High Risk for HIV/HCV (WISH)

Hepatitis C | Drug Abuse | Acquired Immune Deficiency Syndrome Virus

United States
Columbia University
National Institutes of Health (NIH)

Completed

Antiretroviral Therapy and Inflammatory and Coagulation Biomarkers: iMACS Study (iMACS)

Tuberculosis | HIV (Human Immunodeficiency Virus) | AIDS (Acquired Immune Deficiency Syndrome) | Non-communicable Diseases (NCD)

Kenya
University of Surrey
University of Reading

Recruiting

Estimation of the Dietary Requirement for Vitamin D in Ethnic Groups

Vitamin D Deficiency | Immune Health | Muscle Function

United Kingdom
National Cancer Institute (NCI)

Recruiting

Pilot Study of Reduced-Intensity Hematopoietic Stem Cell Transplant of DOCK8 Deficiency

DOCK8 Deficiency

United States
Centre Hospitalier Universitaire de Nīmes

Completed

Peripheral Immunological Effects of High-dose Vitamin D Treatment in Healthy Subjects (VDSS)

Vitamin d Deficiency

France
Centagen, Inc.

Completed

Effects of a 10 Component Dietary Supplement on Health and the Quality of Life

Quality of Life | Stress | Blood Pressure | Joint Instability | Immune Deficiency | Lung Function Decreased | HDL Low | Energy Supply; Deficiency | Concentration Ability Impaired

United States
Octapharma

Completed

Gammanorm Quality of Life Study in Immunodeficient Patients Using Rapid Push or Pumps

Primary Immunodeficiency (PID)

France
CHU de Reims

Unknown

Tolerance and Patients' Satisfaction With IGHy

Secondary or Primary Immunodeficiency

France
University of Minnesota
Joint Clinical Research Center

Completed

Optimizing Iron Status While Minimizing Morbidity in HIV-infected Ugandan Children

Iron-deficiency | Anemia | Hiv | Iron Deficiency Anemia

Uganda
Instituto Nacional de Enfermedades Respiratorias

Unknown

Effect of Zinc and Selenium Supplementation on HIV+ Individuals on Antiretroviral Treatment.

Inflammation | HIV | Zinc Deficiency | ART | Metabolic Complication | Selenium Deficiency

Mexico
Eunice Kennedy Shriver National Institute of Child...

Completed

TDSM- Testosterone Dose Response in Surgically Menopausal Women

Menopause | Hysterectomy | Testosterone Deficiency | Ovariectomy

United States
CES University
IPS Fundación SIAM

Unknown

Zinc Supplementation Effect on Immune Recovery in HIV Patients

HIV | AIDS | Immunological Deficiency | Inadequate Immune Recovery | Viral Replication

Colombia
Rambam Health Care Campus

Recruiting

Evaluating Bronchodilator Response in Patients With Bronchiectasis

Bronchiectasis | Cystic Fibrosis | Bronchiolitis Obliterans | Primary Ciliary Dyskinesia | Primary Immune Deficiency

Israel
Jasper Therapeutics, Inc.

Recruiting

JSP191 Antibody Targeting Conditioning in SCID Patients

SCID

United States
Taiga Biotechnologies, Inc.

Not yet recruiting

Safety and Early Efficacy Study of TBX-1400 in Patients With Severe Combined Immunodeficiency

Severe Combined Immunodeficiency

Israel
Donald B. Kohn, M.D.
National Institutes of Health (NIH); FDA Office of Orphan Products Development

Completed

MND-ADA Transduction of CD34+ Cells From Children With ADA-SCID

Severe Combined Immunodeficiency

United States
National Institute of Allergy and Infectious Diseases...

Recruiting

Detection and Characterization of Infections and Infection Susceptibility

Immune Deficiencies

United States
Universitaire Ziekenhuizen KU Leuven

Completed

Comparison of Multigam IV (5% vs. 10%) in Patients With an Immunodeficiency Secondary to a Hematological Disorder (MULTISIM)

Hematologic Diseases | Secondary Immune Deficiency

Belgium
University Hospital, Caen

Unknown

ENCAPSID Study : ENCApsulated Bacterial Infection and Primary, Secondary ImmunoDeficiency (ENCAPSID)

Immune Deficiency

France
Oregon Health and Science University

Completed

Fatty Acid Oxidation Defects and Insulin Sensitivity

Normal Volunteers | Trifunctional Protein Deficiency | Very Long-chain Acyl-CoA Dehydrogenase Deficiency | Long-chain 3-hydroxyacyl-CoA Dehydrogenase Deficiency | Medium-chain Acyl-CoA Dehydrogenase Deficiency | Carnitine Palmitoyltransferase II Deficiency, Myopathic

United States
University of California, Los Angeles
National Institute of Mental Health (NIMH); Human Sciences Research Council

Completed

Mentor Mothers: A Sustainable Family Intervention in South African Townships

Tuberculosis | Human Immunodeficiency Virus | Acquired Immune Deficiency Syndrome

South Africa
King's College London
University of Sheffield; University of Manchester; National Health Service, United... and other collaborators

Recruiting

The Experience of Screening for SCID

Severe Combined Immunodeficiency

United Kingdom
National Heart, Lung, and Blood Institute (NHLBI)

Recruiting

Genetic Basis of Immunodeficiency

Severe Combined Immunodeficiency

United States

Clinical Trials on Primary Immune Deficiency

Sponsors and Collaborators

Medical Conditions

Drug Interventions

CROs by country

CROs in Serbia

Conditions

Rare Diseases

Drug Interventions

Dietary Supplements

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