Clinical Trials on Progressive Pulmonary Fibrosis in South Africa

Total 1172 results

Medecins Sans Frontieres, Netherlands
London School of Hygiene and Tropical Medicine; University of Liverpool; Ministry... and other collaborators

Completed

Economic Evaluation of New MDR TB Regimens (PRACTECAL-EE)

Multi-drug Resistant Tuberculosis | Pulmonary Tuberculoses | Extensively Drug-Resistant Tuberculosis

Belarus, South Africa, Uzbekistan
Novartis Pharmaceuticals

Completed

Pharmacokinetics and Safety of Single Subcutaneous Pasireotide (SOM230) in Subjects With Varying Degrees of Hepatic Function

Alcoholism | Hepatic Cirrhosis

Germany, Belgium, United States, South Africa
Brigham and Women's Hospital
University of California, Los Angeles; University of Stellenbosch; University... and other collaborators

Recruiting

Ultra-Short Course Bedaquiline, Clofazimine, Pyrazinamide and Delamanid Versus Standard Therapy for Drug-Susceptible TB (PRESCIENT)

HIV | Tuberculosis, Pulmonary

South Africa, Haiti
Duke University
National Heart, Lung, and Blood Institute (NHLBI)

Completed

Evaluating the Effectiveness of Prednisone, Azathioprine, and N-acetylcysteine in Patients With IPF (PANTHER-IPF)

Pulmonary Fibrosis

United States
Fundació Institut Germans Trias i Pujol
National Center for Tuberculosis and Lung Disease, Tbilisi, Georgia; Perinatal...

Recruiting

Adjunctive Acetylsalicylic Acid and Ibuprofen for Tuberculosis (SMA-TB)

Tuberculosis, Pulmonary | Tuberculosis Infection | Tuberculosis, MDR

South Africa, Georgia
Global Alliance for TB Drug Development

Completed

A Phase 2 to Evaluate the Efficacy, Safety and Tolerability of Combinations of Bedaquiline, Moxifloxacin, PA-824 and Pyrazinamide in Adult Subjects With Drug-Sensitive or Multi Drug-Resistant Pulmonary Tuberculosis. (NC-005)

Tuberculosis

Tanzania, South Africa, Uganda
Genentech, Inc.

Recruiting

A Study Evaluating the Efficacy and Safety of Vixarelimab in Participants With Idiopathic Pulmonary Fibrosis and in Participants With Systemic Sclerosis-Associated Interstitial Lung Disease

Idiopathic Pulmonary Fibrosis | Systemic Sclerosis With Lung Involvement

United States, Korea, Republic of, Taiwan, Australia, Spain, Italy, Israel, Belgium, Argentina, France, Brazil, Greece, Poland, Chile, South Africa, Canada, New Zealand
Novartis

Completed

A Crossover Study to Determine the Effect on Lung Function of Indacaterol in Patients With Moderate to Severe Chronic Obstructive Pulmonary Disease (COPD), Using Tiotropium as an Active Control

Chronic Obstructive Pulmonary Disease (COPD)

Spain, Germany, South Africa, Australia, Poland, New Zealand, Netherlands
University of Miami
National Institute of Neurological Disorders and Stroke (NINDS); National Institutes...

Recruiting

Phenotype, Genotype and Biomarkers 2 (PGB2)

Amyotrophic Lateral Sclerosis | Primary Lateral Sclerosis | Frontotemporal Dementia | Progressive Muscular Atrophy | Hereditary Spastic Paraplegia

United States, South Africa
Michael Hoelscher
Radboud University Medical Center; German Federal Ministry of Education and... and other collaborators

Completed

Evaluation of SQ109, High-dose Rifampicin, and Moxifloxacin in Adults With Smear-positive Pulmonary TB in a MAMS Design

Tuberculosis, Pulmonary

South Africa, Tanzania
The Aurum Institute NPC
Karolinska Institutet; Ludwig-Maximilians - University of Munich; University... and other collaborators

Unknown

TB Sequel: Pathogenesis and Risk Factors of Long-term Sequelae of Pulmonary TB (TBSEQUEL)

Respiratory Tract Infections | Tuberculosis, Pulmonary

Mozambique, South Africa, Tanzania, Gambia
AstraZeneca

Completed

Effect of Roflumilast on Exacerbation Rate in Patients With Chronic Obstructive Pulmonary Disease. Ratio-Study. (BY217/M2-112)

Chronic Obstructive Pulmonary Disease | COPD

Austria, France, Hungary, Italy, Poland, Portugal, Russian Federation, South Africa, Spain, Canada, United Kingdom, Australia, Netherlands, Switzerland
Bayer

Terminated

Efficacy and Safety of Riociguat in Patients With Symptomatic Pulmonary Hypertension (PH) Associated With Idiopathic Interstitial Pneumonias (IIP) (RISE-IIP)

Idiopathic Interstitial Pneumonias / Hypertension,Pulmonary

Belgium, Israel, Spain, United States, Switzerland, New Zealand, Greece, Portugal, Japan, Argentina, Canada, Denmark, France, Germany, Russian Federation, Turkey, Colombia, Saudi Arabia, Australia, Italy, United Kingdom
Norwegian Institute of Public Health
University of Stellenbosch; European and Developing Countries Clinical Trials... and other collaborators

Recruiting

Evaluation of a Rapid Point-of-Care Serological Triage Test for Active TB (SeroSelectTB)

Tuberculosis, Pulmonary

South Africa, Tanzania, Ethiopia
Foundation for Innovative New Diagnostics, Switzerland

Completed

Accuracy and Feasibility of Xpert Ultra

Tuberculosis, Pulmonary

Belarus, Georgia, India, South Africa
Incyte Corporation

Recruiting

To Assess the Efficacy, Safety, and Tolerability of INCB000928 in Participants With Fibrodysplasia Ossificans Progressiva (Progress)

Fibrodysplasia Ossificans Progressiva (FOP)

United States, France, Korea, Republic of, Spain, Italy, United Kingdom, Russian Federation, China, Australia, Brazil, Mexico, New Zealand, Argentina, Canada, Netherlands, Turkey, Chile, Germany, South Africa, Portugal
Johns Hopkins University
United States Agency for International Development (USAID)

Not yet recruiting

Shortened Regimen for Drug-susceptible TB in Children (SMILE-TB)

Tuberculosis | Tuberculosis, Pulmonary | Mycobacterium Tuberculosis | Tuberculosis, Lymph Node

Uganda, South Africa, Mozambique, Indonesia, Zambia
Prof Gerhard Walzl
London School of Hygiene and Tropical Medicine; Makerere University; Leiden University... and other collaborators

Completed

Evaluation of Host Biomarker-based Point-of-care Tests for Targeted Screening for Active TB (ScreenTB)

Pulmonary Tuberculosis

United Kingdom, Uganda, Ethiopia, Gambia, Germany, Namibia, Netherlands, South Africa
Bristol-Myers Squibb

Completed

A Study Measuring the Effectiveness, Safety, and Tolerability of BMS-986278 in Participants With Lung Fibrosis

Pulmonary Fibrosis

Canada, France, United States, Argentina, Australia, Belgium, Brazil, Chile, China, Germany, Israel, Italy, Japan, Korea, Republic of, Mexico, Spain, Taiwan, United Kingdom
Respirion Pharmaceuticals Pty Ltd

Recruiting

A Double-Blind, Active-Controlled, Multiple-Ascending Dose Study of Aerosolized RSP-1502 in Subjects With CF and Chronic PA Lung Infection

Pseudomonas Aeruginosa | Cystic Fibrosis Lung | Respiratory Infections, Recurrent, Chronic

United States, Australia
Novartis Pharmaceuticals

Completed

Mayzent (Siponimod) Onboarding of Secondary Progressive Multiple Sclerosis (SPMS) Patients With MSGo

Secondary Progressive Multiple Sclerosis

Australia
Mundipharma Research Limited

Completed

A Study to Show That Flutiform is Well Tolerated and Effective in the Treatment of COPD

Chronic Obstructive Pulmonary Disease

Ukraine, United Kingdom, Spain, Bulgaria, South Africa, Russian Federation, Germany, Hungary, Lithuania, Slovakia, Macedonia, The Former Yugoslav Republic of, Latvia, Romania, Korea, Republic of, Poland
Scynexis, Inc.

Completed

Study to Evaluate the Safety and Efficacy of the Coadministration of Ibrexafungerp (SCY-078) With Voriconazole in Patients With Invasive Pulmonary Aspergillosis (SCYNERGIA)

Invasive Pulmonary Aspergillosis

United States, Belgium, Canada, Germany, South Africa
Sheffield Teaching Hospitals NHS Foundation Trust
University of Sheffield

Completed

Chronic Thrombo-embolic Pulmonary Hypertension: Classification and Long Term Outcome

Idiopathic Pulmonary Arterial Hypertension | Chronic Thromboembolic Pulmonary Hypertension

United Kingdom
Atara Biotherapeutics

Terminated

Phase 1/2 Study to Evaluate the Safety and Efficacy of ATA188 in Subjects With Progressive Multiple Sclerosis (EMBOLD)

Primary Progressive Multiple Sclerosis | Secondary Progressive Multiple Sclerosis

United States, Australia, Canada
Mylan Inc.
Theravance Biopharma

Completed

A 52-Week Parallel Group Safety Study of TD-4208 in Chronic Obstructive Pulmonary Disease (COPD)

Chronic Obstructive Pulmonary Disease (COPD)

United States
Mylan Inc.
Theravance Biopharma

Completed

Efficacy Study of Nebulized TD-4208 for Chronic Obstructive Pulmonary Disease (COPD) (COPD)

Chronic Obstructive Pulmonary Disease (COPD)

United States
GlaxoSmithKline

Completed

Dose-Finding Study of Batefenterol (GSK961081) Via Dry Powder Inhaler in Patients With Chronic Obstructive Pulmonary Disease (COPD)

Pulmonary Disease, Chronic Obstructive

Germany, United States, South Africa
AstraZeneca

Completed

Pharmacokinetic, Safety and Tolerability Study of Aclidinium/Formoterol Fixed Dose Combination and Formoterol in Patients With Moderate to Severe Chronic Obstructive Pulmonary Disease (COPD)

Chronic Obstructive Pulmonary Disease (COPD)

United States
Southern Adelaide Local Health Network

Active, not recruiting

Virtual Management of Lung Nodules

Pulmonary Nodule, Solitary | Pulmonary Nodule, Multiple

Australia
Mylan Inc.
Theravance Biopharma

Completed

A 28-Day Parallel Group Study of TD-4208 in Chronic Obstructive Pulmonary Disease (COPD)

COPD

United States
The George Institute
National Health and Medical Research Council, Australia

Completed

Theophylline and Steroids in Chronic Obstructive Pulmonary Disease (COPD) Study (TASCS)

Chronic Obstructive Pulmonary Disease

Australia
Pearl Therapeutics, Inc.

Completed

Study to Evaluate the Safety and Efficacy of Inhaled PT005 in Patients With Chronic Obstructive Pulmonary Disease (COPD)

Chronic Obstructive Pulmonary Disease

Australia, New Zealand
Nephron Pharmaceuticals Corporation
Rho, Inc.

Completed

Tiotropium Bromide Inhalation Solution in Subjects With Chronic Obstructive Pulmonary Disease

Chronic Obstructive Pulmonary Disease (COPD)

United States
Global Alliance for TB Drug Development

Recruiting

Phase 2 Trial Assessing TBAJ876 or Bedaquiline, With Pretomanid and Linezolid in Adults With Drug-sensitive Pulmonary Tuberculosis

Drug Sensitive Tuberculosis | Pulmonary Tuberculosis | Pulmonary TB

Philippines, South Africa, Tanzania, Georgia, Uganda
Alexza Pharmaceuticals, Inc.

Completed

Staccato Loxapine Pulmonary Safety in Patients With COPD

Chronic Obstructive Pulmonary Disease

United States
Endo Pharmaceuticals
Alkermes, Inc.

Completed

Study of Trospium Chloride Inhalation Powder (TrIP) in Patients With Chronic Obstructive Pulmonary Disease

Chronic Obstructive Pulmonary Disease

United States
Actelion

Completed

Efficacy and Safety of Oral Bosentan in Pulmonary Fibrosis Associated With Scleroderma

Scleroderma, Systemic | Pulmonary Fibrosis

United States, Israel, France, United Kingdom, Netherlands, Switzerland, Germany, Italy, Sweden
Novartis Pharmaceuticals

Completed

Long Term Safety of Tobramycin Inhalation Powder in Patients With Cystic Fibrosis

Pulmonary Infections | Pseudomonas Aeruginosa in Cystic Fibrosis

United States, Italy, Germany, France, Australia, Canada, Spain, Hungary, Mexico, Argentina
Sheffield Teaching Hospitals NHS Foundation Trust
Actelion

Completed

Assessing the Repeatability of NT-proBNP Testing Using Laboratory and Point of Care Testing in PAH (REPEAT-PAH)

Pulmonary Artery Hypertension

United Kingdom
Medical University of South Carolina
Novartis

Completed

Novartis Everolimus Transition

Graft Dysfunction | Interstitial Fibrosis

United States
Cumberland Pharmaceuticals

Recruiting

Oral Ifetroban to Treat Diffuse Cutaneous Systemic Sclerosis (SSc) or SSc-associated Pulmonary Arterial Hypertension

Pathologic Processes | Skin Diseases | Autoimmune Diseases | Connective Tissue Diseases | Scleroderma, Systemic | Scleroderma, Diffuse | Scleroderma, Limited | Sclerosis, Progressive Systemic

United States, India
Medecins Sans Frontieres, Netherlands
London School of Hygiene and Tropical Medicine; University College, London; University... and other collaborators

Completed

Pragmatic Clinical Trial for a More Effective Concise and Less Toxic MDR-TB Treatment Regimen(s) (TB-PRACTECAL)

Tuberculosis, Pulmonary | Tuberculosis, Multidrug-Resistant | Extensively Drug-Resistant Tuberculosis

Belarus, South Africa, Uzbekistan
Northern Sydney Anaesthesia Research Institute
Merck Sharp & Dohme LLC; Northern Sydney and Central Coast Area Health Service

Terminated

Prevention of Postoperative Events Following Reversal With Sugammadex or Neostigmine (P-PERSON)

Pulmonary Complications

Australia
Chris Goss
Medical University of South Carolina; University of Washington; Cystic Fibrosis... and other collaborators

Completed

Standardized Treatment of Pulmonary Exacerbations II (STOP2)

Pulmonary Cystic Fibrosis

United States, Canada
Monash University
University of Melbourne; La Trobe University; Institute for Breathing and Sleep... and other collaborators

Recruiting

An Implementation Trial to Improve Access to Pulmonary Rehabilitation in People With COPD (HomeBase2)

Chronic Obstructive Pulmonary Disease

Australia
Alkermes, Inc.

Completed

ALK27-001: A Study of Trospium Inhalation Powder (TrIP)Administered to Subjects With COPD

Chronic Obstructive Pulmonary Disease (COPD)

United States
The University of Queensland

Recruiting

The TELO-SCOPE Study: Attenuating Telomere Attrition With Danazol. Is There Scope to Dramatically Improve Health Outcomes for Adults and Children With Pulmonary Fibrosis

Pulmonary Fibrosis | Dyskeratosis Congenita | Telomere Shortening | Telomere Disease

Australia
International AIDS Vaccine Initiative
University of Cape Town Lung Institute; European and Developing Countries Clinical... and other collaborators

Active, not recruiting

Study to Evaluate H56:IC31 in Preventing Rate of TB Recurrence

Tuberculosis, Pulmonary

South Africa, Tanzania
Ipsen

Active, not recruiting

A Rollover Study to Further Evaluate the Safety and Efficacy of Palovarotene Capsules in Male and Female Participants Aged ≥14 Years With Fibrodysplasia Ossificans Progressiva (FOP) Who Have Completed the Relevant Parent Studies. (PIVOINE)

Fibrodysplasia Ossificans Progressiva (FOP)

United States, France, Australia, Argentina, Italy, Canada, Sweden, United Kingdom, Brazil, Spain

Clinical Trials on Progressive Pulmonary Fibrosis in South Africa

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