Clinical Trials on Pyruvate Carboxylase Deficiency Disease

Total 8805 results

University of Colorado, Denver
Colorado Clinical & Translational Sciences Institute

Completed

Immunogenicity of Fluzone High Dose in Immunocompromised Children and Young Adults

Rheumatologic Disorder | Dialysis | Human Immunodeficiency Virus (HIV) | Solid Organ Transplant Recipient (Liver, Kidney, Heart) | Bone Marrow Transplant (BMT)

United States
M.D. Anderson Cancer Center
National Cancer Institute (NCI)

Withdrawn

Epacadostat and Pembrolizumab in Treating Participants With Advanced Pancreatic Cancer

Pancreatic Ductal Adenocarcinoma | Stage II Pancreatic Cancer AJCC v8 | Stage III Pancreatic Cancer AJCC v8 | Stage IV Pancreatic Cancer AJCC v8 | Homologous Recombination Deficiency | Stage IIA Pancreatic Cancer AJCC v8 | Stage IIB Pancreatic Cancer AJCC v8 | ATM Gene Mutation | Deleterious BRCA1 Gene... and other conditions
Lei Li

Recruiting

HRD and Resistance to PAPPi in EOC Patients

Epithelial Ovarian Cancer | Homologous Recombination Deficiency | Homologous Recombination Repair Gene Mutation | Drug Resistance | Overall Survival | Progression-free Survival | Poly(ADP-ribose) Polymerase Inhibitor

China
Temple University
The Comprehensive NeuroAIDS Center (CNAC) at Temple University

Terminated

Liraglutide for HIV-associated Neurocognitive Disorder

HIV Infection | Obesity | Overweight | Metabolic Syndrome | Diabetes Mellitus Type 2

United States
Centre for the AIDS Programme of Research in South...
Johns Hopkins University; National Institute of Allergy and Infectious Diseases... and other collaborators

Active, not recruiting

INSTI's For The Management of HIV-associated TB (INSIGHT)

HIV/AIDS | Tuberculosis, Pulmonary

South Africa
Leiden University Medical Center

Terminated

Electrophysiology of the Human Pituitary Gland

Pituitary Adenoma | Pituitary Tumor | Diabetes Insipidus Cranial Type | Endocrine; Deficiency

Netherlands
Cystinosis Research Foundation

Unknown

Cure Cystinosis International Registry (CCIR)

Cystinosis | Nephropathic Cystinosis | Renal Fanconi Syndrome

United States
Jesse Roman
Genentech, Inc.

Unknown

Efficacy and Safety of Pirfenidone Treatment in HPS-ILD (PEARL)

Interstitial Lung Disease | Hermansky Pudlak Syndrome

United States, Puerto Rico
Apollo Therapeutics Ltd

Not yet recruiting

A Study to Investigate APL-4098 Alone and/or in Combination With Azacitidine in R/R AML and High-Risk MDS

Myelodysplastic Syndrome With Excess Blasts | Acute Myeloid Leukemia, in Relapse | Acute Myeloid Leukemia Refractory | Myelodysplastic Syndrome Acute Myeloid Leukemia
Janssen-Cilag International NV

Completed

An Efficacy and Safety Study of Telaprevir in Patients Infected With Both Chronic Hepatitis C Virus (HCV-1) and Human Immunodeficiency Virus (HIV-1) (INSIGHT)

Chronic Hepatitis C

Australia, France, United Kingdom, Spain, Russian Federation, Brazil, Poland, Sweden
Janssen R&D Ireland

Completed

A Study to Assess the Safety, Tolerability and Efficacy of TMC435 Along With Pegylated Interferon Alpha-2a (Pegasys) and Ribavirin (Copegus) Triple Therapy in Chronic Hepatitis C Genotype-1 Infected Patients Co-infected With Human Immunodeficiency Virus-Type 1

Hepatitis C Virus Genotype-1

United States, France, United Kingdom, Germany, Spain, Portugal, Canada, Puerto Rico
Gilead Sciences

Completed

Efficacy and Safety of Sofosbuvir/Velpatasvir Fixed Dose Combination for 12 Weeks in Adults With Chronic Hepatitis C Virus (HCV) and Human Immunodeficiency Virus (HIV)-1 Coinfection (ASTRAL-5)

Hepatitis C Virus Infection

United States
Jazz Pharmaceuticals

Completed

Lurbinectedin Monotherapy in Participants With Advanced or Metastatic Solid Tumors (EMERGE-201) (EMERGE-201)

Advanced Solid Tumor | Metastatic Solid Tumor | Urothelial Cancer | Poorly Differentiated Neuroendocrine Carcinomas | Homologous Recombination Deficient-Positive Malignancies Agnostic

United States
National Cancer Institute (NCI)

Completed

Cancer Risk in Carriers of the Gene for Xeroderma Pigmentosum

Melanoma | Skin Cancer | Basal Cell Carcinoma | Squamous Cell Carcinoma | Xeroderma Pigmentosum

United States
University of Southern Denmark
Odense University Hospital; University of Ghana; Odense Patient Data Explorative... and other collaborators

Completed

POC Strategies to Improve TB Care in Advanced HIV Disease (TBPOC)

Acquired Immunodeficiency Syndrome | Tuberculosis, Pulmonary | Human Immunodeficiency Virus (HIV) | Extrapulmonary Tuberculosis

Ghana
Assistance Publique - Hôpitaux de Paris

Completed

Microcephaly Genetic Deficiency in Neural Progenitors (MICROFANC)

Microcephaly

France
OHSU Knight Cancer Institute
National Cancer Institute (NCI)

Completed

Tissue Sample Collection From Patients With Fanconi Anemia

Unspecified Childhood Solid Tumor, Protocol Specific | Unspecified Adult Solid Tumor, Protocol Specific | Fanconi Anemia

United States
Bio Products Laboratory

Completed

Efficacy, Safety and Pharmacokinetics of Gammaplex in Primary Immunodeficiency Diseases.

Primary Immunodeficiency | Wiskott-Aldrich Syndrome | Hypogammaglobulinemia | Common Variable Hypogammaglobulinemia | X-linked Hypogammaglobulinemia | Immunodeficiency With Hyper-IgM

United States
ViiV Healthcare
Pfizer

Withdrawn

Maraviroc Versus Etravirine In Combination With Antiretroviral Therapy In Drug Experienced HIV And Hepatitis Co-Infected Patients

Hepatitis B | Hepatitis C, Chronic | Human Immunodeficiency Virus

United States, Canada, Poland
National Institute of Allergy and Infectious Diseases...

Completed

Lamivudine and Adefovir to Treat Chronic Hepatitis B Infection in People With and Without HIV Infection

HIV Infections | Chronic Hepatitis B

United States
National Heart, Lung, and Blood Institute (NHLBI)

Completed

Pediatric Pulmonary and Cardiovascular Complications of Vertically Transmitted HIV Infection (P2C2)

Heart Diseases | Cardiovascular Diseases | HIV Infections | Acquired Immunodeficiency Syndrome | Heart Failure | Lung Diseases | Cytomegalovirus Infections | Pneumocystis Carinii Infections | Ebstein-Barr Virus Infections
Massachusetts General Hospital

Recruiting

Prostate Cancer Genetic Risk Evaluation and Screening Study (PROGRESS)

Lynch Syndrome | Genetic Predisposition to Disease | Prostate Cancer | BRCA1 Mutation | BRCA2 Mutation | Prostatic Neoplasm | ATM Gene Mutation | MMR Mutation

United States
Sanofi Pasteur, a Sanofi Company

Completed

Safety and Immunogenicity of a Tetravalent Dengue Vaccine in HIV-Positive Adults

Human Immunodeficiency Virus | Dengue Fever | Dengue Hemorrhagic Fever

Brazil
New York University
National Institute on Alcohol Abuse and Alcoholism (NIAAA)

Completed

Computer-based Intervention for Alcohol-using HIV/HCV+ Women

Hepatitis C | Human Immunodeficiency Virus | Alcohol Abuse

United States, Russian Federation
Paul Szabolcs

Recruiting

Data Collection Study of Patients With Non-Malignant Disorders Undergoing UCBT, BMT or PBSCT With RIC (PRO-RIC)

Congenital Bone Marrow Failure Syndromes | Inflammatory Conditions | Primary Immunodeficiency (PID) | Inherited Metabolic Disorders (IMD) | Hereditary Anemias

United States
National Cancer Institute (NCI)

Active, not recruiting

Examination of Clinical and Laboratory Abnormalities in Patients With Defective DNA Repair: Xeroderma Pigmentosum, Cockayne Syndrome, or Trichothiodystrophy

Skin Neoplasms | Xeroderma Pigmentosum | Cockayne Syndrome | Trichothiodystrophy Syndromes | Genodermatosis

United States
Rush University Medical Center

Recruiting

Gut Microbiota-Mediated Inflammatory Interactions Between AUD and HIV Infection

Alcohol Use Disorder | Human Immunodeficiency Virus

United States
National Institute of Cancerología
Instituto Nacional de Enfermedades Respiratorias

Completed

Impact of Valganciclovir on Severe IRIS-Kaposi Sarcoma Mortality: an Open-label, Parallel, Randomized Controlled-trial.

Kaposi Sarcoma | Human Immunodeficiency Virus | Immune Reconstitution Syndrome

Mexico
The University of Texas Health Science Center at...
National Heart, Lung, and Blood Institute (NHLBI)

Completed

KSHV Infection in Blood Donors From Texas

HIV Infections | Acquired Immunodeficiency Syndrome | Sarcoma, Kaposi | Blood Transfusion | Blood Donors | Herpesvirus, Kaposi Sarcoma-Associated
National Institute of Allergy and Infectious Diseases...
National Institute on Drug Abuse (NIDA); National Institute of Diabetes and... and other collaborators

Unknown

Observational Study of Changes in Fat Distribution and Blood Metabolites in HIV Infected Adults

HIV Infections | Diabetes | Atherosclerosis | Hyperlipidemia | Lipodystrophy
Oregon Health and Science University

Terminated

Dietary Cholesterol and Defects in Cholesterol Synthesis in Mevalonate Kinase Deficiency

Immune System Diseases | Lipid Metabolism, Inborn Errors | Mevalonic Aciduria | Mevalonate Kinase Deficiency | Periodic Fever Syndromes, Hereditary

United States
M.D. Anderson Cancer Center
National Cancer Institute (NCI)

Active, not recruiting

Weight Management and Health Behavior Intervention in Lowering Cancer Risk for BRCA Positive and Lynch Syndrome Families

Lynch Syndrome | Hereditary Breast Carcinoma | Hereditary Ovarian Carcinoma

United States
National Human Genome Research Institute (NHGRI)

Recruiting

Clinical and Basic Investigations Into Hermansky-Pudlak Syndrome

Hermansky-Pudlak Syndrome (HPS)

United States
UNC Lineberger Comprehensive Cancer Center
National Cancer Institute (NCI)

Recruiting

Acceptability and Feasibility of Combination Treatment for Cervical Precancer Among South African Women Living With HIV (ACT2)

Cervical Cancer | Human Immunodeficiency Virus | Human Papillomavirus | CIN2 | CIN3

South Africa
Assistance Publique - Hôpitaux de Paris

Not yet recruiting

Pembrolizumab in Progressive Multifocal Leukoencephalopathy (PML) in Immunocompromised Patients Without HIV Infection (PENALTY)

Progressive Multifocal Leukoencephalopathy

France
University of Minnesota

Recruiting

Natural History Study for DNA Repair Disorders

DNA Repair Disorder | Xeroderma Pigmentosum | Cockayne Syndrome | Trichothiodystrophy

United States
University Hospital, Essen

Recruiting

HIV-HEART Aging Study (HIVH)

Myocardial Infarction | HIV Infections | Heart Failure | Coronary Disease | Aging | Weight Gain | HIV Encephalopathy

Germany
Children's Hospital Medical Center, Cincinnati

Recruiting

Time-restricted Feeding to Reduce Inflammation in Fanconi Anemia

Fanconi Anemia

United States
Rocket Pharmaceuticals Inc.

Active, not recruiting

Lentiviral-mediated Gene Therapy for Pediatric Patients With Fanconi Anemia Subtype A

Fanconi Anemia Complementation Group A

Spain, United Kingdom
Rocket Pharmaceuticals Inc.

Active, not recruiting

Gene Therapy for Fanconi Anemia, Complementation Group A

Fanconi Anemia Complementation Group A

United States
Boston Children's Hospital

Terminated

Safety and Efficacy Trial of Danazol in Patients With Fanconi Anemia or Dyskeratosis Congenita

Fanconi Anemia | Dyskeratosis Congenita

United States
Yale University
National Institute on Drug Abuse (NIDA); Howard University; George Mason University

Completed

HIV, Buprenorphine, and the Criminal Justice System (STRIDE2)

Acquired Immunodeficiency Syndrome | Human Immunodeficiency Virus | Opiate Addiction | Drug Dependence

United States
Yale University
National Institute on Drug Abuse (NIDA); Baystate Medical Center

Completed

Naltrexone for Opioid Dependent Released Human Immunodeficiency Virus Positive (HIV+) Criminal Justice Populations (NewHope)

HIV | Opioid Dependence | AIDS | Drug Dependence

United States
University Hospital Inselspital, Berne
Merck Sharp & Dohme LLC; Pfizer

Completed

Prevalence of Sexually Transmitted Infections (STIs) in HIV-infected Patients (CTNG)

HIV Infections | Herpes Simplex | Chlamydia Trachomatis | Neisseria Gonorrhoeae

Switzerland
Yale University
National Institute on Drug Abuse (NIDA); Howard University; George Mason University

Completed

HIV, Buprenorphine, and the Criminal Justice System (STRIDE)

Acquired Immunodeficiency Syndrome | Human Immunodeficiency Virus | Opiate Addiction | Drug Dependence

United States
Emory University

Completed

New Strategies to Assess Anal Cancer Risk In Women (ANCAR-WIHS)

Human Immunodeficiency Virus (HIV) | Human Papillomavirus (HPV)

United States
National Cancer Institute (NCI)

Recruiting

Specimen Collections From Participants With HIV Infection, KSHV Infection, Viral-Related Pre-malignant Lesions and Cancer

HIV | Kaposi's Sarcoma | Primary Effusion Lymphoma | Lymphomas | Multicentric Castleman's Disease

United States
Rolfs Consulting und Verwaltungs-GmbH (RCV)
Rhythm Pharmaceuticals, Inc.

Recruiting

Early Genetic Identification of Obesity (WEGIO)

Cognitive Impairment | Hyperphagia | Obesity, Childhood | Bardet-Biedl Syndrome | Polydactyly | Retinopathy | Syndactyly | POMC Deficiency

Germany
Center for Neurological Studies
Novo Nordisk A/S

Recruiting

Growth Hormone Replacement Therapy for Retried Professional Football Players

TBI (Traumatic Brain Injury) | Growth Hormone Deficiency | Hypopituitarism | Sport Injury | Concussion, Brain | Anterior Pituitary Hyposecretion Syndrome

United States
Mayo Clinic

Completed

Spontaneous Coronary Artery Dissection (SCAD) and Autoimmunity

Multiple Sclerosis | Rheumatoid Arthritis | Systemic Lupus Erythematosus | Uveitis | Vasculitis | Psoriasis | Graves Disease | Systemic Sclerosis | Celiac Disease | Crohn Disease | Type 1 Diabetes Mellitus | Myasthenia Gravis | Ulcerative Colitis | Dermatomyositis | Polymyositis | Vitiligo | Hepatitis, Autoimmune | Polymyalgia... and other conditions

United States

Clinical Trials on Pyruvate Carboxylase Deficiency Disease

Sponsors and Collaborators

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Drug Interventions

CROs by country

CROs in Jordan

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