- ICH GCP
- US Clinical Trials Registry
- Clinical Trial NCT03445351
Quality of Life, Sleep, and Biomarkers in People With HIV/AIDS (PLHA)
February 19, 2018 updated by: JULIANY DE SOUZA ARAUJO
Effect of Exercise on Quality of Life, Sleep, and Biomarkers in People With HIV/AIDS
Aim: Evaluate the influence of exercise, in different times, on quality of life, sleep and clinical parameters in people living with HIV/AIDS (PLHA).
Methods: Intervention study, prospective.
Study Overview
Status
Completed
Conditions
Intervention / Treatment
Detailed Description
Aim: Evaluate the influence of exercise, in different times, on quality of life, sleep and clinical parameters in people living with HIV/AIDS (PLHA).
Methods: Intervention study, prospective, a cohort with 17 PLHA participants of the exercise program, higher than 18 years, under antiretroviral therapy with CD4+ ≥ 350/mm3.
Research Ethical Committee of the institution approved the study and the participants sign the informed consent and informed.
All subjects underwent an exercise program in conformity to American College of Sports Medicine, 3 times per week during 40 minutes.
Were evaluated the quality of life (QoL) with the Quality of Life - HAT - QoL and the sleep quality (SQ) with the Pittsburg questionnaire.
The subjects were evaluated before the start of exercise program and in three times: short-term (2 to 4 months), medium-term (between 5 and 17 months) and long-term (between 18 to 25 months).
Study Type
Interventional
Enrollment (Actual)
17
Phase
- Not Applicable
Participation Criteria
Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.
Eligibility Criteria
Ages Eligible for Study
18 years to 60 years (ADULT)
Accepts Healthy Volunteers
No
Genders Eligible for Study
All
Description
Inclusion Criteria:
- Must have age ≥ 18 years old;
- diagnosis of HIV/AIDS;
- use of antiretroviral therapy;
- Must have lymphocyte T CD4+ cell count ≥ 350 cel/mm3
- Must have physical fitness by the assistant physician.
Exclusion Criteria:
- pregnancy;
- severe hearing deficiency.
Study Plan
This section provides details of the study plan, including how the study is designed and what the study is measuring.
How is the study designed?
Design Details
- Primary Purpose: PREVENTION
- Allocation: NA
- Interventional Model: SINGLE_GROUP
- Masking: NONE
Arms and Interventions
Participant Group / Arm |
Intervention / Treatment |
---|---|
EXPERIMENTAL: Aerobic, resistance and concorrent
The group underwent exercise program with protocols of resistance training, aerobic training and concurrent training, with frequency of three times per week.
|
All protocols followed the American College of Sports Medicine (ACSM) guidelines , with frequency of three times per week, duration between 40-50 minutes, low to high intensity, modified according to the physical needs of each participant, respecting the physical training principles.
|
What is the study measuring?
Primary Outcome Measures
Outcome Measure |
Measure Description |
Time Frame |
---|---|---|
Quality of life
Time Frame: 24 MONTHS
|
A translation adapted and validated for Brazil of the HIV/AIDS Targeted Quality of Life questionnaire (HAT-QoL) developed by Holmes & Shea, was used .
The HAT-QoL present 34 questions divided in nine domains: Overall Function (OVEFUN), Life Satisfaction (LISA), Health Worries (HEAWOR), Financial Worries (FINWOR), Medication Concerns (MEDCON), HIV Mastery (HIVMAS), Disclosure Worries (DISWOR), Provider Trust (PROTRU) and Sexual Function (SEXFUN).
The score ranges from 0 to 100.
The responses have a five-point Likert scale: "all the time", "most of the time", "part of the time", "little time" and "never".
In each domain, zero is the lowest score and 100 the best score possible.
The higher the score, the lower the impact of HIV infection on the individuals' quality of life.
|
24 MONTHS
|
Secondary Outcome Measures
Outcome Measure |
Measure Description |
Time Frame |
---|---|---|
Quality of sleep
Time Frame: 24 MONTHS
|
For the QoS the Pittsburgh Sleep Quality Index validated for Brazilian population, was applied.
This scale is composed of 19 items that evaluate aspects related to sleep latency, duration, usual efficiency, sleep disturbance, use of hypnotic drugs and daytime dysfunction in the last month.
Scores smaller than 5 define good sleep quality; values ranging between 6 to 11 bad sleep quality and values greater than 11 sleep disturbance.
To answer the questionnaires, the subjects were oriented to think about the QoL and QoS in the previous four weeks.
|
24 MONTHS
|
Collaborators and Investigators
This is where you will find people and organizations involved with this study.
Sponsor
Investigators
- Principal Investigator: RAFAELA MEDEIROS, Universidade Federal do Rio Grande do Norte
Study record dates
These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.
Study Major Dates
Study Start (ACTUAL)
January 20, 2013
Primary Completion (ACTUAL)
April 22, 2015
Study Completion (ACTUAL)
September 13, 2016
Study Registration Dates
First Submitted
November 21, 2017
First Submitted That Met QC Criteria
February 19, 2018
First Posted (ACTUAL)
February 26, 2018
Study Record Updates
Last Update Posted (ACTUAL)
February 26, 2018
Last Update Submitted That Met QC Criteria
February 19, 2018
Last Verified
February 1, 2018
More Information
Terms related to this study
Keywords
Additional Relevant MeSH Terms
- Metabolic Diseases
- Skin Diseases
- RNA Virus Infections
- Virus Diseases
- Infections
- Blood-Borne Infections
- Communicable Diseases
- Sexually Transmitted Diseases, Viral
- Sexually Transmitted Diseases
- Lentivirus Infections
- Retroviridae Infections
- Immunologic Deficiency Syndromes
- Immune System Diseases
- Lipid Metabolism Disorders
- Slow Virus Diseases
- Skin Diseases, Metabolic
- HIV Infections
- Acquired Immunodeficiency Syndrome
- Lipodystrophy
Other Study ID Numbers
- AFISA
Plan for Individual participant data (IPD)
Plan to Share Individual Participant Data (IPD)?
NO
Drug and device information, study documents
Studies a U.S. FDA-regulated drug product
No
Studies a U.S. FDA-regulated device product
No
This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.
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