Clinical Trials on Rectum Cancer, Adenocarcinoma

Total 58620 results

Mayo Clinic

Completed

A Vaccine (PolyPEPI1018 Vaccine) and TAS-102 for the Treatment of Metastatic Colorectal Cancer

Metastatic Colorectal Adenocarcinoma | Metastatic Colon Adenocarcinoma | Metastatic Colorectal Carcinoma | Metastatic Rectal Adenocarcinoma | Stage IV Colorectal Cancer AJCC v8 | Stage IVA Colorectal Cancer AJCC v8 | Stage IVB Colorectal Cancer AJCC v8 | Stage IVC Colorectal Cancer AJCC v8 | Metastatic... and other conditions

United States
SCRI Development Innovations, LLC
Genentech, Inc.

Completed

5-Fluorouracil, Bevacizumab, and Radiation Followed by Modified FOLFOX6 and Bevacizumab in Stage II/III Rectal Cancer

Colorectal Cancer | Rectal Cancer | Cancer of the Rectum

United States
Corporacion Parc Tauli

Not yet recruiting

Prehabilitation in Rectal Cancer: During Neoadjuvant Therapy vs Preoperative (PREHAREC)

Rectal Cancer, Adenocarcinoma | Chemoradiotherapy

Spain
Gustave Roussy, Cancer Campus, Grand Paris

Recruiting

Preoperative Radiotherapy And ASTX660 in Rectum Cancer (PRAAR1)

Locally-advanced Rectal Cancer

France
National Cancer Institute (NCI)
NRG Oncology

Completed

Veliparib, Pembrolizumab, and Combination Chemotherapy in Treating Patient With Locally Advanced Rectal Cancer

Rectal Adenocarcinoma | Stage III Rectal Cancer AJCC v7 | Stage II Rectal Cancer AJCC v7

United States, Puerto Rico
Samsung Medical Center

Completed

The Safety and Feasibility of MONOFIX on Fascial Closure of Mid-line Wound After Minimally Invasive Colorectal Cancer Surgery

Rectal Cancer | Colon Cancer | Rectal Adenocarcinoma | Colon Adenocarcinoma

Korea, Republic of
National Cancer Institute (NCI)

Completed

Bevacizumab, Radiation Therapy, and Combination Chemotherapy in Treating Patients Who Are Undergoing Surgery for Locally Advanced Nonmetastatic Rectal Cancer

Rectal Adenocarcinoma | Stage III Rectal Cancer AJCC v7 | Stage II Rectal Cancer AJCC v7

United States
Washington University School of Medicine

Terminated

PET/MR for Rectal Cancer Treatment Monitoring and Surveillance

Rectal Cancer | Cancer of the Rectum

United States
Peking University Third Hospital

Completed

The Physical Dosimetry Study and Preliminary Clinical Results of 3D-printing Non Co-planar Template Assisted With CT-guidance for Iodine-125 Seed Brachytherapy in Pelvic Recurrent Rectum Carcinoma After Surgery and External Beam Radiotherapy

Rectum Cancer, Recurrent | Brachytherapy, Radioisotope
OHSU Knight Cancer Institute
Oregon Health and Science University; Taiho Pharmaceutical Co., Ltd.

Recruiting

TAS-102 With Concurrent Radiation for the Treatment of Untreated Resectable Stage II-III Rectal Cancer

Stage III Rectal Cancer AJCC v8 | Stage IIIA Rectal Cancer AJCC v8 | Stage IIIB Rectal Cancer AJCC v8 | Stage IIIC Rectal Cancer AJCC v8 | Rectal Adenocarcinoma | Stage IIA Rectal Cancer AJCC v8 | Stage IIB Rectal Cancer AJCC v8

United States
Instituto do Cancer do Estado de São Paulo

Completed

Carnoy's Solution Versus Formalin in Rectal and Gastric Cancer Specimens Following: a Randomized Trial

Rectal Cancer | Gastric Adenocarcinoma
Peking Union Medical College Hospital
Geneplus-Beijing Co. Ltd.

Unknown

Investigation of the Value of ctDNA in Diagnosis, Treatment, and Surveillance of Surgically Resectable Colorectal Cancer

Rectal Cancer, Adenocarcinoma | Neoadjuvant Chemoradiation
Siemens Molecular Imaging

Completed

Efficacy Study of [F-18]RGD-K5 Positron Emission Tomography (PET) as a Tool to Monitor Response to an Anti-angiogenic Drug (K5-101)

Non-squamous Non-small Cell Lung Cancer | Metastatic Breast Cancer | Metastatic Colon/Rectum Cancer

United States
Weill Medical College of Cornell University
Sanofi

Withdrawn

Phase II Study of Zaltrap and Chemotherapy for Advanced Resectable Colorectal Cancer

Adenocarcinoma of the Rectum | Adenocarcinoma of the Colon

United States
Centre Leon Berard
Merck Sharp & Dohme LLC; Debiopharm International SA

Completed

Pembrolizumab In Combination With Debio 1143 In Pancreatic and Colorectal Advanced/Metastatic Adenocarcinoma (CATRIPCA)

Adenocarcinoma of the Pancreas | Adenocarcinoma of the Rectum | Adenocarcinoma of the Colon

France
H. Lee Moffitt Cancer Center and Research Institute

Completed

Capecitabine and Lenvatinib With External Radiation in Rectal Adenocarcinoma

Rectal Cancer | Rectal Adenocarcinoma

United States
University of Manchester
The Christie NHS Foundation Trust

Unknown

Optimisation of Radiotherapy in Rectal Cancer (ORREC) (ORREC)

Rectal Adenocarcinoma

United Kingdom
Cliniques universitaires Saint-Luc- Université...

Completed

Interest of Saline MR Peritoneography for Pre-operative Assessment of Rectal Cancer

Rectal Adenocarcinoma

Belgium
National Cancer Institute (NCI)

Terminated

Testing the Addition of a Radiation Sensitizing Drug, IPdR, to the Usual Chemotherapy Treatment (Capecitabine) During Radiation Therapy for Rectal Cancer

Stage III Rectal Cancer AJCC v8 | Rectal Adenocarcinoma | Stage II Rectal Cancer AJCC v8 | Locally Advanced Rectal Carcinoma

United States
Wake Forest University Health Sciences
National Cancer Institute (NCI)

Completed

Effectiveness and Implementation of mPATH-CRC

Cancer | Colorectal Cancer | Colon Cancer | Rectum Cancer

United States
OHSU Knight Cancer Institute
Natera, Inc.

Recruiting

Establishing a ctDNA Biomarker to Improve Organ Preserving Strategies in Patients With Rectal Cancer

Stage III Rectal Cancer AJCC v8 | Stage IIIA Rectal Cancer AJCC v8 | Stage IIIB Rectal Cancer AJCC v8 | Stage IIIC Rectal Cancer AJCC v8 | Rectal Adenocarcinoma | Stage IIA Rectal Cancer AJCC v8 | Stage IIB Rectal Cancer AJCC v8 | Stage II Rectal Cancer AJCC v8 | Stage IIC Rectal Cancer AJCC v8

United States
M.D. Anderson Cancer Center
National Cancer Institute (NCI)

Recruiting

Active Surveillance and Chemotherapy Before Surgery in Treating Participants With Stage II-III Rectal Cancer

Stage III Rectal Cancer AJCC v8 | Stage IIIA Rectal Cancer AJCC v8 | Stage IIIB Rectal Cancer AJCC v8 | Stage IIIC Rectal Cancer AJCC v8 | Rectal Adenocarcinoma | Stage IIA Rectal Cancer AJCC v8 | Stage IIB Rectal Cancer AJCC v8 | Stage II Rectal Cancer AJCC v8 | Stage IIC Rectal Cancer AJCC v8

United States
Kantonsspital Winterthur KSW

Recruiting

Long-term Cohort Study of Mesorectal Excision for Rectal Cancer (TME-KSW)

Cancer | Rectum

Switzerland
Sir Run Run Shaw Hospital

Recruiting

Total Neoadjuvant Therapy With Short-course Radiation Followed by Envafolimab Plus CAPEOX for MSS Locally Advanced Ultra Low Rectal Adenocarcinoma (RECMULRA-TNT)

Rectal Cancer

China
Sir Run Run Shaw Hospital

Recruiting

Preoperative Short-course Radiation Followed by Envafolimab Plus CAPEOX for MSS Locally Advanced Rectal Adenocarcinoma

Rectal Cancer

China
Institut de cancérologie Strasbourg Europe

Recruiting

Interest of PET-MRI in the Evaluation of the Response After Neoadjuvant Treatment of Locally Advanced Rectal Adenocarcinoma (TEPIREC)

Rectal Cancer

France
Ascension South East Michigan

Recruiting

Treatment of Adenocarcinoma of the Rectum With Transanal Local Excision for Complete Responders

Rectal Cancer

United States
University of Wisconsin, Madison
Bristol-Myers Squibb; Eli Lilly and Company; Sanofi

Terminated

Phase II Trial of Neoadjuvant FOLFOX4 and Cetuximab for Localized Adenocarcinoma of Rectum

Rectal Cancer

United States
Instituto do Cancer do Estado de São Paulo

Unknown

A Study Comparing Adjuvant Chemotherapy Versus Observation for Patients With Rectal Adenocarcinoma After Neoadjuvant Chemo-Radiotherapy Treatment.

Rectal Cancer

Brazil
Radboud University Medical Center

Unknown

Microbiome Analysis in esoPhageal, PancreatIc and Colorectal CaNcer Patients Undergoing Gastrointestinal Surgery (MA-PPING)

Colorectal Cancer | Pancreatic Cancer | Esophageal Cancer | Esophageal Neoplasms | Anastomotic Leak | Colonic Neoplasms | Pancreatic Ductal Adenocarcinoma | Gastrointestinal Cancer | Microbiota | Gastrointestinal Microbiome | Rectum Neoplasm
Umraniye Education and Research Hospital

Completed

Evaluating Factors Affecting Survival in Colon and Rectum Cancer

Colon Cancer | Rectum Cancer
University of Texas Southwestern Medical Center
Apexigen America, Inc.

Active, not recruiting

INNATE: Immunotherapy During Neoadjuvant Therapy for Rectal Cancer

Locally Advanced Rectal Adenocarcinoma

United States
University of California, San Francisco

Completed

Self-monitoring and Reminder Texts to Increase Physical Activity After Cancer: a Pilot Randomized Controlled Trial (Smart Pace)

Colon Cancer | Rectum Cancer

United States
M.D. Anderson Cancer Center
Bayer; Xencor, Inc.

Withdrawn

Regorafenib and XmAb20717 in Treatment of High-risk Patients With Colorectal Cancer With Radiographic Occult Molecular Residual Disease After End of Established Definitive Therapy (RX-CROME)

Colorectal Cancer | Colon Cancer | Rectum Cancer

United States
TheraOp

Active, not recruiting

MoLiMoR - A Study With FOLFIRI-based First-line Therapy With or Without Intermittent Cetuximab

Adenocarcinoma of the Rectum | Adenocarcinoma of the Colon

Germany
Instituto Nacional de Cancer, Brazil

Terminated

Induction Chemotherapy Plus Chemoradiotherapy With or Without Aspirin in High Risk Rectal Cancer (ICAR)

Chemoradiation | Rectal Cancer, Adenocarcinoma | Locally Advanced Malignant Neoplasm

Brazil
Peking Union Medical College Hospital
Peking University People's Hospital; Beijing Friendship Hospital; Cancer Institute... and other collaborators

Unknown

Multicenter, Prospective, RCT：Investigation of Combined Modality Therapy for Locally Advanced Mid/Low Rectal Cancer.

Rectal Cancer, Adenocarcinoma | Neoadjuvant Chemoradiation
University Hospital Ostrava

Recruiting

PREHAB - Improving Condition Before Surgery

Cancer, Rectum | Cancer, Digestive System

Czechia
Institut Paoli-Calmettes
University of California, Los Angeles

Recruiting

Monitoring Treatment Response With On-board DWI During Neo-adjuvant Chemo-radiation for Rectal Cancer Using Magnetic Resonance-guided-radiotherapy Systems (DWI_RECT_MRGRT)

Rectal Adenocarcinoma

France, United States
Assiut University

Completed

Metastatic Left Colon and Rectal Cancer Treatment With Anti_EGFR Targeted Therapy (EGFR)

Metastatic Colorectal Adenocarcinoma
University of Texas Southwestern Medical Center

Withdrawn

Altered Chemotherapy Sequencing During Neoadjuvant Therapy for Patients With Stage II or III Rectal Adenocarcinoma

Stage II Rectal Cancer | Stage III Rectal Cancer

United States
Fundación de Investigación Biomédica - Hospital...
Hospital Universitario La Fe; Hospital Alemão Oswaldo Cruz; Complejo Hospitalario...

Recruiting

Local Excision for Organ Preservation in Early REctal Cancer With No Adjuvant Treatment (LORENA)

Rectal Cancer | Rectum Neoplasm

Spain
Tampere University Hospital
Turku University Hospital; Helsinki University Central Hospital; Oulu University... and other collaborators

Recruiting

Nordic ORgan Preservation Pilot Approach Nonrandomised Single-Arm Trial for Non-Operative Management of Rectal Cancer (NORPPA-1)

Rectal Cancer | Rectal Adenocarcinoma

Finland, Estonia
Liz-Anne Lewsley
AstraZeneca; NHS Greater Glasgow and Clyde; University of Glasgow

Not yet recruiting

A Trial of Durvalumab (MEDI 4736) in Combination With Extended Neoadjuvant Regimens in Rectal Cancer (PRIME-RT)

Rectal Cancer | Rectal Neoplasms | Rectal Adenocarcinoma
University of California, San Francisco

Terminated

Evaluation of Rectal Cancer Treatment Response Using PET/MRI (Rectal PET/MRI)

Rectal Adenocarcinoma

United States
IHU Strasbourg

Terminated

Evaluation of Rectal Tumor Margin Using Confocal Endomicroscopy and Comparison to Histopathology (TRaMA)

Rectal Cancer | Rectal Adenocarcinoma

France
Blokhin's Russian Cancer Research Center

Enrolling by invitation

Induction and Consolidation Chemotherapy in Patients With Locally Advanced CRM-positive Rectal Cancer (RuCorT-03)

Rectal Cancer | Rectum Carcinoma | Rectal Neoplasms Malignant

Russian Federation
Blokhin's Russian Cancer Research Center

Enrolling by invitation

Neoadjuvant Chemotherapy in Patients With Moderate Risk Mid Rectal Cancer (RuCorT-02)

Rectal Cancer | Rectum Carcinoma | Rectal Neoplasms Malignant

Russian Federation
Mayo Clinic
National Cancer Institute (NCI)

Completed

TAS-102 and Radiation Therapy in Treating Patients With Rectal Cancer That Is Locally Recurrent, Metastatic, or Cannot Be Removed by Surgery

Recurrent Rectal Carcinoma | Rectal Adenocarcinoma | Stage IV Rectal Cancer AJCC v7 | Stage IVA Rectal Cancer AJCC v7 | Stage IVB Rectal Cancer AJCC v7

United States
Blokhin's Russian Cancer Research Center

Enrolling by invitation

Neoadjuvant Chemotherapy in Patients With Intermediate Risk Upper and Mid Rectal Cancer (RuCorT-01)

Rectal Cancer | Rectum Carcinoma | Rectal Neoplasms Malignant

Russian Federation

Clinical Trials on Rectum Cancer, Adenocarcinoma

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