Clinical Trials on Resistance Mutations

Total 6410 results

Pfizer
Medivation, Inc.; Myriad Genetic Laboratories, Inc.

Terminated

A Phase 2, 2-Stage, 2-Cohort Study of Talazoparib (BMN 673), in Locally Advanced and/or Metastatic Breast Cancer Patients With BRCA Mutation (ABRAZO Study) (ABRAZO)

Breast Neoplasms | BRCA 1 Gene Mutation | BRCA 2 Gene Mutation

United States, Spain, United Kingdom, Germany, France
Gynecologic Oncology Group
National Cancer Institute (NCI)

Withdrawn

Breast Cancer Risk in Women Who Are BRCA1/BRCA2 Mutation Carriers

Breast Carcinoma | BRCA1 Mutation Carrier | BRCA2 Mutation Carrier

United States
Hadassah Medical Organization

Unknown

Transformation Potential of E2 Exposed Breast Cancer Susceptibility Gene Mutation Heterozygous Epithelial Breast Cells

BRCA1 Gene Mutation | BRCA2 Gene Mutation

Israel
Eloxx Pharmaceuticals, Inc.

Terminated

Safety, Tolerability, Pharmacokinetics of ELX-02 in Healthy Adult Volunteers

Genetic Diseases | Nonsense Mutations
Eunice Kennedy Shriver National Institute of Child...

Completed

Exercise in Insulin-Resistant Minority Adolescents

Insulin-Resistance

United States
University Hospital, Bordeaux

Completed

Detection of Colistin-resistant Isolates From Patients of Intensive Care Units and Oncohaematology Wards. (RESCO)

Colistin Resistance in Bacteria

France
Cukurova University

Completed

Effects of Dexmedetomidine and Propofol on Pulmonary Mechanics

Abnormal Respiratory Airway Resistance

Turkey
Pfizer

Completed

Zyvox (Linezolid) Special Investigation For Vancomycin-Resistant Enterococci (VRE)

Vancomycin Resistance Enterococcus Faecium
Second Affiliated Hospital of Wenzhou Medical University

Recruiting

Application of Aerobic and Resistance Exercise in Blood Glucose Control in Pregnant Women With GDM

Aerobic and Resistance Exercise

China
Federal University of Rio Grande do Sul

Completed

Resistance Training in the Fasted State

Exercise | Fasting | Resistance Training

Brazil
University of Miami

Completed

High Speed Circuit Training and Cognition

Resistance Training | Educational Control

United States
Danone North America

Completed

Comparison of Plant and Animal Proteins on Amino Acid Concentrations

Healthy Resistance-Trained Males

Canada
ART Fertility Clinics LLC

Completed

Evaluating the AMH Levels During Natural Cycle

Anti-Mullerian Hormone Resistance

United Arab Emirates
University Hospital, Limoges

Completed

Prevalence of Digestive Carriage of Integrons (APIHA)

Bacterial Resistance to Antimicrobial

France
Centre Hospitalier Universitaire de Nice

Unknown

Identification of Large-Scale Mutations of POLG Gene by QMPSF in Patients With Mitochondrial DNA Instability.

Mitochondrial Diseases | Diagnosis | DNA Mutations

France
Dana-Farber Cancer Institute
Johns Hopkins University; GlaxoSmithKline; Translational Breast Cancer Research...

Recruiting

Niraparib + Dostarlimab In BRCA Mutated Breast Cancer

Breast Cancer | Stage I Breast Cancer | Stage II Breast Cancer | HER2-negative Breast Cancer | Stage III Breast Cancer | Deleterious PALB2 Gene Mutation | Germline BRCA1 Gene Mutation | Germline BRCA2 Gene Mutation

United States
Pharming Technologies B.V.
Laboratory Corporation of America; CMIC Co, Ltd. Japan; Axial Biotech, Inc

Recruiting

An Open-Label Study to Assess the Safety & Efficacy of Leniolisib in Japanese Patients With APDS

APDS Gene Mutation

Japan
The University of Hong Kong

Completed

Combination of Sorafenib and Omacetaxine Mepesuccinate in Newly Diagnosed or Relapsed/Refractory AML Carrying FLT3-ITD

AML | FLT3-ITD Mutation

Hong Kong
SUNHO（China）BioPharmaceutical CO., Ltd.

Recruiting

IAH0968 in Combination With GC for the Treatment of HER2-Positive Unresectable Advanced/Metastatic Malignant Tumors

HER2 Gene Mutation

China
MapKure, LLC

Recruiting

Study of Safety, Pharmacokinetics, and Antitumor Activity of BGB-3245 in Participants With Advanced or Refractory Tumors

Solid Tumor | B-Raf Mutation-Related Tumors

United States, Australia
Pfizer

Completed

A Phase Ib/II Study of LGX818 in Combination With MEK162 in Adult Patients With BRAF Dependent Advanced Solid Tumors

Solid Tumors Harboring a BRAF V600 Mutation

United States, France, Italy, Singapore, Australia, Spain, Switzerland, Canada, Belgium
Fujian Cosunter Pharmaceutical Co. Ltd

Unknown

Safety, Tolerability, Pharmacokinetic Characteristics, and Preliminary Efficacy Evaluation of GST-HG161

Solid Tumor | C-Met Mutation-Related Tumors

China
Qingdao Central Hospital

Completed

Weekly Use First-generation EGFR-TKI in the Treatment of EGFR-TKI Acquired Resistance Non-small Cell Lung Cancer (NSCLC)

EGFR-TKI Resistant Mutation

China
German Diabetes Center
Yale University

Recruiting

Overfeeding Induced Fat-tissue Stimulation (OVID_FASTI)

Lipid-induced Insulin Resistance

Germany
Seoul National University Bundang Hospital

Recruiting

Prevalence and Trends of Antimicrobial Resistance of Helicobacter Pylori in Korea

Helicobacter Pylori Infection | Helicobacter Pylori 23S rRNA Clarithromycin Resistance Mutation | Helicobacter Pylori Associated Gastrointestinal Disease | Helicobacter Pylori Infection, Susceptibility to

Korea, Republic of
Imperial College London
The Behavioural Insights Team

Not yet recruiting

Testing New Ways to Name Antimicrobial Resistance

Antimicrobial Resistance | Attitude to Health
Universitat Internacional de Catalunya

Recruiting

Effectiveness of Iso-inertial Resistance Training in Physically Active Older Adults

Aged | Muscle Strength | Resistance Training

Spain
Texas Tech University
Legion Athletics, Inc

Completed

Influence of Caffeinated and Non-caffeinated Pre-workout Supplements on Resistance Exercise Performance

Caffeine | Resistance Training | Dietary Supplements

United States
Christoph Hatz
University of Zurich

Completed

The Effect of Hand Hygiene on Colonization Rates With Multidrug Resistant Enteric Pathogens in Travellers

Drug Resistance, Multiple | Travel Medicine

Switzerland
University Health Network, Toronto

Active, not recruiting

Integrative Sequencing In Germline and Hereditary Tumours (INSIGHT)

Mutation | Hereditary Cancer Syndrome | High-Risk | Germline Mutation

Canada
Chang Gung Memorial Hospital
Intuitive Surgical

Active, not recruiting

Pilot Study of Single-port Robot-assisted Nipple-sparing Mastectomy

Breast Cancer | BRCA1 Mutation | BRCA2 Mutation | Nipple-sparing Mastectomy | Prophylactic Mastectomy

Taiwan
Centre Jean Perrin
International Cancer Research Group; Institut Max Planck d'optique quantique

Active, not recruiting

Interest of Broadband Spectroscopy Analysis by Infrared Laser on Liquid Biopsies in Breast Cancer Screening (ICRG0101)

BRCA1 Mutation | BRCA2 Mutation | Breast Cancer Female

France
Georgetown University
George Washington University

Enrolling by invitation

Genetic Education in BRCA Families

BRCA1 Mutation | BRCA2 Mutation

United States
VA Office of Research and Development

Recruiting

Carboplatin or Olaparib for BRcA Deficient Prostate Cancer (COBRA)

Metastatic Castrate Resistant Prostate Cancer | BARD1, BRCA1, BRCA2, BRIP1, CHEK1, FANCL, PALB2 | RAD51B, RAD51C, RAD51D, or RAD54L Mutations

United States
Phramongkutklao College of Medicine and Hospital

Unknown

Optimizing Antibiotic Dosing Regimens for the Treatment of Infection Caused by Carbapenem Resistant Enterobacteriaceae

Sepsis | Critical Illness | Septic Shock | Clinical Outcomes | Treatment Outcomes | Drug Resistance | Carbapenem-Resistant Enterobacteriaceae Infection

Thailand
Assiut University

Completed

Impact of Acute Insulin Resistance on Myocardial Blush in Non- Diabetic Patients Undergoing Primary Percutaneous Coronary Intervention

Insulin Resistance and PCI

Egypt
Charite University, Berlin, Germany

Unknown

RM-493 Treatment Trial in Proopiomelanocortin (POMC) Deficient Patients

Homozygous or Compound Heterozygous POMC, LEPR or PCSK1 Gene Mutation

Germany
ArriVent BioPharma, Inc.

Recruiting

Study of Furmonertinib in Patients With Advanced or Metastatic Non-Small Cell Lung Cancer (NSCLC) With Activating, Including Uncommon, Epidermal Growth Factor Receptor (EGFR) or Human Epidermal Growth Factor Receptor 2 (HER2) Mutations

Advanced Non-Small Cell Lung Cancer | Metastatic Non-Small Cell Lung Cancer | Non-Small Cell Lung Cancer (NSCLC) | HER2 Exon 20 Mutations | EGFR Exon 20 Mutations | EGFR Uncommon Mutations, Including G719X and S768I

United States, Australia, Spain, United Kingdom, France, China, Korea, Republic of, Canada, Japan, Netherlands, Italy
Columbia University
American Cancer Society, Inc.

Completed

Decision Support for BRCA Testing in Ethnically Diverse Women

Breast Cancer | Ovarian Cancer | BRCA1 Mutation | BRCA2 Mutation

United States
Oslo Metropolitan University
Sophies Minde Foundation; UniCare Bakke AS

Completed

Prosthetic Use, Mobility and Daily Functioning (ProMob)

Lower Leg Amputations

Norway
Clinical Directors Network
Patient-Centered Outcomes Research Institute; Rockefeller University

Unknown

Patient-Centered Comparative Effectiveness Research (CER) Study of Home-based Interventions to Prevent CA-MRSA Infection Recurrence (CAMP-2)

Recurrence | Staphylococcal Skin Infections | Antibiotic Resistance | Methicillin-Resistant Staphylococcus Aureus

United States
Stanford University

Not yet recruiting

Stronger: Muscle Strengthening for Menopause

Resistance Training

United States
Riphah International University

Recruiting

Plyometric vs Explosive Strength Training on Agility, Power, and Balance in Basketball Players

Resistance Training | Plyometric Exercise | Basketball

Pakistan
University of California, San Francisco
Bill and Melinda Gates Foundation; Ministry of Health, Niger

Recruiting

Azithromycin for Child Survival in Niger: Mortality and Resistance Trial (AVENIR)

Mortality | Child, Only | Resistance Bacterial

Niger
Riphah International University

Completed

Big Toe Strength Training on Athletic Performance Parameter

Running | Athletic Performance | Resistance Training

Pakistan
Universidade Regional do Cariri

Completed

Eight Week Strength Training Reduces Blood Pressure of Middle Age Women

Blood Pressure | Resistance Training | Women

Brazil
Novartis Pharmaceuticals

Completed

Safety, Efficacy, Pharmacokinetics, Pharmacodynamics of ACZ885 in Patients With NALP3 Mutations and Clinical Symptoms

NALP3 Mutation

United Kingdom, France, Germany, India, Spain
Dr. Manuel González-Sánchez

Completed

Core Training Protocol vs Traditional Abdomen Exercise Protocol

Exercise | Resistance Training | Functional Performance

Spain
Basilea Pharmaceutica

Completed

Effect of Ceftobiprole on Human Intestinal Microflora

Drug Resistance | Antimicrobial Agent | Cephalosporins
BeBetter Med Inc
Xiangya Hospital of Central South University

Recruiting

Study of BEBT-607 Tablets in The Treatment of Advanced or Metastatic Solid Tumors With KRAS G12C Mutation

Advanced or Metastatic Solid Tumor | KRAS G12C Mutation

China

Clinical Trials on Resistance Mutations

Sponsors and Collaborators

Medical Conditions

Drug Interventions

CROs by country

CROs in Gambia

Conditions

Rare Diseases

Drug Interventions

Dietary Supplements

Sponsor/Collaborators

Locations