- ICH GCP
- US Clinical Trials Registry
- Clinical Trial NCT04022707
High Speed Circuit Training and Cognition
May 15, 2020 updated by: Joseph Signorile, University of Miami
The Impact of Circuit Resistance Training on Cognition and Estimated Maximal Oxygen Consumption in Older Adults.
The purpose of this research study is to see if a weight training program can make a positive change in participant fitness as measured by the ability to use oxygen and help the participant remember things.
Study Overview
Status
Completed
Conditions
Intervention / Treatment
Detailed Description
The purpose of this research study is to see if a weight training program can make a positive change in cardiac fitness, that is a person's ability to use oxygen; and, if the program can help a person's memory, as measured by some standard tests.
The researchers will also ask the participant to attend two sessions with researchers at the Bascom-Palmer Eye Institute so they can take pictures of the participants' eyes to see how training changes the number of blood vessels.
This can be used by doctors and other clinicians to evaluate improvements blood flow to the brain due to training.
Study Type
Interventional
Enrollment (Actual)
30
Phase
- Not Applicable
Contacts and Locations
This section provides the contact details for those conducting the study, and information on where this study is being conducted.
Study Locations
-
-
Florida
-
Coral Gables, Florida, United States, 33147
- Laboratory of Neruomuscular Research and Active Aging
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Coral Gables, Florida, United States, 33146-2416
- Max Orovitz Laboratories
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-
Participation Criteria
Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.
Eligibility Criteria
Ages Eligible for Study
60 years to 85 years (Adult, Older Adult)
Accepts Healthy Volunteers
Yes
Genders Eligible for Study
All
Description
Inclusion Criteria:
- Men and women between 60 and 85 years of age (inclusive)
- Ability to provide informed consent
- No medical contraindication to participation in an exercise program including unstable or active untreated major medical illness (i.e., cardiovascular disease, neurological or neuromuscular diseases, stroke, cancer, etc.).
Exclusion Criteria:
- Existing muscle-skeletal injury
- Mini-mental score <18
- Enrolled in another exercise program
- Unstable or active major medical illness
- Answer "Yes" to any questions on the Elder PAR-Q
- Pregnancy
Study Plan
This section provides details of the study plan, including how the study is designed and what the study is measuring.
How is the study designed?
Design Details
- Primary Purpose: Treatment
- Allocation: Randomized
- Interventional Model: Parallel Assignment
- Masking: Double
Arms and Interventions
Participant Group / Arm |
Intervention / Treatment |
---|---|
Experimental: High-Velocity Resistance Circuttraining (HVRCT)
The participants will perform three circuits of 11 exercises that target the upper and lower body.
Training will gradually increase over the first three weeks from 1 to 3 circuits.
|
The program will include three circuits of 11 exercises that target the upper and lower body.
Training will gradually increase over the first three week from 1 to 3 circuits.
Other Names:
Lectures on health and fitness
Other Names:
|
Experimental: Educational Control (CON)
A supervised program will be provided to the participants that includes lectures on health and fitness.
|
The program will include three circuits of 11 exercises that target the upper and lower body.
Training will gradually increase over the first three week from 1 to 3 circuits.
Other Names:
Lectures on health and fitness
Other Names:
|
What is the study measuring?
Primary Outcome Measures
Outcome Measure |
Measure Description |
Time Frame |
---|---|---|
Changes in Cognition due to training
Time Frame: Baseline, Week 14
|
The MoCA will be used to detect mild cognitive impairment in the participants.
The total possible score is 30 points; a score of 26 or above is considered normal.
|
Baseline, Week 14
|
Submaximal cycle ergometer test to measure aerobic capacity
Time Frame: Baseline, Week 14
|
The Young Men's Club of America (YMCA) cycle ergometer test will be used to compute aerobic capacity using heart rate(HR).
Predicted oxygen consumption will be computed using the HR of the last two consecutive workloads performed and the maximum workload.
A maximal oxygen consumption of 36 milliliters per kilogram body weight per minute and above is considered excellent for men, while 30 milliliters per kilogram body weight per minute is considered excellent for women.
|
Baseline, Week 14
|
Change in episodic memory
Time Frame: Baseline, Week 14
|
The National Institutes of Health (NIH) Toolbox: Picture Sequence Memory Test measures episodic memory.
Participants are asked to reproduce a sequence of pictures that is shown on the screen.
Participants are given credit for each adjacent pair of pictures they correctly place (i.e., if pictures in locations 7 and 8 are placed in that order and adjacent to each other anywhere, such as slots 1 and 2, one point is awarded), up to the maximum value for the sequence, which is one less than the sequence length or 17.
|
Baseline, Week 14
|
Change in attention and inhibitory control
Time Frame: Baseline, Week 14
|
The NIH Toolbox Flanker test measures attention and inhibitory control.
Participant focuses on a given stimulus while inhibiting attention to stimuli flanking it.
This computed score ranges from 0-10, but if the score is less than 4, it indicates that the participant did not score high enough in accuracy (80 percent correct or less) to receive a reaction time score.
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Baseline, Week 14
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Change in working memory
Time Frame: Baseline, Week 14
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The NIH Toolbox List Sorting test measures working memory.
Participant recalls and sequences different visually and orally presented stimuli.
List Sorting is scored by summing the total number of items correctly recalled and sequenced on 1-List and 2-List, which can range from 0-26.
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Baseline, Week 14
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Change in speed of cognitive processing
Time Frame: Baseline, Week 14
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The NIH Toolbox Pattern Comparison Processing Speed test measures speed of processing.
Participants discern whether two side-by-side pictures are the same or not, with 85 seconds to respond to as many items as possible.
Items are simple so as to purely measure processing speed.
The participant's raw score is the number of items answered correctly in 85 seconds of response time, with a range of 0-130.
|
Baseline, Week 14
|
Changes in the power muscles can produce
Time Frame: Baseline, Week 14
|
The participants will stand up and down 3 times with a thin string attached to the participant's belt.
A total of five attempts will be performed by each participant, and the highest power output will be selected for use in the analysis.
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Baseline, Week 14
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Change in retinal microvascular density as a marker of cortical changes
Time Frame: Baseline, Week 14
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Retinal microvascular density will be assessed using the Retinal Function Imager (RFI) scan protocol and Optical Coherence Tomography Angiography (OCTA).
Pictures will be taken of the subject's retina as they look into a special self-contained camera system.
|
Baseline, Week 14
|
Secondary Outcome Measures
Outcome Measure |
Measure Description |
Time Frame |
---|---|---|
Changes in body fat-free mass
Time Frame: Baseline, Week 14
|
Fat-free mass will be measured using a Tanita BC-418 bioelectrical impedance scale.
|
Baseline, Week 14
|
Changes in body weight
Time Frame: Baseline, Week 14
|
Body weight will be measured on an electronic scale
|
Baseline, Week 14
|
Collaborators and Investigators
This is where you will find people and organizations involved with this study.
Sponsor
Study record dates
These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.
Study Major Dates
Study Start (Actual)
August 1, 2019
Primary Completion (Actual)
April 30, 2020
Study Completion (Actual)
April 30, 2020
Study Registration Dates
First Submitted
July 10, 2019
First Submitted That Met QC Criteria
July 16, 2019
First Posted (Actual)
July 17, 2019
Study Record Updates
Last Update Posted (Actual)
May 18, 2020
Last Update Submitted That Met QC Criteria
May 15, 2020
Last Verified
May 1, 2020
More Information
Terms related to this study
Other Study ID Numbers
- 20190518
Plan for Individual participant data (IPD)
Plan to Share Individual Participant Data (IPD)?
NO
Drug and device information, study documents
Studies a U.S. FDA-regulated drug product
No
Studies a U.S. FDA-regulated device product
No
This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.
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