Clinical Trials on SMARCA4-deficient Primary CNS Malignant Tumors in United States
Total 351 results
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Susan Chi, MDBristol-Myers Squibb; Epizyme, Inc.RecruitingChordoma | Epithelioid Sarcoma | Atypical Teratoid Rhabdoid Tumor | INI1 (SMARCB1)-Deficient Primary CNS Malignant Tumors | SMARCA4-deficient Primary CNS Malignant Tumors | Malignant Rhabdoid Tumor (MRT) | Rhabdoid Tumor of the Kidney (RTK)United States
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Dana-Farber Cancer InstituteGateway for Cancer ResearchRecruitingEpithelioid Sarcoma | Atypical Teratoid/Rhabdoid Tumor | Malignant Rhabdoid Tumor | Rhabdoid Tumor of the Kidney | Chordoma (Poorly Differentiated or De-differentiated) | Other INI1 Negative Tumors (With PI Approval) | Other SMARCA4-deficient Malignant Tumors (With PI Approval)United States
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University of MiamiRecruitingGlioma | Brain Tumor | Malignant Glioma | Primary Brain Tumor | Malignant Primary Brain TumorUnited States
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Memorial Sloan Kettering Cancer CenterRockefeller UniversityCompletedPrimary or Metastatic Central Nervous System (CNS) TumorUnited States
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National Cancer Institute (NCI)CompletedAdvanced Malignant Solid Neoplasm | Refractory Malignant Solid Neoplasm | Recurrent Malignant Solid Neoplasm | Metastatic Malignant Solid Neoplasm | Ovarian Carcinoma | Pancreatic Neuroendocrine Tumor | Unresectable Solid Neoplasm | Fibrolamellar CarcinomaUnited States
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NewLink Genetics CorporationCompletedGlioma | Glioblastoma Multiforme | Gliosarcoma | Ependymoma | Medulloblastoma | Diffuse Intrinsic Pontine Glioma | Malignant Brain Tumor | Primary CNS TumorUnited States
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Masonic Cancer Center, University of MinnesotaCompletedSoft Tissue Sarcoma | Medulloblastoma | Retinoblastoma | Rhabdomyosarcoma | Hepatoblastoma | Primary Malignant Brain Neoplasms | CNS Tumors | Germ Cell Tumors | Ewing's Family Tumors | Renal Tumors | Supra-tentorial Primative Neuro-Ectodermal Tumor (PNET) | Atypical Teratoid/Rhabdoid Tumor (AT/RT)United States
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Constantinos HadjipanayisNational Cancer Institute (NCI); NX PharmaGenWithdrawnGlioblastoma | Brain Cancer | Brain Tumors | Brain Tumor, Recurrent | Benign Neoplasms, Brain | Brain Neoplasms, Benign | Brain Neoplasms, Malignant | Brain Tumor, Primary | Intracranial Neoplasms | Neoplasms, Brain | Neoplasms, Intracranial | Primary Brain Neoplasms | Primary Malignant Brain Neoplasms | Primary Malignant... and other conditionsUnited States
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National Cancer Institute (NCI)TerminatedPNET | Gliomas | Pineal Tumors | Ependymomas | PCNSL (Primary CNS Lymphoma)United States
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Ikena OncologyRecruitingSolid Tumor | Solid Tumors, Adult | Malignant Pleural Mesothelioma (MPM) | Epithelioid Hemangioendothelioma (EHE) | NF2 Deficient Mesothelioma | Other NF2 Deficient Solid Tumors and Solid Tumors With YAP1/TAZ Fusion Genes | NF2 Deficiency | YAP1 or TAZ Gene FusionsUnited States, United Kingdom
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University of Illinois at ChicagoMillennium Pharmaceuticals, Inc.CompletedMelanoma | Head and Neck Neoplasms | Malignant Neoplasm of Breast | Malignant Neoplasm of Thorax | CNS Malignancy | Malignant Neoplasm of Gastrointestinal Tract | Genitourinary Neoplasms Malignancy and Gender UnspecifiedUnited States
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Pediatric Brain Tumor ConsortiumNational Cancer Institute (NCI); American Lebanese Syrian Associated Charities...Active, not recruitingGlioblastoma Multiforme | Anaplastic Astrocytoma | Anaplastic Oligodendroglioma | DIPG | High-grade Astrocytoma NOS | CNS Primary Tumor, NOS (Malignant Glioma)United States
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NanobiotixRecruitingMetastatic Renal Cell Carcinoma | Squamous Cell Carcinoma of Head and Neck | Radiotherapy | Immunotherapy | Microsatellite Instability-High Solid Malignant Tumour | Metastasis From Malignant Tumor of Liver | Metastasis From Malignant Tumor of Cervix | Metastasis From Malignant Melanoma of Skin (Disorder) and other conditionsUnited States
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Memorial Sloan Kettering Cancer CenterRecruitingSolid Tumor | Neuroblastoma | Solid Tumor, Adult | Primary Brain Tumor | Solid Carcinoma | Low-grade Glioma | Central Nervous System Tumor | Refractory Cancer | CNS Tumor, Adult | CNS Tumors | NF1 | Plexiform Neurofibroma | CNS Tumor, Childhood | Optic Pathway Gliomas | MAP Kinase Family Gene MutationUnited States
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Seattle Children's HospitalRecruitingDiffuse Intrinsic Pontine Glioma | Diffuse Midline Glioma | Refractory Primary Malignant Central Nervous System Neoplasm | Recurrent CNS Tumor, Adult | Recurrent, CNS Tumor, ChildhoodUnited States
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Turning Point Therapeutics, Inc.RecruitingLymphoma | Locally Advanced Solid Tumors | Metastatic Solid Tumors | Primary CNS TumorsUnited States, Korea, Republic of, Spain, Singapore, Taiwan, Australia, Italy, Canada, France, Denmark, United Kingdom
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Sidney Kimmel Comprehensive Cancer Center at Johns...Accuray IncorporatedCompletedStage IV Skin Melanoma | Metastatic Malignant Neoplasm in the Brain | Metastatic Malignant Neoplasm in the SpineUnited States
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Robert WesolowskiCompletedBreast Cancer | Ovarian Cancer | Malignant Solid Tumour | GIST | Malignant Tumor of ColonUnited States
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St. Jude Children's Research HospitalNovartis PharmaceuticalsCompletedGlioma | Neoplasms | Glioblastoma | Neoplasms, Neuroepithelial | Central Nervous System Neoplasms | Brain Cancer | Brain Tumor | Ependymoma | Medulloblastoma | Anaplastic Astrocytoma | Anaplastic Ganglioglioma | Anaplastic Ependymoma | Anaplastic Oligodendroglioma | Pineoblastoma | Recurrent Medulloblastoma | CNS Tumor | Pediatric... and other conditionsUnited States
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Children's National Research InstituteRecruitingAstroblastoma | BCOR ITD Sarcoma | CNS Sarcoma | Unclassified Tumor, MalignantUnited States
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M.D. Anderson Cancer CenterCompletedMixed Tumor, MullerianUnited States
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Pediatric Brain Tumor ConsortiumNational Cancer Institute (NCI)CompletedMalignant Glioma | Recurrent Childhood Ependymoma | Recurrent Medulloblastoma | Recurrent Diffuse Intrinsic Pontine Glioma | Recurrent Atypical Teratoid/Rhabdoid Tumor | Refractory Diffuse Intrinsic Pontine Glioma | CNS Embryonal Tumor, Not Otherwise SpecifiedUnited States
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Gregory K. Friedman, MDCannonball Kids' Cancer Foundation; Treovir, IncActive, not recruitingBrain Diseases | Central Nervous System Diseases | Nervous System Diseases | Neoplasms | Neoplasms by Histologic Type | Neoplasms by Site | Neoplasms, Glandular and Epithelial | Neoplasms, Germ Cell and Embryonal | Astrocytoma | Neoplasms, Neuroepithelial | Neuroectodermal Tumors | Neoplasms, Nerve Tissue | Neuroectodermal... and other conditionsUnited States
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Pediatric Brain Tumor ConsortiumNational Cancer Institute (NCI); Memorial Sloan Kettering Cancer Center; American...Active, not recruitingGlioblastoma Multiforme | Medulloblastoma | Low-Grade Astrocytoma, Nos | Anaplastic Astrocytoma | Anaplastic Oligodendroglioma | Pilocytic Astrocytoma | Pineoblastoma | Supratentorial Primitive Neuroectodermal Tumor | Atypical Teratoid/Rhabdoid Tumor | Choroid Plexus Carcinoma | High-grade Astrocytoma NOS | CNS... and other conditionsUnited States
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Timothy CripeCompletedSoft Tissue Sarcoma | Osteosarcoma | Ewing Sarcoma | Neuroblastoma | Rhabdomyosarcoma | Wilms Tumor | Malignant Peripheral Nerve Sheath Tumor | Clival Chordoma | Non-CNS Solid TumorsUnited States
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Memorial Sloan Kettering Cancer CenterColumbia University; University of Wisconsin, Madison; Keryx Biopharmaceuticals; Keryx / AOI Pharmaceuticals, Inc... and other collaboratorsCompletedCancer | Brain Cancer | Malignant Gliomas | CNSUnited States
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Wake Forest University Health SciencesNational Cancer Institute (NCI)CompletedInfertility | Brain and Central Nervous System Tumors | Chemotherapeutic Agent ToxicityUnited States
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National Cancer Institute (NCI)CompletedUnspecified Adult Solid Tumor, Protocol Specific | Malignant NeoplasmUnited States
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St. Jude Children's Research HospitalPfizer; IpsenRecruitingRefractory Malignant Solid Neoplasm | Recurrent Ewing Sarcoma | Recurrent Hepatoblastoma | Recurrent Malignant Germ Cell Tumor | Recurrent Malignant Solid Neoplasm | Recurrent Neuroblastoma | Recurrent Osteosarcoma | Recurrent Peripheral Primitive Neuroectodermal Tumor | Recurrent Rhabdoid Tumor | Recurrent... and other conditionsUnited States, Canada
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Massachusetts Eye and Ear InfirmaryM.D. Anderson Cancer Center; Wills EyeTerminatedNevus | Racial Melanosis | Primary Acquired Melanosis | Conjunctival Malignant MelanomaUnited States
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University of PittsburghNational Institute of Nursing Research (NINR)CompletedPrimary Malignant Brain TumorsUnited States
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Memorial Sloan Kettering Cancer CenterGenentech, Inc.; Weill Medical College of Cornell UniversityCompletedBrain Cancer | Primary Brain Tumor | Recurrent Malignant GliomasUnited States
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DEKK-TEC, Inc.National Cancer Institute (NCI); The University of Texas Health Science Center... and other collaboratorsCompletedMetastatic Malignant Neoplasm to Brain | Primary Brain TumorsUnited States
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M.D. Anderson Cancer CenterNational Cancer Institute (NCI)RecruitingRefractory Malignant Solid Neoplasm | Recurrent Malignant Solid Neoplasm | Recurrent Cutaneous Melanoma | Recurrent Malignant Female Reproductive System Neoplasm | Refractory Malignant Female Reproductive System Neoplasm | Recurrent Lip and Oral Cavity Carcinoma | Recurrent Malignant Endocrine... and other conditionsUnited States
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Mayo ClinicNational Cancer Institute (NCI)RecruitingMetastatic Melanoma | Clinical Stage IV Cutaneous Melanoma AJCC v8 | Metastatic Malignant Neoplasm in the Brain | Metastatic Malignant Neoplasm in the Central Nervous SystemUnited States
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National Cancer Institute (NCI)TerminatedTesticular Seminoma | Recurrent Ovarian Germ Cell Tumor | Stage II Ovarian Germ Cell Tumor | Stage III Ovarian Germ Cell Tumor | Ovarian Dysgerminoma | Recurrent Malignant Testicular Germ Cell Tumor | Stage II Malignant Testicular Germ Cell Tumor | Stage III Malignant Testicular Germ Cell TumorUnited States
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National Cancer Institute (NCI)Active, not recruitingMetastatic Malignant Neoplasm in the Bone | Peripheral Primitive Neuroectodermal Tumor of Soft Tissues | Metastatic Malignant Neoplasm in the Lung | Metastatic Ewing Sarcoma | Metastatic Malignant Neoplasm in the Bone Marrow | Metastatic Peripheral Primitive Neuroectodermal Tumor of BoneUnited States, Canada, Puerto Rico
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Memorial Sloan Kettering Cancer CenterActive, not recruitingAdvanced Care Planning | Primary Malignant Brain TumorsUnited States
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Virginia Commonwealth UniversityNot yet recruitingGlioblastoma | Astrocytoma | Oligodendroglioma | Meningioma | Primary Brain Tumor | Primary Central Nervous System (CNS) LymphomaUnited States
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Laser Tissue Welding, Inc.National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)WithdrawnBenign Renal Tumors | Malignant Renal TumorsUnited States
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M.D. Anderson Cancer CenterAmerican Regent, Inc.TerminatedMalignant Neoplasms of Mesothelial and Soft Tissue | Gastrointestinal Stromal Tumor With Neurogenic DifferentiationUnited States
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City of Hope Medical CenterNational Cancer Institute (NCI); Eisai Inc.CompletedPrimary Brain Tumor | Metastatic Malignant Neoplasm in the Adult BrainUnited States
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City of Hope Medical CenterActive, not recruitingUnspecified Childhood Solid Tumor, Protocol Specific | Solid Tumor | Ewing Sarcoma | Unspecified Adult Solid Tumor, Protocol Specific | Recurrent Childhood Medulloblastoma | Recurrent Childhood Ependymoma | Recurrent Neuroblastoma | Recurrent Adult Soft Tissue Sarcoma | Recurrent Adult Brain Tumor | Recurrent... and other conditionsUnited States
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Loyola UniversityRecruitingKidney Tumor | Renal Malignant Tumor | Renal Benign NeoplasmUnited States
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Daiichi Sankyo, Inc.CompletedAdvanced Solid Malignant Tumors | Advanced Ovarian CancerUnited States
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University of Southern CaliforniaNational Cancer Institute (NCI)TerminatedMultiple Sclerosis | Metastatic Malignant Neoplasm in the Brain | Adult Anaplastic Astrocytoma | Adult Anaplastic Ependymoma | Adult Anaplastic Oligodendroglioma | Adult Diffuse Astrocytoma | Adult Ependymoma | Adult Giant Cell Glioblastoma | Adult Glioblastoma | Adult Gliosarcoma | Adult Mixed Glioma | Adult... and other conditionsUnited States
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National Cancer Institute (NCI)Children's Oncology GroupRecruitingMalignant Solid Neoplasm | Advanced Malignant Solid Neoplasm | Refractory Malignant Solid Neoplasm | Recurrent Ependymoma | Recurrent Hepatoblastoma | Recurrent Langerhans Cell Histiocytosis | Recurrent Malignant Germ Cell Tumor | Recurrent Malignant Glioma | Recurrent Malignant Solid Neoplasm | Recurrent... and other conditionsUnited States, Puerto Rico, Australia
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Baptist Health South FloridaIon Beam Applications SANot yet recruitingGlioma | Recurrent Glioma | Glioma, MalignantUnited States
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Epizyme, Inc.CompletedSynovial Sarcoma | Epithelioid Sarcoma | Renal Medullary Carcinoma | Malignant Rhabdoid Tumors (MRT) | Rhabdoid Tumors of the Kidney (RTK) | Atypical Teratoid Rhabdoid Tumors (ATRT) | Selected Tumors With Rhabdoid Features | INI1-negative Tumors | Malignant Rhabdoid Tumor of Ovary | Poorly Differentiated... and other conditionsFrance, United States, Australia, Taiwan, Belgium, United Kingdom, Canada, Germany, Italy
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Sabine Mueller, MD, PhDNational Cancer Institute (NCI); Dana-Farber Cancer Institute; Mithil Prasad... and other collaboratorsRecruitingGlioblastoma | Recurrent Ependymoma | CNS Tumor | Diffuse Midline Glioma (DMG) | Recurrent Malignant Central Nervous System Neoplasm | Spinal Cord Glioma | Central Nervous System Tumor | World Health Organization (WHO) Grade III GliomaUnited States, Switzerland