Clinical Trials on Secondarily Generalized Seizures

Total 2955 results

Eisai Inc.

Completed

Study to Evaluate the Efficacy and Safety of Perampanel as Monotherapy or First Adjunctive Therapy in Subjects With Partial Onset Seizures With or Without Secondarily Generalized Seizures or With Primary Generalized Tonic-Clonic Seizures

Partial Onset Seizures | Primary Generalized Tonic-Clonic Seizures | Secondarily Generalized Seizures

United States
Eisai Co., Ltd.

Completed

Investigation of the Clinical Safety and Efficacy of Long-term Treatment With Fycompa Tablets in Adult Epilepsy Patients With Partial-onset Seizures (With or Without Secondary Generalized Seizures) or Primary Generalized Tonic-clonic Seizures (FYC01S)

Partial Seizures (With or Without Secondary Generalized Seizures) | Primary Generalized Tonic-clonic Seizures

Japan
Eisai Co., Ltd.

Completed

Investigation of the Clinical Safety and Efficacy of Long-term Treatment With Fycompa Tablets in Adolescence Epilepsy Patients With Partial-onset Seizures (With or Without Secondary Generalized Seizures) or Primary Generalized Tonic-clonic Seizures (FYC02T)

Partial Seizures (With or Without Secondary Generalized Seizures) | Primary Generalized Tonic-clonic Seizures

Japan
Eisai Limited

Completed

A Study to Investigate Dosage, Effectiveness, and Safety of Perampanel When Used as First Add-on Therapy in Participants >=12 Years With Partial Onset Seizures With or Without Secondary Generalization or With Primary Generalized Tonic-Clonic Seizures Associated With Idiopathic Generalized Epilepsy

Idiopathic Generalized Epilepsy | Partial Onset Seizures | Generalised Tonic-Clonic Seizures

France, Spain, Italy, Denmark, Germany, Portugal, Russian Federation
NeuroPace

Active, not recruiting

RNS System NAUTILUS Study (NAUTILUS)

Epilepsy | Idiopathic Generalized Epilepsy | Generalized Tonic Clonic Seizure

United States
Children's Hospital of Fudan University

Recruiting

Etiology and Treatment of Neonatal Seizure

Seizures | Seizure Disorder | Seizure Newborn | Seizure Generalized

China
Michael A. Gelfand, MD, PhD
Epilepsy Foundation

Completed

Novel Helmet Design in Patients With Seizures

Generalized Tonic Clonic Seizure | Drug Resistant Epilepsy | Drop Seizures | Complex Partial Seizure | Fall Due to Seizure

United States
Zogenix, Inc.

Recruiting

A Study to Investigate the Efficacy and Safety of ZX008 in Subjects With CDKL5 Deficiency Disorder

Generalized Tonic Clonic Seizure | CDKL5 Deficiency Disorder | Epileptic Spasm | Refractory Seizures

United States, Japan, Germany, Netherlands, Portugal, Spain, Belgium, United Kingdom, Austria, Georgia, Israel, Ireland
Eisai Limited

Terminated

Efficacy and Safety of Adjunctive Zonisamide in Myoclonic Seizures Associated With Idiopathic Generalised Epilepsy

Epilepsy

Australia, Serbia, Germany, Czech Republic, Romania, Estonia, Lithuania, Croatia, Finland, Hungary, Poland, Russian Federation, Ukraine
Eisai Inc.

Completed

A Efficacy and Safety Study of Adjunctive Perampanel in Primary Generalized Tonic Clonic Seizures

Seizure Disorder Generalized Tonic Clonic
Pfizer's Upjohn has merged with Mylan to form Viatris...

Completed

A Safety, Efficacy and Tolerability Trial of Pregabalin as Add-On Treatment in Pediatric and Adult Subjects With Primary Generalized Tonic-Clonic (i.e., Grand Mal) Seizures.

Generalized Tonic Clonic Seizures

Korea, Republic of, United States, Austria, Serbia, India, Spain, Poland, Malaysia, China, Bulgaria, Denmark, Greece, Hungary, United Kingdom, Belarus, France, Montenegro, Philippines, Romania, Russian Federation, Slovakia, Ukraine, Lebano... and more
Xenon Pharmaceuticals Inc.
Worldwide Clinical Trials

Recruiting

A Study to Evaluate XEN1101 as Adjunctive Therapy in Primary Generalized Tonic-Clonic Seizures (X-ACKT)

Primary Generalized Tonic-Clonic Seizures

United States, Australia, Spain, United Kingdom, Bulgaria, Poland, Czechia, Canada, Portugal, Croatia, Italy
Children's Hospital of Fudan University

Recruiting

A Cohort Study on the Prognosis of Neonatal KCNQ2 Gene-associated Epileptic Encephalopathy

Seizures | Seizure Disorder | Epileptic Encephalopathy | Seizures, Generalized | Seizure Newborn | Epileptic Encephalopathy, Neonatal-onset | Epileptic Encephalopathy, Infant-onset | KCNQ2

China
GlaxoSmithKline

Completed

LAMICTAL (Lamotrigine) For The Treatment Of Absence Seizures

Seizure, Absence

United States
SK Life Science, Inc.

Enrolling by invitation

Cenobamate Open-Label Extension Study for YKP3089C025

Primary Generalized Tonic Clonic Seizures in the Setting of Idiopathic Generalized Epilepsy

United States, Bulgaria, Czechia, Hungary, Poland, Slovakia, Ukraine
Eisai Inc.

Completed

Perampanel as Adjunctive Therapy in Pediatrics With Partial Onset Seizures or Primary Generalized Tonic Clonic Seizures

Partial-Onset or Primary Generalized Tonic-Clonic Seizures

Canada, France, Italy, Korea, Republic of, Spain, United States, Belgium, Czechia, Hungary, Japan, Latvia, Poland
Rachel Kuperman
Wake Forest University Health Sciences; University of California, San Francisco and other collaborators

Completed

Detecting Absence Seizures Using Eye Tracking

Epilepsy, Generalized | Seizures | Seizure Disorder | Absence Epilepsy | Absence Seizures

United States
University Hospital, Clermont-Ferrand

Unknown

Impact of Early Lactate Dosage Compared to CK for Diagnosis of a Suspected Seizure

Creatine Kinase | Lactate | Epileptic Seizure | Epileptic Generalized Tonic-clonic Seizure

France
UCB Japan Co. Ltd.

Completed

A Study of Levetiracetam in Japanese Pediatric Patients With Generalized Tonic-clonic Seizures

Epilepsy | Generalized Tonic-clonic Seizures

Japan
Mazandaran University of Medical Sciences

Completed

Levetiracetam Versus Valproate in Idiopathic Generalized Tonic-clonic Seizures

Epilepsy, Idiopathic Generalized

Iran, Islamic Republic of
Pfizer's Upjohn has merged with Mylan to form Viatris...

Completed

A 12-Month Study To Evaluate The Safety And Tolerability Of Pregabalin As Add-On Therapy In Pediatric Subjects 1 Month To 16 Years Of Age With Partial Onset Seizures And Pediatric And Adult Subjects 5 To 65 Years Of Age With Primary Generalized Tonic-Clonic Seizures

Epilepsy, Partial Seizures | Epilepsy, Primary Generalized Tonic-Clonic Seizures

United States, Korea, Republic of, Taiwan, Lebanon, Singapore, Malaysia, China, Spain, Bulgaria, Czechia, United Kingdom, Israel, Russian Federation, France, Belarus, Belgium, Bosnia and Herzegovina, Germany, Greece, Hungary, India and more
Bio-Signal Group Corp.
National Institute of Neurological Disorders and Stroke (NINDS); State University... and other collaborators

Completed

Putting Electroencephalography (EEG) in the Emergency Department

Altered Mental Status | Generalized Nonconvulsive Seizure Disorder | Status-epilepticus

United States
UCB Pharma

Completed

An Open Label Study of L059 (Levetiracetam) in Japanese Epilepsy Subjects With Generalized Tonic-clonic Seizures

Epilepsy | Generalized Tonic-clonic Seizures

Japan
Biohaven Therapeutics Ltd.

Not yet recruiting

A Study to Determine if BHV-7000 is Effective and Safe in Adults With Idiopathic Generalized Epilepsy With Generalized Tonic-clonic Seizures (SHINE)

Generalized Epilepsy

United States
Centre Hospitalier Universitaire Vaudois

Recruiting

Severity: Quantifying the Severity of Generalized Tonic-clonic Seizures (GTCS) With Connected Devices

Epilepsy, Generalized

Switzerland
Neuroelectrics Corporation

Recruiting

Pivotal-Safety and Therapeutic Measures of tDCS in Patients With Refractory Focal Epilepsy

Epilepsy | Seizures | Refractory Epilepsy | Epilepsy, Tonic-Clonic | Epilepsy in Children | Seizures, Focal | Focal Seizure

Spain, United States, France, Belgium
Lars Bo Andersen

Unknown

Physical Exercise in Subjects With Juvenile Myoclonic Epilepsy (EFA)

Epilepsy | Seizure Disorder | Epileptic Seizures | Epilepsia

Denmark
Chinese University of Hong Kong

Unknown

Post-market Study of AMPA Receptor Antagonists for Epilepsy Patients in Hong Kong

Generalized Epilepsy | Focal Epilepsy | Partial Seizures, Simple

Hong Kong
GlaxoSmithKline

Completed

Treatment Of Primary Generalized Tonic-Clonic Seizures With An Investigational New Drug

Epilepsy, Tonic-Clonic

United States, Chile, Peru, Argentina
Eisai Inc.

Completed

A Study to Evaluate the Safety and Efficacy of Zonisamide an Antiepileptic Drug as Monotherapy or Adjunctive Therapy in Treatment of Adult Patients With Partial, Generalized or Combined Seizures.

Partial, Generalized and Combined Seizures

India
GlaxoSmithKline

Completed

Study Evaluating LAMICTAL Extended-Release Therapy Added To Current Seizure Treatments In Patients With Primary Generalized Tonic-Clonic Seizures (PGTC) Seizures

Epilepsy, Tonic-Clonic

United States, Germany, Korea, Republic of, Chile, India, Russian Federation, Brazil, Ukraine, Puerto Rico, Argentina, Malaysia
Sohag University

Completed

Effectiveness of Combined Levetiracetam and Midazolam in Generalized Convulsive Status Epilepticus in Children

Status Epilepticus | Generalized Convulsive Status Epilepticus | Status Epilepticus, Generalized | Status Epilepticus, Generalized Convulsive

Egypt
SK Life Science, Inc.

Recruiting

Randomized, Double-Blind Study to Evaluate Efficacy and Safety of Cenobamate Adjunctive Therapy in PGTC Seizures

Primary Generalized Epilepsy

United States, Spain, Germany, Hungary, Korea, Republic of, Australia, Bulgaria, Czechia, Poland, Slovakia, Ukraine
El Instituto Nacional de Neurologia y Neurocirugia...

Completed

TMS vs Conventional Therapy for the Treatment of Functional Neurological Non Epileptic Seizure Disorder

Psychogenic Non-Epileptic Seizure

Mexico
UCB Pharma

Completed

Study to Evaluate the Safety and Efficacy of Levetiracetam in Patients Suffering From Idiopathic Generalized Epilepsy With Primary Generalized Tonic-clonic Seizures

Generalized Convulsive Epilepsy
Brain Sentinel

Unknown

An Exploratory Trial Using sEMG to Differentiate PNES From Epileptic Seizures

Epilepsy | Non-Epileptic Seizure | Motor Seizure

Austria
Wei Zhao
The Affiliated Hospital of Qingdao University; Qianfoshan Hospital; The Second...

Recruiting

Antiepileptic Drugs in Elderly Patients

Seizure, Epileptic

China
Dartmouth-Hitchcock Medical Center

Completed

Project UPLIFT for Psychogenic Non-Epileptic Seizures (PNES)

Depression | Non-Epileptic Seizure | Psychogenic Non-Epileptic Seizure | Psychogenic Seizure

United States
Zogenix International Limited, Inc., a subsidiary...

Completed

A Trial of Two Fixed Doses of ZX008 (Fenfluramine HCl) in Children and Young Adults With Dravet Syndrome

Dravet Syndrome | Seizure Disorder

United States, United Kingdom, Australia, Belgium, Canada, Denmark, France, Germany, Italy, Japan, Spain
Eisai Inc.

Completed

Study to Investigate Dosage, Efficacy, and Safety of Perampanel Given as Monotherapy in Patients With Epilepsy

Epilepsy | Primary Generalized Tonic-Clonic Seizures | Partial-Onset Seizures
UCB Japan Co. Ltd.

Completed

A Double-blind, Placebo-controlled Study of Levetiracetam in Epilepsy Patients With Generalized Tonic-clonic Seizures (Except Partial Seizures Evolving to Secondarily Generalized Seizures)

Epilepsy | Generalized Tonic-Clonic Seizures

China, Japan
Brain Sentinel

Completed

Detecting Generalized Tonic-Clonic Seizures With a Seizure Detection and Warning System in Epilepsy Patients

Epilepsy | Generalized Tonic-Clonic Seizures

United States
Overseas Pharmaceuticals, Ltd.
GX pharma technology (beijing) Co., Ltd

Active, not recruiting

An Open Label, Balanced, Randomized, 3×3 Latin Square Design Comparing of Brivaracetam Sustained-release Tablets and Brivaracetam Tablets in the Oral Comparative Pharmacokinetic(PK) Study in Chinese Healthy Adult Subjects Under Fasting Conditions.

Partial Seizure

China
Central Hospital, Nancy, France
Dr Coraline HINGRAY; Pr Raymund SCHWAN; Dr Vincent LAPREVOTE; Dr Jean Pierre VIGNAL and other collaborators

Unknown

Evaluation of a Telephone Follow-up Procedure on the Quality of Life in Psychogenic Non-epileptic Seizures (EDUQ-CPNE)

Psychogenic Non Epileptic Seizure

France
Byteflies
Thomas Jefferson University

Recruiting

EpiCare@Home Validation Study for Focal Onset Seizures

Epilepsy | Seizures | Seizures, Focal | Seizure, Refractory

United States
Brain Sentinel

Completed

Seizure Detection and Warning System in Epilepsy Patients

Epilepsy | Generalized Tonic-Clonic Seizures

United States
UCB BIOSCIENCES, Inc.
Pharmaceutical Research Associates

Completed

A Study to Assess the Safety and Efficacy of Lacosamide Versus Placebo (a Pill Without Active Medication) in Patients With Idiopathic Generalised Epilepsy Who Are Already Taking Anti-epileptic Medications (VALOR)

Epilepsy

United States, Australia, Belgium, Brazil, Bulgaria, China, Czechia, France, Germany, Hungary, Israel, Italy, Japan, Korea, Republic of, Mexico, Poland, Portugal, Romania, Russian Federation, Slovakia, Spain, Taiwan
Abbott

Terminated

A Study of the Safety and Efficacy of Depakote Sprinkle Capsules in the Treatment of Partial Seizures in Children

Partial Seizure Disorder

United States
UCB Pharma

Completed

A Study to Investigate the Safety and Efficacy of Lacosamide Added to the Patients Current Therapy in Patients Aged 1 Month to Less Than 18 Years Old With Epilepsy Syndromes Associated With Generalized Seizures.

Epilepsy

United States, France, Hungary, Mexico, Poland
UCB BIOSCIENCES, Inc.

Completed

Open-Label Study to Assess Lacosamide Safety as Add-on Therapy for Primary Generalized Tonic-Clonic Seizures in Subjects With Epilepsy

Epilepsy

United States

Clinical Trials on Secondarily Generalized Seizures

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