Clinical Trials on Septic Shock in South Africa

Total 197 results

University of Athens

Recruiting

Vitamin C, Steroids, and Thiamine, and Cerebral Autoregulation and Functional Outcome in Septic Shock (CORVICTES-ΥΜ)

Septic Shock

Greece
The George Institute

Completed

Fludrocortisone Dose Response Relationship in Septic Shock - FluDReSS (FluDReSS)

Septic Shock | Critically Ill

Australia
University of Athens
Naval Hospital, Athens; General Hospital of Nikaia "Saint Panteleimon"

Recruiting

Vitamin C, Hydrocortisone and Thiamine for Septic Shock (CORVICTES)

Shock, Septic

Greece
AstraZeneca

Completed

A Study to Compare the Efficacy and Safety of 2 Dosing Regimens of IV Infusions of AZD9773 (CytoFab™) With Placebo in Adult Patients With Severe Sepsis and/or Septic Shock

Septic Shock | Severe Sepsis

Czech Republic, France, Spain, Finland, Canada, Australia, Belgium
The George Institute
National Health and Medical Research Council, Australia; Australian and New...

Completed

ADjunctive coRticosteroid trEatment iN criticAlly ilL Patients With Septic Shock (ADRENAL)

Septic Shock

Australia, Denmark, Saudi Arabia, New Zealand, United Kingdom
Spectral Diagnostics (US) Inc.

Recruiting

Safety and Efficacy of Polymyxin B Hemoperfusion (PMX) for Endotoxemic Septic Shock in a Randomized, Open-Label Study (TIGRIS)

Septic Shock | Endotoxemia

United States
Eli Lilly and Company

Completed

Efficacy and Safety of Drotrecogin Alfa (Activated) in Adult Patients With Septic Shock

Sepsis

Italy, United Kingdom, United States, Germany, Spain, Belgium, France, Australia, Czech Republic, Netherlands, Canada, Mexico, New Zealand, Finland, Portugal, Brazil, India, Switzerland
Australian and New Zealand Intensive Care Research...

Recruiting

Australasian Resuscitation In Sepsis Evaluation: FLUid or Vasopressors In Emergency Department Sepsis (ARISE FLUIDS)

Shock, Septic

Australia
The George Institute for Global Health, Australia

Completed

Days Alive and Out of Hospital for Patients With Sepsis

Sepsis | Septic Shock

Australia
Wentworth Area Health Services
Abbott

Unknown

Levosimendan Versus Dobutamine in Shock Patients

Septic Shock | Cardiogenic Shock

Australia
Massachusetts General Hospital

Completed

Crystalloid Liberal or Vasopressors Early Resuscitation in Sepsis (CLOVERS)

Septic Shock

United States
Pfizer

Completed

Pharmacokinetics Of Orally Administered Fx-1006A In Subjects With Hepatic Dysfunction

Mild Hepatic Dysfunction | Moderate Hepatic Dysfunction

South Africa
University of Pretoria

Completed

Efficacy of Using a Closing Pack to Reduce Postpartum Sepsis

Prevention of Postpartum Sepsis

South Africa
Sangart

Completed

Phase IIa Study of MP4OX in Traumatic Hemorrhagic Shock Patients

Shock, Hemorrhagic | Acidosis, Lactic | Shock, Traumatic

France, United Kingdom, South Africa, Germany
University of Pretoria

Not yet recruiting

Kefazolin Versus Kefazolin Plus Metronidazole to Reduce Postpartum Infection

Prevention of Postpartum Sepsis

South Africa
The George Institute
Sunnybrook Health Sciences Centre; Imperial College London

Completed

Selective Decontamination of the Digestive Tract in Intensive Care Unit Patients (SuDDICU)

Sepsis | Critical Illness | Septic Shock | Ventilator Associated Pneumonia

Australia, Canada, United Kingdom
University of Stellenbosch
Fogarty International Center of the National Institute of Health

Unknown

Neonatal Bacterial Colonization Study

Prematurity | Bloodstream Infection | Neonatal SEPSIS | Very Low Birth Weight Baby

South Africa
University of KwaZulu
Bristol-Myers Squibb

Completed

Prophylactic Intrapartum Antibiotics and Immunological Markers for Postpartum Morbidity in HIV Positive Women

Puerperal Sepsis

South Africa
Centers for Disease Control and Prevention
United States Agency for International Development (USAID); Bill and Melinda... and other collaborators

Unknown

Prevention of Perinatal Sepsis (PoPS): Evaluation of Chlorhexidine Wipes of Birth Canal and Newborn

Sepsis | Infant, Newborn, Diseases | Puerperal Infection

South Africa
Pfizer

Completed

An Open-label Study of APX001 for Treatment of Patients With Candidemia/Invasive Candidiasis Caused by Candida Auris (APEX)

Candidemia | Candida Infection | Invasive Candidiases

South Africa
La Jolla Pharmaceutical Company

Completed

A Phase 3 Study of LJPC-501 in Patients With Catecholamine-Resistant Hypotension (ATHOS-3)

Sepsis | Catecholamine-resistant Hypotension (CRH) | Distributive Shock | High Output Shock

United States, Canada, Belgium, Australia, United Kingdom, Finland, New Zealand, France, Switzerland, Germany
Australian and New Zealand Intensive Care Research...
Australian and New Zealand Intensive Care Society Clinical Trials Group; Australasian... and other collaborators

Recruiting

Fibrinogen Early In Severe Trauma StudY II (FEISTY II)

Trauma | Coagulopathy | Haemorrhagic Shock

Australia
Horizon Health Network
University of Manitoba; University of British Columbia; University of Michigan; Dalhousie University and other collaborators

Completed

Sonography in Hypotension and Cardiac Arrest in the Emergency Department. (SHoC-ED)

Shock | Hypotension | Point of Care Ultrasound

Canada, South Africa
Sangart

Completed

Phase IIb Study of MP4OX in Traumatic Hemorrhagic Shock Patients

Shock, Hemorrhagic | Acidosis, Lactic | Shock, Traumatic

Norway, Singapore, Israel, France, United Kingdom, Germany, Switzerland, Australia, Brazil, South Africa, New Zealand, Colombia, Austria, Spain
Sangart

Withdrawn

Phase 2c Dose Comparison Study of MP4OX in Trauma

Trauma | Hemorrhagic Shock | Lactic Acidosis

New Zealand, United Kingdom, Israel, France, Switzerland, Australia, Belgium, Brazil, Germany, Norway, South Africa
Cycle Pharmaceuticals Ltd.
Parexel

Completed

Assessment of Intra-subject Variability in the Bioavailability of Chlorpromazine Hydrochloride

Acute Intermittent Porphyria | Anti-Psychotic | Management of Manifestations of Psychotic Disorders | Treatment of Schizophrenia | Control Nausea and Vomiting | Relief of Restlessness and Apprehension Before Surgery | Adjunct in the Treatment of Tetanus | Control Manifestations of the Manic Type... and other conditions

South Africa
South West Sydney Local Health District

Completed

Renin as a Biomarker of Haemodynamic Normalisation

Shock

Australia
Erasmus Medical Center

Completed

PULsecath mechanicaL Support Evaluation (PULSE)

Coronary Artery Disease | Heart Failure | Cardiogenic Shock

France, Netherlands, United Kingdom
Nationwide Children's Hospital
Eunice Kennedy Shriver National Institute of Child Health and Human Development...

Recruiting

GM-CSF for Reversal of Immunoparalysis in Pediatric Sepsis-induced MODS (GRACE-2)

Pediatric Sepsis-induced Multiple Organ Dysfunction Syndrome

United States
TherOx

Withdrawn

Incorporating Supersaturated Oxygen in Shock (ISO-SHOCK)

Cardiogenic Shock | STEMI

United States
Novartis Pharmaceuticals

Completed

Pharmacokinetics and Safety of Single Subcutaneous Pasireotide (SOM230) in Subjects With Varying Degrees of Hepatic Function

Alcoholism | Hepatic Cirrhosis

Germany, Belgium, United States, South Africa
Nationwide Children's Hospital
Eunice Kennedy Shriver National Institute of Child Health and Human Development...

Recruiting

Targeted Reversal of Inflammation in Pediatric Sepsis-induced MODS (TRIPS)

Pediatric Sepsis-induced Multiple Organ Dysfunction Syndrome (MODS)

United States
South Valley University

Recruiting

Monitoring Effect Of Shock Wave On Microcirculation Changes In Type2 Diabetes Mellitus

Shock Wave and Nitric Oxide

Egypt
Abiomed Inc.

Active, not recruiting

SURPASS Impella 5.5 Study

Acute Decompensated Heart Failure | Cardiogenic Shock

United States
Drugs for Neglected Diseases
Universiteit Antwerpen; PENTA Foundation; St George's, University of London

Completed

NeoAMR Observational Study in Neonatal Sepsis

Neonatal SEPSIS

Bangladesh, Uganda, Thailand, South Africa, Italy, Greece, India, Brazil, China, Kenya, Vietnam
John Hunter Children's Hospital
Thrasher Research Fund; Aerocrine AB; University of Newcastle, Australia; Hunter... and other collaborators

Completed

PEAnut Anaphylaxis Predictors (PEAAP)

Peanut Hypersensitivity | Anaphylaxis

Australia
St Vincent's Hospital, Sydney

Completed

Blood Management During ECMO for Cardiac Support (OBLEX)

Hemorrhage | Embolism | Venous Thrombosis | Arrhythmias, Cardiac | Shock, Cardiogenic | Blood Transfusion | Death, Sudden, Cardiac | Disseminated Intravascular Coagulation | HEART ARREST

Australia
Universitas Sriwijaya
Indonesia University

Completed

Resuscitation Failure, Oxidative Stress, and Necroptosis as Mortality Predictor in Septic Patient

Sepsis

Indonesia
PMD Solutions
Hospital of South West Jutland

Completed

Can Respiratory Rate Predict the Risk of Deterioration of Septic Patients

Sepsis

Denmark
Scynexis, Inc.

Completed

Open-Label Study to Evaluate the Efficacy and Safety of Oral Ibrexafungerp (SCY-078) in Patients With Candidiasis Caused by Candida Auris (CARES) (CARES)

Candidemia | Candidiasis, Invasive

Pakistan, India, United States, South Africa
AstraZeneca

Completed

A Study to Prevent Rebleeding After Initial Successful Primary Endoscopic Haemostasis of a Bleeding Peptic Ulcer

Gastrointestinal Hemorrhage

Sweden, Russian Federation, South Africa, Spain, Turkey, United Kingdom, Germany, Romania, Finland, Norway, Hong Kong, Austria, Denmark, Netherlands, Greece, France
Cardiff and Vale University Health Board
Cardiff University

Recruiting

nSeP: Detecting Neonatal Sepsis by Immune-Metabolic Network Analysis (nSeP)

Sepsis

United Kingdom
Pfizer

Completed

A Safety and Tolerability Study of CP-690,550 in Subjects With Hepatic Impairment and Normal Hepatic Function

Hepatic Insufficiency

United States
Astellas Pharma Inc

Completed

Study of Mycamine® in Children With Fungal Infections to Evaluate Safety and Blood Levels of the Drug

Candidemia | Invasive Candidiasis | Esophageal Candidiasis | Oropharyngeal Candidiasis

United States, South Africa
University of Notre Dame

Completed

Effectiveness of Using 3D Printed Models to Educate Otolaryngology (Ear, Nose, Nose and Throat (ENT)) Patients About Surgery: A Survey

Pathological Conditions, Anatomical | Deviated Nasal Septum

United States
The University of Queensland
Australasian Society for Infectious Diseases; International Society of Chemotherapy and other collaborators

Terminated

RCT Meropenem vs Piperacillin-Tazobactam for Definitive Treatment of BSI's Due to Ceftriaxone Non-susceptible Escherichia Coli and Klebsiella Spp. (MERINO)

Bloodstream Infections

Australia, Singapore, South Africa, Italy, Saudi Arabia, Canada, Lebanon, New Zealand, Turkey
Abbott Medical Devices

Completed

Closure of Perimembranous Ventricular Septal Defects With The AMPLATZER® Membranous VSD OCCLUDER

Membranous Ventricular Septal Defects

United States
Pfizer

Completed

A Study To Compare Pharmacokinetics Of Dacomitinib (PF-00299804) Between Healthy Subjects And Subjects With Mild And Moderate Hepatic Impairment

Healthy | Otherwise Healthy Volunteers With Mild or Moderate Hepatic Dysfunction

United States
Prisma Health-Upstate

Completed

Therapeutic Plasma Exchange Alone or in Combination With Ruxolitinib in COVID-19 Associated CRS

COVID19 | Cytokine Release Syndrome

United States
Medical University of South Carolina
Emory University

Completed

Study to Evaluate if the Drug Vasopressin Protects the Kidneys for Patients Undergoing Liver Transplant

Liver Failure

United States

Clinical Trials on Septic Shock in South Africa

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