Clinical Trials on Severe Respiratory Disease

Total 378752 results

Centre Hospitalier Intercommunal de Toulon La Seyne...

Completed

Comparison of Non-invasive Oxygenation Strategies in Patients Admitted for Covid-19 Acute Respiratory Distress Syndrome (SONIC-19)

Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2)

France
Apellis Pharmaceuticals, Inc.

Completed

A Study of APL-9 in Adults With Mild to Moderate ARDS Due to COVID-19

Severe Acute Respiratory Syndrome | Coronavirus Infection | Covid-19 | COVID | Acute Respiratory Distress Syndrome | Coronavirus | Ards | Severe Acute Respiratory Syndrome Coronavirus 2 | Sars-CoV2

United States, Brazil
University of Oxford
London School of Hygiene and Tropical Medicine; University College, London; KEMRI-Wellcome... and other collaborators

Unknown

First Line Antimicrobials in Children With Complicated Severe Acute Malnutrition (FLACSAM)

Antibiotic Resistance | Malnutrition Severe | Antibiotic Toxicity

Kenya, Uganda
Victor M. Aguayo
Gandhi Medical College, Bhopal; Bundelkhand Medical College, Sagar, Madhya... and other collaborators

Completed

Integrated Program for Children With Severe Acute Malnutrition in Madhya Pradesh, India

Severe Malnutrition

India
Hôpital Européen Marseille

Active, not recruiting

Pulmonary Fibrosis During Severe COVID-19 Pneumonia (FIBRO-COVID)

Pulmonary Fibrosis | Acute Respiratory Distress Syndrome | Severe Acute Respiratory Syndrome Coronavirus 2

France
GlaxoSmithKline

Completed

Investigating Otilimab in Patients With Severe Pulmonary COVID-19 Related Disease (OSCAR)

Severe Acute Respiratory Syndrome

United States, Russian Federation, Peru, Netherlands, Spain, South Africa, United Kingdom, Argentina, Brazil, France, Canada, Mexico, Poland, Belgium, India, Japan, Chile, Colombia, Italy
R-Pharm
Covance; Cromos Pharma LLC

Withdrawn

Study of the Efficacy and Safety of a Single Administration of Olokizumab vs. Placebo in Addition to Standard Treatment in Patients With Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Infection (COVID-19).

COVID-19
Bluejay Diagnostics, Inc.

Active, not recruiting

Symphony IL-6 Cutoff Establishment Study for Patients at Risk of Severe Sepsis Due to COVID-19

Severe Sepsis

United States
University Health Network, Toronto
University of Toronto; Makerere University

Completed

Inhaled Nitric Oxide for the Adjunctive Therapy of Severe Malaria: a Randomized Controlled Trial

Severe Malaria

Uganda
Organicell Regenerative Medicine

Available

Expanded Access to Zofin for Patients With COVID-19

Covid19 | Acute Respiratory Distress Syndrome | Corona Virus Infection | SARS (Severe Acute Respiratory Syndrome)
Hospital de Clinicas de Porto Alegre
Universidade Federal do Rio de Janeiro; Pontifícia Universidade Católica do...

Recruiting

Cell Therapy Associated With Endobronchial Valve (CEL&VAL)

Chronic Obstructive Pulmonary Disease Severe

Brazil
Chiesi Farmaceutici S.p.A.

Completed

Phase II Study to Evaluate the Cardiac Safety of 2 Doses of CHF5993 Both Combined With CHF1535 BID Versus CHF1535 BID in Patients With Moderate to Severe COPD (CARSAF)

Moderate to Severe Chronic Obstructive Pulmonary Disease (COPD)

Bulgaria, Germany, Hungary, Poland, Russian Federation, United Kingdom
Bernhard Nocht Institute for Tropical Medicine
Institut National de la Santé Et de la Recherche Médicale, France; University... and other collaborators

Completed

Pharmacokinetics, Tolerability and Safety of Favipiravir Compared to Ribavirin for the Treatment of Lassa Fever (SAFARI)

Lassa Fever

Nigeria
National Institute of Respiratory Diseases, Mexico

Completed

Hydroxychloroquine Treatment for Severe COVID-19 Pulmonary Infection (HYDRA Trial) (HYDRA)

Severe Acute Respiratory Syndrome | COVID-19

Mexico
Dow University of Health Sciences
Higher Education Commission (Pakistan)

Completed

SARS-CoV-2 Antibodies Based IVIG Therapy for COVID-19 Patients

COVID-19

Pakistan
Irrua Specialist Teaching Hospital
University of Bordeaux; Médecins Sans Frontières, Belgium; ANRS, Emerging Infectious... and other collaborators

Not yet recruiting

ISTH/ANRS 0409s INTEGRATE Lassa Fever Study

Lassa Fever
University of Oxford

Completed

Cardiovascular Function and Ribavirin PK/PD in Lassa Fever in Lassa Fever

Lassa Fever

Nigeria
Centre Hospitalier Universitaire de Besancon

Unknown

Ventilatory Adaptation to Concentric Versus Eccentric Exercise in Patients With Severe COPD (CONvEX)

Chronic Obstructive Pulmonary Disease Severe

France
Assistance Publique - Hôpitaux de Paris

Completed

Work of Breathing in Bronchiolitis Under Non-invasive Ventilation (BRONCHIO-VNI)

Severe Viral Bronchiolitis

France
National Institute of Respiratory Diseases, Mexico

Completed

Hydroxychloroquine Chemoprophylaxis in Healthcare Personnel in Contact With COVID-19 Patients (PHYDRA Trial) (PHYDRA)

Severe Acute Respiratory Syndrome | COVID-19

Mexico
R-Pharm International, LLC
Data Management 365; K-Research, LLC

Completed

Study of the Efficacy and Safety of a Single Administration of Olokizumab and RPH-104 With Standard Therapy in Patients With Severe Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Infection (COVID-19)

COVID-19

Russian Federation
Versailles Hospital

Active, not recruiting

RT-PCR on Conjunctival Sample for the Detection of SARS-CoV-2 in Patients With Covid-19 (P20/09)

SARS-CoV Infection | Pinkeye

France
Institut Pasteur
Hôpital Lariboisière, AP-HP

Completed

Study of the Pathogenesis of Olfactory Disorders in COVID-19 (COVIDSMELL)

Severe Acute Respiratory Syndrome | Coronavirus Infection | Sars-CoV2

France
Mahidol University

Completed

Efficacy of HFNC Versus NIV for Prevent Reintubation in Sepsis Patients

Septic Shock | Severe Sepsis | Re-intubation | Post Extubation Respiratory Failure

Thailand
Novartis Pharmaceuticals
Genentech, Inc.

Completed

Observational and Epidemiologic Study of the Disease Course and Unmet Needs in Children With Symptomatic Moderate to Severe Allergic Asthma

Moderate to Severe Allergic Asthma

United States, Puerto Rico
Bluejay Diagnostics, Inc.

Recruiting

Symphony IL-6 Study in Patients at Risk of Severe Sepsis

Severe Sepsis

United States
Government Medical College, Bhavnagar

Completed

Controller Medications in the Management of Bronchial Asthma

Moderate to Severe Persistent Bronchial Asthma

India
Tripler Army Medical Center
U.S. Army Medical Research Acquisition Activity

Unknown

Asthma In-Home Monitoring (AIM) Trial

Mild, Moderate and Severe Persistent Asthma as Defined by NHLBI-2 Guidelines

United States
Pulmonx Corporation

Recruiting

Zephyr Valve Japan Post-Marketing Surveillance

Emphysema | COPD | Severe Emphysema

Japan
Pulmonx Corporation

Active, not recruiting

Fissure Closure With the AeriSeal System for CONVERTing Collateral Ventilation Status (CONVERT) (CONVERT)

Emphysema | COPD | Severe Emphysema

United Kingdom, France, Netherlands, Germany, Australia, Italy, Switzerland
Direction Centrale du Service de Santé des Armées

Recruiting

Recovery of Exertion Ability Following COVID-19 Infection in Military Staff (CovEx)

SARS-CoV Infection

France
University of Oxford
Bill and Melinda Gates Foundation; Department for International Development... and other collaborators

Recruiting

Randomised Evaluation of COVID-19 Therapy (RECOVERY)

Severe Acute Respiratory Syndrome

Ghana, Indonesia, Nepal, South Africa, United Kingdom, Vietnam, India
Zulekha Hospitals
Al-Azhar University

Completed

Effect of Early Implementation of Prone Positioning (prone)

Severe Acute Respiratory Syndrome

Egypt
National Taiwan University Hospital

Withdrawn

The Interaction Between Severe Acute Respiratory Distress Syndrome Viral Proteins and Monocytes

Severe Acute Respiratory Syndrome

China
University of Colorado, Denver
OpenBiome

Withdrawn

FMT as a Treatment for Severe Motility Disorder

Severe Motility Disorder
AstraZeneca
MedImmune LLC

Completed

Efficacy and Safety of Benralizumab in Moderate to Very Severe Chronic Obstructive Pulmonary Disease (COPD) With Exacerbation History (TERRANOVA)

Moderate to Very Severe Chronic Obstructive Pulmonary Disease

United States, Denmark, France, Sweden, Thailand, Vietnam, Belgium, Brazil, Peru, Philippines, Turkey, Taiwan, Argentina, Australia, Israel, Poland, Ukraine, Slovenia, Serbia, Mexico, Bulgaria, Colombia, New Zealand, Chile, Norway, Croatia
AstraZeneca
MedImmune LLC

Completed

Benralizumab Efficacy in Moderate to Very Severe Chronic Obstructive Pulmonary Disease (COPD) With Exacerbation History (GALATHEA)

Moderate to Very Severe Chronic Obstructive Pulmonary Disease

United States, Canada, Germany, Italy, Netherlands, Spain, United Kingdom, Poland, Japan, Austria, Korea, Republic of, Russian Federation, South Africa, Czechia, Hungary, Romania, Switzerland
Democritus University of Thrace

Recruiting

Combination of Inhaled DNase, Baricitinib and Tocilizumab in Severe COVID-19

COVID-19 Severe Respiratory Failure

Greece
National Institute of Allergy and Infectious Diseases...
The Emmes Company, LLC; US Military HIV Research Program

Completed

Clinical Trial of Ebola Vaccines cAd3-EBO, cAd3-EBOZ and MVA-EbolaZ in Healthy Adults in Uganda

Hemorrhagic Fever, Ebola

Uganda
Universitätsklinikum Hamburg-Eppendorf
University Hospital, Geneva; Wellcome Trust; KEMRI-Wellcome Trust Collaborative... and other collaborators

Completed

Phase I Trial to Assess the Safety, Tolerability and Immunogenicity of a Ebola Virus Vaccine (rVSVΔG-ZEBOV-GP)

Hemorrhagic Fever, Ebola

Germany
University Hospital for Infectious Diseases, Croatia

Unknown

Serum IL-6 and Soluble IL-6 Receptor in Severe COVID-19 Pneumonia Treated With Tocilizumab (UHID-COVID19)

COVID-19 | Severe Pneumonia

Croatia
Suzhou Connect Biopharmaceuticals, Ltd.

Completed

Efficacy and Safety of CBP-201 in Patients With Moderate to Severe Persistent Asthma With Type 2 Inflammation

Moderate to Severe Persistent Asthma

United States, China, Hungary, Korea, Republic of, Poland
Assistance Publique - Hôpitaux de Paris

Completed

Systematic Offer of Nurse-Driven Screening for COVID-19 in Emergency Departments in the Paris Metropolitan Area, DEPIST-COVID (DEPIST-COVID)

SARS-CoV Infection | Nurse's Role

France
Hospital Central Militar

Completed

Study on the Safety and Efficacy of Convalescent Plasma in Patients With Severe COVID-19 Disease (PC-COVID-HCM)

Severe COVID-19 Disease

Mexico
Poitiers University Hospital

Recruiting

Early High-flow Oxygen Therapy With nebuLized Beta-2-agonist Using a Vibrating Mesh for the Management of Moderate to Severe Asthma Exacerbation in the Emergency Department (EOLE)

Moderate Asthma Exacerbation | Severe Asthma Exacerbation

France
Sarepta Therapeutics, Inc.
United States Department of Defense

Completed

A Study to Assess the Safety, Tolerability and Pharmacokinetics of AVI-7288 in Healthy Adult Volunteers

Marburg Hemorrhagic Fever

United States
Hospital Universitario Ramon y Cajal

Recruiting

Pulmonary Inflammation in COVID-19 ARDS (IMPU-COVID)

COVID-19 Acute Respiratory Distress Syndrome | ARDS Due to Disease Caused by Severe Acute Respiratory Syndrome Coronavirus 2

Spain
Sanotize Research and Development corp.

Withdrawn

Nitric Oxide Releasing Solution to Treat and Prevent Exacerbation of Mild COVID-19 Infection

SARS-CoV Infection
Ridgeback Biotherapeutics, LP
Institut National de Recherche Biomédicale. Kinshasa, République Démocratique...

Available

Open-Label Expanded Access for Ebola-Infected Patients to Receive Human mAb Ansuvimab as Therapeutic or for HR PEP

Hemorrhagic Fever, Ebola

Congo, The Democratic Republic of the, Sierra Leone
Gamaleya Research Institute of Epidemiology and...

Completed

Open Study of the Duration of Immunity After Vaccination With GamEvac

Hemorrhagic Fever, Ebola

Russian Federation

Clinical Trials on Severe Respiratory Disease

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