Clinical Trials on Severe Combined Immunodeficiency Disease

Total 5548 results

Bristol-Myers Squibb

Completed

Phase IIIb Study to Evaluate the Effectiveness and Safety of Atazanavir/Ritonavir as Single Enhanced Protease Inhibitor Therapy in Human Immunodeficiency Virus (HIV)-Infected Subjects Evidencing Virologic Suppression (OREY)

Human Immunodeficiency Virus (HIV) Infections

Spain
Janssen Vaccines & Prevention B.V.
Bavarian Nordic GmbH

Terminated

Long-term Safety Follow-up of Participants Exposed to the Candidate Ebola Vaccines Ad26.ZEBOV and/or MVA-BN-Filo

Hemorrhagic Fever, Ebola

France, United Kingdom, Kenya, United States, Uganda, Burkina Faso, Tanzania
Janssen Vaccines & Prevention B.V.
Walter Reed Army Institute of Research (WRAIR)

Completed

Safety, Tolerability and Immunogenicity Study of 2-dose Heterologous Regimens for Ebola Vaccines Ad26.ZEBOV/MVA-BN-Filo

Hemorrhagic Fever, Ebola

United States, Uganda, Kenya, Mozambique, Nigeria, Tanzania
Centers for Disease Control and Prevention
Department of Health and Human Services; University of Sierra Leone; Ministry... and other collaborators

Completed

STRIVE (Sierra Leone Trial to Introduce a Vaccine Against Ebola) (STRIVE)

Hemorrhagic Fever, Ebola

Sierra Leone
Sarepta Therapeutics, Inc.
United States Department of Defense

Completed

Safety Study of Single Administration Post-exposure Prophylaxis Treatment for Marburg Virus

Marburg Hemorrhagic Fever

United States
Merck Sharp & Dohme LLC

Recruiting

Doravirine (DOR) in Human Immunodeficiency Virus (HIV)-Infected Children Ages 4 Weeks to <12 Years and <45 kg (MK-1439-066)

Human Immunodeficiency Virus (HIV) Infection

United States, Mexico, Russian Federation, South Africa, Thailand
AbbVie

Completed

Study to Assess Adverse Events and How Intravenous (IV) or Subcutaneous (SC) ABBV-382 Moves Through the Body of Adult Participants With Human Immuno-Deficiency Virus (HIV-1)

Human Immunodeficiency Virus (HIV)

United States, Puerto Rico
EMD Serono

Completed

Safety and Efficacy Study of Serostim® Human Immunodeficiency Virus-Associated Adipose Redistribution Syndrome

Human Immunodeficiency Virus-Associated Adipose Redistribution Syndrome

United States, Canada
National Human Genome Research Institute (NHGRI)

Completed

Developing Newborn Screening for Infants With Primary Immunodeficiency

Immune System Diseases

United States
First Affiliated Hospital of Zhejiang University

Completed

CD Patients Immune Status Evaluation

Severe Crohn's Diease

China
Emory University
National Institute of Allergy and Infectious Diseases (NIAID)

Enrolling by invitation

Characterization of Human Memory Immune Responses to Prior Yellow Fever Vaccination

Yellow Fever Vaccine

United States
University of Pennsylvania
National Institute of Mental Health (NIMH)

Completed

Being Responsible for Ourselves HIV Risk Reduction for Black MSM (BRO)

Sexually Transmitted Disease (STD) | Human Immunodeficiency Virus Infection (HIV)

United States
RTI International
Centers for Disease Control and Prevention

Completed

Positive Health Check Evaluation Trial ((PHC))

Human Immunodeficiency Virus (HIV) Positive

United States
Assistance Publique - Hôpitaux de Paris

Not yet recruiting

Composition and Function of Gut Microbiota in Porto-sinusoidal Vascular Disease Associated With Variable Common Immunodeficiency (MI-MVPS)

Vascular Diseases | Common Variable Immunodeficiency

France
ViiV Healthcare
GlaxoSmithKline

Completed

Dose Ranging Study of GSK1265744 Plus Nucleoside Reverse Transcriptase Inhibitors for Induction of Human Immunodeficiency Virus-1 (HIV-1) Virologic Suppression Followed by Virologic Suppression Maintenance by GSK1265744 Plus Rilpivirine

HIV Infections | Infection, Human Immunodeficiency Virus

United States, Canada
The Immunobiological Technology Institute (Bio-Manguinhos)...
Wellcome Trust

Unknown

Duration of Immunity 10 Years After a Dose-response Study With Yellow Fever Vaccine - Complementary Study

Yellow Fever Vaccine

Brazil
The Immunobiological Technology Institute (Bio-Manguinhos)...

Completed

Clinical Study of Immunity Duration of Yellow Fever Vaccine in Military

Yellow Fever Vaccine

Brazil
National Institute of Allergy and Infectious Diseases...

Completed

Experimental Ebola Vaccine Trial

Healthy | Hemorrhagic Fever, Ebola

United States
Sanofi Pasteur, a Sanofi Company

Active, not recruiting

Study on an Investigational Yellow Fever Vaccine Compared With YF-VAX in Adults in the USA (VYF02)

Yellow Fever (Healthy Volunteers)

United States
Fred Hutchinson Cancer Center
National Cancer Institute (NCI); National Heart, Lung, and Blood Institute...

Completed

Alemtuzumab, Fludarabine Phosphate, and Total-Body Irradiation Followed by a Donor Stem Cell Transplant in Treating Patients With Immunodeficiency or Other Nonmalignant Inherited Disorders

Immunodeficiency Syndrome | Non-Cancer Diagnosis

United States
Baxalta now part of Shire

Completed

Safety, Pharmacokinetic and Efficacy Study of a 10% Triple Virally Reduced Intravenous Immune Globulin Solution in Patients With Primary Immunodeficiency (Hypo- or Agammaglobulinemia)

Primary Immunodeficiency Diseases (PID) | Hypogammaglobulinemia | Agammaglobulinemia

Finland, Sweden
University of Maryland, Baltimore
National Institute of Allergy and Infectious Diseases (NIAID)

Completed

Ebola CVD-Mali #2000 (Bivalent) VRC-EBOAdc069-00-vp (cAd3-EBO)

Ebola Virus Disease | Hemorrhagic Fever

Mali
University of Maryland, Baltimore
National Institute of Allergy and Infectious Diseases (NIAID); Wellcome Trust; Leidos Biomedical Research, Inc...

Completed

Phase 1 Trial of Ebola Vaccine in Mali

Ebola Virus Disease | Hemorrhagic Fever

Mali
ViiV Healthcare
GlaxoSmithKline

Completed

Prospective Epidemiological Study Of The Prevalence Of HLAB*5701 In HIV-1 Infected Patients

Infection, Human Immunodeficiency Virus
Tibotec Pharmaceuticals, Ireland

Completed

A Study With TMC125 in Human Immunodeficiency Virus (HIV) Type 1 Infected Patients, Who Were Treated With TMC125 Arm in a Sponsor-Selected TMC125 Study

Human Immunodeficiency Virus Type 1
Abbott

Completed

Study of Lopinavir/Ritonavir Tablets Versus Soft Gel Capsules and Once Daily Versus Twice Daily Administration, When Coadministered With Nucleoside Reverse Transcriptase Inhibitors in Antiretroviral Naive Human Immunodeficiency Virus Type 1 Infected Subjects

Human Immunodeficiency Virus Infections

United States, Australia, Belgium, Canada, Czech Republic, France, Germany, Greece, Ireland, Italy, Netherlands, Poland, Puerto Rico, Russian Federation, Singapore, Spain, Switzerland, Taiwan, United Kingdom
Abbott

Completed

Study of Lopinavir/Ritonavir Tablets Comparing Once-Daily Versus Twice-Daily Administration When Coadministered With Nucleoside/Nucleotide Reverse Transcriptase Inhibitors in Antiretroviral-Experienced Human Immunodeficiency Virus Type 1 Infected Subjects

Human Immunodeficiency Virus Infections

United States
PATH
Bill and Melinda Gates Foundation; Centre National de Greffe de Moelle Osseuse and other collaborators

Not yet recruiting

Evaluation of an IgG Deficiency Rapid Screening Test: A Performance Study With Primary Immunodeficiency (PID) Patients in Tunisia

Primary Immunodeficiency Diseases

Tunisia
US Army Medical Research Institute of Infectious...

Completed

Study of the Safety and Immunogenicity of Reduced Doses of the US Yellow Fever Vaccine

Yellow Fever Vaccination Reaction

United States
Sanofi Pasteur, a Sanofi Company

Completed

Dose-ranging Study of an Investigational Yellow Fever Candidate Vaccine in Adults (VYF01)

Yellow Fever (Healthy Volunteers)

United States
U.S. Army Medical Research and Development Command
Walter Reed Army Institute of Research (WRAIR); US Army Medical Research Institute... and other collaborators

Completed

Phase 2a Immunogenicity Study of Hantaan/Puumala Virus DNA Vaccine for Prevention of Hemorrhagic Fever

Hemorrhagic Fever With Renal Syndrome

United States
U.S. Army Medical Research and Development Command

Enrolling by invitation

Ribavirin for Hemorrhagic Fever With Renal Syndrome

Hemorrhagic Fever With Renal Syndrome

Korea, Republic of
U.S. Army Medical Research and Development Command
Walter Reed Army Institute of Research (WRAIR); US Army Medical Research Institute... and other collaborators

Completed

Study to Evaluate the Safety, Tolerability, and Immunogenicity of Hantaan and Puumala Virus DNA Vaccines (HTNV/PUUV)

Hemorrhagic Fever With Renal Syndrome

United States
Tongji Hospital

Recruiting

Efficacy of Intravenous Immunoglobulin in Patients With Hemorrhagic Fever With Renal Syndrome: a Prospective Study

HFRS (Hemorrhagic Fever With Renal Syndrome)

China
National Institute of Allergy and Infectious Diseases...

Completed

Experimental Vaccine for Prevention of Ebola Virus Infection

Ebola Virus Disease | Ebola Hemorrhagic Fever | Ebola Virus Vaccines | Envelope Glycoprotein, Ebola Virus | Filovirus

United States
The Immunobiological Technology Institute (Bio-Manguinhos)...
Ministry of Health, Brazil

Active, not recruiting

Immunity Period After One Dose of Yellow Fever Vaccine in Adults and Children (Paraiba Study)

Immunity | Yellow Fever Vaccine

Brazil
PATH

Not yet recruiting

Developing a Screening Tool for Primary Immunodeficiency Disease (PID) in Pakistan

Primary Immunodeficiency Diseases

Pakistan
Octapharma
Premier Research Group plc

Completed

A Study of NewGam, Human Immunoglobulin 10%, in Patients With Primary Immunodeficiency Diseases

Primary Immunodeficiency Diseases

United States
Innogene Kalbiotech Pte. Ltd

Unknown

Effect of Hypertonic Sodium Lactate on sVCAM-1 Level as Surrogate Marker of Endothelial Capillary Leakage in Pediatric Dengue Shock Syndrome Patients (DSS)

Dengue Shock Syndrome

Indonesia
Ilocos Training and Regional Medical Center

Not yet recruiting

Effectiveness Of High Dose Melatonin As Adjunctive Therapy For Dengue Fever With Warning Signs

Dengue Fever With Warning Signs
University Children's Hospital, Zurich
University Hospital, Geneva; University Children's Hospital Basel

Recruiting

Genetic Study of Immunodeficiency: Search for New Genetic Causes for Primary Immunodeficiencies (GSI)

Immunologic Deficiency Syndromes

Switzerland
Prothya Biosolutions

Completed

Pharmacokinetics and Safety of IVIG Nanogam 100 mg/ml (Nanogam)

Primary Immunodeficiency

Netherlands
Solvay Pharmaceuticals

Completed

A Controlled-Study of Fenofibrate 145 mg and Ezetimibe 10 mg in Type IIb Dyslipidemic Patients With Features of the Metabolic Syndrome

Hyperlipidemia Combined

Belgium, France, Germany
ViiV Healthcare
Janssen Research and Development

Completed

A Sub-study of Cabotegravir (CAB) and Rilpivirine (RPV) in Human Immunodeficiency Viruses (HIV)-Infected Participants

Human Immunodeficiency Virus Type 1 (HIV-1)

Germany, Spain, United States, Italy, Canada, Argentina, Sweden
Abbott

Completed

Long-term Effectiveness and Safety in Hepatitis-co-infected Patients

Human Immunodeficiency Virus-Infection

Germany
U.S. Army Medical Research and Development Command

Withdrawn

Ribavirin for Hemorrhagic Fever With Renal Syndrome in Germany (HFRS)

Hemorrhagic Fever With Renal Syndrome

Germany
ViiV Healthcare
GlaxoSmithKline; Janssen Pharmaceuticals

Completed

A Phase IIb Study to Evaluate a Long-Acting Intramuscular Regimen for Maintenance of Virologic Suppression (Following Induction With an Oral Regimen of GSK1265744 and Abacavir/Lamivudine) in Human Immunodeficiency Virus Type 1 (HIV-1) Infected, Antiretroviral Therapy-Naive Adult Subjects

HIV Infections | Infection, Human Immunodeficiency Virus

Germany, Spain, France, United States, Canada
ViiV Healthcare
GlaxoSmithKline; PPD

Completed

An Efficacy, Safety, and Tolerability Study Comparing Dolutegravir Plus Lamivudine With Dolutegravir Plus Tenofovir/Emtricitabine in Treatment naïve HIV Infected Subjects (Gemini 1)

HIV Infections | Infection, Human Immunodeficiency Virus

Taiwan, France, Germany, Belgium, United States, Canada, Netherlands, Spain, Korea, Republic of, Italy, Australia, United Kingdom, Russian Federation, Portugal, Argentina, South Africa, Romania, Mexico
IMMUNOe Research Centers

Completed

A Study to Evaluate the Benefit of RUCONEST® in Subjects Who Experience ADRs Related to IVIG Infusions

CVI - Common Variable Immunodeficiency

United States
ViiV Healthcare
GlaxoSmithKline

Completed

Effect of Rifabutin on the Pharmacokinetics of Oral Cabotegravir in Healthy Subjects

HIV Infections | Infection, Human Immunodeficiency Virus

United Kingdom

Clinical Trials on Severe Combined Immunodeficiency Disease

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