Clinical Trials on Spinocerebellar Ataxia Type 4

Total 281 results

Murdoch Childrens Research Institute
Friedreich's Ataxia Research Alliance

Completed

A Study of Resveratrol as Treatment for Friedreich Ataxia

Friedreich Ataxia

Australia
Fondation Ophtalmologique Adolphe de Rothschild

Terminated

Genetic Factors of Idiopathic Polypoidal Vasculopathies in the ATM Gene (Ataxia Telangiectasia Mutated) (ATM)

Choroidal Neovascularization

France
University of Minnesota

Withdrawn

Biomarkers in Neurodegenerative Diseases

Mild Cognitive Impairment (MCI) | Amyotrophic Lateral Sclerosis (ALS) | Dementia With Lewy Bodies (DLB) | Alzheimer Disease (AD) | Frontotemporal Lobar Degeneration (FTLD) | Parkinsons Disease With Dementia (PDD) | Transient Epileptic Amnesia (TEA) | Temporal Lobe Epilepsy (TLE) | Spinocerebellar Ataxias... and other conditions

United States
Larimar Therapeutics, Inc.
Clinilabs, Inc.

Completed

Determine Range of Tissue Frataxin Concentrations and Other Potential Biomarkers

Healthy Volunteers | Friedreich Ataxia

United States
Lexeo Therapeutics

Recruiting

Gene Therapy for Cardiomyopathy Associated With Friedreich's Ataxia

Friedreich Ataxia | Cardiomyopathy, Secondary

United States, Canada
Johann Wolfgang Goethe University Hospital
CSL Behring

Completed

Susceptibility to Infections in Ataxia Telangiectasia

Infections | Lung Disease | Immunodeficiency | Ataxia Telangiectasia
CENTOGENE GmbH Rostock

Enrolling by invitation

Biomarker for Friedreich's Ataxia (BioFridA) (BioFridA)

Hereditary Diseases | FXN Gene | FRDA

Lebanon
Weill Medical College of Cornell University
National Heart, Lung, and Blood Institute (NHLBI)

Recruiting

Phase IA Study of AAVrh.10hFXN Gene Therapy for the Cardiomyopathy of Friedreich's Ataxia

Myocardial Fibrosis | Cardiomyopathies | Friedreich Ataxia | Cardiac Hypertrophy

United States
S. Andrea Hospital

Completed

Effect of Riluzole as a Symptomatic Approach in Patients With Chronic Cerebellar Ataxia

Multiple Sclerosis | Cerebellar Ataxia | Hereditary Ataxia

Italy
Imperial College London

Unknown

Effect of Nicotinamide in Friedreich's Ataxia

Neurodegenerative Disorders

United Kingdom
University of California, Los Angeles
University of South Florida; University of Rochester

Withdrawn

4-Aminopyridine in Episodic Ataxia Type 2 (4AP in EA2)

Episodic Ataxia Type 2

United States
University of Sao Paulo

Completed

Enalapril in Collagen Type 4 Nephropathy

Collagen Type-4 Nephropathies
University of Pittsburgh

Completed

Genetic and Environmental Determinants That Control Metabolism in Pulmonary Hypertension

Pulmonary Hypertension | Friedreich Ataxia | Iron-sulfur Cluster Deficiency

United States
Jose Luis Urcelay Segura

Unknown

Relationship Between Neurological Disability and Visual Impairment in Patients With ALS or Friedreich's Ataxia

Amyotrophic Lateral Sclerosis

Spain
H. Lee Moffitt Cancer Center and Research Institute

Recruiting

The Pancreas Interception Center (PIC) for Early Detection, Prevention, and Novel Therapeutics

Lynch Syndrome | Pancreatic Ductal Adenocarcinoma | Chronic Pancreatitis | Pancreatic Cyst | Ataxia Telangiectasia | FAP | Peutz-Jeghers Syndrome | PALB2 Gene Mutation | BRCA Mutation | Fatty Pancreas | Genetic Pancreatic Cancer | Genetic Pancreatitis | Familial Atypical Multiple Mole-Melanoma

United States
Prof. Dr. Cemil Tascıoglu Education and Research...

Completed

Pectoralis Major Pedicle Bone Graft For 4-Part Proximal Humerus Fractures

Patients With Closed Neer Type 4 Proximal Humerus Fractures

Turkey
Private Ortopedia Hospital, Seyhan Adana

Completed

The Results of Total Hip Arthroplasty in Crowe Type 4 Hips.

The Results of Total Hip Arthroplasty in Crowe Type 4 Dysplastic Hips

Turkey
University of Arkansas

Withdrawn

Pancreatic Cancer Screening of High-Risk Individuals in Arkansas

Pancreatic Neoplasms | Colorectal Neoplasms, Hereditary Nonpolyposis | BRCA1 Gene Mutation | BRCA2 Gene Mutation | Hereditary Pancreatitis | Ataxia Telangiectasia | Peutz-Jegher's Syndrome | Familial Atypical Mole-Malignant Melanoma Syndrome

United States
Ahmad Slim
GlaxoSmithKline

Terminated

Rosiglitazone And Fenofibrate Additive Effects on Lipids (RAFAEL) (RAFAEL)

Hypertriglyceridemia in Type 4 Hyperlipidemia | Non Diabetic Subjects With Normoglycemia

United States
Cairo University

Recruiting

Efficacy of Dual Task Training on Children With Ataxia After Medulloblastoma Resection

Medulloblastoma | Ataxia

Egypt
University Hospital Muenster
Isotope Technologies Munich (ITM) Oncologics; Helmholtz Zentrum München Deutsches...

Recruiting

Radioimmunotherapy With Lu-177 Labeled 6A10 Fab-fragments in Patients With Glioblastoma After Standard Treatment (RIT in GBM)

Glioblastom WHO Grade 4

Germany
Northern Sydney and Central Coast Area Health Service
Merck KGaA, Darmstadt, Germany

Unknown

Temozolomide and Procarbazine With Cilengitide for Patients With Glioblastoma Multiforme Without Methylation of the MGMT Promoter Gene (ExCentric)

Newly Diagnosed Non Methylated Glioblastoma Multiforme Grade 4

Australia
Dana-Farber Cancer Institute

Active, not recruiting

The Incidence of Adjacent Synchronous Ipsilateral Infiltrating Carcinoma and/or DCIS in Patients Diagnosed With Intraductal Papilloma Without Atypia or Flat Epithelial Atypia by Core Needle Biopsy

Flat Epithelia Atypia | Intraductal Papilloma Without Atypia

United States
Chinese PLA General Hospital

Unknown

Effects of a Dipeptidyl Peptidase-4 Inhibitor Sitagliptininsulin on the Progression of Coronary Atherosclerosis in Patients With Type 2 Diabetes

Atherosclerosis Type 2 Diabetes Mellitus Dipeptidyl Peptidase-4 Inhibitor GLP-1
Duke University
Genentech, Inc.

Completed

Bevacizumab Beyond Progression (BBP) (BBP)

Glioblastoma | Malignant Glioma | Gliosarcoma | Grade 4 Malignant Glioma

United States
Academic and Community Cancer Research United
National Cancer Institute (NCI)

Not yet recruiting

Retifanlimab With Bevacizumab and Hypofractionated Radiotherapy for the Treatment of Recurrent Glioblastoma

Recurrent Glioblastoma | Recurrent WHO Grade 4 Glioma

United States
Abramson Cancer Center of the University of Pennsylvania

Completed

Cardiovascular Effects of Sunitinib Therapy (CREST)

Renal Cell Carcinoma 4

United States
Rennes University Hospital

Completed

Analysis of the Modulation of Serum Hepcidin Level in Response to Iron Oral Intake: Potential Interest for the Differential Diagnosis Between Ferroportin Disease and Dysmetabolic Hepatosiderosis.

Diagnosis | Hemochromatosis, Type 4 | Ferroportin Disease | Dysmetabolic Hepatosiderosis

France
National Cancer Institute (NCI)

Suspended

A Study Testing the Effect of Immunotherapy (Ipilimumab and Nivolumab) in Patients With Recurrent Glioma With Elevated Mutational Burden

Diffuse Glioma | Secondary Glioblastoma | Glioblastoma, IDH-Wildtype | Astrocytoma, IDH-Mutant, Grade 4

United States, Puerto Rico
Lexicon Pharmaceuticals
Sanofi

Completed

A Study to Evaluate Safety and Effects of Sotagliflozin 400 and 200 mg on Glucose Control in Participants With Type 2 Diabetes, Severe Impairment of Kidney Function and Inadequate Blood Sugar Control (SOTA-CKD4)

Type 2 Diabetes Mellitus | Chronic Kidney Disease Stage 4

United States, Argentina, Brazil, Colombia, Germany, Hungary, Israel, Italy, Mexico, Poland, Romania, Russian Federation, South Africa, Spain, Ukraine
Marco Capogrosso
Roche-Genentech

Active, not recruiting

Spinal Cord Stimulation in Spinal Muscular Atrophy (SCSinSMA)

Spinal Muscular Atrophy Type 3 | Spinal Muscular Atrophy Type 4

United States
Mayo Clinic

Not yet recruiting

An Investigational Scan (Ga-68 PSMA-11 PET/CT) for Detection of Disease Recurrence or Progression in Patients With Glioma

WHO Grade 3 Glioma | WHO Grade 2 Glioma | WHO Grade 4 Glioma

United States
Children's Oncology Group
National Cancer Institute (NCI)

Active, not recruiting

Induction Therapy Including 131 I-MIBG and Chemotherapy in Treating Patients With Newly Diagnosed High-Risk Neuroblastoma Undergoing Stem Cell Transplant, Radiation Therapy, and Maintenance Therapy With Isotretinoin

Localized Resectable Neuroblastoma | Localized Unresectable Neuroblastoma | Regional Neuroblastoma | Stage 4S Neuroblastoma | Ganglioneuroblastoma | Stage 4 Neuroblastoma

United States
Children's Oncology Group
National Cancer Institute (NCI)

Recruiting

Biomarkers in Tumor Tissue Samples From Patients With Newly Diagnosed Neuroblastoma or Ganglioneuroblastoma

Localized Resectable Neuroblastoma | Localized Unresectable Neuroblastoma | Regional Neuroblastoma | Stage 4S Neuroblastoma | Ganglioneuroblastoma | Stage 4 Neuroblastoma

United States, Puerto Rico, Canada, Australia, New Zealand, Netherlands, Saudi Arabia, Switzerland
Children's Cancer Hospital Egypt 57357

Completed

Dual Task Training On Children With Ataxia After Medulloblastoma Resection

Medulloblastoma, Childhood | Childhood Cancer

Egypt
Children's Oncology Group
National Cancer Institute (NCI)

Completed

Genetic Analysis Using Blood or Bone Marrow From Participants With Neuroblastoma or Noncancerous Conditions

Recurrent Neuroblastoma | Localized Resectable Neuroblastoma | Localized Unresectable Neuroblastoma | Regional Neuroblastoma | Stage 4 Neuroblastoma

United States
National Cancer Institute (NCI)

Active, not recruiting

Isotretinoin With or Without Dinutuximab, Aldesleukin, and Sargramostim Following Stem Cell Transplant in Treating Patients With Neuroblastoma

Recurrent Neuroblastoma | Localized Resectable Neuroblastoma | Localized Unresectable Neuroblastoma | Regional Neuroblastoma | Stage 4S Neuroblastoma | Stage 4 Neuroblastoma

United States, Canada, Australia, New Zealand, Puerto Rico
Children's Oncology Group
National Cancer Institute (NCI)

Completed

Comparing Two Different Myeloablation Therapies in Treating Young Patients Who Are Undergoing a Stem Cell Transplant for High-Risk Neuroblastoma

Recurrent Neuroblastoma | Localized Resectable Neuroblastoma | Localized Unresectable Neuroblastoma | Regional Neuroblastoma | Stage 4S Neuroblastoma | Stage 4 Neuroblastoma

United States, Canada, Australia, New Zealand, Puerto Rico, Switzerland
National Medical Research Center for Therapy and...
Moscow State University of Medicine and Dentistry

Recruiting

Genetic Testing and Motivational Counseling for FH (GENMOTIV-FH)

Medication Adherence | Adherence, Medication | Treatment Adherence | Familial Hypercholesterolemia | Motivational Interviewing | Adherence, Patient | Treatment Adherence and Compliance | Patient Compliance | Adherence | Hypercholesterolemia, Familial | Patient Adherence | Hypercholesterolemia, Autosomal Dominant and other conditions

Russian Federation
National Institute of Neurological Disorders and...

Recruiting

Clinical Manifestations and Biomarkers in Amyotrophic Lateral Sclerosis Type 4 and Other Inherited Neurological Disorders of RNA Processing

Amyotrophic Lateral Sclerosis Type 4 | Inherited Neurological Disorders of RNA Processing

United States
Children's Oncology Group
National Cancer Institute (NCI)

Active, not recruiting

Busulfan, Melphalan, and Stem Cell Transplant After Chemotherapy in Treating Patients With Newly Diagnosed High-Risk Neuroblastoma

Stage 4S Neuroblastoma | Ganglioneuroblastoma | Stage 2A Neuroblastoma | Stage 2B Neuroblastoma | Stage 3 Neuroblastoma | Stage 4 Neuroblastoma | Stage 1 Neuroblastoma | Stage 2 Neuroblastoma

United States, Canada, Australia, New Zealand
Children's Oncology Group
National Cancer Institute (NCI)

Active, not recruiting

Late Effects After Treatment in Patients With Previously Diagnosed High-Risk Neuroblastoma

Recurrent Neuroblastoma | Stage 4S Neuroblastoma | Stage 2A Neuroblastoma | Stage 2B Neuroblastoma | Stage 3 Neuroblastoma | Stage 4 Neuroblastoma

United States, Canada, Australia, New Zealand
Burke Medical Research Institute

Active, not recruiting

Home Based Tele-exercise for People With Chronic Neurological Impairments (Telex)

Stroke | Multiple Sclerosis | Cerebral Palsy | Parkinson Disease | Spinal Cord Injuries | Neurologic Disorder | Hemiplegia | Hemiparesis | Friedreich Ataxia | Trauma, Brain | Transverse Myelitis

United States
Samus Therapeutics, Inc.

Terminated

Study of Icapamespib (PU-AD) in Patients With Recurrent Malignant Glioma (Glio)

Recurrent Glioblastoma Multiforme (GBM) | Grade 3 Isocitrate Dehydrogenase (IDH) Wildtype Astrocytoma | Grade 3 or 4 Astrocytoma | Glioblastoma Surgery

United States
Dr.Waleed Samir

Unknown

Impact of IL-28B rs12979860 and rs4803217 Gene Polymorphisms Associated With miRNAs Deregulation on HCV-related Hepatocellular Carcinoma

HCV Infection ( Genotype 4)

Egypt
Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University
Sun Yat-sen University

Not yet recruiting

Deep Learning-based sbORN Diagnostic Model

Nasopharyngeal Carcinoma | Herpesvirus 4, Human

China
Northwestern University
National Cancer Institute (NCI); BrainUp Inc

Not yet recruiting

Triapine in Combination With Temozolomide for the Treatment of Patients With Recurrent Glioblastoma

Recurrent WHO Grade 2 Glioma | Recurrent Glioblastoma, IDH-Wildtype | Recurrent WHO Grade 3 Glioma | Recurrent WHO Grade 4 Glioma

United States
Children's Oncology Group
National Cancer Institute (NCI)

Completed

Cyclophosphamide and Prednisone With or Without Immunoglobulin in Treating Abnormal Muscle Movement in Children With Neuroblastoma

Localized Resectable Neuroblastoma | Localized Unresectable Neuroblastoma | Regional Neuroblastoma | Stage 4S Neuroblastoma | Stage 4 Neuroblastoma

United States, Canada, Australia
National Cancer Institute (NCI)

Completed

Vorinostat and Isotretinoin in Treating Patients With High-Risk Refractory or Recurrent Neuroblastoma

Recurrent Neuroblastoma | Localized Unresectable Neuroblastoma | Regional Neuroblastoma | Stage 4S Neuroblastoma | Stage 4 Neuroblastoma

United States, Canada
National Cancer Institute (NCI)

Completed

Epidemiology of Burkitt Lymphoma in East Africa Children or Minors (EMBLEM)

Lymphoma, Non-Hodgkin | Malaria | Herpesvirus 4, Human

Tanzania, Uganda

Clinical Trials on Spinocerebellar Ataxia Type 4

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